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WEE1 (WEE1 G2 checkpoint kinase)

Identity

Alias_nameswee1 (S. pombe) homolog
WEE1 homolog (S. pombe)
Alias_symbol (synonym)WEE1A
Other aliasWEE1hu
HGNC (Hugo) WEE1
LocusID (NCBI) 7465
Atlas_Id 42807
Location 11p15.4  [Link to chromosome band 11p15]
Location_base_pair Starts at 9574687 and ends at 9589766 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
HEATR6 (17q23.1) / WEE1 (11p15.4)SWAP70 (11p15.4) / WEE1 (11p15.4)WEE1 (11p15.4) / MICU2 (13q12.11)
HEATR6 17q23.1 / WEE1 11p15.4SWAP70 11p15.4 / WEE1 11p15.4

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)WEE1   12761
Cards
Entrez_Gene (NCBI)WEE1  7465  WEE1 G2 checkpoint kinase
AliasesWEE1A; WEE1hu
GeneCards (Weizmann)WEE1
Ensembl hg19 (Hinxton)ENSG00000166483 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000166483 [Gene_View]  chr11:9574687-9589766 [Contig_View]  WEE1 [Vega]
ICGC DataPortalENSG00000166483
TCGA cBioPortalWEE1
AceView (NCBI)WEE1
Genatlas (Paris)WEE1
WikiGenes7465
SOURCE (Princeton)WEE1
Genetics Home Reference (NIH)WEE1
Genomic and cartography
GoldenPath hg38 (UCSC)WEE1  -     chr11:9574687-9589766 +  11p15.4   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)WEE1  -     11p15.4   [Description]    (hg19-Feb_2009)
EnsemblWEE1 - 11p15.4 [CytoView hg19]  WEE1 - 11p15.4 [CytoView hg38]
Mapping of homologs : NCBIWEE1 [Mapview hg19]  WEE1 [Mapview hg38]
OMIM193525   
Gene and transcription
Genbank (Entrez)AK122837 BC051831 BC070052 BQ024511 BX641032
RefSeq transcript (Entrez)NM_001143976 NM_003390
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)WEE1
Cluster EST : UnigeneHs.249441 [ NCBI ]
CGAP (NCI)Hs.249441
Alternative Splicing GalleryENSG00000166483
Gene ExpressionWEE1 [ NCBI-GEO ]   WEE1 [ EBI - ARRAY_EXPRESS ]   WEE1 [ SEEK ]   WEE1 [ MEM ]
Gene Expression Viewer (FireBrowse)WEE1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)7465
GTEX Portal (Tissue expression)WEE1
Protein : pattern, domain, 3D structure
UniProt/SwissProtP30291   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP30291  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP30291
Splice isoforms : SwissVarP30291
Catalytic activity : Enzyme2.7.10.2 [ Enzyme-Expasy ]   2.7.10.22.7.10.2 [ IntEnz-EBI ]   2.7.10.2 [ BRENDA ]   2.7.10.2 [ KEGG ]   
PhosPhoSitePlusP30291
Domaine pattern : Prosite (Expaxy)PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_ST (PS00108)   
Domains : Interpro (EBI)Kinase-like_dom    Prot_kinase_dom    Protein_kinase_ATP_BS    Ser/Thr_kinase_AS    Wee1-like_protein_kinase   
Domain families : Pfam (Sanger)Pkinase (PF00069)   
Domain families : Pfam (NCBI)pfam00069   
Domain families : Smart (EMBL)S_TKc (SM00220)  
Conserved Domain (NCBI)WEE1
DMDM Disease mutations7465
Blocks (Seattle)WEE1
PDB (SRS)1X8B    2IN6    2IO6    2Z2W    3BI6    3BIZ    3CQE    3CR0   
PDB (PDBSum)1X8B    2IN6    2IO6    2Z2W    3BI6    3BIZ    3CQE    3CR0   
PDB (IMB)1X8B    2IN6    2IO6    2Z2W    3BI6    3BIZ    3CQE    3CR0   
PDB (RSDB)1X8B    2IN6    2IO6    2Z2W    3BI6    3BIZ    3CQE    3CR0   
Structural Biology KnowledgeBase1X8B    2IN6    2IO6    2Z2W    3BI6    3BIZ    3CQE    3CR0   
SCOP (Structural Classification of Proteins)1X8B    2IN6    2IO6    2Z2W    3BI6    3BIZ    3CQE    3CR0   
CATH (Classification of proteins structures)1X8B    2IN6    2IO6    2Z2W    3BI6    3BIZ    3CQE    3CR0   
SuperfamilyP30291
Human Protein AtlasENSG00000166483
Peptide AtlasP30291
HPRD01907
IPIIPI00025830   IPI00921363   IPI00977499   IPI00976918   IPI00975892   IPI00978908   
Protein Interaction databases
DIP (DOE-UCLA)P30291
IntAct (EBI)P30291
FunCoupENSG00000166483
BioGRIDWEE1
STRING (EMBL)WEE1
ZODIACWEE1
Ontologies - Pathways
QuickGOP30291
Ontology : AmiGOG1/S transition of mitotic cell cycle  G2/M transition of mitotic cell cycle  microtubule cytoskeleton organization  magnesium ion binding  protein tyrosine kinase activity  non-membrane spanning protein tyrosine kinase activity  protein binding  ATP binding  nucleus  nucleoplasm  nucleolus  cytoplasm  kinase activity  peptidyl-tyrosine phosphorylation  establishment of cell polarity  neuron projection morphogenesis  cell division  regulation of cell cycle  
Ontology : EGO-EBIG1/S transition of mitotic cell cycle  G2/M transition of mitotic cell cycle  microtubule cytoskeleton organization  magnesium ion binding  protein tyrosine kinase activity  non-membrane spanning protein tyrosine kinase activity  protein binding  ATP binding  nucleus  nucleoplasm  nucleolus  cytoplasm  kinase activity  peptidyl-tyrosine phosphorylation  establishment of cell polarity  neuron projection morphogenesis  cell division  regulation of cell cycle  
Pathways : BIOCARTARB Tumor Suppressor/Checkpoint Signaling in response to DNA damage [Genes]    Cell Cycle: G2/M Checkpoint [Genes]    cdc25 and chk1 Regulatory Pathway in response to DNA damage [Genes]   
Pathways : KEGGCell cycle   
NDEx NetworkWEE1
Atlas of Cancer Signalling NetworkWEE1
Wikipedia pathwaysWEE1
Orthology - Evolution
OrthoDB7465
GeneTree (enSembl)ENSG00000166483
Phylogenetic Trees/Animal Genes : TreeFamWEE1
HOVERGENP30291
HOGENOMP30291
Homologs : HomoloGeneWEE1
Homology/Alignments : Family Browser (UCSC)WEE1
Gene fusions - Rearrangements
Fusion : MitelmanHEATR6/WEE1 [17q23.1/11p15.4]  [t(11;17)(p15;q23)]  
Fusion : MitelmanSWAP70/WEE1 [11p15.4/11p15.4]  [t(11;11)(p15;p15)]  
Fusion: TCGAHEATR6 17q23.1 WEE1 11p15.4 BRCA
Fusion: TCGASWAP70 11p15.4 WEE1 11p15.4 HNSC LUAD
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerWEE1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)WEE1
dbVarWEE1
ClinVarWEE1
1000_GenomesWEE1 
Exome Variant ServerWEE1
ExAC (Exome Aggregation Consortium)WEE1 (select the gene name)
Genetic variants : HAPMAP7465
Genomic Variants (DGV)WEE1 [DGVbeta]
DECIPHERWEE1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisWEE1 
Mutations
ICGC Data PortalWEE1 
TCGA Data PortalWEE1 
Broad Tumor PortalWEE1
OASIS PortalWEE1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICWEE1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDWEE1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch WEE1
DgiDB (Drug Gene Interaction Database)WEE1
DoCM (Curated mutations)WEE1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)WEE1 (select a term)
intoGenWEE1
Cancer3DWEE1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM193525   
Orphanet
MedgenWEE1
Genetic Testing Registry WEE1
NextProtP30291 [Medical]
TSGene7465
GENETestsWEE1
Target ValidationWEE1
Huge Navigator WEE1 [HugePedia]
snp3D : Map Gene to Disease7465
BioCentury BCIQWEE1
ClinGenWEE1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD7465
Chemical/Pharm GKB GenePA366
Clinical trialWEE1
Miscellaneous
canSAR (ICR)WEE1 (select the gene name)
Probes
Litterature
PubMed141 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineWEE1
EVEXWEE1
GoPubMedWEE1
iHOPWEE1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Aug 1 17:18:55 CEST 2017

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