WNT11 (Wnt family member 11)

2003-12-01  

Identity

HGNC
LOCATION
11q13.5
LOCUSID
ALIAS
HWNT11
FUSION GENES

Other Information

Locus ID:

NCBI: 7481
MIM: 603699
HGNC: 12776
Ensembl: ENSG00000085741

Variants:

dbSNP: 7481
ClinVar: 7481
TCGA: ENSG00000085741
COSMIC: WNT11

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000085741ENST00000322563O96014
ENSG00000085741ENST00000621122H8YS97

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45

Pathways

PathwaySourceExternal ID
mTOR signaling pathwayKEGGko04150
Wnt signaling pathwayKEGGko04310
MelanogenesisKEGGko04916
Basal cell carcinomaKEGGko05217
mTOR signaling pathwayKEGGhsa04150
Wnt signaling pathwayKEGGhsa04310
MelanogenesisKEGGhsa04916
Pathways in cancerKEGGhsa05200
Basal cell carcinomaKEGGhsa05217
HTLV-I infectionKEGGko05166
HTLV-I infectionKEGGhsa05166
Hippo signaling pathwayKEGGhsa04390
Hippo signaling pathwayKEGGko04390
Proteoglycans in cancerKEGGhsa05205
Proteoglycans in cancerKEGGko05205
Signaling pathways regulating pluripotency of stem cellsKEGGhsa04550
Signaling pathways regulating pluripotency of stem cellsKEGGko04550
Wnt signalingKEGGhsa_M00677
Wnt signalingKEGGM00677
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR ligand bindingREACTOMER-HSA-500792
Class B/2 (Secretin family receptors)REACTOMER-HSA-373080
Signaling by WntREACTOMER-HSA-195721
WNT ligand biogenesis and traffickingREACTOMER-HSA-3238698
Beta-catenin independent WNT signalingREACTOMER-HSA-3858494
PCP/CE pathwayREACTOMER-HSA-4086400
Ca2+ pathwayREACTOMER-HSA-4086398
Breast cancerKEGGko05224
Breast cancerKEGGhsa05224

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
200620602010Genome-wide association study of PR interval.185
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
184133252008Variation in WNT genes is associated with non-syndromic cleft lip with or without cleft palate.58
202190912010Wnt-11 promotes neuroendocrine-like differentiation, survival and migration of prostate cancer cells.58
208707442010WNT11 expression is induced by estrogen-related receptor alpha and beta-catenin and acts in an autocrine manner to increase cancer cell migration.53
235498732013Identification of prognosis-relevant subgroups in patients with chemoresistant triple-negative breast cancer.53
157085672005Wnt11-R, a protein closely related to mammalian Wnt11, is required for heart morphogenesis in Xenopus.43
179677892007Notch signaling contributes to the expression of cardiac markers in human circulating progenitor cells.40
157016292005Non-canonical Wnt signaling enhances differentiation of human circulating progenitor cells to cardiomyogenic cells.39
240821142013Paracrine activation of WNT/β-catenin pathway in uterine leiomyoma stem cells promotes tumor growth.37

Citation

Dessen P

WNT11 (Wnt family member 11)

Atlas Genet Cytogenet Oncol Haematol. 2003-12-01

Online version: http://atlasgeneticsoncology.org/gene/42818/wnt11