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WIPF2 (WAS/WASL interacting protein family member 2)

Identity

Alias_namesWAS/WASL interacting protein family
Alias_symbol (synonym)WICH
WIRE
Other alias
HGNC (Hugo) WIPF2
LocusID (NCBI) 147179
Atlas_Id 54783
Location 17q21.2  [Link to chromosome band 17q21]
Location_base_pair Starts at 40219322 and ends at 40282187 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
A2M (12p13.31) / WIPF2 (17q21.1)AKAP1 (17q22) / WIPF2 (17q21.1)MSI2 (17q22) / WIPF2 (17q21.1)
RARA (17q21.2) / WIPF2 (17q21.1)SYT7 (11q12.2) / WIPF2 (17q21.1)WIPF2 (17q21.1) / CDC42EP4 (17q25.1)
WIPF2 (17q21.1) / DSP (6p24.3)WIPF2 (17q21.1) / ERBB2 (17q12)WIPF2 (17q21.1) / EZH1 (17q21.2)
WIPF2 (17q21.1) / IL2RB (22q12.3)WIPF2 (17q21.1) / LRRC3C (17q12)WIPF2 (17q21.1) / MSL1 (17q21.1)
WIPF2 (17q21.1) / PSMD11 (17q11.2)WIPF2 (17q21.1) / RAPGEFL1 (17q21.1)WIPF2 (17q21.1) / SEZ6 (17q11.2)
WIPF2 (17q21.1) / USP32 (17q23.1)WIPF2 (17q21.1) / WIPF2 (17q21.1)AKAP1 17q22 / WIPF2 17q21.1
MSI2 17q22 / WIPF2 17q21.1RARA 17q21.2 / WIPF2 17q21.1WIPF2 17q21.1 / CDC42EP4 17q25.1
WIPF2 17q21.1 / EZH1 17q21.2WIPF2 17q21.1 / IL2RB 22q12.3WIPF2 17q21.1 / LRRC3C 17q12
WIPF2 17q21.1 / MSL1 17q21.1WIPF2 17q21.1 / PSMD11 17q11.2WIPF2 17q21.1 / RAPGEFL1 17q21.1
WIPF2 17q21.1 / SEZ6 17q11.2WIPF2 17q21.1 / USP32 17q23.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)WIPF2   30923
Cards
Entrez_Gene (NCBI)WIPF2  147179  WAS/WASL interacting protein family member 2
AliasesWICH; WIRE
GeneCards (Weizmann)WIPF2
Ensembl hg19 (Hinxton)ENSG00000171475 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000171475 [Gene_View]  chr17:40219322-40282187 [Contig_View]  WIPF2 [Vega]
ICGC DataPortalENSG00000171475
TCGA cBioPortalWIPF2
AceView (NCBI)WIPF2
Genatlas (Paris)WIPF2
WikiGenes147179
SOURCE (Princeton)WIPF2
Genetics Home Reference (NIH)WIPF2
Genomic and cartography
GoldenPath hg38 (UCSC)WIPF2  -     chr17:40219322-40282187 +  17q21.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)WIPF2  -     17q21.2   [Description]    (hg19-Feb_2009)
EnsemblWIPF2 - 17q21.2 [CytoView hg19]  WIPF2 - 17q21.2 [CytoView hg38]
Mapping of homologs : NCBIWIPF2 [Mapview hg19]  WIPF2 [Mapview hg38]
OMIM609692   
Gene and transcription
Genbank (Entrez)AB043786 AF370396 AJ431177 AK026913 AK055025
RefSeq transcript (Entrez)NM_133264
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)WIPF2
Cluster EST : UnigeneHs.731598 [ NCBI ]
CGAP (NCI)Hs.731598
Alternative Splicing GalleryENSG00000171475
Gene ExpressionWIPF2 [ NCBI-GEO ]   WIPF2 [ EBI - ARRAY_EXPRESS ]   WIPF2 [ SEEK ]   WIPF2 [ MEM ]
Gene Expression Viewer (FireBrowse)WIPF2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)147179
GTEX Portal (Tissue expression)WIPF2
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ8TF74   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ8TF74  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ8TF74
Splice isoforms : SwissVarQ8TF74
PhosPhoSitePlusQ8TF74
Domaine pattern : Prosite (Expaxy)WH2 (PS51082)   
Domains : Interpro (EBI)WH2_dom    WIPF2   
Domain families : Pfam (Sanger)WH2 (PF02205)   
Domain families : Pfam (NCBI)pfam02205   
Domain families : Smart (EMBL)WH2 (SM00246)  
Conserved Domain (NCBI)WIPF2
DMDM Disease mutations147179
Blocks (Seattle)WIPF2
SuperfamilyQ8TF74
Human Protein AtlasENSG00000171475
Peptide AtlasQ8TF74
HPRD18304
IPIIPI00435947   IPI00552647   IPI00792123   
Protein Interaction databases
DIP (DOE-UCLA)Q8TF74
IntAct (EBI)Q8TF74
FunCoupENSG00000171475
BioGRIDWIPF2
STRING (EMBL)WIPF2
ZODIACWIPF2
Ontologies - Pathways
QuickGOQ8TF74
Ontology : AmiGOactin binding  protein binding  cytosol  cytoskeleton  Fc-gamma receptor signaling pathway involved in phagocytosis  
Ontology : EGO-EBIactin binding  protein binding  cytosol  cytoskeleton  Fc-gamma receptor signaling pathway involved in phagocytosis  
NDEx NetworkWIPF2
Atlas of Cancer Signalling NetworkWIPF2
Wikipedia pathwaysWIPF2
Orthology - Evolution
OrthoDB147179
GeneTree (enSembl)ENSG00000171475
Phylogenetic Trees/Animal Genes : TreeFamWIPF2
HOVERGENQ8TF74
HOGENOMQ8TF74
Homologs : HomoloGeneWIPF2
Homology/Alignments : Family Browser (UCSC)WIPF2
Gene fusions - Rearrangements
Fusion : MitelmanAKAP1/WIPF2 [17q22/17q21.1]  [t(17;17)(q21;q22)]  
Fusion : MitelmanMSI2/WIPF2 [17q22/17q21.1]  [t(17;17)(q21;q22)]  
Fusion : MitelmanRARA/WIPF2 [17q21.2/17q21.1]  [t(17;17)(q21;q21)]  
Fusion : MitelmanWIPF2/CDC42EP4 [17q21.1/17q25.1]  [t(17;17)(q21;q25)]  
Fusion : MitelmanWIPF2/ERBB2 [17q21.1/17q12]  [t(17;17)(q12;q21)]  
Fusion : MitelmanWIPF2/EZH1 [17q21.1/17q21.2]  [t(17;17)(q21;q21)]  
Fusion : MitelmanWIPF2/IL2RB [17q21.1/22q12.3]  [t(17;22)(q21;q12)]  
Fusion : MitelmanWIPF2/LRRC3C [17q21.1/17q12]  [t(17;17)(q12;q21)]  
Fusion : MitelmanWIPF2/MSL1 [17q21.1/17q21.1]  [t(17;17)(q21;q21)]  
Fusion : MitelmanWIPF2/PSMD11 [17q21.1/17q11.2]  [t(17;17)(q11;q21)]  
Fusion : MitelmanWIPF2/RAPGEFL1 [17q21.1/17q21.1]  [t(17;17)(q21;q21)]  
Fusion : MitelmanWIPF2/SEZ6 [17q21.1/17q11.2]  [t(17;17)(q11;q21)]  
Fusion : MitelmanWIPF2/USP32 [17q21.1/17q23.1]  [t(17;17)(q21;q23)]  
Fusion: TCGAAKAP1 17q22 WIPF2 17q21.1 BRCA
Fusion: TCGAMSI2 17q22 WIPF2 17q21.1 BRCA
Fusion: TCGARARA 17q21.2 WIPF2 17q21.1 BRCA
Fusion: TCGAWIPF2 17q21.1 CDC42EP4 17q25.1 LUAD
Fusion: TCGAWIPF2 17q21.1 EZH1 17q21.2 BRCA
Fusion: TCGAWIPF2 17q21.1 IL2RB 22q12.3 BRCA
Fusion: TCGAWIPF2 17q21.1 LRRC3C 17q12 BRCA
Fusion: TCGAWIPF2 17q21.1 MSL1 17q21.1 BLCA
Fusion: TCGAWIPF2 17q21.1 PSMD11 17q11.2 BRCA
Fusion: TCGAWIPF2 17q21.1 RAPGEFL1 17q21.1 KIRC
Fusion: TCGAWIPF2 17q21.1 SEZ6 17q11.2 BRCA
Fusion: TCGAWIPF2 17q21.1 USP32 17q23.1 BRCA
Fusion Cancer (Beijing)A2M [12p13.31]  -  WIPF2 [17q21.1]  [FUSC002802]
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerWIPF2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)WIPF2
dbVarWIPF2
ClinVarWIPF2
1000_GenomesWIPF2 
Exome Variant ServerWIPF2
ExAC (Exome Aggregation Consortium)WIPF2 (select the gene name)
Genetic variants : HAPMAP147179
Genomic Variants (DGV)WIPF2 [DGVbeta]
DECIPHERWIPF2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisWIPF2 
Mutations
ICGC Data PortalWIPF2 
TCGA Data PortalWIPF2 
Broad Tumor PortalWIPF2
OASIS PortalWIPF2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICWIPF2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDWIPF2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch WIPF2
DgiDB (Drug Gene Interaction Database)WIPF2
DoCM (Curated mutations)WIPF2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)WIPF2 (select a term)
intoGenWIPF2
Cancer3DWIPF2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM609692   
Orphanet
MedgenWIPF2
Genetic Testing Registry WIPF2
NextProtQ8TF74 [Medical]
TSGene147179
GENETestsWIPF2
Huge Navigator WIPF2 [HugePedia]
snp3D : Map Gene to Disease147179
BioCentury BCIQWIPF2
ClinGenWIPF2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD147179
Chemical/Pharm GKB GenePA162409210
Clinical trialWIPF2
Miscellaneous
canSAR (ICR)WIPF2 (select the gene name)
Probes
Litterature
PubMed27 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineWIPF2
EVEXWIPF2
GoPubMedWIPF2
iHOPWIPF2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Fri May 19 12:44:09 CEST 2017

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