WFDC2 (WAP four-disulfide core domain 2)

2003-06-01  

Identity

HGNC
LOCATION
20q13.12
LOCUSID
ALIAS
EDDM4,HE4,WAP5,dJ461P17.6
FUSION GENES

Other Information

Locus ID:

NCBI: 10406
MIM: 617548
HGNC: 15939
Ensembl: ENSG00000101443

Variants:

dbSNP: 10406
ClinVar: 10406
TCGA: ENSG00000101443
COSMIC: WFDC2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000101443ENST00000217425Q14508
ENSG00000101443ENST00000339946Q14508
ENSG00000101443ENST00000342873Q14508
ENSG00000101443ENST00000372676Q14508
ENSG00000101443ENST00000372676A0A384MTN6
ENSG00000101443ENST00000447118A8K2M3

Expression (GTEx)

0
100
200
300
400
500
600
700
800

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
128399612003The HE4 (WFDC2) protein is a biomarker for ovarian carcinoma.185
157816272005Human epididymis protein 4 (HE4) is a secreted glycoprotein that is overexpressed by serous and endometrioid ovarian carcinomas.135
193372522009Serum HE4 concentration differentiates malignant ovarian tumours from ovarian endometriotic cysts.60
233535562013Identification of human epididymis protein-4 as a fibroblast-derived mediator of fibrosis.44
166000322006WFDC2 (HE4): a potential role in the innate immunity of the oral cavity and respiratory tract and the development of adenocarcinomas of the lung.35
197320032009HE4 as a biomarker for ovarian and endometrial cancer management.35
222849612012Serum HE4 levels are less frequently elevated than CA125 in women with benign gynecologic disorders.35
185466152008SMRP and HE4 as biomarkers for ovarian carcinoma when used alone and in combination with CA125 and/or each other.32
234267162013Serum human epididymis protein 4 vs carbohydrate antigen 125 for ovarian cancer diagnosis: a systematic review.31
223014402012Serum levels of the ovarian cancer biomarker HE4 are decreased in pregnancy and increase with age.30

Citation

Dessen P

WFDC2 (WAP four-disulfide core domain 2)

Atlas Genet Cytogenet Oncol Haematol. 2003-06-01

Online version: http://atlasgeneticsoncology.org/gene/42808/wfdc2