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WNT3 (Wnt family member 3)

Identity

Alias_namesINT4
wingless-type MMTV integration site family
Alias_symbol (synonym)MGC131950
MGC138321
MGC138323
Other aliasTETAMS
HGNC (Hugo) WNT3
LocusID (NCBI) 7473
Atlas_Id 42822
Location 17q21.31  [Link to chromosome band 17q21]
Location_base_pair Starts at 46762506 and ends at 46818760 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(1;17)(p36;q21) WNT3 or NSF/PRDM16

External links

Nomenclature
HGNC (Hugo)WNT3   12782
Cards
Entrez_Gene (NCBI)WNT3  7473  Wnt family member 3
AliasesINT4; TETAMS
GeneCards (Weizmann)WNT3
Ensembl hg19 (Hinxton)ENSG00000108379 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000108379 [Gene_View]  ENSG00000108379 [Sequence]  chr17:46762506-46818760 [Contig_View]  WNT3 [Vega]
ICGC DataPortalENSG00000108379
TCGA cBioPortalWNT3
AceView (NCBI)WNT3
Genatlas (Paris)WNT3
WikiGenes7473
SOURCE (Princeton)WNT3
Genetics Home Reference (NIH)WNT3
Genomic and cartography
GoldenPath hg38 (UCSC)WNT3  -     chr17:46762506-46818760 -  17q21.31   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)WNT3  -     17q21.31   [Description]    (hg19-Feb_2009)
EnsemblWNT3 - 17q21.31 [CytoView hg19]  WNT3 - 17q21.31 [CytoView hg38]
Mapping of homologs : NCBIWNT3 [Mapview hg19]  WNT3 [Mapview hg38]
OMIM165330   273395   
Gene and transcription
Genbank (Entrez)AB067628 AY009397 BC112116 BC112118 BC114219
RefSeq transcript (Entrez)NM_030753
RefSeq genomic (Entrez)NC_000017 NG_008084 NT_167251 NT_187663
Consensus coding sequences : CCDS (NCBI)WNT3
Cluster EST : UnigeneHs.745220 [ NCBI ]
CGAP (NCI)Hs.745220
Alternative Splicing GalleryENSG00000108379
Gene ExpressionWNT3 [ NCBI-GEO ]   WNT3 [ EBI - ARRAY_EXPRESS ]   WNT3 [ SEEK ]   WNT3 [ MEM ]
Gene Expression Viewer (FireBrowse)WNT3 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)7473
GTEX Portal (Tissue expression)WNT3
Human Protein AtlasENSG00000108379-WNT3 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP56703   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP56703  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP56703
Splice isoforms : SwissVarP56703
PhosPhoSitePlusP56703
Domaine pattern : Prosite (Expaxy)WNT1 (PS00246)   
Domains : Interpro (EBI)Wnt    Wnt3    Wnt_CS   
Domain families : Pfam (Sanger)wnt (PF00110)   
Domain families : Pfam (NCBI)pfam00110   
Domain families : Smart (EMBL)WNT1 (SM00097)  
Conserved Domain (NCBI)WNT3
DMDM Disease mutations7473
Blocks (Seattle)WNT3
SuperfamilyP56703
Human Protein Atlas [tissue]ENSG00000108379-WNT3 [tissue]
Peptide AtlasP56703
HPRD01318
IPIIPI00011023   
Protein Interaction databases
DIP (DOE-UCLA)P56703
IntAct (EBI)P56703
FunCoupENSG00000108379
BioGRIDWNT3
STRING (EMBL)WNT3
ZODIACWNT3
Ontologies - Pathways
QuickGOP56703
Ontology : AmiGOcell morphogenesis  mesoderm formation  frizzled binding  frizzled binding  protein binding  extracellular region  extracellular space  extracellular space  endoplasmic reticulum lumen  Golgi lumen  plasma membrane  gamete generation  axon guidance  anterior/posterior axis specification  dorsal/ventral axis specification  regulation of signaling receptor activity  positive regulation of gene expression  Wnt signaling pathway  Wnt signaling pathway  protein domain specific binding  positive regulation of Wnt signaling pathway  neuron differentiation  neuron differentiation  endocytic vesicle membrane  embryonic forelimb morphogenesis  embryonic hindlimb morphogenesis  canonical Wnt signaling pathway involved in mesenchymal stem cell differentiation  canonical Wnt signaling pathway involved in osteoblast differentiation  cell fate commitment  receptor ligand activity  receptor ligand activity  positive regulation of collateral sprouting in absence of injury  negative regulation of axon extension involved in axon guidance  regulation of neurogenesis  Spemann organizer formation at the anterior end of the primitive streak  canonical Wnt signaling pathway  canonical Wnt signaling pathway  limb bud formation  head morphogenesis  mammary gland epithelium development  extracellular exosome  cellular response to retinoic acid  stem cell proliferation  canonical Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation  canonical Wnt signaling pathway involved in stem cell proliferation  Wnt signalosome  Wnt signalosome  
Ontology : EGO-EBIcell morphogenesis  mesoderm formation  frizzled binding  frizzled binding  protein binding  extracellular region  extracellular space  extracellular space  endoplasmic reticulum lumen  Golgi lumen  plasma membrane  gamete generation  axon guidance  anterior/posterior axis specification  dorsal/ventral axis specification  regulation of signaling receptor activity  positive regulation of gene expression  Wnt signaling pathway  Wnt signaling pathway  protein domain specific binding  positive regulation of Wnt signaling pathway  neuron differentiation  neuron differentiation  endocytic vesicle membrane  embryonic forelimb morphogenesis  embryonic hindlimb morphogenesis  canonical Wnt signaling pathway involved in mesenchymal stem cell differentiation  canonical Wnt signaling pathway involved in osteoblast differentiation  cell fate commitment  receptor ligand activity  receptor ligand activity  positive regulation of collateral sprouting in absence of injury  negative regulation of axon extension involved in axon guidance  regulation of neurogenesis  Spemann organizer formation at the anterior end of the primitive streak  canonical Wnt signaling pathway  canonical Wnt signaling pathway  limb bud formation  head morphogenesis  mammary gland epithelium development  extracellular exosome  cellular response to retinoic acid  stem cell proliferation  canonical Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation  canonical Wnt signaling pathway involved in stem cell proliferation  Wnt signalosome  Wnt signalosome  
Pathways : KEGG   
NDEx NetworkWNT3
Atlas of Cancer Signalling NetworkWNT3
Wikipedia pathwaysWNT3
Orthology - Evolution
OrthoDB7473
GeneTree (enSembl)ENSG00000108379
Phylogenetic Trees/Animal Genes : TreeFamWNT3
HOVERGENP56703
HOGENOMP56703
Homologs : HomoloGeneWNT3
Homology/Alignments : Family Browser (UCSC)WNT3
Gene fusions - Rearrangements
Fusion : QuiverWNT3
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerWNT3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)WNT3
dbVarWNT3
ClinVarWNT3
1000_GenomesWNT3 
Exome Variant ServerWNT3
ExAC (Exome Aggregation Consortium)ENSG00000108379
GNOMAD BrowserENSG00000108379
Varsome BrowserWNT3
Genetic variants : HAPMAP7473
Genomic Variants (DGV)WNT3 [DGVbeta]
DECIPHERWNT3 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisWNT3 
Mutations
ICGC Data PortalWNT3 
TCGA Data PortalWNT3 
Broad Tumor PortalWNT3
OASIS PortalWNT3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICWNT3  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDWNT3
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch WNT3
DgiDB (Drug Gene Interaction Database)WNT3
DoCM (Curated mutations)WNT3 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)WNT3 (select a term)
intoGenWNT3
Cancer3DWNT3(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM165330    273395   
Orphanet2939   
DisGeNETWNT3
MedgenWNT3
Genetic Testing Registry WNT3
NextProtP56703 [Medical]
TSGene7473
GENETestsWNT3
Target ValidationWNT3
Huge Navigator WNT3 [HugePedia]
snp3D : Map Gene to Disease7473
BioCentury BCIQWNT3
ClinGenWNT3
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD7473
Chemical/Pharm GKB GenePA37383
Clinical trialWNT3
Miscellaneous
canSAR (ICR)WNT3 (select the gene name)
Probes
Litterature
PubMed64 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineWNT3
EVEXWNT3
GoPubMedWNT3
iHOPWNT3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Mon Aug 27 12:01:56 CEST 2018
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