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WWP2 (WW domain containing E3 ubiquitin protein ligase 2)

Identity

Alias_symbol (synonym)AIP2
Other aliasWWp2-like
HGNC (Hugo) WWP2
LocusID (NCBI) 11060
Atlas_Id 47485
Location 16q22.1  [Link to chromosome band 16q22]
Location_base_pair Starts at 69924983 and ends at 69941741 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CACNA1C (12p13.33) / WWP2 (16q22.1)NFAT5 (16q22.1) / WWP2 (16q22.1)RBM10 (Xp11.23) / WWP2 (16q22.1)
WWP2 (16q22.1) / TANGO6 (16q22.1)WWP2 (16q22.1) / TCIRG1 (11q13.2)WWP2 (16q22.1) / TSEN54 (17q25.1)
WWP2 (16q22.1) / ZNF629 (16p11.2)CACNA1C 12p13.33 / WWP2 16q22.1WWP2 16q22.1 TMCO7
WWP2 16q22.1 / TSEN54 17q25.1WWP2 16q22.1 / ZNF629 16p11.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 4 ]
  t(12;16)(p13;q22) CACNA1C/WWP2
t(16;16)(p11;q22) WWP2/ZNF629
WWP2/TANGO6 (16q22)
t(16;17)(q22;q25) WWP2/TSEN54


External links

Nomenclature
HGNC (Hugo)WWP2   16804
Cards
Entrez_Gene (NCBI)WWP2  11060  WW domain containing E3 ubiquitin protein ligase 2
AliasesAIP2; WWp2-like
GeneCards (Weizmann)WWP2
Ensembl hg19 (Hinxton)ENSG00000198373 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000198373 [Gene_View]  ENSG00000198373 [Sequence]  chr16:69924983-69941741 [Contig_View]  WWP2 [Vega]
ICGC DataPortalENSG00000198373
TCGA cBioPortalWWP2
AceView (NCBI)WWP2
Genatlas (Paris)WWP2
WikiGenes11060
SOURCE (Princeton)WWP2
Genetics Home Reference (NIH)WWP2
Genomic and cartography
GoldenPath hg38 (UCSC)WWP2  -     chr16:69924983-69941741 +  16q22.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)WWP2  -     16q22.1   [Description]    (hg19-Feb_2009)
EnsemblWWP2 - 16q22.1 [CytoView hg19]  WWP2 - 16q22.1 [CytoView hg38]
Mapping of homologs : NCBIWWP2 [Mapview hg19]  WWP2 [Mapview hg38]
OMIM602308   
Gene and transcription
Genbank (Entrez)AI494370 AI635734 AJ001982 AK126332 AK295070
RefSeq transcript (Entrez)NM_001270453 NM_001270454 NM_001270455 NM_007014 NM_199424
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)WWP2
Cluster EST : UnigeneHs.408458 [ NCBI ]
CGAP (NCI)Hs.408458
Alternative Splicing GalleryENSG00000198373
Gene ExpressionWWP2 [ NCBI-GEO ]   WWP2 [ EBI - ARRAY_EXPRESS ]   WWP2 [ SEEK ]   WWP2 [ MEM ]
Gene Expression Viewer (FireBrowse)WWP2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)11060
GTEX Portal (Tissue expression)WWP2
Human Protein AtlasENSG00000198373-WWP2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO00308   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO00308  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO00308
Splice isoforms : SwissVarO00308
PhosPhoSitePlusO00308
Domaine pattern : Prosite (Expaxy)HECT (PS50237)    WW_DOMAIN_1 (PS01159)    WW_DOMAIN_2 (PS50020)   
Domains : Interpro (EBI)C2_dom    C2_domain_sf    E3_ub_ligase_SMURF1    HECT_dom    Hect_E3_ubiquitin_ligase    WW_dom    WW_dom_sf   
Domain families : Pfam (Sanger)HECT (PF00632)    WW (PF00397)   
Domain families : Pfam (NCBI)pfam00632    pfam00397   
Domain families : Smart (EMBL)C2 (SM00239)  HECTc (SM00119)  WW (SM00456)  
Conserved Domain (NCBI)WWP2
DMDM Disease mutations11060
Blocks (Seattle)WWP2
PDB (SRS)4Y07    5TJ7    5TJ8    5TJQ   
PDB (PDBSum)4Y07    5TJ7    5TJ8    5TJQ   
PDB (IMB)4Y07    5TJ7    5TJ8    5TJQ   
PDB (RSDB)4Y07    5TJ7    5TJ8    5TJQ   
Structural Biology KnowledgeBase4Y07    5TJ7    5TJ8    5TJQ   
SCOP (Structural Classification of Proteins)4Y07    5TJ7    5TJ8    5TJQ   
CATH (Classification of proteins structures)4Y07    5TJ7    5TJ8    5TJQ   
SuperfamilyO00308
Human Protein Atlas [tissue]ENSG00000198373-WWP2 [tissue]
Peptide AtlasO00308
HPRD03812
IPIIPI00013010   IPI00399310   IPI01010457   IPI00902762   IPI00399309   
Protein Interaction databases
DIP (DOE-UCLA)O00308
IntAct (EBI)O00308
FunCoupENSG00000198373
BioGRIDWWP2
STRING (EMBL)WWP2
ZODIACWWP2
Ontologies - Pathways
QuickGOO00308
Ontology : AmiGOnegative regulation of transcription by RNA polymerase II  negative regulation of transcription by RNA polymerase II  negative regulation of transcription by RNA polymerase II  ubiquitin ligase complex  protein polyubiquitination  RNA polymerase II transcription factor binding  RNA polymerase II transcription factor binding  transcriptional activator activity, RNA polymerase II transcription factor binding  ubiquitin-protein transferase activity  ubiquitin-protein transferase activity  protein binding  nucleus  cytoplasm  cytoplasm  cytosol  transcription by RNA polymerase II  cellular protein modification process  extracellular transport  transcription factor binding  negative regulation of gene expression  membrane  protein ubiquitination  protein ubiquitination  protein ubiquitination  negative regulation of transporter activity  regulation of ion transmembrane transport  regulation of ion transmembrane transport  regulation of membrane potential  proteasome-mediated ubiquitin-dependent protein catabolic process  proteasome-mediated ubiquitin-dependent protein catabolic process  negative regulation of DNA-binding transcription factor activity  positive regulation of protein catabolic process  negative regulation of Notch signaling pathway  negative regulation of transcription, DNA-templated  positive regulation of transcription by RNA polymerase II  viral entry into host cell  negative regulation of protein transport  protein autoubiquitination  ubiquitin protein ligase activity  ubiquitin protein ligase activity  extracellular exosome  protein K63-linked ubiquitination  protein K63-linked ubiquitination  regulation of potassium ion transmembrane transporter activity  
Ontology : EGO-EBInegative regulation of transcription by RNA polymerase II  negative regulation of transcription by RNA polymerase II  negative regulation of transcription by RNA polymerase II  ubiquitin ligase complex  protein polyubiquitination  RNA polymerase II transcription factor binding  RNA polymerase II transcription factor binding  transcriptional activator activity, RNA polymerase II transcription factor binding  ubiquitin-protein transferase activity  ubiquitin-protein transferase activity  protein binding  nucleus  cytoplasm  cytoplasm  cytosol  transcription by RNA polymerase II  cellular protein modification process  extracellular transport  transcription factor binding  negative regulation of gene expression  membrane  protein ubiquitination  protein ubiquitination  protein ubiquitination  negative regulation of transporter activity  regulation of ion transmembrane transport  regulation of ion transmembrane transport  regulation of membrane potential  proteasome-mediated ubiquitin-dependent protein catabolic process  proteasome-mediated ubiquitin-dependent protein catabolic process  negative regulation of DNA-binding transcription factor activity  positive regulation of protein catabolic process  negative regulation of Notch signaling pathway  negative regulation of transcription, DNA-templated  positive regulation of transcription by RNA polymerase II  viral entry into host cell  negative regulation of protein transport  protein autoubiquitination  ubiquitin protein ligase activity  ubiquitin protein ligase activity  extracellular exosome  protein K63-linked ubiquitination  protein K63-linked ubiquitination  regulation of potassium ion transmembrane transporter activity  
Pathways : KEGGUbiquitin mediated proteolysis   
NDEx NetworkWWP2
Atlas of Cancer Signalling NetworkWWP2
Wikipedia pathwaysWWP2
Orthology - Evolution
OrthoDB11060
GeneTree (enSembl)ENSG00000198373
Phylogenetic Trees/Animal Genes : TreeFamWWP2
HOVERGENO00308
HOGENOMO00308
Homologs : HomoloGeneWWP2
Homology/Alignments : Family Browser (UCSC)WWP2
Gene fusions - Rearrangements
Fusion : MitelmanCACNA1C/WWP2 [12p13.33/16q22.1]  [t(12;16)(p13;q22)]  
Fusion : MitelmanWWP2/TANGO6 [16q22.1/16q22.1]  [t(16;16)(q22;q22)]  
Fusion : MitelmanWWP2/TSEN54 [16q22.1/17q25.1]  [t(16;17)(q22;q25)]  
Fusion : MitelmanWWP2/ZNF629 [16q22.1/16p11.2]  [t(16;16)(p11;q22)]  
Fusion PortalCACNA1C 12p13.33 WWP2 16q22.1 PRAD
Fusion PortalWWP2 16q22.1 TMCO7 OV
Fusion PortalWWP2 16q22.1 TSEN54 17q25.1 BRCA
Fusion PortalWWP2 16q22.1 ZNF629 16p11.2 SKCM
Fusion : QuiverWWP2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerWWP2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)WWP2
dbVarWWP2
ClinVarWWP2
1000_GenomesWWP2 
Exome Variant ServerWWP2
ExAC (Exome Aggregation Consortium)ENSG00000198373
GNOMAD BrowserENSG00000198373
Varsome BrowserWWP2
Genetic variants : HAPMAP11060
Genomic Variants (DGV)WWP2 [DGVbeta]
DECIPHERWWP2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisWWP2 
Mutations
ICGC Data PortalWWP2 
TCGA Data PortalWWP2 
Broad Tumor PortalWWP2
OASIS PortalWWP2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICWWP2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDWWP2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch WWP2
DgiDB (Drug Gene Interaction Database)WWP2
DoCM (Curated mutations)WWP2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)WWP2 (select a term)
intoGenWWP2
Cancer3DWWP2(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM602308   
Orphanet
DisGeNETWWP2
MedgenWWP2
Genetic Testing Registry WWP2
NextProtO00308 [Medical]
TSGene11060
GENETestsWWP2
Target ValidationWWP2
Huge Navigator WWP2 [HugePedia]
snp3D : Map Gene to Disease11060
BioCentury BCIQWWP2
ClinGenWWP2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD11060
Chemical/Pharm GKB GenePA134946925
Clinical trialWWP2
Miscellaneous
canSAR (ICR)WWP2 (select the gene name)
Probes
Litterature
PubMed99 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineWWP2
EVEXWWP2
GoPubMedWWP2
iHOPWWP2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Aug 27 12:02:02 CEST 2018

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