WIPF1 (WAS/WASL interacting protein family member 1)

2009-09-01  

Identity

HGNC
LOCATION
2q31.1
LOCUSID
ALIAS
PRPL-2,WAS2,WASPIP,WIP
FUSION GENES

Other Information

Locus ID:

NCBI: 7456
MIM: 602357
HGNC: 12736
Ensembl: ENSG00000115935

Variants:

dbSNP: 7456
ClinVar: 7456
TCGA: ENSG00000115935
COSMIC: WIPF1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000115935ENST00000272746O43516
ENSG00000115935ENST00000359761O43516
ENSG00000115935ENST00000359761A0A140VJZ9
ENSG00000115935ENST00000392546O43516
ENSG00000115935ENST00000392546A0A140VJZ9
ENSG00000115935ENST00000392547O43516
ENSG00000115935ENST00000392547A0A140VJZ9
ENSG00000115935ENST00000409415E9PB87
ENSG00000115935ENST00000409891O43516
ENSG00000115935ENST00000410117B8ZZ90
ENSG00000115935ENST00000436221C9JTB9
ENSG00000115935ENST00000455428C9JB04

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90

Pathways

PathwaySourceExternal ID
EndocytosisKEGGko04144
EndocytosisKEGGhsa04144
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
Fcgamma receptor (FCGR) dependent phagocytosisREACTOMER-HSA-2029480
Regulation of actin dynamics for phagocytic cup formationREACTOMER-HSA-2029482
Signal TransductionREACTOMER-HSA-162582
Signaling by Rho GTPasesREACTOMER-HSA-194315
RHO GTPase EffectorsREACTOMER-HSA-195258
RHO GTPases Activate WASPs and WAVEsREACTOMER-HSA-5663213

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
172133092007WIP is a chaperone for Wiskott-Aldrich syndrome protein (WASP).55
124379292002Structure of the N-WASP EVH1 domain-WIP complex: insight into the molecular basis of Wiskott-Aldrich Syndrome.48
166066942006Formation of a WIP-, WASp-, actin-, and myosin IIA-containing multiprotein complex in activated NK cells and its alteration by KIR inhibitory signaling.42
222313032012A novel primary human immunodeficiency due to deficiency in the WASP-interacting protein WIP.42
178902242007Wiskott-Aldrich syndrome protein is a key regulator of the phagocytic cup formation in macrophages.34
179499832007WASP-interacting protein (WIP): working in polymerisation and much more.32
182587432008WIP is essential for lytic granule polarization and NK cell cytotoxicity.30
191552182009FBP17 Mediates a Common Molecular Step in the Formation of Podosomes and Phagocytic Cups in Macrophages.28
193994712009An expression module of WIPF1-coexpressed genes identifies patients with favorable prognosis in three tumor types.25
281661942017Mutant p53 oncogenic functions in cancer stem cells are regulated by WIP through YAP/TAZ.21

Citation

Dessen P

WIPF1 (WAS/WASL interacting protein family member 1)

Atlas Genet Cytogenet Oncol Haematol. 2009-09-01

Online version: http://atlasgeneticsoncology.org/gene/51113/wipf1