WLS (Wnt ligand secretion mediator)

2013-05-01  

Identity

HGNC
LOCATION
1p31.3
LOCUSID
ALIAS
C1orf139,EVI,GPR177,MRP,mig-14
FUSION GENES

Other Information

Locus ID:

NCBI: 79971
MIM: 611514
HGNC: 30238
Ensembl: ENSG00000116729

Variants:

dbSNP: 79971
ClinVar: 79971
TCGA: ENSG00000116729
COSMIC: WLS

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000116729ENST00000262348Q5T9L3
ENSG00000116729ENST00000354777Q5T9L3
ENSG00000116729ENST00000370971Q7Z430
ENSG00000116729ENST00000370973E9PKJ0
ENSG00000116729ENST00000370976Q5T9L3
ENSG00000116729ENST00000471243E9PQK1
ENSG00000116729ENST00000491076E9PM23
ENSG00000116729ENST00000527864H0YDL2
ENSG00000116729ENST00000530486E9PM62
ENSG00000116729ENST00000533537E9PJW4
ENSG00000116729ENST00000534713H0YCG9

Expression (GTEx)

0
50
100
150

Pathways

PathwaySourceExternal ID
Signal TransductionREACTOMER-HSA-162582
Signaling by WntREACTOMER-HSA-195721
WNT ligand biogenesis and traffickingREACTOMER-HSA-3238698

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
205489442010An integration of genome-wide association study and gene expression profiling to prioritize the discovery of novel susceptibility Loci for osteoporosis-related traits.90
241620182013Wnt secretion is required to maintain high levels of Wnt activity in colon cancer cells.83
247681652014WLS retrograde transport to the endoplasmic reticulum during Wnt secretion.33
202148002010Interaction of the mu-opioid receptor with GPR177 (Wntless) inhibits Wnt secretion: potential implications for opioid dependence.28
221475532012The Wnt secretion protein Evi/Gpr177 promotes glioma tumourigenesis.28
231887102013Gpr177, a novel locus for bone mineral density and osteoporosis, regulates osteogenesis and chondrogenesis in skeletal development.21
220278312011Identification of an endocytosis motif in an intracellular loop of Wntless protein, essential for its recycling and the control of Wnt protein signaling.19
239189542013Loss of epidermal Evi/Wls results in a phenotype resembling psoriasiform dermatitis.18
206529572010Expression of GPR177 (Wntless/Evi/Sprinter), a highly conserved Wnt-transport protein, in rat tissues, zebrafish embryos, and cultured human cells.14
269115902016Genome-wide association study using family-based cohorts identifies the WLS and CCDC170/ESR1 loci as associated with bone mineral density.12

Citation

Dessen P

WLS (Wnt ligand secretion mediator)

Atlas Genet Cytogenet Oncol Haematol. 2013-05-01

Online version: http://atlasgeneticsoncology.org/gene/53306/wls