WNT6 (Wnt family member 6)

2003-02-01 Affiliation

Identity

HGNC

WNT6

LOCATION

2q35

LOCUSID

7475

ALIAS

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 7475
MIM: 604663
HGNC: 12785
Ensembl: ENSG00000115596

Variants:

dbSNP: 7475
ClinVar: 7475
TCGA: ENSG00000115596
COSMIC: WNT6

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000115596	ENST00000233948	Q9Y6F9

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
mTOR signaling pathway	KEGG	ko04150
Wnt signaling pathway	KEGG	ko04310
Melanogenesis	KEGG	ko04916
Basal cell carcinoma	KEGG	ko05217
mTOR signaling pathway	KEGG	hsa04150
Wnt signaling pathway	KEGG	hsa04310
Melanogenesis	KEGG	hsa04916
Pathways in cancer	KEGG	hsa05200
Basal cell carcinoma	KEGG	hsa05217
HTLV-I infection	KEGG	ko05166
HTLV-I infection	KEGG	hsa05166
Hippo signaling pathway	KEGG	hsa04390
Hippo signaling pathway	KEGG	ko04390
Proteoglycans in cancer	KEGG	hsa05205
Proteoglycans in cancer	KEGG	ko05205
Signaling pathways regulating pluripotency of stem cells	KEGG	hsa04550
Signaling pathways regulating pluripotency of stem cells	KEGG	ko04550
Wnt signaling	KEGG	hsa_M00677
Wnt signaling	KEGG	M00677
Signal Transduction	REACTOME	R-HSA-162582
Signaling by GPCR	REACTOME	R-HSA-372790
GPCR ligand binding	REACTOME	R-HSA-500792
Class B/2 (Secretin family receptors)	REACTOME	R-HSA-373080
Signaling by Wnt	REACTOME	R-HSA-195721
WNT ligand biogenesis and trafficking	REACTOME	R-HSA-3238698
Breast cancer	KEGG	ko05224
Breast cancer	KEGG	hsa05224

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
22370641	2013	WNT6 is a novel target gene of caveolin-1 promoting chemoresistance to epirubicin in human gastric cancer cells.	33
20634891	2010	Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia.	18
16953426	2006	Analysis of candidate genes on chromosome 2 in oral cleft case-parent trios from three populations.	16
21547848	2011	Polymorphisms in WNT6 and WNT10A and colorectal adenoma risk.	11
20113781	2010	Effect of Wnt6 on human dental papilla cells in vitro.	10
30535429	2019	Overexpressed PLAGL2 transcriptionally activates Wnt6 and promotes cancer development in colorectal cancer.	8
26617869	2015	Increased WNT6 expression in tumor cells predicts unfavorable survival in esophageal squamous cell carcinoma patients.	7
30279739	2018	WNT6 is a novel oncogenic prognostic biomarker in human glioblastoma.	7
24935540	2014	WNT6 promotes the migration and differentiation of human dental pulp cells partly through c-Jun N-terminal kinase signaling pathway.	3
25750203	2015	Novel missense mutation in WNT6 in 100 couples with unexplained recurrent miscarriage.	1

Citation

Dessen P

WNT6 (Wnt family member 6)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/42827/wnt6