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WNT2 (Wnt family member 2)

Identity

Alias_namesINT1L1
wingless-type MMTV integration site family member 2
Alias_symbol (synonym)IRP
Other alias
HGNC (Hugo) WNT2
LocusID (NCBI) 7472
Atlas_Id 42820
Location 7q31.2  [Link to chromosome band 7q31]
Location_base_pair Starts at 117276631 and ends at 117323289 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
MET (7q31.2) / WNT2 (7q31.2)MET 7q31.2 / WNT2 7q31.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)WNT2   12780
Cards
Entrez_Gene (NCBI)WNT2  7472  Wnt family member 2
AliasesINT1L1; IRP
GeneCards (Weizmann)WNT2
Ensembl hg19 (Hinxton)ENSG00000105989 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000105989 [Gene_View]  chr7:117276631-117323289 [Contig_View]  WNT2 [Vega]
ICGC DataPortalENSG00000105989
TCGA cBioPortalWNT2
AceView (NCBI)WNT2
Genatlas (Paris)WNT2
WikiGenes7472
SOURCE (Princeton)WNT2
Genetics Home Reference (NIH)WNT2
Genomic and cartography
GoldenPath hg38 (UCSC)WNT2  -     chr7:117276631-117323289 -  7q31.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)WNT2  -     7q31.2   [Description]    (hg19-Feb_2009)
EnsemblWNT2 - 7q31.2 [CytoView hg19]  WNT2 - 7q31.2 [CytoView hg38]
Mapping of homologs : NCBIWNT2 [Mapview hg19]  WNT2 [Mapview hg38]
OMIM147870   
Gene and transcription
Genbank (Entrez)AK056742 BC029854 BC078170 BT019608 DQ892457
RefSeq transcript (Entrez)NM_003391
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)WNT2
Cluster EST : UnigeneHs.567356 [ NCBI ]
CGAP (NCI)Hs.567356
Alternative Splicing GalleryENSG00000105989
Gene ExpressionWNT2 [ NCBI-GEO ]   WNT2 [ EBI - ARRAY_EXPRESS ]   WNT2 [ SEEK ]   WNT2 [ MEM ]
Gene Expression Viewer (FireBrowse)WNT2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)7472
GTEX Portal (Tissue expression)WNT2
Protein : pattern, domain, 3D structure
UniProt/SwissProtP09544   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP09544  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP09544
Splice isoforms : SwissVarP09544
PhosPhoSitePlusP09544
Domaine pattern : Prosite (Expaxy)WNT1 (PS00246)   
Domains : Interpro (EBI)Wnt    Wnt2    Wnt_CS   
Domain families : Pfam (Sanger)wnt (PF00110)   
Domain families : Pfam (NCBI)pfam00110   
Domain families : Smart (EMBL)WNT1 (SM00097)  
Conserved Domain (NCBI)WNT2
DMDM Disease mutations7472
Blocks (Seattle)WNT2
SuperfamilyP09544
Human Protein AtlasENSG00000105989
Peptide AtlasP09544
HPRD00999
IPIIPI00015175   IPI00657998   IPI00947499   
Protein Interaction databases
DIP (DOE-UCLA)P09544
IntAct (EBI)P09544
FunCoupENSG00000105989
BioGRIDWNT2
STRING (EMBL)WNT2
ZODIACWNT2
Ontologies - Pathways
QuickGOP09544
Ontology : AmiGOpositive regulation of endothelial cell proliferation  positive regulation of mesenchymal cell proliferation  lens development in camera-type eye  frizzled binding  cytokine activity  protein binding  extracellular region  extracellular region  proteinaceous extracellular matrix  extracellular space  cytoplasm  plasma membrane  cell-cell signaling  positive regulation of cell proliferation  Wnt signaling pathway  Wnt signaling pathway  neurogenesis  neuron differentiation  lung development  extracellular matrix  cell proliferation in midbrain  cell fate commitment  positive regulation of transcription from RNA polymerase II promoter  receptor agonist activity  receptor agonist activity  positive regulation of fibroblast proliferation  positive regulation of neurogenesis  positive regulation of sequence-specific DNA binding transcription factor activity  atrial cardiac muscle tissue morphogenesis  positive regulation of cardiac muscle cell proliferation  canonical Wnt signaling pathway  canonical Wnt signaling pathway  cardiac epithelial to mesenchymal transition  lung induction  positive regulation of epithelial cell proliferation involved in lung morphogenesis  labyrinthine layer blood vessel development  iris morphogenesis  mammary gland epithelium development  cellular response to retinoic acid  cellular response to transforming growth factor beta stimulus  positive regulation of canonical Wnt signaling pathway  midbrain dopaminergic neuron differentiation  canonical Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation  Wnt signalosome  
Ontology : EGO-EBIpositive regulation of endothelial cell proliferation  positive regulation of mesenchymal cell proliferation  lens development in camera-type eye  frizzled binding  cytokine activity  protein binding  extracellular region  extracellular region  proteinaceous extracellular matrix  extracellular space  cytoplasm  plasma membrane  cell-cell signaling  positive regulation of cell proliferation  Wnt signaling pathway  Wnt signaling pathway  neurogenesis  neuron differentiation  lung development  extracellular matrix  cell proliferation in midbrain  cell fate commitment  positive regulation of transcription from RNA polymerase II promoter  receptor agonist activity  receptor agonist activity  positive regulation of fibroblast proliferation  positive regulation of neurogenesis  positive regulation of sequence-specific DNA binding transcription factor activity  atrial cardiac muscle tissue morphogenesis  positive regulation of cardiac muscle cell proliferation  canonical Wnt signaling pathway  canonical Wnt signaling pathway  cardiac epithelial to mesenchymal transition  lung induction  positive regulation of epithelial cell proliferation involved in lung morphogenesis  labyrinthine layer blood vessel development  iris morphogenesis  mammary gland epithelium development  cellular response to retinoic acid  cellular response to transforming growth factor beta stimulus  positive regulation of canonical Wnt signaling pathway  midbrain dopaminergic neuron differentiation  canonical Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation  Wnt signalosome  
Pathways : KEGGWnt signaling pathway    Hedgehog signaling pathway    Hippo signaling pathway    Melanogenesis    HTLV-I infection    Pathways in cancer    Proteoglycans in cancer    Basal cell carcinoma   
NDEx NetworkWNT2
Atlas of Cancer Signalling NetworkWNT2
Wikipedia pathwaysWNT2
Orthology - Evolution
OrthoDB7472
GeneTree (enSembl)ENSG00000105989
Phylogenetic Trees/Animal Genes : TreeFamWNT2
HOVERGENP09544
HOGENOMP09544
Homologs : HomoloGeneWNT2
Homology/Alignments : Family Browser (UCSC)WNT2
Gene fusions - Rearrangements
Fusion : MitelmanMET/WNT2 [7q31.2/7q31.2]  [t(7;7)(q31;q31)]  
Fusion: TCGAMET 7q31.2 WNT2 7q31.2 LUAD
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerWNT2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)WNT2
dbVarWNT2
ClinVarWNT2
1000_GenomesWNT2 
Exome Variant ServerWNT2
ExAC (Exome Aggregation Consortium)WNT2 (select the gene name)
Genetic variants : HAPMAP7472
Genomic Variants (DGV)WNT2 [DGVbeta]
DECIPHERWNT2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisWNT2 
Mutations
ICGC Data PortalWNT2 
TCGA Data PortalWNT2 
Broad Tumor PortalWNT2
OASIS PortalWNT2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICWNT2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDWNT2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch WNT2
DgiDB (Drug Gene Interaction Database)WNT2
DoCM (Curated mutations)WNT2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)WNT2 (select a term)
intoGenWNT2
Cancer3DWNT2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM147870   
Orphanet
MedgenWNT2
Genetic Testing Registry WNT2
NextProtP09544 [Medical]
TSGene7472
GENETestsWNT2
Target ValidationWNT2
Huge Navigator WNT2 [HugePedia]
snp3D : Map Gene to Disease7472
BioCentury BCIQWNT2
ClinGenWNT2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD7472
Chemical/Pharm GKB GenePA37381
Clinical trialWNT2
Miscellaneous
canSAR (ICR)WNT2 (select the gene name)
Probes
Litterature
PubMed73 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineWNT2
EVEXWNT2
GoPubMedWNT2
iHOPWNT2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed Jun 7 13:02:55 CEST 2017

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