WNT16 (Wnt family member 16)

2003-02-01  

Identity

HGNC
LOCATION
7q31.31
LOCUSID
ALIAS
-

Other Information

Locus ID:

NCBI: 51384
MIM: 606267
HGNC: 16267
Ensembl: ENSG00000002745

Variants:

dbSNP: 51384
ClinVar: 51384
TCGA: ENSG00000002745
COSMIC: WNT16

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000002745ENST00000222462Q9UBV4
ENSG00000002745ENST00000361301E9PH60

Expression (GTEx)

0
5
10
15

Pathways

PathwaySourceExternal ID
mTOR signaling pathwayKEGGko04150
Wnt signaling pathwayKEGGko04310
MelanogenesisKEGGko04916
Basal cell carcinomaKEGGko05217
mTOR signaling pathwayKEGGhsa04150
Wnt signaling pathwayKEGGhsa04310
MelanogenesisKEGGhsa04916
Pathways in cancerKEGGhsa05200
Basal cell carcinomaKEGGhsa05217
HTLV-I infectionKEGGko05166
HTLV-I infectionKEGGhsa05166
Transcriptional misregulation in cancerKEGGko05202
Transcriptional misregulation in cancerKEGGhsa05202
Hippo signaling pathwayKEGGhsa04390
Hippo signaling pathwayKEGGko04390
Proteoglycans in cancerKEGGhsa05205
Proteoglycans in cancerKEGGko05205
Signaling pathways regulating pluripotency of stem cellsKEGGhsa04550
Signaling pathways regulating pluripotency of stem cellsKEGGko04550
Wnt signalingKEGGhsa_M00677
Wnt signalingKEGGM00677
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR ligand bindingREACTOMER-HSA-500792
Class B/2 (Secretin family receptors)REACTOMER-HSA-373080
Signaling by WntREACTOMER-HSA-195721
WNT ligand biogenesis and traffickingREACTOMER-HSA-3238698
Breast cancerKEGGko05224
Breast cancerKEGGhsa05224

References

Pubmed IDYearTitleCitations
228637862012Treatment-induced damage to the tumor microenvironment promotes prostate cancer therapy resistance through WNT16B.220
253062332014Osteoblast-derived WNT16 represses osteoclastogenesis and prevents cortical bone fragility fractures.93
227920712012WNT16 influences bone mineral density, cortical bone thickness, bone strength, and osteoporotic fracture risk.81
227920702012Meta-analysis of genome-wide scans for total body BMD in children and adults reveals allelic heterogeneity and age-specific effects at the WNT16 locus.58
249454042014Phenotypic dissection of bone mineral density reveals skeletal site specificity and facilitates the identification of novel loci in the genetic regulation of bone mass attainment.55
199519882009WNT16B is a new marker of cellular senescence that regulates p53 activity and the phosphoinositide 3-kinase/AKT pathway.43
240821142013Paracrine activation of WNT/β-catenin pathway in uterine leiomyoma stem cells promotes tumor growth.37
160072262005Inhibition of Wnt16 in human acute lymphoblastoid leukemia cells containing the t(1;19) translocation induces apoptosis.35
230741522013Meta-analysis of genome-wide studies identifies WNT16 and ESR1 SNPs associated with bone mineral density in premenopausal women.35
234173542013Missense polymorphisms of the WNT16 gene are associated with bone mass, hip geometry and fractures.26

Citation

Dessen P

WNT16 (Wnt family member 16)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/42819/wnt16