WNT2 (Wnt family member 2)

2003-02-01  

Identity

HGNC
LOCATION
7q31.2
LOCUSID
ALIAS
INT1L1,IRP
FUSION GENES

Other Information

Locus ID:

NCBI: 7472
MIM: 147870
HGNC: 12780
Ensembl: ENSG00000105989

Variants:

dbSNP: 7472
ClinVar: 7472
TCGA: ENSG00000105989
COSMIC: WNT2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000105989ENST00000265441P09544
ENSG00000105989ENST00000265441A0A384MDX3
ENSG00000105989ENST00000449446F8WDR1
ENSG00000105989ENST00000491214C9JUI2
ENSG00000105989ENST00000647844A0A3B3ITC9

Expression (GTEx)

0
5
10
15
20
25

Pathways

PathwaySourceExternal ID
mTOR signaling pathwayKEGGko04150
Wnt signaling pathwayKEGGko04310
MelanogenesisKEGGko04916
Basal cell carcinomaKEGGko05217
mTOR signaling pathwayKEGGhsa04150
Wnt signaling pathwayKEGGhsa04310
MelanogenesisKEGGhsa04916
Pathways in cancerKEGGhsa05200
Basal cell carcinomaKEGGhsa05217
HTLV-I infectionKEGGko05166
HTLV-I infectionKEGGhsa05166
Hippo signaling pathwayKEGGhsa04390
Hippo signaling pathwayKEGGko04390
Proteoglycans in cancerKEGGhsa05205
Proteoglycans in cancerKEGGko05205
Signaling pathways regulating pluripotency of stem cellsKEGGhsa04550
Signaling pathways regulating pluripotency of stem cellsKEGGko04550
Wnt signalingKEGGhsa_M00677
Wnt signalingKEGGM00677
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR ligand bindingREACTOMER-HSA-500792
Class B/2 (Secretin family receptors)REACTOMER-HSA-373080
Signaling by WntREACTOMER-HSA-195721
WNT ligand biogenesis and traffickingREACTOMER-HSA-3238698
Breast cancerKEGGko05224
Breast cancerKEGGhsa05224

References

Pubmed IDYearTitleCitations
227634542012RNA sequencing of pancreatic circulating tumour cells implicates WNT signalling in metastasis.201
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
189490172009Downregulation of Wnt2 and beta-catenin by siRNA suppresses malignant glioma cell growth.78
194211422009The Wnt receptor FZD1 mediates chemoresistance in neuroblastoma through activation of the Wnt/beta-catenin pathway.70
236949622013DNA methylation biomarkers for noninvasive diagnosis of colorectal cancer.44
197343172009Mesenchymal stem cells produce Wnt isoforms and TGF-beta1 that mediate proliferation and procollagen expression by lung fibroblasts.42
164078292006Alterations of the Wnt signaling pathway during the neoplastic progression of Barrett's esophagus.39
206286242010Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility "hot-spot".29
220414572012Wnt/β-catenin pathway forms a negative feedback loop during TGF-β1 induced human normal skin fibroblast-to-myofibroblast transition.28
175348952007Inhibition of Wnt-2 and galectin-3 synergistically destabilizes beta-catenin and induces apoptosis in human colorectal cancer cells.26

Citation

Dessen P

WNT2 (Wnt family member 2)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/42820/wnt2