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WNT11 (Wnt family member 11)

Identity

Alias_nameswingless-type MMTV integration site family
Other aliasHWNT11
HGNC (Hugo) WNT11
LocusID (NCBI) 7481
Atlas_Id 42818
Location 11q13.5  [Link to chromosome band 11q13]
Location_base_pair Starts at 76186326 and ends at 76206530 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
SHANK2 (11q13.3) / WNT11 (11q13.5)WNT11 (11q13.5) / TSPAN8 (12q21.1)SHANK2 11q13.3 / WNT11 11q13.5
WNT11 11q13.5 / TSPAN8 12q21.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)WNT11   12776
Cards
Entrez_Gene (NCBI)WNT11  7481  Wnt family member 11
AliasesHWNT11
GeneCards (Weizmann)WNT11
Ensembl hg19 (Hinxton)ENSG00000085741 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000085741 [Gene_View]  chr11:76186326-76206530 [Contig_View]  WNT11 [Vega]
ICGC DataPortalENSG00000085741
TCGA cBioPortalWNT11
AceView (NCBI)WNT11
Genatlas (Paris)WNT11
WikiGenes7481
SOURCE (Princeton)WNT11
Genetics Home Reference (NIH)WNT11
Genomic and cartography
GoldenPath hg38 (UCSC)WNT11  -     chr11:76186326-76206530 -  11q13.5   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)WNT11  -     11q13.5   [Description]    (hg19-Feb_2009)
EnsemblWNT11 - 11q13.5 [CytoView hg19]  WNT11 - 11q13.5 [CytoView hg38]
Mapping of homologs : NCBIWNT11 [Mapview hg19]  WNT11 [Mapview hg38]
OMIM603699   
Gene and transcription
Genbank (Entrez)AB070218 AK075540 AK313570 BC074790 BC074791
RefSeq transcript (Entrez)NM_004626
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)WNT11
Cluster EST : UnigeneHs.108219 [ NCBI ]
CGAP (NCI)Hs.108219
Alternative Splicing GalleryENSG00000085741
Gene ExpressionWNT11 [ NCBI-GEO ]   WNT11 [ EBI - ARRAY_EXPRESS ]   WNT11 [ SEEK ]   WNT11 [ MEM ]
Gene Expression Viewer (FireBrowse)WNT11 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)7481
GTEX Portal (Tissue expression)WNT11
Protein : pattern, domain, 3D structure
UniProt/SwissProtO96014   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO96014  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO96014
Splice isoforms : SwissVarO96014
PhosPhoSitePlusO96014
Domaine pattern : Prosite (Expaxy)WNT1 (PS00246)   
Domains : Interpro (EBI)Wnt    Wnt-11    Wnt_CS   
Domain families : Pfam (Sanger)wnt (PF00110)   
Domain families : Pfam (NCBI)pfam00110   
Domain families : Smart (EMBL)WNT1 (SM00097)  
Conserved Domain (NCBI)WNT11
DMDM Disease mutations7481
Blocks (Seattle)WNT11
SuperfamilyO96014
Human Protein AtlasENSG00000085741
Peptide AtlasO96014
HPRD04741
IPIIPI00014069   IPI00977509   IPI00976849   
Protein Interaction databases
DIP (DOE-UCLA)O96014
IntAct (EBI)O96014
FunCoupENSG00000085741
BioGRIDWNT11
STRING (EMBL)WNT11
ZODIACWNT11
Ontologies - Pathways
QuickGOO96014
Ontology : AmiGOosteoblast differentiation  epithelial to mesenchymal transition  outflow tract morphogenesis  planar cell polarity pathway involved in axis elongation  GTPase activator activity  frizzled binding  frizzled binding  protein binding  extracellular region  proteinaceous extracellular matrix  extracellular space  cytoplasm  protein phosphorylation  Wnt signaling pathway, calcium modulating pathway  positive regulation of gene expression  Wnt signaling pathway  neuron differentiation  neuron differentiation  bone mineralization  protein kinase activator activity  negative regulation of cell growth  adrenal gland development  positive regulation of cell migration  negative regulation of cell migration  response to nutrient levels  activation of protein kinase activity  positive regulation of transforming growth factor beta2 production  protein localization to cell surface  positive regulation of apoptotic process  negative regulation of apoptotic process  positive regulation of GTPase activity  transcription regulatory region DNA binding  cell fate commitment  maintenance of epithelial cell apical/basal polarity  negative regulation of transcription, DNA-templated  positive regulation of transcription, DNA-templated  paraxial mesoderm formation  notochord morphogenesis  embryonic skeletal system development  artery morphogenesis  positive regulation of stress fiber assembly  palate development  convergent extension involved in axis elongation  canonical Wnt signaling pathway  Wnt signaling pathway, planar cell polarity pathway  Wnt signaling pathway, planar cell polarity pathway  cloacal septation  ventricular septum morphogenesis  lung-associated mesenchyme development  negative regulation of cell death  ureteric bud morphogenesis  planar cell polarity pathway involved in gastrula mediolateral intercalation  negative regulation of cartilage development  somite development  neuroendocrine cell differentiation  bicellular tight junction assembly  cellular response to mechanical stimulus  cellular response to retinoic acid  mesonephric duct development  negative regulation of mesenchymal cell proliferation  positive regulation of protein kinase C signaling  negative regulation of canonical Wnt signaling pathway  negative regulation of fibroblast growth factor production  
Ontology : EGO-EBIosteoblast differentiation  epithelial to mesenchymal transition  outflow tract morphogenesis  planar cell polarity pathway involved in axis elongation  GTPase activator activity  frizzled binding  frizzled binding  protein binding  extracellular region  proteinaceous extracellular matrix  extracellular space  cytoplasm  protein phosphorylation  Wnt signaling pathway, calcium modulating pathway  positive regulation of gene expression  Wnt signaling pathway  neuron differentiation  neuron differentiation  bone mineralization  protein kinase activator activity  negative regulation of cell growth  adrenal gland development  positive regulation of cell migration  negative regulation of cell migration  response to nutrient levels  activation of protein kinase activity  positive regulation of transforming growth factor beta2 production  protein localization to cell surface  positive regulation of apoptotic process  negative regulation of apoptotic process  positive regulation of GTPase activity  transcription regulatory region DNA binding  cell fate commitment  maintenance of epithelial cell apical/basal polarity  negative regulation of transcription, DNA-templated  positive regulation of transcription, DNA-templated  paraxial mesoderm formation  notochord morphogenesis  embryonic skeletal system development  artery morphogenesis  positive regulation of stress fiber assembly  palate development  convergent extension involved in axis elongation  canonical Wnt signaling pathway  Wnt signaling pathway, planar cell polarity pathway  Wnt signaling pathway, planar cell polarity pathway  cloacal septation  ventricular septum morphogenesis  lung-associated mesenchyme development  negative regulation of cell death  ureteric bud morphogenesis  planar cell polarity pathway involved in gastrula mediolateral intercalation  negative regulation of cartilage development  somite development  neuroendocrine cell differentiation  bicellular tight junction assembly  cellular response to mechanical stimulus  cellular response to retinoic acid  mesonephric duct development  negative regulation of mesenchymal cell proliferation  positive regulation of protein kinase C signaling  negative regulation of canonical Wnt signaling pathway  negative regulation of fibroblast growth factor production  
Pathways : KEGGWnt signaling pathway    Hedgehog signaling pathway    Hippo signaling pathway    Melanogenesis    HTLV-I infection    Pathways in cancer    Proteoglycans in cancer    Basal cell carcinoma   
NDEx NetworkWNT11
Atlas of Cancer Signalling NetworkWNT11
Wikipedia pathwaysWNT11
Orthology - Evolution
OrthoDB7481
GeneTree (enSembl)ENSG00000085741
Phylogenetic Trees/Animal Genes : TreeFamWNT11
HOVERGENO96014
HOGENOMO96014
Homologs : HomoloGeneWNT11
Homology/Alignments : Family Browser (UCSC)WNT11
Gene fusions - Rearrangements
Fusion : MitelmanSHANK2/WNT11 [11q13.3/11q13.5]  [t(11;11)(q13;q13)]  
Fusion : MitelmanWNT11/TSPAN8 [11q13.5/12q21.1]  [t(11;12)(q13;q21)]  
Fusion: TCGASHANK2 11q13.3 WNT11 11q13.5 LUAD
Fusion: TCGAWNT11 11q13.5 TSPAN8 12q21.1 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerWNT11 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)WNT11
dbVarWNT11
ClinVarWNT11
1000_GenomesWNT11 
Exome Variant ServerWNT11
ExAC (Exome Aggregation Consortium)WNT11 (select the gene name)
Genetic variants : HAPMAP7481
Genomic Variants (DGV)WNT11 [DGVbeta]
DECIPHERWNT11 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisWNT11 
Mutations
ICGC Data PortalWNT11 
TCGA Data PortalWNT11 
Broad Tumor PortalWNT11
OASIS PortalWNT11 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICWNT11  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDWNT11
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch WNT11
DgiDB (Drug Gene Interaction Database)WNT11
DoCM (Curated mutations)WNT11 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)WNT11 (select a term)
intoGenWNT11
Cancer3DWNT11(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM603699   
Orphanet
MedgenWNT11
Genetic Testing Registry WNT11
NextProtO96014 [Medical]
TSGene7481
GENETestsWNT11
Target ValidationWNT11
Huge Navigator WNT11 [HugePedia]
snp3D : Map Gene to Disease7481
BioCentury BCIQWNT11
ClinGenWNT11
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD7481
Chemical/Pharm GKB GenePA37378
Clinical trialWNT11
Miscellaneous
canSAR (ICR)WNT11 (select the gene name)
Probes
Litterature
PubMed39 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineWNT11
EVEXWNT11
GoPubMedWNT11
iHOPWNT11
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed Jun 7 13:02:54 CEST 2017

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