Atlas of Genetics and Cytogenetics in Oncology and Haematology

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WNT3 (Wnt family member 3)

Identity

Alias (NCBI)INT4
TETAMS
HGNC (Hugo) WNT3
HGNC Alias symbMGC131950
MGC138321
MGC138323
HGNC Alias nameWNT-3 proto-oncogene protein
HGNC Previous nameINT4
HGNC Previous namewingless-type MMTV integration site family, member 3
LocusID (NCBI) 7473
Atlas_Id 42822
Location 17q21.31  [Link to chromosome band 17q21]
Location_base_pair Starts at 46762506 and ends at 46818692 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(1;17)(p36;q21) WNT3 or NSF/PRDM16

External links

 

Nomenclature
HGNC (Hugo)WNT3   12782
Cards
Entrez_Gene (NCBI)WNT3    Wnt family member 3
AliasesINT4; TETAMS
GeneCards (Weizmann)WNT3
Ensembl hg19 (Hinxton)ENSG00000108379 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000108379 [Gene_View]  ENSG00000108379 [Sequence]  chr17:46762506-46818692 [Contig_View]  WNT3 [Vega]
ICGC DataPortalENSG00000108379
TCGA cBioPortalWNT3
AceView (NCBI)WNT3
Genatlas (Paris)WNT3
SOURCE (Princeton)WNT3
Genetics Home Reference (NIH)WNT3
Genomic and cartography
GoldenPath hg38 (UCSC)WNT3  -     chr17:46762506-46818692 -  17q21.31   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)WNT3  -     17q21.31   [Description]    (hg19-Feb_2009)
GoldenPathWNT3 - 17q21.31 [CytoView hg19]  WNT3 - 17q21.31 [CytoView hg38]
ImmunoBaseENSG00000108379
Genome Data Viewer NCBIWNT3 [Mapview hg19]  
OMIM165330   273395   
Gene and transcription
Genbank (Entrez)AB067628 AY009397 BC112116 BC112118 BC114219
RefSeq transcript (Entrez)NM_030753
Consensus coding sequences : CCDS (NCBI)WNT3
Gene ExpressionWNT3 [ NCBI-GEO ]   WNT3 [ EBI - ARRAY_EXPRESS ]   WNT3 [ SEEK ]   WNT3 [ MEM ]
Gene Expression Viewer (FireBrowse)WNT3 [ Firebrowse - Broad ]
GenevisibleExpression of WNT3 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)7473
GTEX Portal (Tissue expression)WNT3
Human Protein AtlasENSG00000108379-WNT3 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP56703   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP56703  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP56703
PhosPhoSitePlusP56703
Domaine pattern : Prosite (Expaxy)WNT1 (PS00246)   
Domains : Interpro (EBI)Wnt    Wnt3    Wnt_C    Wnt_CS   
Domain families : Pfam (Sanger)wnt (PF00110)   
Domain families : Pfam (NCBI)pfam00110   
Domain families : Smart (EMBL)WNT1 (SM00097)  
Conserved Domain (NCBI)WNT3
PDB (RSDB)6AHY   
PDB Europe6AHY   
PDB (PDBSum)6AHY   
PDB (IMB)6AHY   
Structural Biology KnowledgeBase6AHY   
SCOP (Structural Classification of Proteins)6AHY   
CATH (Classification of proteins structures)6AHY   
SuperfamilyP56703
AlphaFold pdb e-kbP56703   
Human Protein Atlas [tissue]ENSG00000108379-WNT3 [tissue]
HPRD01318
Protein Interaction databases
DIP (DOE-UCLA)P56703
IntAct (EBI)P56703
BioGRIDWNT3
STRING (EMBL)WNT3
ZODIACWNT3
Ontologies - Pathways
QuickGOP56703
Ontology : AmiGOcell morphogenesis  mesoderm formation  frizzled binding  frizzled binding  cytokine activity  protein binding  extracellular region  extracellular space  extracellular space  endoplasmic reticulum lumen  Golgi lumen  plasma membrane  gamete generation  axon guidance  anterior/posterior axis specification  dorsal/ventral axis specification  positive regulation of gene expression  Wnt signaling pathway  protein domain specific binding  positive regulation of Wnt signaling pathway  neuron differentiation  neuron differentiation  endocytic vesicle membrane  extracellular matrix  embryonic forelimb morphogenesis  embryonic hindlimb morphogenesis  canonical Wnt signaling pathway involved in mesenchymal stem cell differentiation  canonical Wnt signaling pathway involved in osteoblast differentiation  cell fate commitment  receptor ligand activity  receptor ligand activity  positive regulation of collateral sprouting in absence of injury  negative regulation of axon extension involved in axon guidance  regulation of neurogenesis  Spemann organizer formation at the anterior end of the primitive streak  canonical Wnt signaling pathway  canonical Wnt signaling pathway  canonical Wnt signaling pathway  limb bud formation  head morphogenesis  mammary gland epithelium development  extracellular exosome  cellular response to retinoic acid  stem cell proliferation  canonical Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation  canonical Wnt signaling pathway involved in stem cell proliferation  Wnt signalosome  Wnt signalosome  
Ontology : EGO-EBIcell morphogenesis  mesoderm formation  frizzled binding  frizzled binding  cytokine activity  protein binding  extracellular region  extracellular space  extracellular space  endoplasmic reticulum lumen  Golgi lumen  plasma membrane  gamete generation  axon guidance  anterior/posterior axis specification  dorsal/ventral axis specification  positive regulation of gene expression  Wnt signaling pathway  protein domain specific binding  positive regulation of Wnt signaling pathway  neuron differentiation  neuron differentiation  endocytic vesicle membrane  extracellular matrix  embryonic forelimb morphogenesis  embryonic hindlimb morphogenesis  canonical Wnt signaling pathway involved in mesenchymal stem cell differentiation  canonical Wnt signaling pathway involved in osteoblast differentiation  cell fate commitment  receptor ligand activity  receptor ligand activity  positive regulation of collateral sprouting in absence of injury  negative regulation of axon extension involved in axon guidance  regulation of neurogenesis  Spemann organizer formation at the anterior end of the primitive streak  canonical Wnt signaling pathway  canonical Wnt signaling pathway  canonical Wnt signaling pathway  limb bud formation  head morphogenesis  mammary gland epithelium development  extracellular exosome  cellular response to retinoic acid  stem cell proliferation  canonical Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation  canonical Wnt signaling pathway involved in stem cell proliferation  Wnt signalosome  Wnt signalosome  
Pathways : KEGGWnt signaling pathway    Hedgehog signaling pathway    Hippo signaling pathway    Melanogenesis    HTLV-I infection    Pathways in cancer    Proteoglycans in cancer    MicroRNAs in cancer    Basal cell carcinoma   
NDEx NetworkWNT3
Atlas of Cancer Signalling NetworkWNT3
Wikipedia pathwaysWNT3
Orthology - Evolution
OrthoDB7473
GeneTree (enSembl)ENSG00000108379
Phylogenetic Trees/Animal Genes : TreeFamWNT3
Homologs : HomoloGeneWNT3
Homology/Alignments : Family Browser (UCSC)WNT3
Gene fusions - Rearrangements
Fusion : QuiverWNT3
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerWNT3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)WNT3
dbVarWNT3
ClinVarWNT3
MonarchWNT3
1000_GenomesWNT3 
Exome Variant ServerWNT3
GNOMAD BrowserENSG00000108379
Varsome BrowserWNT3
ACMGWNT3 variants
VarityP56703
Genomic Variants (DGV)WNT3 [DGVbeta]
DECIPHERWNT3 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisWNT3 
Mutations
ICGC Data PortalWNT3 
TCGA Data PortalWNT3 
Broad Tumor PortalWNT3
OASIS PortalWNT3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICWNT3  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DWNT3
Mutations and Diseases : HGMDWNT3
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaWNT3
DgiDB (Drug Gene Interaction Database)WNT3
DoCM (Curated mutations)WNT3
CIViC (Clinical Interpretations of Variants in Cancer)WNT3
Cancer3DWNT3
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM165330    273395   
Orphanet2939   
DisGeNETWNT3
MedgenWNT3
Genetic Testing Registry WNT3
NextProtP56703 [Medical]
GENETestsWNT3
Target ValidationWNT3
Huge Navigator WNT3 [HugePedia]
ClinGenWNT3
Clinical trials, drugs, therapy
MyCancerGenomeWNT3
Protein Interactions : CTDWNT3
Pharm GKB GenePA37383
PharosP56703
Clinical trialWNT3
Miscellaneous
canSAR (ICR)WNT3
HarmonizomeWNT3
DataMed IndexWNT3
Probes
Litterature
PubMed71 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXWNT3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Mon Oct 4 15:38:26 CEST 2021
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