WRNIP1 (WRN helicase interacting protein 1)

2004-04-01  

Identity

HGNC
WRNIP1
LOCATION
6p25.2
LOCUSID
56897
ALIAS
CFAP93,FAP93,WHIP,bA420G6.2

Other Information

Locus ID:

NCBI: 56897
MIM: 608196
HGNC: 20876
Ensembl: ENSG00000124535

Variants:

dbSNP: 56897
ClinVar: 56897
TCGA: ENSG00000124535
COSMIC: WRNIP1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000124535ENST00000380764Q96S55
ENSG00000124535ENST00000380769Q96S55
ENSG00000124535ENST00000380771Q96S55
ENSG00000124535ENST00000380773Q96S55
ENSG00000124535ENST00000618555Q96S55

Expression (GTEx)

0
10
20
30
40
50
60
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
272423632016WRNIP1 protects stalled forks from degradation and promotes fork restart after replication stress.33
188425862008Human Wrnip1 is localized in replication factories in a ubiquitin-binding zinc finger-dependent manner.32
175508992007Werner helicase-interacting protein 1 binds polyubiquitin via its zinc finger domain.31
156702102005Human Werner helicase interacting protein 1 (WRNIP1) functions as a novel modulator for DNA polymerase delta.20
290539562017Assembly of the WHIP-TRIM14-PPP6C Mitochondrial Complex Promotes RIG-I-Mediated Antiviral Signaling.19
265490242016RAD18, WRNIP1 and ATMIN promote ATM signalling in response to replication stress.18
195567102009Physical and functional interaction between WRNIP1 and RAD18.14
270624412016A novel mode of ubiquitin recognition by the ubiquitin-binding zinc finger domain of WRNIP1.7
222098482012WRNIP1 accumulates at laser light irradiated sites rapidly via its ubiquitin-binding zinc finger domain and independently from its ATPase domain.6
206760422010The discovery of a Werner Helicase Interacting Protein (WHIP) association with the nuclear pore complex.4

Citation

Dessen P

WRNIP1 (WRN helicase interacting protein 1)

Atlas Genet Cytogenet Oncol Haematol. 2004-04-01

Online version: http://atlasgeneticsoncology.org/gene/42834/wrnip1