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WNT4 (Wnt family member 4)

Identity

Alias (NCBI)SERKAL
WNT-4
HGNC (Hugo) WNT4
HGNC Alias symbWNT-4
HGNC Previous namewingless-type MMTV integration site family, member 4
LocusID (NCBI) 54361
Atlas_Id 42824
Location 1p36.12  [Link to chromosome band 1p36]
Location_base_pair Starts at 22117313 and ends at 22143097 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)WNT4   12783
Cards
Entrez_Gene (NCBI)WNT4    Wnt family member 4
AliasesSERKAL; WNT-4
GeneCards (Weizmann)WNT4
Ensembl hg19 (Hinxton)ENSG00000162552 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000162552 [Gene_View]  ENSG00000162552 [Sequence]  chr1:22117313-22143097 [Contig_View]  WNT4 [Vega]
ICGC DataPortalENSG00000162552
TCGA cBioPortalWNT4
AceView (NCBI)WNT4
Genatlas (Paris)WNT4
SOURCE (Princeton)WNT4
Genetics Home Reference (NIH)WNT4
Genomic and cartography
GoldenPath hg38 (UCSC)WNT4  -     chr1:22117313-22143097 -  1p36.12   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)WNT4  -     1p36.12   [Description]    (hg19-Feb_2009)
GoldenPathWNT4 - 1p36.12 [CytoView hg19]  WNT4 - 1p36.12 [CytoView hg38]
ImmunoBaseENSG00000162552
Genome Data Viewer NCBIWNT4 [Mapview hg19]  
OMIM158330   603490   611812   
Gene and transcription
Genbank (Entrez)AA984007 AB061675 AF086347 AF316543 AK296058
RefSeq transcript (Entrez)NM_030761
Consensus coding sequences : CCDS (NCBI)WNT4
Gene ExpressionWNT4 [ NCBI-GEO ]   WNT4 [ EBI - ARRAY_EXPRESS ]   WNT4 [ SEEK ]   WNT4 [ MEM ]
Gene Expression Viewer (FireBrowse)WNT4 [ Firebrowse - Broad ]
GenevisibleExpression of WNT4 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)54361
GTEX Portal (Tissue expression)WNT4
Human Protein AtlasENSG00000162552-WNT4 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP56705   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP56705  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP56705
PhosPhoSitePlusP56705
Domaine pattern : Prosite (Expaxy)WNT1 (PS00246)   
Domains : Interpro (EBI)Wnt    Wnt4    Wnt_C    Wnt_CS   
Domain families : Pfam (Sanger)wnt (PF00110)   
Domain families : Pfam (NCBI)pfam00110   
Domain families : Smart (EMBL)WNT1 (SM00097)  
Conserved Domain (NCBI)WNT4
SuperfamilyP56705
AlphaFold pdb e-kbP56705   
Human Protein Atlas [tissue]ENSG00000162552-WNT4 [tissue]
HPRD04601
Protein Interaction databases
DIP (DOE-UCLA)P56705
IntAct (EBI)P56705
BioGRIDWNT4
STRING (EMBL)WNT4
ZODIACWNT4
Ontologies - Pathways
QuickGOP56705
Ontology : AmiGObranching involved in ureteric bud morphogenesis  kidney development  epithelial to mesenchymal transition  embryonic epithelial tube formation  liver development  transcription corepressor activity  frizzled binding  cytokine activity  extracellular region  extracellular space  extracellular space  cytoplasm  endoplasmic reticulum lumen  Golgi lumen  plasma membrane  male gonad development  male gonad development  female gonad development  cellular response to starvation  cell surface  negative regulation of gene expression  negative regulation of steroid biosynthetic process  regulation of cell-cell adhesion  neuron differentiation  female sex determination  adrenal gland development  negative regulation of cell migration  positive regulation of bone mineralization  endocytic vesicle membrane  extracellular matrix  positive regulation of aldosterone biosynthetic process  positive regulation of collagen biosynthetic process  immature T cell proliferation in thymus  non-canonical Wnt signaling pathway via MAPK cascade  negative regulation of fibroblast growth factor receptor signaling pathway  hormone metabolic process  positive regulation of GTPase activity  cell fate commitment  negative regulation of cell differentiation  positive regulation of osteoblast differentiation  positive regulation of meiotic nuclear division  negative regulation of transcription, DNA-templated  negative regulation of transcription, DNA-templated  positive regulation of transcription, DNA-templated  positive regulation of transcription, DNA-templated  receptor ligand activity  oocyte development  smooth muscle cell differentiation  positive regulation of stress fiber assembly  positive regulation of focal adhesion assembly  canonical Wnt signaling pathway  canonical Wnt signaling pathway  somatotropin secreting cell differentiation  thyroid-stimulating hormone-secreting cell differentiation  mesenchymal to epithelial transition  tertiary branching involved in mammary gland duct morphogenesis  negative regulation of wound healing  mammary gland epithelium development  positive regulation of dermatome development  paramesonephric duct development  negative regulation of testicular blood vessel morphogenesis  extracellular exosome  cellular response to transforming growth factor beta stimulus  renal vesicle formation  renal vesicle induction  metanephric mesenchymal cell differentiation  metanephric tubule formation  metanephric nephron morphogenesis  negative regulation of male gonad development  positive regulation of cortisol biosynthetic process  negative regulation of androgen biosynthetic process  negative regulation of testosterone biosynthetic process  negative regulation of apoptotic signaling pathway  
Ontology : EGO-EBIbranching involved in ureteric bud morphogenesis  kidney development  epithelial to mesenchymal transition  embryonic epithelial tube formation  liver development  transcription corepressor activity  frizzled binding  cytokine activity  extracellular region  extracellular space  extracellular space  cytoplasm  endoplasmic reticulum lumen  Golgi lumen  plasma membrane  male gonad development  male gonad development  female gonad development  cellular response to starvation  cell surface  negative regulation of gene expression  negative regulation of steroid biosynthetic process  regulation of cell-cell adhesion  neuron differentiation  female sex determination  adrenal gland development  negative regulation of cell migration  positive regulation of bone mineralization  endocytic vesicle membrane  extracellular matrix  positive regulation of aldosterone biosynthetic process  positive regulation of collagen biosynthetic process  immature T cell proliferation in thymus  non-canonical Wnt signaling pathway via MAPK cascade  negative regulation of fibroblast growth factor receptor signaling pathway  hormone metabolic process  positive regulation of GTPase activity  cell fate commitment  negative regulation of cell differentiation  positive regulation of osteoblast differentiation  positive regulation of meiotic nuclear division  negative regulation of transcription, DNA-templated  negative regulation of transcription, DNA-templated  positive regulation of transcription, DNA-templated  positive regulation of transcription, DNA-templated  receptor ligand activity  oocyte development  smooth muscle cell differentiation  positive regulation of stress fiber assembly  positive regulation of focal adhesion assembly  canonical Wnt signaling pathway  canonical Wnt signaling pathway  somatotropin secreting cell differentiation  thyroid-stimulating hormone-secreting cell differentiation  mesenchymal to epithelial transition  tertiary branching involved in mammary gland duct morphogenesis  negative regulation of wound healing  mammary gland epithelium development  positive regulation of dermatome development  paramesonephric duct development  negative regulation of testicular blood vessel morphogenesis  extracellular exosome  cellular response to transforming growth factor beta stimulus  renal vesicle formation  renal vesicle induction  metanephric mesenchymal cell differentiation  metanephric tubule formation  metanephric nephron morphogenesis  negative regulation of male gonad development  positive regulation of cortisol biosynthetic process  negative regulation of androgen biosynthetic process  negative regulation of testosterone biosynthetic process  negative regulation of apoptotic signaling pathway  
Pathways : KEGGKEGG_WNT_SIGNALING    KEGG_HEDGEHOG_SIGNALING    KEGG_MELANOGENESIS    KEGG_PATHWAYS_IN_CANCER    KEGG_BASAL_CELL_CARCINOMA   
NDEx NetworkWNT4
Atlas of Cancer Signalling NetworkWNT4
Wikipedia pathwaysWNT4
Orthology - Evolution
OrthoDB54361
GeneTree (enSembl)ENSG00000162552
Phylogenetic Trees/Animal Genes : TreeFamWNT4
Homologs : HomoloGeneWNT4
Homology/Alignments : Family Browser (UCSC)WNT4
Gene fusions - Rearrangements
Fusion : QuiverWNT4
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerWNT4 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)WNT4
dbVarWNT4
ClinVarWNT4
MonarchWNT4
1000_GenomesWNT4 
Exome Variant ServerWNT4
GNOMAD BrowserENSG00000162552
Varsome BrowserWNT4
ACMGWNT4 variants
VarityP56705
Genomic Variants (DGV)WNT4 [DGVbeta]
DECIPHERWNT4 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisWNT4 
Mutations
ICGC Data PortalWNT4 
TCGA Data PortalWNT4 
Broad Tumor PortalWNT4
OASIS PortalWNT4 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICWNT4  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DWNT4
Mutations and Diseases : HGMDWNT4
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaWNT4
DgiDB (Drug Gene Interaction Database)WNT4
DoCM (Curated mutations)WNT4
CIViC (Clinical Interpretations of Variants in Cancer)WNT4
Cancer3DWNT4
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM158330    603490    611812   
Orphanet16903    19544   
DisGeNETWNT4
MedgenWNT4
Genetic Testing Registry WNT4
NextProtP56705 [Medical]
GENETestsWNT4
Target ValidationWNT4
Huge Navigator WNT4 [HugePedia]
ClinGenWNT4
Clinical trials, drugs, therapy
MyCancerGenomeWNT4
Protein Interactions : CTDWNT4
Pharm GKB GenePA37384
PharosP56705
Clinical trialWNT4
Miscellaneous
canSAR (ICR)WNT4
HarmonizomeWNT4
ARCHS4WNT4
DataMed IndexWNT4
Probes
Litterature
PubMed115 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXWNT4
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Jan 20 13:06:37 CET 2022

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