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WNT3A (Wnt family member 3A)

Identity

Alias_nameswingless-type MMTV integration site family
Other alias-
HGNC (Hugo) WNT3A
LocusID (NCBI) 89780
Atlas_Id 42823
Location 1q42.13  [Link to chromosome band 1q42]
Location_base_pair Starts at 228007022 and ends at 228061271 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)WNT3A   15983
Cards
Entrez_Gene (NCBI)WNT3A  89780  Wnt family member 3A
Aliases
GeneCards (Weizmann)WNT3A
Ensembl hg19 (Hinxton)ENSG00000154342 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000154342 [Gene_View]  chr1:228007022-228061271 [Contig_View]  WNT3A [Vega]
ICGC DataPortalENSG00000154342
TCGA cBioPortalWNT3A
AceView (NCBI)WNT3A
Genatlas (Paris)WNT3A
WikiGenes89780
SOURCE (Princeton)WNT3A
Genetics Home Reference (NIH)WNT3A
Genomic and cartography
GoldenPath hg38 (UCSC)WNT3A  -     chr1:228007022-228061271 +  1q42.13   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)WNT3A  -     1q42.13   [Description]    (hg19-Feb_2009)
EnsemblWNT3A - 1q42.13 [CytoView hg19]  WNT3A - 1q42.13 [CytoView hg38]
Mapping of homologs : NCBIWNT3A [Mapview hg19]  WNT3A [Mapview hg38]
OMIM606359   
Gene and transcription
Genbank (Entrez)AB060284 AK056278 BC103921 BC103922 BC103923
RefSeq transcript (Entrez)NM_033131
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)WNT3A
Cluster EST : UnigeneHs.336930 [ NCBI ]
CGAP (NCI)Hs.336930
Alternative Splicing GalleryENSG00000154342
Gene ExpressionWNT3A [ NCBI-GEO ]   WNT3A [ EBI - ARRAY_EXPRESS ]   WNT3A [ SEEK ]   WNT3A [ MEM ]
Gene Expression Viewer (FireBrowse)WNT3A [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)89780
GTEX Portal (Tissue expression)WNT3A
Human Protein AtlasENSG00000154342-WNT3A [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP56704   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP56704  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP56704
Splice isoforms : SwissVarP56704
PhosPhoSitePlusP56704
Domaine pattern : Prosite (Expaxy)WNT1 (PS00246)   
Domains : Interpro (EBI)Wnt    Wnt3    Wnt_CS   
Domain families : Pfam (Sanger)wnt (PF00110)   
Domain families : Pfam (NCBI)pfam00110   
Domain families : Smart (EMBL)WNT1 (SM00097)  
Conserved Domain (NCBI)WNT3A
DMDM Disease mutations89780
Blocks (Seattle)WNT3A
SuperfamilyP56704
Human Protein Atlas [tissue]ENSG00000154342-WNT3A [tissue]
Peptide AtlasP56704
HPRD05897
IPIIPI00654606   IPI00011026   
Protein Interaction databases
DIP (DOE-UCLA)P56704
IntAct (EBI)P56704
FunCoupENSG00000154342
BioGRIDWNT3A
STRING (EMBL)WNT3A
ZODIACWNT3A
Ontologies - Pathways
QuickGOP56704
Ontology : AmiGOosteoblast differentiation  in utero embryonic development  positive regulation of cytokine production  positive regulation of protein phosphorylation  heart looping  positive regulation of receptor internalization  negative regulation of heart induction by canonical Wnt signaling pathway  transcription coactivator activity  receptor binding  frizzled binding  frizzled-2 binding  protein binding  extracellular region  proteinaceous extracellular matrix  extracellular space  extracellular space  extracellular space  endoplasmic reticulum lumen  Golgi lumen  plasma membrane  axon guidance  cell proliferation  positive regulation of cell proliferation  cell surface  COP9 signalosome assembly  regulation of receptor activity  positive regulation of gene expression  negative regulation of neuron projection development  Wnt signaling pathway  protein domain specific binding  spinal cord association neuron differentiation  hippocampus development  cell proliferation in forebrain  Wnt signaling pathway involved in forebrain neuroblast division  dorsal/ventral neural tube patterning  hemopoiesis  neuron differentiation  extracellular matrix organization  endocytic vesicle membrane  mammary gland development  positive regulation of B cell proliferation  early endosome membrane  positive regulation of protein binding  positive regulation of peptidyl-serine phosphorylation  cell proliferation in midbrain  cellular protein localization  positive regulation of catenin import into nucleus  skeletal muscle cell differentiation  post-anal tail morphogenesis  synaptic vesicle recycling  co-receptor binding  inner ear morphogenesis  positive regulation of cysteine-type endopeptidase activity involved in apoptotic process  negative regulation of fat cell differentiation  positive regulation of transcription, DNA-templated  positive regulation of transcription by RNA polymerase II  positive regulation of transcription by RNA polymerase II  receptor ligand activity  positive regulation of mesodermal cell fate specification  paraxial mesodermal cell fate commitment  positive regulation of skeletal muscle tissue development  positive regulation of collateral sprouting in absence of injury  negative regulation of axon extension involved in axon guidance  negative regulation of neurogenesis  positive regulation of DNA binding transcription factor activity  palate development  canonical Wnt signaling pathway  canonical Wnt signaling pathway  positive regulation of protein tyrosine kinase activity  positive regulation of dermatome development  canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment  extracellular exosome  regulation of microtubule cytoskeleton organization  platelet aggregation  cellular response to retinoic acid  axis elongation involved in somitogenesis  positive regulation of canonical Wnt signaling pathway  calcium ion transmembrane transport via low voltage-gated calcium channel  presynapse  presynapse assembly  negative regulation of neuron death  positive regulation of protein localization to plasma membrane  negative regulation of dopaminergic neuron differentiation  positive regulation of core promoter binding  beta-catenin destruction complex disassembly  Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation  Wnt-Frizzled-LRP5/6 complex  positive regulation of cell-cell adhesion mediated by cadherin  positive regulation of canonical Wnt signaling pathway involved in controlling type B pancreatic cell proliferation  positive regulation of neural precursor cell proliferation  positive regulation of hepatocyte proliferation  positive regulation of cardiac muscle cell differentiation  
Ontology : EGO-EBIosteoblast differentiation  in utero embryonic development  positive regulation of cytokine production  positive regulation of protein phosphorylation  heart looping  positive regulation of receptor internalization  negative regulation of heart induction by canonical Wnt signaling pathway  transcription coactivator activity  receptor binding  frizzled binding  frizzled-2 binding  protein binding  extracellular region  proteinaceous extracellular matrix  extracellular space  extracellular space  extracellular space  endoplasmic reticulum lumen  Golgi lumen  plasma membrane  axon guidance  cell proliferation  positive regulation of cell proliferation  cell surface  COP9 signalosome assembly  regulation of receptor activity  positive regulation of gene expression  negative regulation of neuron projection development  Wnt signaling pathway  protein domain specific binding  spinal cord association neuron differentiation  hippocampus development  cell proliferation in forebrain  Wnt signaling pathway involved in forebrain neuroblast division  dorsal/ventral neural tube patterning  hemopoiesis  neuron differentiation  extracellular matrix organization  endocytic vesicle membrane  mammary gland development  positive regulation of B cell proliferation  early endosome membrane  positive regulation of protein binding  positive regulation of peptidyl-serine phosphorylation  cell proliferation in midbrain  cellular protein localization  positive regulation of catenin import into nucleus  skeletal muscle cell differentiation  post-anal tail morphogenesis  synaptic vesicle recycling  co-receptor binding  inner ear morphogenesis  positive regulation of cysteine-type endopeptidase activity involved in apoptotic process  negative regulation of fat cell differentiation  positive regulation of transcription, DNA-templated  positive regulation of transcription by RNA polymerase II  positive regulation of transcription by RNA polymerase II  receptor ligand activity  positive regulation of mesodermal cell fate specification  paraxial mesodermal cell fate commitment  positive regulation of skeletal muscle tissue development  positive regulation of collateral sprouting in absence of injury  negative regulation of axon extension involved in axon guidance  negative regulation of neurogenesis  positive regulation of DNA binding transcription factor activity  palate development  canonical Wnt signaling pathway  canonical Wnt signaling pathway  positive regulation of protein tyrosine kinase activity  positive regulation of dermatome development  canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment  extracellular exosome  regulation of microtubule cytoskeleton organization  platelet aggregation  cellular response to retinoic acid  axis elongation involved in somitogenesis  positive regulation of canonical Wnt signaling pathway  calcium ion transmembrane transport via low voltage-gated calcium channel  presynapse  presynapse assembly  negative regulation of neuron death  positive regulation of protein localization to plasma membrane  negative regulation of dopaminergic neuron differentiation  positive regulation of core promoter binding  beta-catenin destruction complex disassembly  Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation  Wnt-Frizzled-LRP5/6 complex  positive regulation of cell-cell adhesion mediated by cadherin  positive regulation of canonical Wnt signaling pathway involved in controlling type B pancreatic cell proliferation  positive regulation of neural precursor cell proliferation  positive regulation of hepatocyte proliferation  positive regulation of cardiac muscle cell differentiation  
Pathways : KEGGWnt signaling pathway    Hedgehog signaling pathway   
NDEx NetworkWNT3A
Atlas of Cancer Signalling NetworkWNT3A
Wikipedia pathwaysWNT3A
Orthology - Evolution
OrthoDB89780
GeneTree (enSembl)ENSG00000154342
Phylogenetic Trees/Animal Genes : TreeFamWNT3A
HOVERGENP56704
HOGENOMP56704
Homologs : HomoloGeneWNT3A
Homology/Alignments : Family Browser (UCSC)WNT3A
Gene fusions - Rearrangements
Fusion : QuiverWNT3A
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerWNT3A [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)WNT3A
dbVarWNT3A
ClinVarWNT3A
1000_GenomesWNT3A 
Exome Variant ServerWNT3A
ExAC (Exome Aggregation Consortium)ENSG00000154342
GNOMAD BrowserENSG00000154342
Genetic variants : HAPMAP89780
Genomic Variants (DGV)WNT3A [DGVbeta]
DECIPHERWNT3A [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisWNT3A 
Mutations
ICGC Data PortalWNT3A 
TCGA Data PortalWNT3A 
Broad Tumor PortalWNT3A
OASIS PortalWNT3A [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICWNT3A  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDWNT3A
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch WNT3A
DgiDB (Drug Gene Interaction Database)WNT3A
DoCM (Curated mutations)WNT3A (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)WNT3A (select a term)
intoGenWNT3A
Cancer3DWNT3A(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM606359   
Orphanet11651   
DisGeNETWNT3A
MedgenWNT3A
Genetic Testing Registry WNT3A
NextProtP56704 [Medical]
TSGene89780
GENETestsWNT3A
Target ValidationWNT3A
Huge Navigator WNT3A [HugePedia]
snp3D : Map Gene to Disease89780
BioCentury BCIQWNT3A
ClinGenWNT3A
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD89780
Chemical/Pharm GKB GenePA38074
Clinical trialWNT3A
Miscellaneous
canSAR (ICR)WNT3A (select the gene name)
Probes
Litterature
PubMed171 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineWNT3A
EVEXWNT3A
GoPubMedWNT3A
iHOPWNT3A
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Jun 18 19:53:05 CEST 2018

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