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WFIKKN2 (WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2)

Identity

Alias_symbol (synonym)WFIKKNRP
WFDC20B
Other aliasGASP-1
hGASP-1
HGNC (Hugo) WFIKKN2
LocusID (NCBI) 124857
Atlas_Id 50420
Location 17q21.33  [Link to chromosome band 17q21]
Location_base_pair Starts at 48912605 and ends at 48919709 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
WFIKKN2 (17q21.33) / SFTPB (2p11.2)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)WFIKKN2   30916
Cards
Entrez_Gene (NCBI)WFIKKN2  124857  WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2
AliasesGASP-1; WFDC20B; WFIKKNRP; hGASP-1
GeneCards (Weizmann)WFIKKN2
Ensembl hg19 (Hinxton)ENSG00000173714 [Gene_View]  chr17:48912605-48919709 [Contig_View]  WFIKKN2 [Vega]
Ensembl hg38 (Hinxton)ENSG00000173714 [Gene_View]  chr17:48912605-48919709 [Contig_View]  WFIKKN2 [Vega]
ICGC DataPortalENSG00000173714
TCGA cBioPortalWFIKKN2
AceView (NCBI)WFIKKN2
Genatlas (Paris)WFIKKN2
WikiGenes124857
SOURCE (Princeton)WFIKKN2
Genetics Home Reference (NIH)WFIKKN2
Genomic and cartography
GoldenPath hg19 (UCSC)WFIKKN2  -     chr17:48912605-48919709 +  17q21.33   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)WFIKKN2  -     17q21.33   [Description]    (hg38-Dec_2013)
EnsemblWFIKKN2 - 17q21.33 [CytoView hg19]  WFIKKN2 - 17q21.33 [CytoView hg38]
Mapping of homologs : NCBIWFIKKN2 [Mapview hg19]  WFIKKN2 [Mapview hg38]
OMIM610895   
Gene and transcription
Genbank (Entrez)AF468657 AK127743 AK131196 AK298172 AK312821
RefSeq transcript (Entrez)NM_175575
RefSeq genomic (Entrez)NC_000017 NC_018928 NT_010783 NW_004929407
Consensus coding sequences : CCDS (NCBI)WFIKKN2
Cluster EST : UnigeneHs.211475 [ NCBI ]
CGAP (NCI)Hs.211475
Alternative Splicing GalleryENSG00000173714
Gene ExpressionWFIKKN2 [ NCBI-GEO ]   WFIKKN2 [ EBI - ARRAY_EXPRESS ]   WFIKKN2 [ SEEK ]   WFIKKN2 [ MEM ]
Gene Expression Viewer (FireBrowse)WFIKKN2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)124857
GTEX Portal (Tissue expression)WFIKKN2
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ8TEU8   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ8TEU8  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ8TEU8
Splice isoforms : SwissVarQ8TEU8
PhosPhoSitePlusQ8TEU8
Domaine pattern : Prosite (Expaxy)BPTI_KUNITZ_1 (PS00280)    BPTI_KUNITZ_2 (PS50279)    IG_LIKE (PS50835)    KAZAL_2 (PS51465)    NTR (PS50189)    WAP (PS51390)   
Domains : Interpro (EBI)Ig-like_dom    Ig-like_fold    Ig_I-set    Ig_sub2    Kazal_dom    Kunitz_BPTI    Netrin_domain    Netrin_module_non-TIMP    Prtase_inh_Kunz-CS    TIMP-like_OB-fold    WAP_dom   
Domain families : Pfam (Sanger)I-set (PF07679)    Kunitz_BPTI (PF00014)    NTR (PF01759)    WAP (PF00095)   
Domain families : Pfam (NCBI)pfam07679    pfam00014    pfam01759    pfam00095   
Domain families : Smart (EMBL)IGc2 (SM00408)  KAZAL (SM00280)  KU (SM00131)  WAP (SM00217)  
Conserved Domain (NCBI)WFIKKN2
DMDM Disease mutations124857
Blocks (Seattle)WFIKKN2
SuperfamilyQ8TEU8
Human Protein AtlasENSG00000173714
Peptide AtlasQ8TEU8
HPRD18303
IPIIPI00152847   IPI00442338   IPI00939739   
Protein Interaction databases
DIP (DOE-UCLA)Q8TEU8
IntAct (EBI)Q8TEU8
FunCoupENSG00000173714
BioGRIDWFIKKN2
STRING (EMBL)WFIKKN2
ZODIACWFIKKN2
Ontologies - Pathways
QuickGOQ8TEU8
Ontology : AmiGOskeletal system development  serine-type endopeptidase inhibitor activity  extracellular region  transforming growth factor beta receptor signaling pathway  metalloendopeptidase inhibitor activity  negative regulation of endopeptidase activity  negative regulation of protein binding  negative regulation of DNA binding  muscle fiber development  palate development  
Ontology : EGO-EBIskeletal system development  serine-type endopeptidase inhibitor activity  extracellular region  transforming growth factor beta receptor signaling pathway  metalloendopeptidase inhibitor activity  negative regulation of endopeptidase activity  negative regulation of protein binding  negative regulation of DNA binding  muscle fiber development  palate development  
NDEx NetworkWFIKKN2
Atlas of Cancer Signalling NetworkWFIKKN2
Wikipedia pathwaysWFIKKN2
Orthology - Evolution
OrthoDB124857
GeneTree (enSembl)ENSG00000173714
Phylogenetic Trees/Animal Genes : TreeFamWFIKKN2
HOVERGENQ8TEU8
HOGENOMQ8TEU8
Homologs : HomoloGeneWFIKKN2
Homology/Alignments : Family Browser (UCSC)WFIKKN2
Gene fusions - Rearrangements
Fusion Cancer (Beijing)WFIKKN2 [17q21.33]  -  SFTPB [2p11.2]  [FUSC003045]
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerWFIKKN2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)WFIKKN2
dbVarWFIKKN2
ClinVarWFIKKN2
1000_GenomesWFIKKN2 
Exome Variant ServerWFIKKN2
ExAC (Exome Aggregation Consortium)WFIKKN2 (select the gene name)
Genetic variants : HAPMAP124857
Genomic Variants (DGV)WFIKKN2 [DGVbeta]
DECIPHER (Syndromes)17:48912605-48919709  ENSG00000173714
CONAN: Copy Number AnalysisWFIKKN2 
Mutations
ICGC Data PortalWFIKKN2 
TCGA Data PortalWFIKKN2 
Broad Tumor PortalWFIKKN2
OASIS PortalWFIKKN2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICWFIKKN2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDWFIKKN2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch WFIKKN2
DgiDB (Drug Gene Interaction Database)WFIKKN2
DoCM (Curated mutations)WFIKKN2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)WFIKKN2 (select a term)
intoGenWFIKKN2
Cancer3DWFIKKN2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM610895   
Orphanet
MedgenWFIKKN2
Genetic Testing Registry WFIKKN2
NextProtQ8TEU8 [Medical]
TSGene124857
GENETestsWFIKKN2
Huge Navigator WFIKKN2 [HugePedia]
snp3D : Map Gene to Disease124857
BioCentury BCIQWFIKKN2
ClinGenWFIKKN2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD124857
Chemical/Pharm GKB GenePA134864812
Clinical trialWFIKKN2
Miscellaneous
canSAR (ICR)WFIKKN2 (select the gene name)
Probes
Litterature
PubMed12 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineWFIKKN2
EVEXWFIKKN2
GoPubMedWFIKKN2
iHOPWFIKKN2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Mar 14 13:34:13 CET 2017

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