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WNK3 (WNK lysine deficient protein kinase 3)

Identity

Alias_namesPRKWNK3
protein kinase, lysine deficient 3
Other alias
HGNC (Hugo) WNK3
LocusID (NCBI) 65267
Atlas_Id 75766
Location Xp11.22  [Link to chromosome band Xp11]
Location_base_pair Starts at 54192823 and ends at 54358005 bp from pter ( according to hg38-Dec_2013)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)WNK3   14543
Cards
Entrez_Gene (NCBI)WNK3  65267  WNK lysine deficient protein kinase 3
AliasesPRKWNK3
GeneCards (Weizmann)WNK3
Ensembl hg19 (Hinxton)ENSG00000196632 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000196632 [Gene_View]  chrX:54192823-54358005 [Contig_View]  WNK3 [Vega]
ICGC DataPortalENSG00000196632
TCGA cBioPortalWNK3
AceView (NCBI)WNK3
Genatlas (Paris)WNK3
WikiGenes65267
SOURCE (Princeton)WNK3
Genetics Home Reference (NIH)WNK3
Genomic and cartography
GoldenPath hg38 (UCSC)WNK3  -     chrX:54192823-54358005 -  Xp11.22   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)WNK3  -     Xp11.22   [Description]    (hg19-Feb_2009)
EnsemblWNK3 - Xp11.22 [CytoView hg19]  WNK3 - Xp11.22 [CytoView hg38]
Mapping of homologs : NCBIWNK3 [Mapview hg19]  WNK3 [Mapview hg38]
OMIM300358   
Gene and transcription
Genbank (Entrez)AB046786 AJ409088 AK054999 AK124653 AY082340
RefSeq transcript (Entrez)NM_001002838 NM_020922
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)WNK3
Cluster EST : UnigeneHs.92423 [ NCBI ]
CGAP (NCI)Hs.92423
Alternative Splicing GalleryENSG00000196632
Gene ExpressionWNK3 [ NCBI-GEO ]   WNK3 [ EBI - ARRAY_EXPRESS ]   WNK3 [ SEEK ]   WNK3 [ MEM ]
Gene Expression Viewer (FireBrowse)WNK3 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)65267
GTEX Portal (Tissue expression)WNK3
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9BYP7   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9BYP7  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9BYP7
Splice isoforms : SwissVarQ9BYP7
Catalytic activity : Enzyme2.7.11.1 [ Enzyme-Expasy ]   2.7.11.12.7.11.1 [ IntEnz-EBI ]   2.7.11.1 [ BRENDA ]   2.7.11.1 [ KEGG ]   
PhosPhoSitePlusQ9BYP7
Domaine pattern : Prosite (Expaxy)PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_ST (PS00108)   
Domains : Interpro (EBI)Kinase-like_dom    Kinase_OSR1/WNK_CCT    Prot_kinase_dom    Ser/Thr_kinase_AS   
Domain families : Pfam (Sanger)OSR1_C (PF12202)    Pkinase (PF00069)   
Domain families : Pfam (NCBI)pfam12202    pfam00069   
Domain families : Smart (EMBL)S_TKc (SM00220)  
Conserved Domain (NCBI)WNK3
DMDM Disease mutations65267
Blocks (Seattle)WNK3
SuperfamilyQ9BYP7
Human Protein AtlasENSG00000196632
Peptide AtlasQ9BYP7
HPRD02289
IPIIPI00387112   IPI00152474   IPI01013858   
Protein Interaction databases
DIP (DOE-UCLA)Q9BYP7
IntAct (EBI)Q9BYP7
FunCoupENSG00000196632
BioGRIDWNK3
STRING (EMBL)WNK3
ZODIACWNK3
Ontologies - Pathways
QuickGOQ9BYP7
Ontology : AmiGOprotein kinase activity  protein serine/threonine kinase activity  protein serine/threonine kinase activity  protein binding  ATP binding  cytoplasm  cytosol  adherens junction  bicellular tight junction  protein phosphorylation  positive regulation of sodium ion transport  positive regulation of peptidyl-threonine phosphorylation  chloride channel inhibitor activity  positive regulation of ion transmembrane transporter activity  intracellular signal transduction  intracellular signal transduction  negative regulation of apoptotic process  protein autophosphorylation  positive regulation of calcium ion transport  protein targeting to plasma membrane  positive regulation of establishment of protein localization to plasma membrane  negative regulation of pancreatic juice secretion  regulation of calcium ion import  regulation of ion homeostasis  positive regulation of sodium ion transmembrane transporter activity  positive regulation of sodium ion transmembrane transporter activity  positive regulation of rubidium ion transport  positive regulation of rubidium ion transmembrane transporter activity  
Ontology : EGO-EBIprotein kinase activity  protein serine/threonine kinase activity  protein serine/threonine kinase activity  protein binding  ATP binding  cytoplasm  cytosol  adherens junction  bicellular tight junction  protein phosphorylation  positive regulation of sodium ion transport  positive regulation of peptidyl-threonine phosphorylation  chloride channel inhibitor activity  positive regulation of ion transmembrane transporter activity  intracellular signal transduction  intracellular signal transduction  negative regulation of apoptotic process  protein autophosphorylation  positive regulation of calcium ion transport  protein targeting to plasma membrane  positive regulation of establishment of protein localization to plasma membrane  negative regulation of pancreatic juice secretion  regulation of calcium ion import  regulation of ion homeostasis  positive regulation of sodium ion transmembrane transporter activity  positive regulation of sodium ion transmembrane transporter activity  positive regulation of rubidium ion transport  positive regulation of rubidium ion transmembrane transporter activity  
NDEx NetworkWNK3
Atlas of Cancer Signalling NetworkWNK3
Wikipedia pathwaysWNK3
Orthology - Evolution
OrthoDB65267
GeneTree (enSembl)ENSG00000196632
Phylogenetic Trees/Animal Genes : TreeFamWNK3
HOVERGENQ9BYP7
HOGENOMQ9BYP7
Homologs : HomoloGeneWNK3
Homology/Alignments : Family Browser (UCSC)WNK3
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerWNK3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)WNK3
dbVarWNK3
ClinVarWNK3
1000_GenomesWNK3 
Exome Variant ServerWNK3
ExAC (Exome Aggregation Consortium)WNK3 (select the gene name)
Genetic variants : HAPMAP65267
Genomic Variants (DGV)WNK3 [DGVbeta]
DECIPHERWNK3 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisWNK3 
Mutations
ICGC Data PortalWNK3 
TCGA Data PortalWNK3 
Broad Tumor PortalWNK3
OASIS PortalWNK3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICWNK3  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDWNK3
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)X-chromosome gene database
BioMutasearch WNK3
DgiDB (Drug Gene Interaction Database)WNK3
DoCM (Curated mutations)WNK3 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)WNK3 (select a term)
intoGenWNK3
Cancer3DWNK3(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM300358   
Orphanet
MedgenWNK3
Genetic Testing Registry WNK3
NextProtQ9BYP7 [Medical]
TSGene65267
GENETestsWNK3
Huge Navigator WNK3 [HugePedia]
snp3D : Map Gene to Disease65267
BioCentury BCIQWNK3
ClinGenWNK3
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD65267
Chemical/Pharm GKB GenePA33784
Clinical trialWNK3
Miscellaneous
canSAR (ICR)WNK3 (select the gene name)
Probes
Litterature
PubMed34 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineWNK3
EVEXWNK3
GoPubMedWNK3
iHOPWNK3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Fri May 19 12:01:41 CEST 2017

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