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WFDC2 (WAP four-disulfide core domain 2)

Identity

Other namesEDDM4
HE4
WAP5
dJ461P17.6
HGNC (Hugo) WFDC2
LocusID (NCBI) 10406
Atlas_Id 42808
Location 20q13.12
Location_base_pair Starts at 44098394 and ends at 44110172 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
NUDT16 (3q22.1) / WFDC2 (20q13.12)WFDC2 (20q13.12) / PI3 (20q13.12)WFDC2 (20q13.12) / SCNN1G (16p12.2)
WFDC2 (20q13.12) / WFDC2 (20q13.12)WFDC2 20q13.12 / PI3 20q13.12

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)WFDC2   15939
Cards
Entrez_Gene (NCBI)WFDC2  10406  WAP four-disulfide core domain 2
GeneCards (Weizmann)WFDC2
Ensembl hg19 (Hinxton)ENSG00000101443 [Gene_View]  chr20:44098394-44110172 [Contig_View]  WFDC2 [Vega]
Ensembl hg38 (Hinxton)ENSG00000101443 [Gene_View]  chr20:44098394-44110172 [Contig_View]  WFDC2 [Vega]
ICGC DataPortalENSG00000101443
TCGA cBioPortalWFDC2
AceView (NCBI)WFDC2
Genatlas (Paris)WFDC2
WikiGenes10406
SOURCE (Princeton)WFDC2
Genomic and cartography
GoldenPath hg19 (UCSC)WFDC2  -     chr20:44098394-44110172 +  20q13.12   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)WFDC2  -     20q13.12   [Description]    (hg38-Dec_2013)
EnsemblWFDC2 - 20q13.12 [CytoView hg19]  WFDC2 - 20q13.12 [CytoView hg38]
Mapping of homologs : NCBIWFDC2 [Mapview hg19]  WFDC2 [Mapview hg38]
Gene and transcription
Genbank (Entrez)AF330259 AF330260 AF330261 AF330262 AK225528
RefSeq transcript (Entrez)NM_006103 NM_080733 NM_080734 NM_080735 NM_080736
RefSeq genomic (Entrez)NC_000020 NC_018931 NT_011362 NW_004929418
Consensus coding sequences : CCDS (NCBI)WFDC2
Cluster EST : UnigeneHs.2719 [ NCBI ]
CGAP (NCI)Hs.2719
Alternative Splicing : Fast-db (Paris)GSHG0018784
Alternative Splicing GalleryENSG00000101443
Gene ExpressionWFDC2 [ NCBI-GEO ]   WFDC2 [ EBI - ARRAY_EXPRESS ]   WFDC2 [ SEEK ]   WFDC2 [ MEM ]
Gene Expression Viewer (FireBrowse)WFDC2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
BioGPS (Tissue expression)10406
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ14508 (Uniprot)
NextProtQ14508  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ14508
Splice isoforms : SwissVarQ14508 (Swissvar)
PhosPhoSitePlusQ14508
Domaine pattern : Prosite (Expaxy)WAP (PS51390)   
Domains : Interpro (EBI)WAP_dom   
Domain families : Pfam (Sanger)WAP (PF00095)   
Domain families : Pfam (NCBI)pfam00095   
Domain families : Smart (EMBL)WAP (SM00217)  
DMDM Disease mutations10406
Blocks (Seattle)WFDC2
SuperfamilyQ14508
Human Protein AtlasENSG00000101443
Peptide AtlasQ14508
HPRD11684
IPIIPI00291488   IPI00103636   IPI00183629   IPI00103639   IPI00103633   IPI00853597   
Protein Interaction databases
DIP (DOE-UCLA)Q14508
IntAct (EBI)Q14508
FunCoupENSG00000101443
BioGRIDWFDC2
STRING (EMBL)WFDC2
ZODIACWFDC2
Ontologies - Pathways
QuickGOQ14508
Ontology : AmiGOendopeptidase inhibitor activity  serine-type endopeptidase inhibitor activity  cysteine-type endopeptidase inhibitor activity  extracellular space  proteolysis  spermatogenesis  negative regulation of endopeptidase activity  negative regulation of endopeptidase activity  negative regulation of endopeptidase activity  aspartic-type endopeptidase inhibitor activity  extracellular exosome  
Ontology : EGO-EBIendopeptidase inhibitor activity  serine-type endopeptidase inhibitor activity  cysteine-type endopeptidase inhibitor activity  extracellular space  proteolysis  spermatogenesis  negative regulation of endopeptidase activity  negative regulation of endopeptidase activity  negative regulation of endopeptidase activity  aspartic-type endopeptidase inhibitor activity  extracellular exosome  
NDEx Network
Atlas of Cancer Signalling NetworkWFDC2
Wikipedia pathwaysWFDC2
Orthology - Evolution
OrthoDB10406
GeneTree (enSembl)ENSG00000101443
Phylogenetic Trees/Animal Genes : TreeFamWFDC2
Homologs : HomoloGeneWFDC2
Homology/Alignments : Family Browser (UCSC)WFDC2
Gene fusions - Rearrangements
Fusion: TCGAWFDC2 20q13.12 PI3 20q13.12 BRCA
Polymorphisms : SNP, variants
NCBI Variation ViewerWFDC2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)WFDC2
dbVarWFDC2
ClinVarWFDC2
1000_GenomesWFDC2 
Exome Variant ServerWFDC2
ExAC (Exome Aggregation Consortium)WFDC2 (select the gene name)
SNP (GeneSNP Utah)WFDC2
SNP : HGBaseWFDC2
Genetic variants : HAPMAPWFDC2
Genomic Variants (DGV)WFDC2 [DGVbeta]
Mutations
ICGC Data PortalWFDC2 
TCGA Data PortalWFDC2 
Broad Tumor PortalWFDC2
OASIS PortalWFDC2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICWFDC2 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch WFDC2
DgiDB (Drug Gene Interaction Database)WFDC2
DoCM (Curated mutations)WFDC2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)WFDC2 (select a term)
intoGenWFDC2
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)20:44098394-44110172
CONAN: Copy Number AnalysisWFDC2 
Mutations and Diseases : HGMDWFDC2
OMIM
MedgenWFDC2
Genetic Testing Registry WFDC2
NextProtQ14508 [Medical]
TSGene10406
GENETestsWFDC2
Huge Navigator WFDC2 [HugePedia]  WFDC2 [HugeCancerGEM]
snp3D : Map Gene to Disease10406
BioCentury BCIQWFDC2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD10406
Chemical/Pharm GKB GenePA38059
Clinical trialWFDC2
Miscellaneous
canSAR (ICR)WFDC2 (select the gene name)
Probes
Litterature
PubMed108 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineWFDC2
GoPubMedWFDC2
iHOPWFDC2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Sat Apr 16 18:10:01 CEST 2016

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