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WDTC1 (WD and tetratricopeptide repeats 1)

Identity

Alias_symbol (synonym)KIAA1037
ADP
DCAF9
Other alias
HGNC (Hugo) WDTC1
LocusID (NCBI) 23038
Atlas_Id 54781
Location 1p36.11  [Link to chromosome band 1p36]
Location_base_pair Starts at 27561007 and ends at 27635124 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
ARID1A (1p36.11) / WDTC1 (1p36.11)BOLA2 (16p11.2) / WDTC1 (1p36.11)CAPG (2p11.2) / WDTC1 (1p36.11)
CRACR2B (11p15.5) / WDTC1 (1p36.11)FAM76A (1p35.3) / WDTC1 (1p36.11)LOC100507412 (-) / WDTC1 (1p36.11)
LTBR (12p13.31) / WDTC1 (1p36.11)PRKRIP1 (7q22.1) / WDTC1 (1p36.11)SLC7A13 (8q21.3) / WDTC1 (1p36.11)
SYTL1 (1p36.11) / WDTC1 (1p36.11)WDTC1 (1p36.11) / CD151 (11p15.5)WDTC1 (1p36.11) / CRACR2B (11p15.5)
WDTC1 (1p36.11) / PRKRIP1 (7q22.1)WDTC1 (1p36.11) / TMEM39B (1p35.1)FAM76A 1p35.3 / WDTC1 1p36.11
WDTC1 1p36.11 / TMEM39B 1p35.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  Lung: Translocations in Squamous Cell Carcinoma


External links

Nomenclature
HGNC (Hugo)WDTC1   29175
Cards
Entrez_Gene (NCBI)WDTC1  23038  WD and tetratricopeptide repeats 1
AliasesADP; DCAF9
GeneCards (Weizmann)WDTC1
Ensembl hg19 (Hinxton)ENSG00000142784 [Gene_View]  chr1:27561007-27635124 [Contig_View]  WDTC1 [Vega]
Ensembl hg38 (Hinxton)ENSG00000142784 [Gene_View]  chr1:27561007-27635124 [Contig_View]  WDTC1 [Vega]
ICGC DataPortalENSG00000142784
TCGA cBioPortalWDTC1
AceView (NCBI)WDTC1
Genatlas (Paris)WDTC1
WikiGenes23038
SOURCE (Princeton)WDTC1
Genetics Home Reference (NIH)WDTC1
Genomic and cartography
GoldenPath hg19 (UCSC)WDTC1  -     chr1:27561007-27635124 +  1p36.11   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)WDTC1  -     1p36.11   [Description]    (hg38-Dec_2013)
EnsemblWDTC1 - 1p36.11 [CytoView hg19]  WDTC1 - 1p36.11 [CytoView hg38]
Mapping of homologs : NCBIWDTC1 [Mapview hg19]  WDTC1 [Mapview hg38]
Gene and transcription
Genbank (Entrez)AB028960 AK001734 AK023101 AK023778 AK315564
RefSeq transcript (Entrez)NM_001276252 NM_015023
RefSeq genomic (Entrez)NC_000001 NC_018912 NT_032977 NW_004929289
Consensus coding sequences : CCDS (NCBI)WDTC1
Cluster EST : UnigeneHs.469154 [ NCBI ]
CGAP (NCI)Hs.469154
Alternative Splicing GalleryENSG00000142784
Gene ExpressionWDTC1 [ NCBI-GEO ]   WDTC1 [ EBI - ARRAY_EXPRESS ]   WDTC1 [ SEEK ]   WDTC1 [ MEM ]
Gene Expression Viewer (FireBrowse)WDTC1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)23038
GTEX Portal (Tissue expression)WDTC1
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ8N5D0   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ8N5D0  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ8N5D0
Splice isoforms : SwissVarQ8N5D0
PhosPhoSitePlusQ8N5D0
Domaine pattern : Prosite (Expaxy)TPR_REGION (PS50293)    WD_REPEATS_2 (PS50082)    WD_REPEATS_REGION (PS50294)   
Domains : Interpro (EBI)TPR-contain_dom    TPR-like_helical_dom    TPR_2    WD40/YVTN_repeat-like_dom    WD40_repeat    WD40_repeat_dom   
Domain families : Pfam (Sanger)TPR_11 (PF13414)    TPR_2 (PF07719)    WD40 (PF00400)   
Domain families : Pfam (NCBI)pfam13414    pfam07719    pfam00400   
Domain families : Smart (EMBL)WD40 (SM00320)  
Conserved Domain (NCBI)WDTC1
DMDM Disease mutations23038
Blocks (Seattle)WDTC1
PDB (SRS)3I7N   
PDB (PDBSum)3I7N   
PDB (IMB)3I7N   
PDB (RSDB)3I7N   
Structural Biology KnowledgeBase3I7N   
SCOP (Structural Classification of Proteins)3I7N   
CATH (Classification of proteins structures)3I7N   
SuperfamilyQ8N5D0
Human Protein AtlasENSG00000142784
Peptide AtlasQ8N5D0
HPRD10307
IPIIPI00186384   IPI00398202   IPI00398203   IPI00398204   IPI00398205   IPI00398206   IPI00985050   
Protein Interaction databases
DIP (DOE-UCLA)Q8N5D0
IntAct (EBI)Q8N5D0
FunCoupENSG00000142784
BioGRIDWDTC1
STRING (EMBL)WDTC1
ZODIACWDTC1
Ontologies - Pathways
QuickGOQ8N5D0
Ontology : AmiGOnegative regulation of transcription from RNA polymerase II promoter  in utero embryonic development  enzyme inhibitor activity  protein binding  nucleus  cytosol  glucose metabolic process  regulation of cell size  protein ubiquitination  cellular response to insulin stimulus  multicellular organism growth  histone binding  histone deacetylase binding  negative regulation of catalytic activity  negative regulation of fatty acid biosynthetic process  cellular chemical homeostasis  
Ontology : EGO-EBInegative regulation of transcription from RNA polymerase II promoter  in utero embryonic development  enzyme inhibitor activity  protein binding  nucleus  cytosol  glucose metabolic process  regulation of cell size  protein ubiquitination  cellular response to insulin stimulus  multicellular organism growth  histone binding  histone deacetylase binding  negative regulation of catalytic activity  negative regulation of fatty acid biosynthetic process  cellular chemical homeostasis  
NDEx NetworkWDTC1
Atlas of Cancer Signalling NetworkWDTC1
Wikipedia pathwaysWDTC1
Orthology - Evolution
OrthoDB23038
GeneTree (enSembl)ENSG00000142784
Phylogenetic Trees/Animal Genes : TreeFamWDTC1
HOVERGENQ8N5D0
HOGENOMQ8N5D0
Homologs : HomoloGeneWDTC1
Homology/Alignments : Family Browser (UCSC)WDTC1
Gene fusions - Rearrangements
Fusion : MitelmanARID1A/WDTC1 [1p36.11/1p36.11]  [t(1;1)(p36;p36)]  
Fusion : MitelmanCRACR2B/WDTC1 [11p15.5/1p36.11]  [t(1;11)(p36;p15)]  
Fusion : MitelmanFAM76A/WDTC1 [1p35.3/1p36.11]  [t(1;1)(p35;p36)]  
Fusion : MitelmanPRKRIP1/WDTC1 [7q22.1/1p36.11]  [t(1;7)(p36;q22)]  
Fusion : MitelmanSLC7A13/WDTC1 [8q21.3/1p36.11]  [t(1;8)(p36;q21)]  
Fusion : MitelmanWDTC1/CD151 [1p36.11/11p15.5]  [t(1;11)(p36;p15)]  
Fusion : MitelmanWDTC1/CRACR2B [1p36.11/11p15.5]  [t(1;11)(p36;p15)]  
Fusion : MitelmanWDTC1/PRKRIP1 [1p36.11/7q22.1]  [t(1;7)(p36;q22)]  
Fusion : MitelmanWDTC1/TMEM39B [1p36.11/1p35.1]  [t(1;1)(p35;p36)]  
Fusion: TCGAFAM76A 1p35.3 WDTC1 1p36.11 LUAD
Fusion: TCGAWDTC1 1p36.11 TMEM39B 1p35.1 HNSC
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerWDTC1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)WDTC1
dbVarWDTC1
ClinVarWDTC1
1000_GenomesWDTC1 
Exome Variant ServerWDTC1
ExAC (Exome Aggregation Consortium)WDTC1 (select the gene name)
Genetic variants : HAPMAP23038
Genomic Variants (DGV)WDTC1 [DGVbeta]
DECIPHER (Syndromes)1:27561007-27635124  ENSG00000142784
CONAN: Copy Number AnalysisWDTC1 
Mutations
ICGC Data PortalWDTC1 
TCGA Data PortalWDTC1 
Broad Tumor PortalWDTC1
OASIS PortalWDTC1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICWDTC1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDWDTC1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch WDTC1
DgiDB (Drug Gene Interaction Database)WDTC1
DoCM (Curated mutations)WDTC1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)WDTC1 (select a term)
intoGenWDTC1
Cancer3DWDTC1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM
Orphanet
MedgenWDTC1
Genetic Testing Registry WDTC1
NextProtQ8N5D0 [Medical]
TSGene23038
GENETestsWDTC1
Huge Navigator WDTC1 [HugePedia]
snp3D : Map Gene to Disease23038
BioCentury BCIQWDTC1
ClinGenWDTC1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD23038
Chemical/Pharm GKB GenePA134981539
Clinical trialWDTC1
Miscellaneous
canSAR (ICR)WDTC1 (select the gene name)
Probes
Litterature
PubMed24 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineWDTC1
EVEXWDTC1
GoPubMedWDTC1
iHOPWDTC1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Mar 14 13:34:12 CET 2017

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