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WNK4 (WNK lysine deficient protein kinase 4)

Identity

Alias_namesPRKWNK4
protein kinase
Other aliasPHA2B
HGNC (Hugo) WNK4
LocusID (NCBI) 65266
Atlas_Id 54785
Location 17q21.2  [Link to chromosome band 17q21]
Location_base_pair Starts at 42780631 and ends at 42797066 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
PPARD (6p21.31) / WNK4 (17q21.31)WNK4 (17q21.31) / MT1G (16q13)WNK4 (17q21.31) / ZNF787 (19q13.43)
PPARD 6p21.31 / WNK4 17q21.31

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)WNK4   14544
Cards
Entrez_Gene (NCBI)WNK4  65266  WNK lysine deficient protein kinase 4
AliasesPHA2B; PRKWNK4
GeneCards (Weizmann)WNK4
Ensembl hg19 (Hinxton)ENSG00000126562 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000126562 [Gene_View]  chr17:42780631-42797066 [Contig_View]  WNK4 [Vega]
ICGC DataPortalENSG00000126562
TCGA cBioPortalWNK4
AceView (NCBI)WNK4
Genatlas (Paris)WNK4
WikiGenes65266
SOURCE (Princeton)WNK4
Genetics Home Reference (NIH)WNK4
Genomic and cartography
GoldenPath hg38 (UCSC)WNK4  -     chr17:42780631-42797066 +  17q21.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)WNK4  -     17q21.2   [Description]    (hg19-Feb_2009)
EnsemblWNK4 - 17q21.2 [CytoView hg19]  WNK4 - 17q21.2 [CytoView hg38]
Mapping of homologs : NCBIWNK4 [Mapview hg19]  WNK4 [Mapview hg38]
OMIM601844   614491   
Gene and transcription
Genbank (Entrez)AF390018 AJ309861 AJ316534 AK096003 AK096052
RefSeq transcript (Entrez)NM_001321299 NM_032387
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)WNK4
Cluster EST : UnigeneHs.105448 [ NCBI ]
CGAP (NCI)Hs.105448
Alternative Splicing GalleryENSG00000126562
Gene ExpressionWNK4 [ NCBI-GEO ]   WNK4 [ EBI - ARRAY_EXPRESS ]   WNK4 [ SEEK ]   WNK4 [ MEM ]
Gene Expression Viewer (FireBrowse)WNK4 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)65266
GTEX Portal (Tissue expression)WNK4
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ96J92   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ96J92  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ96J92
Splice isoforms : SwissVarQ96J92
Catalytic activity : Enzyme2.7.11.1 [ Enzyme-Expasy ]   2.7.11.12.7.11.1 [ IntEnz-EBI ]   2.7.11.1 [ BRENDA ]   2.7.11.1 [ KEGG ]   
PhosPhoSitePlusQ96J92
Domaine pattern : Prosite (Expaxy)PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_ST (PS00108)   
Domains : Interpro (EBI)Kinase-like_dom    Kinase_OSR1/WNK_CCT    Prot_kinase_dom    Ser/Thr_kinase_AS   
Domain families : Pfam (Sanger)OSR1_C (PF12202)    Pkinase (PF00069)   
Domain families : Pfam (NCBI)pfam12202    pfam00069   
Domain families : Smart (EMBL)S_TKc (SM00220)  
Conserved Domain (NCBI)WNK4
DMDM Disease mutations65266
Blocks (Seattle)WNK4
PDB (SRS)2V3S    4CH9    4CHB   
PDB (PDBSum)2V3S    4CH9    4CHB   
PDB (IMB)2V3S    4CH9    4CHB   
PDB (RSDB)2V3S    4CH9    4CHB   
Structural Biology KnowledgeBase2V3S    4CH9    4CHB   
SCOP (Structural Classification of Proteins)2V3S    4CH9    4CHB   
CATH (Classification of proteins structures)2V3S    4CH9    4CHB   
SuperfamilyQ96J92
Human Protein AtlasENSG00000126562
Peptide AtlasQ96J92
HPRD03505
IPIIPI00151141   IPI00398442   IPI00398443   IPI00909943   IPI00953510   
Protein Interaction databases
DIP (DOE-UCLA)Q96J92
IntAct (EBI)Q96J92
FunCoupENSG00000126562
BioGRIDWNK4
STRING (EMBL)WNK4
ZODIACWNK4
Ontologies - Pathways
QuickGOQ96J92
Ontology : AmiGOprotein serine/threonine kinase activity  protein serine/threonine kinase activity  protein binding  ATP binding  cytosol  cytosol  bicellular tight junction  protein phosphorylation  protein phosphorylation  ion transport  chloride transport  protein localization  negative regulation of sodium ion transport  membrane  chloride channel inhibitor activity  intracellular signal transduction  intracellular signal transduction  regulation of cellular process  ion homeostasis  regulation of molecular function  renal sodium ion absorption  distal tubule morphogenesis  negative regulation of pancreatic juice secretion  
Ontology : EGO-EBIprotein serine/threonine kinase activity  protein serine/threonine kinase activity  protein binding  ATP binding  cytosol  cytosol  bicellular tight junction  protein phosphorylation  protein phosphorylation  ion transport  chloride transport  protein localization  negative regulation of sodium ion transport  membrane  chloride channel inhibitor activity  intracellular signal transduction  intracellular signal transduction  regulation of cellular process  ion homeostasis  regulation of molecular function  renal sodium ion absorption  distal tubule morphogenesis  negative regulation of pancreatic juice secretion  
NDEx NetworkWNK4
Atlas of Cancer Signalling NetworkWNK4
Wikipedia pathwaysWNK4
Orthology - Evolution
OrthoDB65266
GeneTree (enSembl)ENSG00000126562
Phylogenetic Trees/Animal Genes : TreeFamWNK4
HOVERGENQ96J92
HOGENOMQ96J92
Homologs : HomoloGeneWNK4
Homology/Alignments : Family Browser (UCSC)WNK4
Gene fusions - Rearrangements
Fusion : MitelmanPPARD/WNK4 [6p21.31/17q21.31]  [t(6;17)(p21;q21)]  
Fusion : MitelmanWNK4/ZNF787 [17q21.31/19q13.43]  [t(17;19)(q21;q13)]  
Fusion: TCGAPPARD 6p21.31 WNK4 17q21.31 LUAD
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerWNK4 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)WNK4
dbVarWNK4
ClinVarWNK4
1000_GenomesWNK4 
Exome Variant ServerWNK4
ExAC (Exome Aggregation Consortium)WNK4 (select the gene name)
Genetic variants : HAPMAP65266
Genomic Variants (DGV)WNK4 [DGVbeta]
DECIPHERWNK4 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisWNK4 
Mutations
ICGC Data PortalWNK4 
TCGA Data PortalWNK4 
Broad Tumor PortalWNK4
OASIS PortalWNK4 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICWNK4  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDWNK4
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch WNK4
DgiDB (Drug Gene Interaction Database)WNK4
DoCM (Curated mutations)WNK4 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)WNK4 (select a term)
intoGenWNK4
Cancer3DWNK4(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM601844    614491   
Orphanet11871   
MedgenWNK4
Genetic Testing Registry WNK4
NextProtQ96J92 [Medical]
TSGene65266
GENETestsWNK4
Target ValidationWNK4
Huge Navigator WNK4 [HugePedia]
snp3D : Map Gene to Disease65266
BioCentury BCIQWNK4
ClinGenWNK4
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD65266
Chemical/Pharm GKB GenePA134875400
Clinical trialWNK4
Miscellaneous
canSAR (ICR)WNK4 (select the gene name)
Probes
Litterature
PubMed72 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineWNK4
EVEXWNK4
GoPubMedWNK4
iHOPWNK4
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed Jun 7 13:02:54 CEST 2017

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