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WNT10B (wingless-type MMTV integration site family, member 10B)

Identity

Other namesSHFM6
WNT-12
HGNC (Hugo) WNT10B
LocusID (NCBI) 7480
Location 12q13.12
Location_base_pair Starts at 49359123 and ends at 49365641 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)WNT10B   12775
Cards
Entrez_Gene (NCBI)WNT10B  7480  wingless-type MMTV integration site family, member 10B
GeneCards (Weizmann)WNT10B
Ensembl (Hinxton)ENSG00000169884 [Gene_View]  chr12:49359123-49365641 [Contig_View]  WNT10B [Vega]
AceView (NCBI)WNT10B
Genatlas (Paris)WNT10B
WikiGenes7480
SOURCE (Princeton)NM_003394
Genomic and cartography
GoldenPath (UCSC)WNT10B  -  12q13.12   chr12:49359123-49365641 -  12q13.12   [Description]    (hg19-Feb_2009)
EnsemblWNT10B - 12q13.12 [CytoView]
Mapping of homologs : NCBIWNT10B [Mapview]
OMIM225300   601906   
Gene and transcription
Genbank (Entrez)AB070724 AK312906 BC096353 BC096354 BC096355
RefSeq transcript (Entrez)NM_003394
RefSeq genomic (Entrez)AC_000144 NC_000012 NC_018923 NG_023347 NT_029419 NW_001838057 NW_004929384
Consensus coding sequences : CCDS (NCBI)WNT10B
Cluster EST : UnigeneHs.91985 [ NCBI ]
CGAP (NCI)Hs.91985
Alternative Splicing : Fast-db (Paris)GSHG0007433
Alternative Splicing GalleryENSG00000169884
Gene ExpressionWNT10B [ NCBI-GEO ]     WNT10B [ SEEK ]   WNT10B [ MEM ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO00744 (Uniprot)
NextProtO00744  [Medical]
With graphics : InterProO00744
Splice isoforms : SwissVarO00744 (Swissvar)
Domaine pattern : Prosite (Expaxy)WNT1 (PS00246)   
Domains : Interpro (EBI)Wnt    Wnt10    Wnt_CS   
Related proteins : CluSTrO00744
Domain families : Pfam (Sanger)wnt (PF00110)   
Domain families : Pfam (NCBI)pfam00110   
Domain families : Smart (EMBL)WNT1 (SM00097)  
DMDM Disease mutations7480
Blocks (Seattle)O00744
Human Protein AtlasENSG00000169884
Peptide AtlasO00744
HPRD03548
IPIIPI00012971   IPI00878156   IPI00878223   IPI00877743   IPI00607683   
Protein Interaction databases
DIP (DOE-UCLA)O00744
IntAct (EBI)O00744
FunCoupENSG00000169884
BioGRIDWNT10B
InParanoidO00744
Interologous Interaction database O00744
IntegromeDBWNT10B
STRING (EMBL)WNT10B
Ontologies - Pathways
Ontology : AmiGOG2/M transition of mitotic cell cycle  negative regulation of transcription from RNA polymerase II promoter  chondrocyte differentiation  frizzled binding  extracellular region  proteinaceous extracellular matrix  extracellular space  lipid metabolic process  cell cycle arrest  smoothened signaling pathway  positive regulation of cell proliferation  positive regulation of G2/M transition of mitotic cell cycle  myoblast differentiation involved in skeletal muscle regeneration  Wnt receptor signaling pathway  neuron differentiation  neuron differentiation  positive regulation of bone mineralization  positive regulation of epithelial cell differentiation  regulation of proteasomal ubiquitin-dependent protein catabolic process  positive regulation of apoptotic process  cell fate commitment  negative regulation of fat cell differentiation  positive regulation of osteoblast differentiation  positive regulation of RNA polymerase II transcriptional preinitiation complex assembly  receptor agonist activity  regulation of skeletal muscle tissue development  skeletal muscle fiber development  negative regulation of epithelial cell proliferation  protein stabilization  sensory perception of taste  positive regulation of sequence-specific DNA binding transcription factor activity  positive regulation of anagen  canonical Wnt receptor signaling pathway  bone trabecula formation  fungiform papilla development  cellular response to retinoic acid  cellular response to cAMP  cellular response to parathyroid hormone stimulus  hematopoietic stem cell proliferation  positive regulation of canonical Wnt receptor signaling pathway  
Ontology : EGO-EBIG2/M transition of mitotic cell cycle  negative regulation of transcription from RNA polymerase II promoter  chondrocyte differentiation  frizzled binding  extracellular region  proteinaceous extracellular matrix  extracellular space  lipid metabolic process  cell cycle arrest  smoothened signaling pathway  positive regulation of cell proliferation  positive regulation of G2/M transition of mitotic cell cycle  myoblast differentiation involved in skeletal muscle regeneration  Wnt receptor signaling pathway  neuron differentiation  neuron differentiation  positive regulation of bone mineralization  positive regulation of epithelial cell differentiation  regulation of proteasomal ubiquitin-dependent protein catabolic process  positive regulation of apoptotic process  cell fate commitment  negative regulation of fat cell differentiation  positive regulation of osteoblast differentiation  positive regulation of RNA polymerase II transcriptional preinitiation complex assembly  receptor agonist activity  regulation of skeletal muscle tissue development  skeletal muscle fiber development  negative regulation of epithelial cell proliferation  protein stabilization  sensory perception of taste  positive regulation of sequence-specific DNA binding transcription factor activity  positive regulation of anagen  canonical Wnt receptor signaling pathway  bone trabecula formation  fungiform papilla development  cellular response to retinoic acid  cellular response to cAMP  cellular response to parathyroid hormone stimulus  hematopoietic stem cell proliferation  positive regulation of canonical Wnt receptor signaling pathway  
Pathways : KEGGWnt signaling pathway    Hedgehog signaling pathway    Hippo signaling pathway    Melanogenesis    HTLV-I infection    Pathways in cancer    Proteoglycans in cancer    Basal cell carcinoma   
REACTOMEWNT10B
Protein Interaction DatabaseWNT10B
Wikipedia pathwaysWNT10B
Gene fusion - rearrangments
Polymorphisms : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)WNT10B
SNP (GeneSNP Utah)WNT10B
SNP : HGBaseWNT10B
Genetic variants : HAPMAPWNT10B
1000_GenomesWNT10B 
ICGC programENSG00000169884 
Somatic Mutations in Cancer : COSMICWNT10B 
CONAN: Copy Number AnalysisWNT10B 
Mutations and Diseases : HGMDWNT10B
OMIM225300    601906   
GENETestsWNT10B
Disease Genetic AssociationWNT10B
Huge Navigator WNT10B [HugePedia]  WNT10B [HugeCancerGEM]
Genomic VariantsWNT10B  WNT10B [DGVbeta]
Exome VariantWNT10B
dbVarWNT10B
ClinVarWNT10B
snp3D : Map Gene to Disease7480
General knowledge
Homologs : HomoloGeneWNT10B
Homology/Alignments : Family Browser (UCSC)WNT10B
Phylogenetic Trees/Animal Genes : TreeFamWNT10B
Chemical/Protein Interactions : CTD7480
Chemical/Pharm GKB GenePA37377
Clinical trialWNT10B
Cancer Resource (Charite)ENSG00000169884
Other databases
Probes
Litterature
PubMed35 Pubmed reference(s) in Entrez
CoreMineWNT10B
iHOPWNT10B
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated12-2013Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Mar 31 09:16:19 CEST 2014

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