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WFIKKN1 (WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 1)

Identity

Other aliasC16orf12
RJD2
WFDC20A
WFIKKN
HGNC (Hugo) WFIKKN1
LocusID (NCBI) 117166
Atlas_Id 57054
Location 16p13.3  [Link to chromosome band 16p13]
Location_base_pair Starts at 631254 and ends at 634105 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)WFIKKN1   30912
Cards
Entrez_Gene (NCBI)WFIKKN1  117166  WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 1
AliasesC16orf12; RJD2; WFDC20A; WFIKKN
GeneCards (Weizmann)WFIKKN1
Ensembl hg19 (Hinxton) [Gene_View]
Ensembl hg38 (Hinxton) [Gene_View]  chr16:631254-634105 [Contig_View]  WFIKKN1 [Vega]
TCGA cBioPortalWFIKKN1
AceView (NCBI)WFIKKN1
Genatlas (Paris)WFIKKN1
WikiGenes117166
SOURCE (Princeton)WFIKKN1
Genetics Home Reference (NIH)WFIKKN1
Genomic and cartography
GoldenPath hg38 (UCSC)WFIKKN1  -     chr16:631254-634105 +  16p13.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)WFIKKN1  -     16p13.3   [Description]    (hg19-Feb_2009)
EnsemblWFIKKN1 - 16p13.3 [CytoView hg19]  WFIKKN1 - 16p13.3 [CytoView hg38]
Mapping of homologs : NCBIWFIKKN1 [Mapview hg19]  WFIKKN1 [Mapview hg38]
OMIM608021   
Gene and transcription
Genbank (Entrez)AF422194 AK075356 AK128777 AK314757 BC101602
RefSeq transcript (Entrez)NM_053284
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)WFIKKN1
Cluster EST : UnigeneHs.345818 [ NCBI ]
CGAP (NCI)Hs.345818
Gene ExpressionWFIKKN1 [ NCBI-GEO ]   WFIKKN1 [ EBI - ARRAY_EXPRESS ]   WFIKKN1 [ SEEK ]   WFIKKN1 [ MEM ]
Gene Expression Viewer (FireBrowse)WFIKKN1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)117166
GTEX Portal (Tissue expression)WFIKKN1
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ96NZ8   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ96NZ8  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ96NZ8
Splice isoforms : SwissVarQ96NZ8
PhosPhoSitePlusQ96NZ8
Domaine pattern : Prosite (Expaxy)BPTI_KUNITZ_1 (PS00280)    BPTI_KUNITZ_2 (PS50279)    IG_LIKE (PS50835)    KAZAL_2 (PS51465)    NTR (PS50189)    WAP (PS51390)   
Domains : Interpro (EBI)Ig-like_dom    Ig-like_fold    Ig_sub    Ig_sub2    Kazal_dom    Kunitz_BPTI    Netrin_domain    Prtase_inh_Kunz-CS    TIMP-like_OB-fold    WAP_dom    WFIKKN1   
Domain families : Pfam (Sanger)Kazal_2 (PF07648)    Kunitz_BPTI (PF00014)    WAP (PF00095)   
Domain families : Pfam (NCBI)pfam07648    pfam00014    pfam00095   
Domain families : Smart (EMBL)IG (SM00409)  IGc2 (SM00408)  KU (SM00131)  WAP (SM00217)  
Conserved Domain (NCBI)WFIKKN1
DMDM Disease mutations117166
Blocks (Seattle)WFIKKN1
PDB (SRS)2DDI    2DDJ   
PDB (PDBSum)2DDI    2DDJ   
PDB (IMB)2DDI    2DDJ   
PDB (RSDB)2DDI    2DDJ   
Structural Biology KnowledgeBase2DDI    2DDJ   
SCOP (Structural Classification of Proteins)2DDI    2DDJ   
CATH (Classification of proteins structures)2DDI    2DDJ   
SuperfamilyQ96NZ8
Peptide AtlasQ96NZ8
IPIIPI00044004   
Protein Interaction databases
DIP (DOE-UCLA)Q96NZ8
IntAct (EBI)Q96NZ8
BioGRIDWFIKKN1
STRING (EMBL)WFIKKN1
ZODIACWFIKKN1
Ontologies - Pathways
QuickGOQ96NZ8
Ontology : AmiGOskeletal system development  serine-type endopeptidase inhibitor activity  protein binding  extracellular region  metalloendopeptidase inhibitor activity  negative regulation of endopeptidase activity  negative regulation of transforming growth factor beta receptor signaling pathway  negative regulation of protein binding  negative regulation of DNA binding  receptor antagonist activity  muscle fiber development  transforming growth factor beta binding  palate development  extracellular negative regulation of signal transduction  
Ontology : EGO-EBIskeletal system development  serine-type endopeptidase inhibitor activity  protein binding  extracellular region  metalloendopeptidase inhibitor activity  negative regulation of endopeptidase activity  negative regulation of transforming growth factor beta receptor signaling pathway  negative regulation of protein binding  negative regulation of DNA binding  receptor antagonist activity  muscle fiber development  transforming growth factor beta binding  palate development  extracellular negative regulation of signal transduction  
NDEx NetworkWFIKKN1
Atlas of Cancer Signalling NetworkWFIKKN1
Wikipedia pathwaysWFIKKN1
Orthology - Evolution
OrthoDB117166
Phylogenetic Trees/Animal Genes : TreeFamWFIKKN1
HOVERGENQ96NZ8
HOGENOMQ96NZ8
Homologs : HomoloGeneWFIKKN1
Homology/Alignments : Family Browser (UCSC)WFIKKN1
Gene fusions - Rearrangements
Tumor Fusion PortalWFIKKN1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerWFIKKN1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)WFIKKN1
dbVarWFIKKN1
ClinVarWFIKKN1
1000_GenomesWFIKKN1 
Exome Variant ServerWFIKKN1
ExAC (Exome Aggregation Consortium)
Genetic variants : HAPMAP117166
Genomic Variants (DGV)WFIKKN1 [DGVbeta]
DECIPHERWFIKKN1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisWFIKKN1 
Mutations
ICGC Data PortalWFIKKN1 
TCGA Data PortalWFIKKN1 
Broad Tumor PortalWFIKKN1
OASIS PortalWFIKKN1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICWFIKKN1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDWFIKKN1
BioMutasearch WFIKKN1
DgiDB (Drug Gene Interaction Database)WFIKKN1
DoCM (Curated mutations)WFIKKN1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)WFIKKN1 (select a term)
intoGenWFIKKN1
Cancer3DWFIKKN1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM608021   
Orphanet
DisGeNETWFIKKN1
MedgenWFIKKN1
Genetic Testing Registry WFIKKN1
NextProtQ96NZ8 [Medical]
TSGene117166
GENETestsWFIKKN1
Target ValidationWFIKKN1
Huge Navigator WFIKKN1 [HugePedia]
snp3D : Map Gene to Disease117166
BioCentury BCIQWFIKKN1
ClinGenWFIKKN1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD117166
Chemical/Pharm GKB GenePA134897686
Clinical trialWFIKKN1
Miscellaneous
canSAR (ICR)WFIKKN1 (select the gene name)
Probes
Litterature
PubMed12 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineWFIKKN1
EVEXWFIKKN1
GoPubMedWFIKKN1
iHOPWFIKKN1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Nov 20 21:06:20 CET 2017

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