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WIPF1 (WAS/WASL interacting protein family member 1)

Identity

Alias_namesWASPIP
Wiskott-Aldrich syndrome protein interacting protein
WAS/WASL interacting protein family, member 1
Alias_symbol (synonym)WIP
Other aliasPRPL-2
WAS2
HGNC (Hugo) WIPF1
LocusID (NCBI) 7456
Atlas_Id 51113
Location 2q31.1  [Link to chromosome band 2q31]
Location_base_pair Starts at 175424302 and ends at 175547627 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
GORASP2 (2q31.1) / WIPF1 (2q31.1)NASP (1p34.1) / WIPF1 (2q31.1)GORASP2 2q31.1 / WIPF1 2q31.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Cancer prone implicated (Data extracted from papers in the Atlas) [ 1 ]
  Wiskott-Aldrich Syndrome (WAS)


External links

Nomenclature
HGNC (Hugo)WIPF1   12736
LRG (Locus Reference Genomic)LRG_374
Cards
Entrez_Gene (NCBI)WIPF1  7456  WAS/WASL interacting protein family member 1
AliasesPRPL-2; WAS2; WASPIP; WIP
GeneCards (Weizmann)WIPF1
Ensembl hg19 (Hinxton)ENSG00000115935 [Gene_View]  chr2:175424302-175547627 [Contig_View]  WIPF1 [Vega]
Ensembl hg38 (Hinxton)ENSG00000115935 [Gene_View]  chr2:175424302-175547627 [Contig_View]  WIPF1 [Vega]
ICGC DataPortalENSG00000115935
TCGA cBioPortalWIPF1
AceView (NCBI)WIPF1
Genatlas (Paris)WIPF1
WikiGenes7456
SOURCE (Princeton)WIPF1
Genetics Home Reference (NIH)WIPF1
Genomic and cartography
GoldenPath hg19 (UCSC)WIPF1  -     chr2:175424302-175547627 -  2q31.1   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)WIPF1  -     2q31.1   [Description]    (hg38-Dec_2013)
EnsemblWIPF1 - 2q31.1 [CytoView hg19]  WIPF1 - 2q31.1 [CytoView hg38]
Mapping of homologs : NCBIWIPF1 [Mapview hg19]  WIPF1 [Mapview hg38]
OMIM602357   614493   
Gene and transcription
Genbank (Entrez)AA599214 AA903457 AF031588 AF106062 AK097901
RefSeq transcript (Entrez)NM_001077269 NM_003387
RefSeq genomic (Entrez)NC_000002 NC_018913 NG_032009 NT_005403 NW_004929305
Consensus coding sequences : CCDS (NCBI)WIPF1
Cluster EST : UnigeneHs.128067 [ NCBI ]
CGAP (NCI)Hs.128067
Alternative Splicing GalleryENSG00000115935
Gene ExpressionWIPF1 [ NCBI-GEO ]   WIPF1 [ EBI - ARRAY_EXPRESS ]   WIPF1 [ SEEK ]   WIPF1 [ MEM ]
Gene Expression Viewer (FireBrowse)WIPF1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)7456
GTEX Portal (Tissue expression)WIPF1
Protein : pattern, domain, 3D structure
UniProt/SwissProtO43516   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO43516  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO43516
Splice isoforms : SwissVarO43516
PhosPhoSitePlusO43516
Domaine pattern : Prosite (Expaxy)WH2 (PS51082)   
Domains : Interpro (EBI)WH2_dom    WIP   
Domain families : Pfam (Sanger)WH2 (PF02205)   
Domain families : Pfam (NCBI)pfam02205   
Domain families : Smart (EMBL)WH2 (SM00246)  
Conserved Domain (NCBI)WIPF1
DMDM Disease mutations7456
Blocks (Seattle)WIPF1
PDB (SRS)2A41   
PDB (PDBSum)2A41   
PDB (IMB)2A41   
PDB (RSDB)2A41   
Structural Biology KnowledgeBase2A41   
SCOP (Structural Classification of Proteins)2A41   
CATH (Classification of proteins structures)2A41   
SuperfamilyO43516
Human Protein AtlasENSG00000115935
Peptide AtlasO43516
HPRD03835
IPIIPI00418328   IPI00797331   IPI00552369   IPI00952673   IPI00965636   IPI00952741   IPI00917534   IPI00915845   IPI00916236   
Protein Interaction databases
DIP (DOE-UCLA)O43516
IntAct (EBI)O43516
FunCoupENSG00000115935
BioGRIDWIPF1
STRING (EMBL)WIPF1
ZODIACWIPF1
Ontologies - Pathways
QuickGOO43516
Ontology : AmiGOactin cortical patch assembly  ruffle  actin binding  protein binding  profilin binding  cytosol  actin filament  protein complex assembly  endocytosis  actin polymerization or depolymerization  regulation of cell shape  actin cytoskeleton  cytoplasmic, membrane-bounded vesicle  actin filament-based movement  actin cortical patch  Fc-gamma receptor signaling pathway involved in phagocytosis  actin filament binding  positive regulation of actin nucleation  actin cortical patch localization  response to other organism  
Ontology : EGO-EBIactin cortical patch assembly  ruffle  actin binding  protein binding  profilin binding  cytosol  actin filament  protein complex assembly  endocytosis  actin polymerization or depolymerization  regulation of cell shape  actin cytoskeleton  cytoplasmic, membrane-bounded vesicle  actin filament-based movement  actin cortical patch  Fc-gamma receptor signaling pathway involved in phagocytosis  actin filament binding  positive regulation of actin nucleation  actin cortical patch localization  response to other organism  
NDEx NetworkWIPF1
Atlas of Cancer Signalling NetworkWIPF1
Wikipedia pathwaysWIPF1
Orthology - Evolution
OrthoDB7456
GeneTree (enSembl)ENSG00000115935
Phylogenetic Trees/Animal Genes : TreeFamWIPF1
HOVERGENO43516
HOGENOMO43516
Homologs : HomoloGeneWIPF1
Homology/Alignments : Family Browser (UCSC)WIPF1
Gene fusions - Rearrangements
Fusion : MitelmanGORASP2/WIPF1 [2q31.1/2q31.1]  [t(2;2)(q31;q31)]  
Fusion : MitelmanNASP/WIPF1 [1p34.1/2q31.1]  [t(1;2)(p34;q31)]  
Fusion: TCGAGORASP2 2q31.1 WIPF1 2q31.1 KIRC
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerWIPF1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)WIPF1
dbVarWIPF1
ClinVarWIPF1
1000_GenomesWIPF1 
Exome Variant ServerWIPF1
ExAC (Exome Aggregation Consortium)WIPF1 (select the gene name)
Genetic variants : HAPMAP7456
Genomic Variants (DGV)WIPF1 [DGVbeta]
DECIPHER (Syndromes)2:175424302-175547627  ENSG00000115935
CONAN: Copy Number AnalysisWIPF1 
Mutations
ICGC Data PortalWIPF1 
TCGA Data PortalWIPF1 
Broad Tumor PortalWIPF1
OASIS PortalWIPF1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICWIPF1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDWIPF1
intOGen PortalWIPF1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)**PUBLIC** CCHMC Molecular Genetics Laboratory Mutation Database
BioMutasearch WIPF1
DgiDB (Drug Gene Interaction Database)WIPF1
DoCM (Curated mutations)WIPF1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)WIPF1 (select a term)
intoGenWIPF1
Cancer3DWIPF1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM602357    614493   
Orphanet144   
MedgenWIPF1
Genetic Testing Registry WIPF1
NextProtO43516 [Medical]
TSGene7456
GENETestsWIPF1
Huge Navigator WIPF1 [HugePedia]
snp3D : Map Gene to Disease7456
BioCentury BCIQWIPF1
ClinGenWIPF1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD7456
Chemical/Pharm GKB GenePA162409189
Clinical trialWIPF1
Miscellaneous
canSAR (ICR)WIPF1 (select the gene name)
Probes
Litterature
PubMed55 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineWIPF1
EVEXWIPF1
GoPubMedWIPF1
iHOPWIPF1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Mar 14 13:34:14 CET 2017

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