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WNT10B (Wnt family member 10B)

Identity

Other namesSHFM6
WNT-12
HGNC (Hugo) WNT10B
LocusID (NCBI) 7480
Atlas_Id 42817
Location 12q13.12
Location_base_pair Starts at 49359123 and ends at 49365641 bp from pter ( according to hg19-Feb_2009)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  inv(7)(p15q34) TRB/HOXA10;t(7;7)(p15;q34) TRB/HOXA10

External links

Nomenclature
HGNC (Hugo)WNT10B   12775
Cards
Entrez_Gene (NCBI)WNT10B  7480  Wnt family member 10B
GeneCards (Weizmann)WNT10B
Ensembl hg19 (Hinxton)ENSG00000169884 [Gene_View]  chr12:49359123-49365641 [Contig_View]  WNT10B [Vega]
Ensembl hg38 (Hinxton)ENSG00000169884 [Gene_View]  chr12:49359123-49365641 [Contig_View]  WNT10B [Vega]
ICGC DataPortalENSG00000169884
TCGA cBioPortalWNT10B
AceView (NCBI)WNT10B
Genatlas (Paris)WNT10B
WikiGenes7480
SOURCE (Princeton)WNT10B
Genomic and cartography
GoldenPath hg19 (UCSC)WNT10B  -     chr12:49359123-49365641 -  12q13.12   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)WNT10B  -     12q13.12   [Description]    (hg38-Dec_2013)
EnsemblWNT10B - 12q13.12 [CytoView hg19]  WNT10B - 12q13.12 [CytoView hg38]
Mapping of homologs : NCBIWNT10B [Mapview hg19]  WNT10B [Mapview hg38]
OMIM225300   601906   
Gene and transcription
Genbank (Entrez)AB070724 AK312906 BC096353 BC096354 BC096355
RefSeq transcript (Entrez)NM_003394
RefSeq genomic (Entrez)NC_000012 NC_018923 NG_023347 NT_029419 NW_004929384
Consensus coding sequences : CCDS (NCBI)WNT10B
Cluster EST : UnigeneHs.91985 [ NCBI ]
CGAP (NCI)Hs.91985
Alternative Splicing GalleryENSG00000169884
Gene ExpressionWNT10B [ NCBI-GEO ]   WNT10B [ EBI - ARRAY_EXPRESS ]   WNT10B [ SEEK ]   WNT10B [ MEM ]
Gene Expression Viewer (FireBrowse)WNT10B [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)7480
GTEX Portal (Tissue expression)WNT10B
Protein : pattern, domain, 3D structure
UniProt/SwissProtO00744 (Uniprot)
NextProtO00744  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO00744
Splice isoforms : SwissVarO00744 (Swissvar)
PhosPhoSitePlusO00744
Domaine pattern : Prosite (Expaxy)WNT1 (PS00246)   
Domains : Interpro (EBI)Wnt    Wnt10    Wnt_CS   
Domain families : Pfam (Sanger)wnt (PF00110)   
Domain families : Pfam (NCBI)pfam00110   
Domain families : Smart (EMBL)WNT1 (SM00097)  
DMDM Disease mutations7480
Blocks (Seattle)WNT10B
SuperfamilyO00744
Human Protein AtlasENSG00000169884
Peptide AtlasO00744
HPRD03548
IPIIPI00012971   IPI00878156   IPI00878223   IPI00877743   IPI00607683   
Protein Interaction databases
DIP (DOE-UCLA)O00744
IntAct (EBI)O00744
FunCoupENSG00000169884
BioGRIDWNT10B
STRING (EMBL)WNT10B
ZODIACWNT10B
Ontologies - Pathways
QuickGOO00744
Ontology : AmiGOG2/M transition of mitotic cell cycle  negative regulation of transcription from RNA polymerase II promoter  chondrocyte differentiation  frizzled binding  extracellular region  proteinaceous extracellular matrix  extracellular space  extracellular space  lipid metabolic process  cell cycle arrest  smoothened signaling pathway  positive regulation of cell proliferation  positive regulation of G2/M transition of mitotic cell cycle  myoblast differentiation involved in skeletal muscle regeneration  Wnt signaling pathway  Wnt signaling pathway  neuron differentiation  neuron differentiation  positive regulation of bone mineralization  positive regulation of epithelial cell differentiation  regulation of proteasomal ubiquitin-dependent protein catabolic process  positive regulation of apoptotic process  cell fate commitment  negative regulation of fat cell differentiation  positive regulation of osteoblast differentiation  positive regulation of RNA polymerase II transcriptional preinitiation complex assembly  receptor agonist activity  regulation of skeletal muscle tissue development  skeletal muscle fiber development  negative regulation of epithelial cell proliferation  protein stabilization  sensory perception of taste  positive regulation of sequence-specific DNA binding transcription factor activity  positive regulation of anagen  canonical Wnt signaling pathway  bone trabecula formation  fungiform papilla development  cellular response to retinoic acid  cellular response to cAMP  cellular response to parathyroid hormone stimulus  hematopoietic stem cell proliferation  cellular response to hydrostatic pressure  positive regulation of canonical Wnt signaling pathway  
Ontology : EGO-EBIG2/M transition of mitotic cell cycle  negative regulation of transcription from RNA polymerase II promoter  chondrocyte differentiation  frizzled binding  extracellular region  proteinaceous extracellular matrix  extracellular space  extracellular space  lipid metabolic process  cell cycle arrest  smoothened signaling pathway  positive regulation of cell proliferation  positive regulation of G2/M transition of mitotic cell cycle  myoblast differentiation involved in skeletal muscle regeneration  Wnt signaling pathway  Wnt signaling pathway  neuron differentiation  neuron differentiation  positive regulation of bone mineralization  positive regulation of epithelial cell differentiation  regulation of proteasomal ubiquitin-dependent protein catabolic process  positive regulation of apoptotic process  cell fate commitment  negative regulation of fat cell differentiation  positive regulation of osteoblast differentiation  positive regulation of RNA polymerase II transcriptional preinitiation complex assembly  receptor agonist activity  regulation of skeletal muscle tissue development  skeletal muscle fiber development  negative regulation of epithelial cell proliferation  protein stabilization  sensory perception of taste  positive regulation of sequence-specific DNA binding transcription factor activity  positive regulation of anagen  canonical Wnt signaling pathway  bone trabecula formation  fungiform papilla development  cellular response to retinoic acid  cellular response to cAMP  cellular response to parathyroid hormone stimulus  hematopoietic stem cell proliferation  cellular response to hydrostatic pressure  positive regulation of canonical Wnt signaling pathway  
Pathways : KEGGWnt signaling pathway    Hedgehog signaling pathway    Hippo signaling pathway    Melanogenesis    HTLV-I infection    Pathways in cancer    Proteoglycans in cancer    Basal cell carcinoma   
NDEx Network
Atlas of Cancer Signalling NetworkWNT10B
Wikipedia pathwaysWNT10B
Orthology - Evolution
OrthoDB7480
GeneTree (enSembl)ENSG00000169884
Phylogenetic Trees/Animal Genes : TreeFamWNT10B
Homologs : HomoloGeneWNT10B
Homology/Alignments : Family Browser (UCSC)WNT10B
Gene fusions - Rearrangements
Polymorphisms : SNP, variants
NCBI Variation ViewerWNT10B [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)WNT10B
dbVarWNT10B
ClinVarWNT10B
1000_GenomesWNT10B 
Exome Variant ServerWNT10B
ExAC (Exome Aggregation Consortium)WNT10B (select the gene name)
Genetic variants : HAPMAP7480
Genomic Variants (DGV)WNT10B [DGVbeta]
Mutations
ICGC Data PortalWNT10B 
TCGA Data PortalWNT10B 
Broad Tumor PortalWNT10B
OASIS PortalWNT10B [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICWNT10B 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch WNT10B
DgiDB (Drug Gene Interaction Database)WNT10B
DoCM (Curated mutations)WNT10B (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)WNT10B (select a term)
intoGenWNT10B
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)12:49359123-49365641  ENSG00000169884
CONAN: Copy Number AnalysisWNT10B 
Mutations and Diseases : HGMDWNT10B
OMIM225300    601906   
MedgenWNT10B
Genetic Testing Registry WNT10B
NextProtO00744 [Medical]
TSGene7480
GENETestsWNT10B
Huge Navigator WNT10B [HugePedia]
snp3D : Map Gene to Disease7480
BioCentury BCIQWNT10B
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD7480
Chemical/Pharm GKB GenePA37377
Clinical trialWNT10B
Miscellaneous
canSAR (ICR)WNT10B (select the gene name)
Probes
Litterature
PubMed40 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineWNT10B
EVEXWNT10B
GoPubMedWNT10B
iHOPWNT10B
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Sun May 8 19:11:36 CEST 2016

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