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WLS (wntless Wnt ligand secretion mediator)

Identity

Alias_namesC1orf139
GPR177
chromosome 1 open reading frame 139
G protein-coupled receptor 177
wntless homolog (Drosophila)
Alias_symbol (synonym)FLJ23091
MRP
wls
EVI
mig-14
Other alias
HGNC (Hugo) WLS
LocusID (NCBI) 79971
Atlas_Id 53306
Location 1p31.3  [Link to chromosome band 1p31]
Location_base_pair Starts at 68098459 and ends at 68232546 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
RYR2 (1q43) / WLS (1p31.3)SMYD3 (1q44) / WLS (1p31.3)WLS (1p31.3) / DIRAS3 (1p31.3)
RYR2 1q43 / WLS 1p31.3SMYD3 1q44 / WLS 1p31.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)WLS   30238
Cards
Entrez_Gene (NCBI)WLS  79971  wntless Wnt ligand secretion mediator
AliasesC1orf139; EVI; GPR177; MRP; 
mig-14
GeneCards (Weizmann)WLS
Ensembl hg19 (Hinxton)ENSG00000116729 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000116729 [Gene_View]  chr1:68098459-68232546 [Contig_View]  WLS [Vega]
ICGC DataPortalENSG00000116729
TCGA cBioPortalWLS
AceView (NCBI)WLS
Genatlas (Paris)WLS
WikiGenes79971
SOURCE (Princeton)WLS
Genetics Home Reference (NIH)WLS
Genomic and cartography
GoldenPath hg38 (UCSC)WLS  -     chr1:68098459-68232546 -  1p31.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)WLS  -     1p31.3   [Description]    (hg19-Feb_2009)
EnsemblWLS - 1p31.3 [CytoView hg19]  WLS - 1p31.3 [CytoView hg38]
Mapping of homologs : NCBIWLS [Mapview hg19]  WLS [Mapview hg38]
OMIM611514   
Gene and transcription
Genbank (Entrez)AB097018 AI217373 AK026744 AK074583 AK074984
RefSeq transcript (Entrez)NM_001002292 NM_001193334 NM_024911
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)WLS
Cluster EST : UnigeneHs.647659 [ NCBI ]
CGAP (NCI)Hs.647659
Alternative Splicing GalleryENSG00000116729
Gene ExpressionWLS [ NCBI-GEO ]   WLS [ EBI - ARRAY_EXPRESS ]   WLS [ SEEK ]   WLS [ MEM ]
Gene Expression Viewer (FireBrowse)WLS [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)79971
GTEX Portal (Tissue expression)WLS
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ5T9L3   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ5T9L3  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ5T9L3
Splice isoforms : SwissVarQ5T9L3
PhosPhoSitePlusQ5T9L3
Domains : Interpro (EBI)Wntless   
Domain families : Pfam (Sanger)
Domain families : Pfam (NCBI)
Conserved Domain (NCBI)WLS
DMDM Disease mutations79971
Blocks (Seattle)WLS
SuperfamilyQ5T9L3
Human Protein AtlasENSG00000116729
Peptide AtlasQ5T9L3
HPRD10980
IPIIPI00171444   IPI00384961   IPI01014060   IPI00641938   IPI00639895   IPI00984161   IPI00978086   IPI00984799   IPI00974133   IPI00640315   IPI00977395   IPI00976098   
Protein Interaction databases
DIP (DOE-UCLA)Q5T9L3
IntAct (EBI)Q5T9L3
FunCoupENSG00000116729
BioGRIDWLS
STRING (EMBL)WLS
ZODIACWLS
Ontologies - Pathways
QuickGOQ5T9L3
Ontology : AmiGOGolgi membrane  mesoderm formation  signal transducer activity  protein binding  early endosome  endoplasmic reticulum  endoplasmic reticulum membrane  Golgi apparatus  trans-Golgi network  plasma membrane  plasma membrane  intracellular protein transport  anterior/posterior axis specification  integral component of membrane  Wnt signaling pathway  Wnt signaling pathway  Wnt-protein binding  Wnt-protein binding  positive regulation of Wnt signaling pathway  endocytic vesicle membrane  midbrain development  hindbrain development  exocrine pancreas development  cytoplasmic vesicle  mu-type opioid receptor binding  early endosome membrane  dendrite membrane  dendrite cytoplasm  positive regulation of I-kappaB kinase/NF-kappaB signaling  Wnt protein secretion  positive regulation of Wnt protein secretion  positive regulation of Wnt protein secretion  extracellular exosome  positive regulation of canonical Wnt signaling pathway  
Ontology : EGO-EBIGolgi membrane  mesoderm formation  signal transducer activity  protein binding  early endosome  endoplasmic reticulum  endoplasmic reticulum membrane  Golgi apparatus  trans-Golgi network  plasma membrane  plasma membrane  intracellular protein transport  anterior/posterior axis specification  integral component of membrane  Wnt signaling pathway  Wnt signaling pathway  Wnt-protein binding  Wnt-protein binding  positive regulation of Wnt signaling pathway  endocytic vesicle membrane  midbrain development  hindbrain development  exocrine pancreas development  cytoplasmic vesicle  mu-type opioid receptor binding  early endosome membrane  dendrite membrane  dendrite cytoplasm  positive regulation of I-kappaB kinase/NF-kappaB signaling  Wnt protein secretion  positive regulation of Wnt protein secretion  positive regulation of Wnt protein secretion  extracellular exosome  positive regulation of canonical Wnt signaling pathway  
NDEx NetworkWLS
Atlas of Cancer Signalling NetworkWLS
Wikipedia pathwaysWLS
Orthology - Evolution
OrthoDB79971
GeneTree (enSembl)ENSG00000116729
Phylogenetic Trees/Animal Genes : TreeFamWLS
HOVERGENQ5T9L3
HOGENOMQ5T9L3
Homologs : HomoloGeneWLS
Homology/Alignments : Family Browser (UCSC)WLS
Gene fusions - Rearrangements
Fusion : MitelmanRYR2/WLS [1q43/1p31.3]  [t(1;1)(p31;q43)]  
Fusion : MitelmanSMYD3/WLS [1q44/1p31.3]  [t(1;1)(p31;q44)]  
Fusion: TCGARYR2 1q43 WLS 1p31.3 LGG
Fusion: TCGASMYD3 1q44 WLS 1p31.3 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerWLS [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)WLS
dbVarWLS
ClinVarWLS
1000_GenomesWLS 
Exome Variant ServerWLS
ExAC (Exome Aggregation Consortium)WLS (select the gene name)
Genetic variants : HAPMAP79971
Genomic Variants (DGV)WLS [DGVbeta]
DECIPHERWLS [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisWLS 
Mutations
ICGC Data PortalWLS 
TCGA Data PortalWLS 
Broad Tumor PortalWLS
OASIS PortalWLS [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICWLS  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDWLS
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch WLS
DgiDB (Drug Gene Interaction Database)WLS
DoCM (Curated mutations)WLS (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)WLS (select a term)
intoGenWLS
Cancer3DWLS(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM611514   
Orphanet
MedgenWLS
Genetic Testing Registry WLS
NextProtQ5T9L3 [Medical]
TSGene79971
GENETestsWLS
Huge Navigator WLS [HugePedia]
snp3D : Map Gene to Disease79971
BioCentury BCIQWLS
ClinGenWLS
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD79971
Chemical/Pharm GKB GenePA165752781
Clinical trialWLS
Miscellaneous
canSAR (ICR)WLS (select the gene name)
Probes
Litterature
PubMed41 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineWLS
EVEXWLS
GoPubMedWLS
iHOPWLS
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Fri May 19 12:44:10 CEST 2017

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