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WFDC2 (WAP four-disulfide core domain 2)

Identity

Alias_symbol (synonym)HE4
WAP5
dJ461P17.6
EDDM4
Other alias
HGNC (Hugo) WFDC2
LocusID (NCBI) 10406
Atlas_Id 42808
Location 20q13.12  [Link to chromosome band 20q13]
Location_base_pair Starts at 45469754 and ends at 45481532 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
NUDT16 (3q22.1) / WFDC2 (20q13.12)WFDC2 (20q13.12) / PI3 (20q13.12)WFDC2 (20q13.12) / SCNN1G (16p12.2)
WFDC2 (20q13.12) / WFDC2 (20q13.12)WFDC2 20q13.12 / PI3 20q13.12

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  WFDC2/PI3 (20q13)

External links

Nomenclature
HGNC (Hugo)WFDC2   15939
Cards
Entrez_Gene (NCBI)WFDC2  10406  WAP four-disulfide core domain 2
AliasesEDDM4; HE4; WAP5; dJ461P17.6
GeneCards (Weizmann)WFDC2
Ensembl hg19 (Hinxton)ENSG00000101443 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000101443 [Gene_View]  ENSG00000101443 [Sequence]  chr20:45469754-45481532 [Contig_View]  WFDC2 [Vega]
ICGC DataPortalENSG00000101443
TCGA cBioPortalWFDC2
AceView (NCBI)WFDC2
Genatlas (Paris)WFDC2
WikiGenes10406
SOURCE (Princeton)WFDC2
Genetics Home Reference (NIH)WFDC2
Genomic and cartography
GoldenPath hg38 (UCSC)WFDC2  -     chr20:45469754-45481532 +  20q13.12   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)WFDC2  -     20q13.12   [Description]    (hg19-Feb_2009)
GoldenPathWFDC2 - 20q13.12 [CytoView hg19]  WFDC2 - 20q13.12 [CytoView hg38]
ImmunoBaseENSG00000101443
Mapping of homologs : NCBIWFDC2 [Mapview hg19]  WFDC2 [Mapview hg38]
OMIM617548   
Gene and transcription
Genbank (Entrez)AF330259 AF330260 AF330261 AF330262 AK225528
RefSeq transcript (Entrez)NM_006103 NM_080733 NM_080734 NM_080735 NM_080736
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)WFDC2
Cluster EST : UnigeneHs.2719 [ NCBI ]
CGAP (NCI)Hs.2719
Alternative Splicing GalleryENSG00000101443
Gene ExpressionWFDC2 [ NCBI-GEO ]   WFDC2 [ EBI - ARRAY_EXPRESS ]   WFDC2 [ SEEK ]   WFDC2 [ MEM ]
Gene Expression Viewer (FireBrowse)WFDC2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)10406
GTEX Portal (Tissue expression)WFDC2
Human Protein AtlasENSG00000101443-WFDC2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ14508   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ14508  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ14508
Splice isoforms : SwissVarQ14508
PhosPhoSitePlusQ14508
Domaine pattern : Prosite (Expaxy)WAP (PS51390)   
Domains : Interpro (EBI)Elafin-like_sf    WAP_dom   
Domain families : Pfam (Sanger)WAP (PF00095)   
Domain families : Pfam (NCBI)pfam00095   
Domain families : Smart (EMBL)WAP (SM00217)  
Conserved Domain (NCBI)WFDC2
DMDM Disease mutations10406
Blocks (Seattle)WFDC2
SuperfamilyQ14508
Human Protein Atlas [tissue]ENSG00000101443-WFDC2 [tissue]
Peptide AtlasQ14508
HPRD11684
IPIIPI00291488   IPI00103636   IPI00183629   IPI00103639   IPI00103633   IPI00853597   
Protein Interaction databases
DIP (DOE-UCLA)Q14508
IntAct (EBI)Q14508
FunCoupENSG00000101443
BioGRIDWFDC2
STRING (EMBL)WFDC2
ZODIACWFDC2
Ontologies - Pathways
QuickGOQ14508
Ontology : AmiGOendopeptidase inhibitor activity  serine-type endopeptidase inhibitor activity  cysteine-type endopeptidase inhibitor activity  extracellular space  proteolysis  spermatogenesis  negative regulation of endopeptidase activity  aspartic-type endopeptidase inhibitor activity  extracellular exosome  
Ontology : EGO-EBIendopeptidase inhibitor activity  serine-type endopeptidase inhibitor activity  cysteine-type endopeptidase inhibitor activity  extracellular space  proteolysis  spermatogenesis  negative regulation of endopeptidase activity  aspartic-type endopeptidase inhibitor activity  extracellular exosome  
NDEx NetworkWFDC2
Atlas of Cancer Signalling NetworkWFDC2
Wikipedia pathwaysWFDC2
Orthology - Evolution
OrthoDB10406
GeneTree (enSembl)ENSG00000101443
Phylogenetic Trees/Animal Genes : TreeFamWFDC2
HOGENOMQ14508
Homologs : HomoloGeneWFDC2
Homology/Alignments : Family Browser (UCSC)WFDC2
Gene fusions - Rearrangements
Fusion : MitelmanWFDC2/PI3 [20q13.12/20q13.12]  
Fusion PortalWFDC2 20q13.12 PI3 20q13.12 BRCA
Fusion : QuiverWFDC2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerWFDC2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)WFDC2
dbVarWFDC2
ClinVarWFDC2
1000_GenomesWFDC2 
Exome Variant ServerWFDC2
ExAC (Exome Aggregation Consortium)ENSG00000101443
GNOMAD BrowserENSG00000101443
Varsome BrowserWFDC2
Genetic variants : HAPMAP10406
Genomic Variants (DGV)WFDC2 [DGVbeta]
DECIPHERWFDC2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisWFDC2 
Mutations
ICGC Data PortalWFDC2 
TCGA Data PortalWFDC2 
Broad Tumor PortalWFDC2
OASIS PortalWFDC2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICWFDC2  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DWFDC2
Mutations and Diseases : HGMDWFDC2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch WFDC2
DgiDB (Drug Gene Interaction Database)WFDC2
DoCM (Curated mutations)WFDC2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)WFDC2 (select a term)
intoGenWFDC2
Cancer3DWFDC2(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM617548   
Orphanet
DisGeNETWFDC2
MedgenWFDC2
Genetic Testing Registry WFDC2
NextProtQ14508 [Medical]
TSGene10406
GENETestsWFDC2
Target ValidationWFDC2
Huge Navigator WFDC2 [HugePedia]
snp3D : Map Gene to Disease10406
BioCentury BCIQWFDC2
ClinGenWFDC2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD10406
Chemical/Pharm GKB GenePA38059
Clinical trialWFDC2
Miscellaneous
canSAR (ICR)WFDC2 (select the gene name)
DataMed IndexWFDC2
Probes
Litterature
PubMed169 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineWFDC2
EVEXWFDC2
GoPubMedWFDC2
iHOPWFDC2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed Nov 13 18:15:19 CET 2019
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