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WIPI2 (WD repeat domain, phosphoinositide interacting 2)

Identity

Alias_symbol (synonym)ATG21
CGI-50
FLJ12979
FLJ14217
FLJ42984
DKFZP434J154
DKFZp686P02188
ATG18B
Other aliasAtg21
WIPI-2
HGNC (Hugo) WIPI2
LocusID (NCBI) 26100
Atlas_Id 54784
Location 17q24.2  [Link to chromosome band 17q24]
Location_base_pair Starts at 5190204 and ends at 5233855 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
AP3D1 (19p13.3) / WIPI2 (7p22.1)LDHA (11p15.1) / WIPI2 (7p22.1)PI4KA (22q11.21) / WIPI2 (7p22.1)
WIPI2 (7p22.1) / ERP29 (12q24.13)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(7;12)(p22;q24) WIPI2/ERP29


External links

Nomenclature
HGNC (Hugo)WIPI2   32225
Cards
Entrez_Gene (NCBI)WIPI2  26100  WD repeat domain, phosphoinositide interacting 2
AliasesATG18B; Atg21; CGI-50; WIPI-2
GeneCards (Weizmann)WIPI2
Ensembl hg19 (Hinxton)ENSG00000157954 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000157954 [Gene_View]  ENSG00000157954 [Sequence]  chr7:5190204-5233855 [Contig_View]  WIPI2 [Vega]
ICGC DataPortalENSG00000157954
TCGA cBioPortalWIPI2
AceView (NCBI)WIPI2
Genatlas (Paris)WIPI2
WikiGenes26100
SOURCE (Princeton)WIPI2
Genetics Home Reference (NIH)WIPI2
Genomic and cartography
GoldenPath hg38 (UCSC)WIPI2  -     chr7:5190204-5233855 +  17q24.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)WIPI2  -     17q24.2   [Description]    (hg19-Feb_2009)
EnsemblWIPI2 - 17q24.2 [CytoView hg19]  WIPI2 - 17q24.2 [CytoView hg38]
Mapping of homologs : NCBIWIPI2 [Mapview hg19]  WIPI2 [Mapview hg38]
OMIM609225   
Gene and transcription
Genbank (Entrez)AF151808 AI074985 AK023041 AK024279 AK124974
RefSeq transcript (Entrez)NM_001033518 NM_001033519 NM_001033520 NM_001278299 NM_015610 NM_016003
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)WIPI2
Cluster EST : UnigeneHs.122363 [ NCBI ]
CGAP (NCI)Hs.122363
Alternative Splicing GalleryENSG00000157954
Gene ExpressionWIPI2 [ NCBI-GEO ]   WIPI2 [ EBI - ARRAY_EXPRESS ]   WIPI2 [ SEEK ]   WIPI2 [ MEM ]
Gene Expression Viewer (FireBrowse)WIPI2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)26100
GTEX Portal (Tissue expression)WIPI2
Human Protein AtlasENSG00000157954-WIPI2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9Y4P8   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9Y4P8  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9Y4P8
Splice isoforms : SwissVarQ9Y4P8
PhosPhoSitePlusQ9Y4P8
Domains : Interpro (EBI)WD40/YVTN_repeat-like_dom_sf    WD40_repeat    WD40_repeat_dom_sf    WIPI2   
Domain families : Pfam (Sanger)
Domain families : Pfam (NCBI)
Domain families : Smart (EMBL)WD40 (SM00320)  
Conserved Domain (NCBI)WIPI2
DMDM Disease mutations26100
Blocks (Seattle)WIPI2
SuperfamilyQ9Y4P8
Human Protein Atlas [tissue]ENSG00000157954-WIPI2 [tissue]
Peptide AtlasQ9Y4P8
HPRD15679
IPIIPI00024056   IPI00651668   IPI00006533   IPI00651628   IPI00657808   IPI00651631   IPI00984506   
Protein Interaction databases
DIP (DOE-UCLA)Q9Y4P8
IntAct (EBI)Q9Y4P8
FunCoupENSG00000157954
BioGRIDWIPI2
STRING (EMBL)WIPI2
ZODIACWIPI2
Ontologies - Pathways
QuickGOQ9Y4P8
Ontology : AmiGOautophagosome assembly  autophagosome assembly  phagophore assembly site  autophagy of mitochondrion  protein binding  nucleoplasm  autophagosome  cytosol  cytosol  cytosol  protein lipidation  membrane  macroautophagy  extrinsic component of membrane  phosphatidylinositol-3-phosphate binding  phosphatidylinositol-3-phosphate binding  protein-containing complex  phagophore assembly site membrane  phagophore assembly site membrane  protein localization to phagophore assembly site  autophagy of nucleus  protein lipidation involved in autophagosome assembly  phosphatidylinositol-3,5-bisphosphate binding  phosphatidylinositol-3,5-bisphosphate binding  autophagosome maturation  xenophagy  
Ontology : EGO-EBIautophagosome assembly  autophagosome assembly  phagophore assembly site  autophagy of mitochondrion  protein binding  nucleoplasm  autophagosome  cytosol  cytosol  cytosol  protein lipidation  membrane  macroautophagy  extrinsic component of membrane  phosphatidylinositol-3-phosphate binding  phosphatidylinositol-3-phosphate binding  protein-containing complex  phagophore assembly site membrane  phagophore assembly site membrane  protein localization to phagophore assembly site  autophagy of nucleus  protein lipidation involved in autophagosome assembly  phosphatidylinositol-3,5-bisphosphate binding  phosphatidylinositol-3,5-bisphosphate binding  autophagosome maturation  xenophagy  
NDEx NetworkWIPI2
Atlas of Cancer Signalling NetworkWIPI2
Wikipedia pathwaysWIPI2
Orthology - Evolution
OrthoDB26100
GeneTree (enSembl)ENSG00000157954
Phylogenetic Trees/Animal Genes : TreeFamWIPI2
HOVERGENQ9Y4P8
HOGENOMQ9Y4P8
Homologs : HomoloGeneWIPI2
Homology/Alignments : Family Browser (UCSC)WIPI2
Gene fusions - Rearrangements
Fusion : MitelmanWIPI2/ERP29 [7p22.1/12q24.13]  
Fusion : QuiverWIPI2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerWIPI2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)WIPI2
dbVarWIPI2
ClinVarWIPI2
1000_GenomesWIPI2 
Exome Variant ServerWIPI2
ExAC (Exome Aggregation Consortium)ENSG00000157954
GNOMAD BrowserENSG00000157954
Varsome BrowserWIPI2
Genetic variants : HAPMAP26100
Genomic Variants (DGV)WIPI2 [DGVbeta]
DECIPHERWIPI2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisWIPI2 
Mutations
ICGC Data PortalWIPI2 
TCGA Data PortalWIPI2 
Broad Tumor PortalWIPI2
OASIS PortalWIPI2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICWIPI2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDWIPI2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch WIPI2
DgiDB (Drug Gene Interaction Database)WIPI2
DoCM (Curated mutations)WIPI2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)WIPI2 (select a term)
intoGenWIPI2
Cancer3DWIPI2(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM609225   
Orphanet
DisGeNETWIPI2
MedgenWIPI2
Genetic Testing Registry WIPI2
NextProtQ9Y4P8 [Medical]
TSGene26100
GENETestsWIPI2
Target ValidationWIPI2
Huge Navigator WIPI2 [HugePedia]
snp3D : Map Gene to Disease26100
BioCentury BCIQWIPI2
ClinGenWIPI2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD26100
Chemical/Pharm GKB GenePA142670576
Clinical trialWIPI2
Miscellaneous
canSAR (ICR)WIPI2 (select the gene name)
Probes
Litterature
PubMed37 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineWIPI2
EVEXWIPI2
GoPubMedWIPI2
iHOPWIPI2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Thu Aug 16 11:41:46 CEST 2018

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