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WSB1 (WD repeat and SOCS box containing 1)

Identity

Alias (NCBI)SWIP1
WSB-1
HGNC (Hugo) WSB1
HGNC Alias symbDKFZp564A122
DKFZp564B0482
SWIP1
HGNC Previous nameWD repeat and SOCS box-containing 1
LocusID (NCBI) 26118
Atlas_Id 50319
Location 17q11.1  [Link to chromosome band 17q11]
Location_base_pair Starts at 27294114 and ends at 27315926 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
IL10RA (11q23.3) / WSB1 (17q11.1)TEX10 (9q31.1) / WSB1 (17q11.1)TRAF4 (17q11.2) / WSB1 (17q11.1)
WSB1 (17q11.1) / FN3KRP (17q25.3)WSB1 (17q11.1) / GATM (15q21.1)WSB1 (17q11.1) / HDAC5 (17q21.31)
WSB1 (17q11.1) / MED1 (17q12)WSB1 (17q11.1) / NBR1 (17q21.31)WSB1 (17q11.1) / RECK (9p13.3)
WSB1 (17q11.1) / WSB1 (17q11.1)WSB1 17q11.1 / FN3KRP 17q25.3WSB1 17q11.1 / MED1 17q12
WSB1 17q11.1 / NBR1 17q21.31

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Leukemias implicated (Data extracted from papers in the Atlas) [ 2 ]
  t(15;17)(q15;q11) WSB1/HYPK
t(17;17)(q11;q21) WSB1/NBR1

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 3 ]
  TRAF4/WSB1 (17q11)
t(17;17)(q11;q12) WSB1/MED1
t(17;17)(q11;q25) WSB1/FN3KRP

External links

Nomenclature
HGNC (Hugo)WSB1   19221
Cards
Entrez_Gene (NCBI)WSB1  26118  WD repeat and SOCS box containing 1
AliasesSWIP1; WSB-1
GeneCards (Weizmann)WSB1
Ensembl hg19 (Hinxton)ENSG00000109046 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000109046 [Gene_View]  ENSG00000109046 [Sequence]  chr17:27294114-27315926 [Contig_View]  WSB1 [Vega]
ICGC DataPortalENSG00000109046
TCGA cBioPortalWSB1
AceView (NCBI)WSB1
Genatlas (Paris)WSB1
WikiGenes26118
SOURCE (Princeton)WSB1
Genetics Home Reference (NIH)WSB1
Genomic and cartography
GoldenPath hg38 (UCSC)WSB1  -     chr17:27294114-27315926 +  17q11.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)WSB1  -     17q11.1   [Description]    (hg19-Feb_2009)
GoldenPathWSB1 - 17q11.1 [CytoView hg19]  WSB1 - 17q11.1 [CytoView hg38]
ImmunoBaseENSG00000109046
genome Data Viewer NCBIWSB1 [Mapview hg19]  
OMIM610091   
Gene and transcription
Genbank (Entrez)AF069313 AF072880 AF106683 AF106684 AF112205
RefSeq transcript (Entrez)NM_001348350 NM_015626 NM_134264 NM_134265
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)WSB1
Alternative Splicing GalleryENSG00000109046
Gene ExpressionWSB1 [ NCBI-GEO ]   WSB1 [ EBI - ARRAY_EXPRESS ]   WSB1 [ SEEK ]   WSB1 [ MEM ]
Gene Expression Viewer (FireBrowse)WSB1 [ Firebrowse - Broad ]
GenevisibleExpression of WSB1 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)26118
GTEX Portal (Tissue expression)WSB1
Human Protein AtlasENSG00000109046-WSB1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9Y6I7   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9Y6I7  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9Y6I7
Splice isoforms : SwissVarQ9Y6I7
PhosPhoSitePlusQ9Y6I7
Domaine pattern : Prosite (Expaxy)SOCS (PS50225)    WD_REPEATS_1 (PS00678)    WD_REPEATS_2 (PS50082)    WD_REPEATS_REGION (PS50294)   
Domains : Interpro (EBI)G-protein_beta_WD-40_rep    SOCS_box    SOCS_box-like_dom_sf    WD40/YVTN_repeat-like_dom_sf    WD40_repeat    WD40_repeat_CS    WD40_repeat_dom    WD40_repeat_dom_sf   
Domain families : Pfam (Sanger)SOCS_box (PF07525)    WD40 (PF00400)   
Domain families : Pfam (NCBI)pfam07525    pfam00400   
Domain families : Smart (EMBL)SOCS (SM00253)  SOCS_box (SM00969)  WD40 (SM00320)  
Conserved Domain (NCBI)WSB1
DMDM Disease mutations26118
Blocks (Seattle)WSB1
SuperfamilyQ9Y6I7
Human Protein Atlas [tissue]ENSG00000109046-WSB1 [tissue]
Peptide AtlasQ9Y6I7
HPRD15680
IPIIPI00107502   IPI00146203   IPI00794974   IPI00909523   
Protein Interaction databases
DIP (DOE-UCLA)Q9Y6I7
IntAct (EBI)Q9Y6I7
FunCoupENSG00000109046
BioGRIDWSB1
STRING (EMBL)WSB1
ZODIACWSB1
Ontologies - Pathways
QuickGOQ9Y6I7
Ontology : AmiGOprotein polyubiquitination  protein binding  intracellular  cytosol  biological_process  intracellular signal transduction  post-translational protein modification  
Ontology : EGO-EBIprotein polyubiquitination  protein binding  intracellular  cytosol  biological_process  intracellular signal transduction  post-translational protein modification  
NDEx NetworkWSB1
Atlas of Cancer Signalling NetworkWSB1
Wikipedia pathwaysWSB1
Orthology - Evolution
OrthoDB26118
GeneTree (enSembl)ENSG00000109046
Phylogenetic Trees/Animal Genes : TreeFamWSB1
HOGENOMQ9Y6I7
Homologs : HomoloGeneWSB1
Homology/Alignments : Family Browser (UCSC)WSB1
Gene fusions - Rearrangements
Fusion : MitelmanWSB1/FN3KRP [17q11.1/17q25.3]  
Fusion : MitelmanWSB1/MED1 [17q11.1/17q12]  
Fusion : MitelmanWSB1/NBR1 [17q11.1/17q21.31]  
Fusion PortalWSB1 17q11.1 FN3KRP 17q25.3 LUAD
Fusion PortalWSB1 17q11.1 MED1 17q12 GBM
Fusion PortalWSB1 17q11.1 NBR1 17q21.31 LAML
Fusion : QuiverWSB1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerWSB1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)WSB1
dbVarWSB1
ClinVarWSB1
MonarchWSB1
1000_GenomesWSB1 
Exome Variant ServerWSB1
GNOMAD BrowserENSG00000109046
Varsome BrowserWSB1
Genetic variants : HAPMAP26118
Genomic Variants (DGV)WSB1 [DGVbeta]
DECIPHERWSB1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisWSB1 
Mutations
ICGC Data PortalWSB1 
TCGA Data PortalWSB1 
Broad Tumor PortalWSB1
OASIS PortalWSB1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICWSB1  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DWSB1
Mutations and Diseases : HGMDWSB1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch WSB1
DgiDB (Drug Gene Interaction Database)WSB1
DoCM (Curated mutations)WSB1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)WSB1 (select a term)
intoGenWSB1
Cancer3DWSB1(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM610091   
Orphanet
DisGeNETWSB1
MedgenWSB1
Genetic Testing Registry WSB1
NextProtQ9Y6I7 [Medical]
TSGene26118
GENETestsWSB1
Target ValidationWSB1
Huge Navigator WSB1 [HugePedia]
snp3D : Map Gene to Disease26118
BioCentury BCIQWSB1
ClinGenWSB1
Clinical trials, drugs, therapy
Protein Interactions : CTD26118
Pharm GKB GenePA134867554
Clinical trialWSB1
Miscellaneous
canSAR (ICR)WSB1 (select the gene name)
HarmonizomeWSB1
DataMed IndexWSB1
Probes
Litterature
PubMed46 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineWSB1
EVEXWSB1
GoPubMedWSB1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Sep 14 14:39:11 CEST 2020
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