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WRB (tryptophan rich basic protein)

Identity

Alias_symbol (synonym)CHD5
GET1
Other alias
HGNC (Hugo) WRB
LocusID (NCBI) 7485
Atlas_Id 75768
Location 21q22.2  [Link to chromosome band 21q22]
Location_base_pair Starts at 40759692 and ends at 40769815 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
UMODL1 (21q22.3) / WRB (21q22.2)WRB (21q22.2) / KCNJ15 (21q22.13)WRB (21q22.2) / NLK (17q11.2)
WRB (21q22.2) / SH3BGR (21q22.2)WRB NLKWRB KCNJ15

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)WRB   12790
LRG (Locus Reference Genomic)LRG_1060
Cards
Entrez_Gene (NCBI)WRB  7485  tryptophan rich basic protein
AliasesCHD5
GeneCards (Weizmann)WRB
Ensembl hg19 (Hinxton)ENSG00000182093 [Gene_View]  chr21:40759692-40769815 [Contig_View]  WRB [Vega]
Ensembl hg38 (Hinxton)ENSG00000182093 [Gene_View]  chr21:40759692-40769815 [Contig_View]  WRB [Vega]
ICGC DataPortalENSG00000182093
TCGA cBioPortalWRB
AceView (NCBI)WRB
Genatlas (Paris)WRB
WikiGenes7485
SOURCE (Princeton)WRB
Genetics Home Reference (NIH)WRB
Genomic and cartography
GoldenPath hg19 (UCSC)WRB  -     chr21:40759692-40769815 +  21q22.2   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)WRB  -     21q22.2   [Description]    (hg38-Dec_2013)
EnsemblWRB - 21q22.2 [CytoView hg19]  WRB - 21q22.2 [CytoView hg38]
Mapping of homologs : NCBIWRB [Mapview hg19]  WRB [Mapview hg38]
OMIM602915   
Gene and transcription
Genbank (Entrez)AK293113 AK293866 AK297186 AK299144 AK299245
RefSeq transcript (Entrez)NM_001146218 NM_004627
RefSeq genomic (Entrez)NC_000021 NC_018932 NT_011512 NW_004929426
Consensus coding sequences : CCDS (NCBI)WRB
Cluster EST : UnigeneHs.744958 [ NCBI ]
CGAP (NCI)Hs.744958
Alternative Splicing GalleryENSG00000182093
Gene ExpressionWRB [ NCBI-GEO ]   WRB [ EBI - ARRAY_EXPRESS ]   WRB [ SEEK ]   WRB [ MEM ]
Gene Expression Viewer (FireBrowse)WRB [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)7485
GTEX Portal (Tissue expression)WRB
Protein : pattern, domain, 3D structure
UniProt/SwissProtO00258   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO00258  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO00258
Splice isoforms : SwissVarO00258
PhosPhoSitePlusO00258
Domains : Interpro (EBI)WRB/Get1   
Domain families : Pfam (Sanger)CHD5 (PF04420)   
Domain families : Pfam (NCBI)pfam04420   
Conserved Domain (NCBI)WRB
DMDM Disease mutations7485
Blocks (Seattle)WRB
SuperfamilyO00258
Human Protein AtlasENSG00000182093
Peptide AtlasO00258
HPRD04224
IPIIPI00010873   IPI00921876   IPI00658165   IPI01021082   IPI00916485   IPI00916351   IPI00916769   IPI00916601   
Protein Interaction databases
DIP (DOE-UCLA)O00258
IntAct (EBI)O00258
FunCoupENSG00000182093
BioGRIDWRB
STRING (EMBL)WRB
ZODIACWRB
Ontologies - Pathways
QuickGOO00258
Ontology : AmiGOnucleus  endoplasmic reticulum membrane  integral component of membrane  tail-anchored membrane protein insertion into ER membrane  
Ontology : EGO-EBInucleus  endoplasmic reticulum membrane  integral component of membrane  tail-anchored membrane protein insertion into ER membrane  
NDEx NetworkWRB
Atlas of Cancer Signalling NetworkWRB
Wikipedia pathwaysWRB
Orthology - Evolution
OrthoDB7485
GeneTree (enSembl)ENSG00000182093
Phylogenetic Trees/Animal Genes : TreeFamWRB
HOVERGENO00258
HOGENOMO00258
Homologs : HomoloGeneWRB
Homology/Alignments : Family Browser (UCSC)WRB
Gene fusions - Rearrangements
Fusion: TCGAWRB NLK
Fusion: TCGAWRB KCNJ15
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerWRB [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)WRB
dbVarWRB
ClinVarWRB
1000_GenomesWRB 
Exome Variant ServerWRB
ExAC (Exome Aggregation Consortium)WRB (select the gene name)
Genetic variants : HAPMAP7485
Genomic Variants (DGV)WRB [DGVbeta]
DECIPHER (Syndromes)21:40759692-40769815  ENSG00000182093
CONAN: Copy Number AnalysisWRB 
Mutations
ICGC Data PortalWRB 
TCGA Data PortalWRB 
Broad Tumor PortalWRB
OASIS PortalWRB [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICWRB  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDWRB
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch WRB
DgiDB (Drug Gene Interaction Database)WRB
DoCM (Curated mutations)WRB (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)WRB (select a term)
intoGenWRB
Cancer3DWRB(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM602915   
Orphanet
MedgenWRB
Genetic Testing Registry WRB
NextProtO00258 [Medical]
TSGene7485
GENETestsWRB
Huge Navigator WRB [HugePedia]
snp3D : Map Gene to Disease7485
BioCentury BCIQWRB
ClinGenWRB
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD7485
Chemical/Pharm GKB GenePA37391
Clinical trialWRB
Miscellaneous
canSAR (ICR)WRB (select the gene name)
Probes
Litterature
PubMed13 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineWRB
EVEXWRB
GoPubMedWRB
iHOPWRB
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Mar 14 12:51:47 CET 2017

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