Atlas of Genetics and Cytogenetics in Oncology and Haematology


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WFIKKN1 (WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 1)

Identity

Alias_namesC16orf12
chromosome 16 open reading frame 12
Alias_symbol (synonym)RJD2
WFIKKN
WFDC20A
Other alias
HGNC (Hugo) WFIKKN1
LocusID (NCBI) 117166
Atlas_Id 75757
Location 16p13.3  [Link to chromosome band 16p13]
Location_base_pair Starts at 681012 and ends at 684116 bp from pter ( according to hg19-Feb_2009)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)WFIKKN1   30912
Cards
Entrez_Gene (NCBI)WFIKKN1  117166  WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 1
AliasesC16orf12; RJD2; WFDC20A; WFIKKN
GeneCards (Weizmann)WFIKKN1
Ensembl hg19 (Hinxton)ENSG00000127578 [Gene_View]  chr16:681012-684116 [Contig_View]  WFIKKN1 [Vega]
Ensembl hg38 (Hinxton)ENSG00000127578 [Gene_View]  chr16:681012-684116 [Contig_View]  WFIKKN1 [Vega]
ICGC DataPortalENSG00000127578
TCGA cBioPortalWFIKKN1
AceView (NCBI)WFIKKN1
Genatlas (Paris)WFIKKN1
WikiGenes117166
SOURCE (Princeton)WFIKKN1
Genetics Home Reference (NIH)WFIKKN1
Genomic and cartography
GoldenPath hg19 (UCSC)WFIKKN1  -     chr16:681012-684116 +  16p13.3   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)WFIKKN1  -     16p13.3   [Description]    (hg38-Dec_2013)
EnsemblWFIKKN1 - 16p13.3 [CytoView hg19]  WFIKKN1 - 16p13.3 [CytoView hg38]
Mapping of homologs : NCBIWFIKKN1 [Mapview hg19]  WFIKKN1 [Mapview hg38]
OMIM608021   
Gene and transcription
Genbank (Entrez)AF422194 AK075356 AK128777 AK314757 BC101602
RefSeq transcript (Entrez)NM_053284
RefSeq genomic (Entrez)NC_000016 NC_018927 NT_010393 NW_004929400
Consensus coding sequences : CCDS (NCBI)WFIKKN1
Cluster EST : UnigeneHs.345818 [ NCBI ]
CGAP (NCI)Hs.345818
Alternative Splicing GalleryENSG00000127578
Gene ExpressionWFIKKN1 [ NCBI-GEO ]   WFIKKN1 [ EBI - ARRAY_EXPRESS ]   WFIKKN1 [ SEEK ]   WFIKKN1 [ MEM ]
Gene Expression Viewer (FireBrowse)WFIKKN1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)117166
GTEX Portal (Tissue expression)WFIKKN1
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ96NZ8   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ96NZ8  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ96NZ8
Splice isoforms : SwissVarQ96NZ8
PhosPhoSitePlusQ96NZ8
Domaine pattern : Prosite (Expaxy)BPTI_KUNITZ_1 (PS00280)    BPTI_KUNITZ_2 (PS50279)    IG_LIKE (PS50835)    KAZAL_2 (PS51465)    NTR (PS50189)    WAP (PS51390)   
Domains : Interpro (EBI)Ig-like_dom    Ig-like_fold    Ig_I-set    Ig_sub2    Kazal_dom    Netrin_domain    Netrin_module_non-TIMP    Prot_inh_Kunz-m    Prtase_inh_Kunz-CS    TIMP-like_OB-fold    WAP   
Domain families : Pfam (Sanger)I-set (PF07679)    Kazal_2 (PF07648)    Kunitz_BPTI (PF00014)    NTR (PF01759)    WAP (PF00095)   
Domain families : Pfam (NCBI)pfam07679    pfam07648    pfam00014    pfam01759    pfam00095   
Domain families : Smart (EMBL)IGc2 (SM00408)  KAZAL (SM00280)  KU (SM00131)  WAP (SM00217)  
Conserved Domain (NCBI)WFIKKN1
DMDM Disease mutations117166
Blocks (Seattle)WFIKKN1
PDB (SRS)2DDI    2DDJ   
PDB (PDBSum)2DDI    2DDJ   
PDB (IMB)2DDI    2DDJ   
PDB (RSDB)2DDI    2DDJ   
Structural Biology KnowledgeBase2DDI    2DDJ   
SCOP (Structural Classification of Proteins)2DDI    2DDJ   
CATH (Classification of proteins structures)2DDI    2DDJ   
SuperfamilyQ96NZ8
Human Protein AtlasENSG00000127578
Peptide AtlasQ96NZ8
HPRD12153
IPIIPI00044004   
Protein Interaction databases
DIP (DOE-UCLA)Q96NZ8
IntAct (EBI)Q96NZ8
FunCoupENSG00000127578
BioGRIDWFIKKN1
STRING (EMBL)WFIKKN1
ZODIACWFIKKN1
Ontologies - Pathways
QuickGOQ96NZ8
Ontology : AmiGOskeletal system development  serine-type endopeptidase inhibitor activity  protein binding  extracellular region  metalloendopeptidase inhibitor activity  negative regulation of endopeptidase activity  negative regulation of protein binding  negative regulation of DNA binding  muscle fiber development  palate development  
Ontology : EGO-EBIskeletal system development  serine-type endopeptidase inhibitor activity  protein binding  extracellular region  metalloendopeptidase inhibitor activity  negative regulation of endopeptidase activity  negative regulation of protein binding  negative regulation of DNA binding  muscle fiber development  palate development  
NDEx NetworkWFIKKN1
Atlas of Cancer Signalling NetworkWFIKKN1
Wikipedia pathwaysWFIKKN1
Orthology - Evolution
OrthoDB117166
GeneTree (enSembl)ENSG00000127578
Phylogenetic Trees/Animal Genes : TreeFamWFIKKN1
HOVERGENQ96NZ8
HOGENOMQ96NZ8
Homologs : HomoloGeneWFIKKN1
Homology/Alignments : Family Browser (UCSC)WFIKKN1
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerWFIKKN1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)WFIKKN1
dbVarWFIKKN1
ClinVarWFIKKN1
1000_GenomesWFIKKN1 
Exome Variant ServerWFIKKN1
ExAC (Exome Aggregation Consortium)WFIKKN1 (select the gene name)
Genetic variants : HAPMAP117166
Genomic Variants (DGV)WFIKKN1 [DGVbeta]
DECIPHER (Syndromes)16:681012-684116  ENSG00000127578
CONAN: Copy Number AnalysisWFIKKN1 
Mutations
ICGC Data PortalWFIKKN1 
TCGA Data PortalWFIKKN1 
Broad Tumor PortalWFIKKN1
OASIS PortalWFIKKN1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICWFIKKN1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDWFIKKN1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch WFIKKN1
DgiDB (Drug Gene Interaction Database)WFIKKN1
DoCM (Curated mutations)WFIKKN1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)WFIKKN1 (select a term)
intoGenWFIKKN1
Cancer3DWFIKKN1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM608021   
Orphanet
MedgenWFIKKN1
Genetic Testing Registry WFIKKN1
NextProtQ96NZ8 [Medical]
TSGene117166
GENETestsWFIKKN1
Huge Navigator WFIKKN1 [HugePedia]
snp3D : Map Gene to Disease117166
BioCentury BCIQWFIKKN1
ClinGenWFIKKN1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD117166
Chemical/Pharm GKB GenePA134897686
Clinical trialWFIKKN1
Miscellaneous
canSAR (ICR)WFIKKN1 (select the gene name)
Probes
Litterature
PubMed11 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineWFIKKN1
EVEXWFIKKN1
GoPubMedWFIKKN1
iHOPWFIKKN1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Mar 14 12:51:45 CET 2017

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