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WIPI1 (WD repeat domain, phosphoinositide interacting 1)

Identity

Alias_symbol (synonym)FLJ10055
WIPI49
ATG18
ATG18A
Other alias
HGNC (Hugo) WIPI1
LocusID (NCBI) 55062
Atlas_Id 46381
Location 17q24.2  [Link to chromosome band 17q24]
Location_base_pair Starts at 68421281 and ends at 68457524 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
BCAS3 (17q23.2) / WIPI1 (17q24.2)MOB2 (11p15.5) / WIPI1 (17q24.2)PTPN18 (2q21.1) / WIPI1 (17q24.2)
SERPINB4 (18q21.33) / WIPI1 (17q24.2)WIPI1 (17q24.2) / AC040934.1 ()WIPI1 (17q24.2) / WIPI1 (17q24.2)
BCAS3 17q23.2 / WIPI1 17q24.2WIPI1 17q24.2 AC040934.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(17;17)(q23;q24) BCAS3/WIPI1


External links

Nomenclature
HGNC (Hugo)WIPI1   25471
Cards
Entrez_Gene (NCBI)WIPI1  55062  WD repeat domain, phosphoinositide interacting 1
AliasesATG18; ATG18A; WIPI49
GeneCards (Weizmann)WIPI1
Ensembl hg19 (Hinxton)ENSG00000070540 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000070540 [Gene_View]  chr17:68421281-68457524 [Contig_View]  WIPI1 [Vega]
ICGC DataPortalENSG00000070540
TCGA cBioPortalWIPI1
AceView (NCBI)WIPI1
Genatlas (Paris)WIPI1
WikiGenes55062
SOURCE (Princeton)WIPI1
Genetics Home Reference (NIH)WIPI1
Genomic and cartography
GoldenPath hg38 (UCSC)WIPI1  -     chr17:68421281-68457524 -  17q24.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)WIPI1  -     17q24.2   [Description]    (hg19-Feb_2009)
EnsemblWIPI1 - 17q24.2 [CytoView hg19]  WIPI1 - 17q24.2 [CytoView hg38]
Mapping of homologs : NCBIWIPI1 [Mapview hg19]  WIPI1 [Mapview hg38]
OMIM609224   
Gene and transcription
Genbank (Entrez)AK000917 AK301830 AY691424 BC039867 BI764142
RefSeq transcript (Entrez)NM_001320772 NM_017983
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)WIPI1
Cluster EST : UnigeneHs.463964 [ NCBI ]
CGAP (NCI)Hs.463964
Alternative Splicing GalleryENSG00000070540
Gene ExpressionWIPI1 [ NCBI-GEO ]   WIPI1 [ EBI - ARRAY_EXPRESS ]   WIPI1 [ SEEK ]   WIPI1 [ MEM ]
Gene Expression Viewer (FireBrowse)WIPI1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)55062
GTEX Portal (Tissue expression)WIPI1
Human Protein AtlasENSG00000070540-WIPI1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ5MNZ9   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ5MNZ9  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ5MNZ9
Splice isoforms : SwissVarQ5MNZ9
PhosPhoSitePlusQ5MNZ9
Domains : Interpro (EBI)WD40/YVTN_repeat-like_dom    WD40_repeat    WD40_repeat_dom    WIPI1   
Domain families : Pfam (Sanger)
Domain families : Pfam (NCBI)
Domain families : Smart (EMBL)WD40 (SM00320)  
Conserved Domain (NCBI)WIPI1
DMDM Disease mutations55062
Blocks (Seattle)WIPI1
SuperfamilyQ5MNZ9
Human Protein Atlas [tissue]ENSG00000070540-WIPI1 [tissue]
Peptide AtlasQ5MNZ9
HPRD08540
IPIIPI00217556   IPI00658123   
Protein Interaction databases
DIP (DOE-UCLA)Q5MNZ9
IntAct (EBI)Q5MNZ9
FunCoupENSG00000070540
BioGRIDWIPI1
STRING (EMBL)WIPI1
ZODIACWIPI1
Ontologies - Pathways
QuickGOQ5MNZ9
Ontology : AmiGOGolgi membrane  phagophore assembly site  autophagosome membrane  autophagy of mitochondrion  receptor binding  cytoplasm  trans-Golgi network  cytosol  cytosol  cytoskeleton  protein lipidation  autophagy  endosome membrane  macroautophagy  extrinsic component of membrane  clathrin-coated vesicle  estrogen receptor binding  phosphatidylinositol-3-phosphate binding  phagophore assembly site membrane  protein localization to phagophore assembly site  IRE1-mediated unfolded protein response  autophagy of nucleus  vesicle targeting, trans-Golgi to endosome  androgen receptor binding  phosphatidylinositol-3,5-bisphosphate binding  
Ontology : EGO-EBIGolgi membrane  phagophore assembly site  autophagosome membrane  autophagy of mitochondrion  receptor binding  cytoplasm  trans-Golgi network  cytosol  cytosol  cytoskeleton  protein lipidation  autophagy  endosome membrane  macroautophagy  extrinsic component of membrane  clathrin-coated vesicle  estrogen receptor binding  phosphatidylinositol-3-phosphate binding  phagophore assembly site membrane  protein localization to phagophore assembly site  IRE1-mediated unfolded protein response  autophagy of nucleus  vesicle targeting, trans-Golgi to endosome  androgen receptor binding  phosphatidylinositol-3,5-bisphosphate binding  
NDEx NetworkWIPI1
Atlas of Cancer Signalling NetworkWIPI1
Wikipedia pathwaysWIPI1
Orthology - Evolution
OrthoDB55062
GeneTree (enSembl)ENSG00000070540
Phylogenetic Trees/Animal Genes : TreeFamWIPI1
HOVERGENQ5MNZ9
HOGENOMQ5MNZ9
Homologs : HomoloGeneWIPI1
Homology/Alignments : Family Browser (UCSC)WIPI1
Gene fusions - Rearrangements
Fusion : MitelmanBCAS3/WIPI1 [17q23.2/17q24.2]  [t(17;17)(q23;q24)]  
Fusion: TCGA_MDACCBCAS3 17q23.2 WIPI1 17q24.2 BRCA
Fusion: TCGA_MDACCWIPI1 17q24.2 AC040934.1 BRCA
Fusion PortalBCAS3 17q23.2 WIPI1 17q24.2 BRCA
Fusion PortalWIPI1 17q24.2 AC040934.1 BRCA
Fusion : QuiverWIPI1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerWIPI1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)WIPI1
dbVarWIPI1
ClinVarWIPI1
1000_GenomesWIPI1 
Exome Variant ServerWIPI1
ExAC (Exome Aggregation Consortium)ENSG00000070540
GNOMAD BrowserENSG00000070540
Genetic variants : HAPMAP55062
Genomic Variants (DGV)WIPI1 [DGVbeta]
DECIPHERWIPI1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisWIPI1 
Mutations
ICGC Data PortalWIPI1 
TCGA Data PortalWIPI1 
Broad Tumor PortalWIPI1
OASIS PortalWIPI1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICWIPI1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDWIPI1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch WIPI1
DgiDB (Drug Gene Interaction Database)WIPI1
DoCM (Curated mutations)WIPI1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)WIPI1 (select a term)
intoGenWIPI1
Cancer3DWIPI1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM609224   
Orphanet
DisGeNETWIPI1
MedgenWIPI1
Genetic Testing Registry WIPI1
NextProtQ5MNZ9 [Medical]
TSGene55062
GENETestsWIPI1
Target ValidationWIPI1
Huge Navigator WIPI1 [HugePedia]
snp3D : Map Gene to Disease55062
BioCentury BCIQWIPI1
ClinGenWIPI1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD55062
Chemical/Pharm GKB GenePA142670575
Clinical trialWIPI1
Miscellaneous
canSAR (ICR)WIPI1 (select the gene name)
Probes
Litterature
PubMed18 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineWIPI1
EVEXWIPI1
GoPubMedWIPI1
iHOPWIPI1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon May 14 12:28:10 CEST 2018

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