WHSC1 (Wolf-Hirschhorn syndrome candidate 1)

Identity

Other names	FLJ23286
	KIAA1090
	MGC176638
	MMSET
	NSD2
	REIIBP
	TRX5
	WHS
HGNC	WHSC1
Location	4p16.3
Location_base_pair	Starts at 1842921 and ends at 1953732 bp from pter ( according to hg18-March_2006).
Note	Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

External links

	Nomenclature
HGNC	WHSC1   12766
Entrez_Gene	WHSC1  7468  Wolf-Hirschhorn syndrome candidate 1
	Cards
GeneCards	WHSC1
Ensembl	ENSG00000109685 [Gene_View]  WHSC1 [Vega]
Genatlas	WHSC1
	Genomic and cartography
GoldenPath	WHSC1  -  4p16.3   chr4:1842921-1953732 +  4p16.3   [Description]    (hg18-March_2006)
Ensembl	WHSC1 - 4p16.3 [CytoView]
NCBI	Mapview
OMIM	602952 Disease map [OMIM]
HomoloGene	WHSC1
	Gene and transcription
Genbank	AB029013 [ ENTREZ ]
Genbank	AF071593 [ ENTREZ ]
Genbank	AF071594 [ ENTREZ ]
Genbank	AF083386 [ ENTREZ ]
Genbank	AF083387 [ ENTREZ ]
RefSeq	NM_001042424 [ SRS ]    NM_001042424 [ ENTREZ ]
RefSeq	NM_007331 [ SRS ]    NM_007331 [ ENTREZ ]
RefSeq	NM_133330 [ SRS ]    NM_133330 [ ENTREZ ]
RefSeq	NM_133331 [ SRS ]    NM_133331 [ ENTREZ ]
RefSeq	NM_133334 [ SRS ]    NM_133334 [ ENTREZ ]
RefSeq	NM_133335 [ SRS ]    NM_133335 [ ENTREZ ]
RefSeq	AC_000047 [ SRS ]    AC_000047 [ ENTREZ ]
RefSeq	AC_000136 [ SRS ]    AC_000136 [ ENTREZ ]
RefSeq	NC_000004 [ SRS ]    NC_000004 [ ENTREZ ]
RefSeq	NT_006081 [ SRS ]    NT_006081 [ ENTREZ ]
RefSeq	NW_001838896 [ SRS ]    NW_001838896 [ ENTREZ ]
RefSeq	NW_921918 [ SRS ]    NW_921918 [ ENTREZ ]
CCDS	WHSC1 CCDS - NCBI
AceView	WHSC1 AceView - NCBI
Unigene	Hs.113876 [ SRS ]    Hs.113876 [ NCBI ]
Fast-db	1163 (alternative variants)
	Protein : pattern, domain, 3D structure
SwissProt	O96028 [ SRS]    O96028 [ EXPASY ]     O96028 [ INTERPRO ]     O96028 [ UNIPROT ] O96028 [ VarSplice FASTA ]
Prosite	PS51215 AWS [ SRS ]    PS51215 AWS [ Expasy ]
Prosite	PS50118 HMG_BOX_2 [ SRS ]    PS50118 HMG_BOX_2 [ Expasy ]
Prosite	PS50868 POST_SET [ SRS ]    PS50868 POST_SET [ Expasy ]
Prosite	PS50812 PWWP [ SRS ]    PS50812 PWWP [ Expasy ]
Prosite	PS50280 SET [ SRS ]    PS50280 SET [ Expasy ]
Prosite	PS01359 ZF_PHD_1 [ SRS ]    PS01359 ZF_PHD_1 [ Expasy ]
Prosite	PS50016 ZF_PHD_2 [ SRS ]    PS50016 ZF_PHD_2 [ Expasy ]
Interpro	IPR006560 AWS [ SRS ]    IPR006560 AWS [ EBI ]
Interpro	IPR000910 HMG_1/2_box [ SRS ]    IPR000910 HMG_1/2_box [ EBI ]
Interpro	IPR003616 Post-SET_Zn_bd [ SRS ]    IPR003616 Post-SET_Zn_bd [ EBI ]
Interpro	IPR000313 PWWP [ SRS ]    IPR000313 PWWP [ EBI ]
Interpro	IPR001214 SET [ SRS ]    IPR001214 SET [ EBI ]
Interpro	IPR001965 Znf_PHD [ SRS ]    IPR001965 Znf_PHD [ EBI ]
Interpro	IPR001841 Znf_RING [ SRS ]    IPR001841 Znf_RING [ EBI ]
Interpro	IPR013083 Znf_RING/FYVE/PHD [ SRS ]    IPR013083 Znf_RING/FYVE/PHD [ EBI ]
CluSTr	O96028
Pfam	PF00505 HMG_box [ SRS ]    PF00505 HMG_box [ Sanger ]    pfam00505 [ NCBI-CDD ]
Pfam	PF00628 PHD [ SRS ]    PF00628 PHD [ Sanger ]    pfam00628 [ NCBI-CDD ]
Pfam	PF00855 PWWP [ SRS ]    PF00855 PWWP [ Sanger ]    pfam00855 [ NCBI-CDD ]
Pfam	PF00856 SET [ SRS ]    PF00856 SET [ Sanger ]    pfam00856 [ NCBI-CDD ]
Smart	SM00570 AWS [EMBL]
Smart	SM00398 HMG [EMBL]
Smart	SM00249 PHD [EMBL]
Smart	SM00508 PostSET [EMBL]
Smart	SM00293 PWWP [EMBL]
Smart	SM00184 RING [EMBL]
Smart	SM00317 SET [EMBL]
Blocks	O96028
HPRD	04259
	Protein Interaction databases
DIP	O96028
IntAct	O96028
	Polymorphism : SNP, mutations, diseases
OMIM	602952    [ map ]
GENETests	602952
SNP	WHSC1 [dbSNP-NCBI]
SNP	NM_001042424 [SNP-NCI]
SNP	NM_007331 [SNP-NCI]
SNP	NM_133330 [SNP-NCI]
SNP	NM_133331 [SNP-NCI]
SNP	NM_133334 [SNP-NCI]
SNP	NM_133335 [SNP-NCI]
SNP	WHSC1 [GeneSNPs - Utah]  WHSC1] [HGBASE - SRS]
HAPMAP	WHSC1 [HAPMAP]
COSMIC	WHSC1 [Somatic mutation (COSMIC-CGP-Sanger)]
TICdb	DNA [Translocation breakpoints In Cancer]
HGMD	WHSC1
Genetic Association	WHSC1
CDC HuGE	WHSC1
	General knowledge
Family Browser	WHSC1 [UCSC Family Browser]
SOURCE	NM_001042424
SOURCE	NM_007331
SOURCE	NM_133330
SOURCE	NM_133331
SOURCE	NM_133334
SOURCE	NM_133335
SMD	Hs.113876
SAGE	Hs.113876
Enzyme	2.1.1.43 [ Enzyme-Expasy ]   2.1.1.43 [ Enzyme-SRS ]   2.1.1.43 [ IntEnz-EBI ]   2.1.1.43 [ BRENDA ]   2.1.1.43 [ KEGG ]
GO	DNA binding [Amigo]  DNA binding
GO	protein binding [Amigo]  protein binding
GO	nucleus [Amigo]  nucleus
GO	cytoplasm [Amigo]  cytoplasm
GO	transcription [Amigo]  transcription
GO	regulation of transcription, DNA-dependent [Amigo]  regulation of transcription, DNA-dependent
GO	methyltransferase activity [Amigo]  methyltransferase activity
GO	zinc ion binding [Amigo]  zinc ion binding
GO	anatomical structure morphogenesis [Amigo]  anatomical structure morphogenesis
GO	chromatin modification [Amigo]  chromatin modification
GO	transferase activity [Amigo]  transferase activity
GO	histone-lysine N-methyltransferase activity [Amigo]  histone-lysine N-methyltransferase activity
GO	metal ion binding [Amigo]  metal ion binding
PubGene	WHSC1
TreeFam	WHSC1
CTD	7468 [Comparative ToxicoGenomics Database]
	Other databases
	Probes
Probe	WHSC1 Related clones (RZPD - Berlin)
	PubMed
PubMed	29 Pubmed reference(s) in Entrez

Genes in title	automatic search in PubMed
REVIEW articles	automatic search in PubMed
Last year publications	automatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written	09-2002	Dessen P, Le Minor S
Updated	03-2008	Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology

indexed on : Thu Nov 27 14:19:15 2008