WIPI1 (WD repeat domain, phosphoinositide interacting 1)

2007-02-01  

Identity

HGNC
WIPI1
LOCATION
17q24.2
LOCUSID
55062
ALIAS
ATG18,ATG18A,WIPI49
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 55062
MIM: 609224
HGNC: 25471
Ensembl: ENSG00000070540

Variants:

dbSNP: 55062
ClinVar: 55062
TCGA: ENSG00000070540
COSMIC: WIPI1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000070540ENST00000262139Q5MNZ9
ENSG00000070540ENST00000546360G5EA37
ENSG00000070540ENST00000585393K7EKC5
ENSG00000070540ENST00000589316K7EK57
ENSG00000070540ENST00000591744K7ELY0
ENSG00000070540ENST00000592645K7EKN0

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Autophagy - animalKEGGko04140
Autophagy - animalKEGGhsa04140
Metabolism of proteinsREACTOMER-HSA-392499
Unfolded Protein Response (UPR)REACTOMER-HSA-381119
IRE1alpha activates chaperonesREACTOMER-HSA-381070
XBP1(S) activates chaperone genesREACTOMER-HSA-381038
Cellular responses to stressREACTOMER-HSA-2262752
MacroautophagyREACTOMER-HSA-1632852
Autophagy - otherKEGGko04136
Autophagy - otherKEGGhsa04136

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
199362222009Forty-three loci associated with plasma lipoprotein size, concentration, and cholesterol content in genome-wide analysis.151
156025732004WIPI-1alpha (WIPI49), a member of the novel 7-bladed WIPI protein family, is aberrantly expressed in human cancer and is linked to starvation-induced autophagy.121
176186242007Human WIPI-1 puncta-formation: a novel assay to assess mammalian autophagy.65
213172852011WIPI1 coordinates melanogenic gene transcription and melanosome formation via TORC1 inhibition.27
215645132011Freeze-fracture replica immunolabelling reveals human WIPI-1 and WIPI-2 as membrane proteins of autophagosomes.21
243845612014Detection of WIPI1 mRNA as an indicator of autophagosome formation.19
249917672014WIPI-dependent autophagy during neutrophil differentiation of NB4 acute promyelocytic leukemia cells.16
306226612018WIPI1, BAG1, and PEX3 Autophagy-Related Genes Are Relevant Melanoma Markers.7
254625582015Fluorescence-based imaging of autophagy progression by human WIPI protein detection.5
252334242014WIPI β-propellers at the crossroads of autophagosome and lipid droplet dynamics.4

Citation

Dessen P

WIPI1 (WD repeat domain, phosphoinositide interacting 1)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46381/wipi1