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WWTR1 (WW domain containing transcription regulator 1)

Identity

Other namesTAZ
HGNC (Hugo) WWTR1
LocusID (NCBI) 25937
Location 3q25.1
Location_base_pair Starts at 149235022 and ends at 149421060 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)WWTR1   24042
Cards
Entrez_Gene (NCBI)WWTR1  25937  WW domain containing transcription regulator 1
GeneCards (Weizmann)WWTR1
Ensembl (Hinxton)ENSG00000018408 [Gene_View]  chr3:149235022-149421060 [Contig_View]  WWTR1 [Vega]
ICGC DataPortalENSG00000018408
AceView (NCBI)WWTR1
Genatlas (Paris)WWTR1
WikiGenes25937
SOURCE (Princeton)NM_001168278 NM_001168280 NM_015472
Genomic and cartography
GoldenPath (UCSC)WWTR1  -  3q25.1   chr3:149235022-149421060 -  3q25.1   [Description]    (hg19-Feb_2009)
EnsemblWWTR1 - 3q25.1 [CytoView]
Mapping of homologs : NCBIWWTR1 [Mapview]
OMIM607392   
Gene and transcription
Genbank (Entrez)AJ299431 AK022036 AK025216 AK127620 AK130514
RefSeq transcript (Entrez)NM_001168278 NM_001168280 NM_015472
RefSeq genomic (Entrez)AC_000135 NC_000003 NC_018914 NT_005612 NW_001838884 NW_004929311
Consensus coding sequences : CCDS (NCBI)WWTR1
Cluster EST : UnigeneHs.477921 [ NCBI ]
CGAP (NCI)Hs.477921
Alternative Splicing : Fast-db (Paris)GSHG0022144
Alternative Splicing GalleryENSG00000018408
Gene ExpressionWWTR1 [ NCBI-GEO ]     WWTR1 [ SEEK ]   WWTR1 [ MEM ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9GZV5 (Uniprot)
NextProtQ9GZV5  [Medical]
With graphics : InterProQ9GZV5
Splice isoforms : SwissVarQ9GZV5 (Swissvar)
Domaine pattern : Prosite (Expaxy)WW_DOMAIN_1 (PS01159)    WW_DOMAIN_2 (PS50020)   
Domains : Interpro (EBI)WW_dom   
Related proteins : CluSTrQ9GZV5
Domain families : Pfam (Sanger)WW (PF00397)   
Domain families : Pfam (NCBI)pfam00397   
Domain families : Smart (EMBL)WW (SM00456)  
DMDM Disease mutations25937
Blocks (Seattle)Q9GZV5
Human Protein AtlasENSG00000018408 [gene] [tissue] [antibody] [cell] [cancer]
Peptide AtlasQ9GZV5
HPRD09580
IPIIPI00180266   IPI00945652   IPI00947216   IPI00945474   IPI00947373   IPI00946549   IPI00945049   IPI00946719   
Protein Interaction databases
DIP (DOE-UCLA)Q9GZV5
IntAct (EBI)Q9GZV5
FunCoupENSG00000018408
BioGRIDWWTR1
InParanoidQ9GZV5
Interologous Interaction database Q9GZV5
IntegromeDBWWTR1
STRING (EMBL)WWTR1
Ontologies - Pathways
Ontology : AmiGOnegative regulation of transcription from RNA polymerase II promoter  osteoblast differentiation  negative regulation of protein phosphorylation  transcription coactivator activity  transcription coactivator activity  transcription corepressor activity  protein binding  nucleus  nucleus  nucleoplasm  transcription factor complex  nucleolus  cytoplasm  cytosol  transcription, DNA-templated  regulation of transcription, DNA-dependent  transcription initiation from RNA polymerase II promoter  negative regulation of protein kinase activity  transforming growth factor beta receptor signaling pathway  positive regulation of cell proliferation  gene expression  positive regulation of epithelial to mesenchymal transition  stem cell division  glomerulus development  hippo signaling cascade  hippo signaling cascade  negative regulation of catenin import into nucleus  protein homodimerization activity  negative regulation of fat cell differentiation  positive regulation of transcription from RNA polymerase II promoter  cilium morphogenesis  regulation of SMAD protein import into nucleus  negative regulation of canonical Wnt receptor signaling pathway  
Ontology : EGO-EBInegative regulation of transcription from RNA polymerase II promoter  osteoblast differentiation  negative regulation of protein phosphorylation  transcription coactivator activity  transcription coactivator activity  transcription corepressor activity  protein binding  nucleus  nucleus  nucleoplasm  transcription factor complex  nucleolus  cytoplasm  cytosol  transcription, DNA-templated  regulation of transcription, DNA-dependent  transcription initiation from RNA polymerase II promoter  negative regulation of protein kinase activity  transforming growth factor beta receptor signaling pathway  positive regulation of cell proliferation  gene expression  positive regulation of epithelial to mesenchymal transition  stem cell division  glomerulus development  hippo signaling cascade  hippo signaling cascade  negative regulation of catenin import into nucleus  protein homodimerization activity  negative regulation of fat cell differentiation  positive regulation of transcription from RNA polymerase II promoter  cilium morphogenesis  regulation of SMAD protein import into nucleus  negative regulation of canonical Wnt receptor signaling pathway  
Pathways : KEGGHippo signaling pathway   
Protein Interaction DatabaseWWTR1
Wikipedia pathwaysWWTR1
Gene fusion - rearrangments
Rearrangement : TICdbWWTR1 [3q25.1]  -  CAMTA1 [8p11.23]
Polymorphisms : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)WWTR1
SNP (GeneSNP Utah)WWTR1
SNP : HGBaseWWTR1
Genetic variants : HAPMAPWWTR1
1000_GenomesWWTR1 
ICGC programENSG00000018408 
Cancer Gene: CensusWWTR1 
Somatic Mutations in Cancer : COSMICWWTR1 
CONAN: Copy Number AnalysisWWTR1 
Mutations and Diseases : HGMDWWTR1
OMIM607392   
MedgenWWTR1
GENETestsWWTR1
Disease Genetic AssociationWWTR1
Huge Navigator WWTR1 [HugePedia]  WWTR1 [HugeCancerGEM]
Genomic VariantsWWTR1  WWTR1 [DGVbeta]
Exome VariantWWTR1
dbVarWWTR1
ClinVarWWTR1
snp3D : Map Gene to Disease25937
General knowledge
Homologs : HomoloGeneWWTR1
Homology/Alignments : Family Browser (UCSC)WWTR1
Phylogenetic Trees/Animal Genes : TreeFamWWTR1
Chemical/Protein Interactions : CTD25937
Chemical/Pharm GKB GenePA134899667
Clinical trialWWTR1
Cancer Resource (Charite)ENSG00000018408
Other databases
Probes
Litterature
PubMed56 Pubmed reference(s) in Entrez
CoreMineWWTR1
iHOPWWTR1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated12-2013Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Sat Jun 21 14:01:24 CEST 2014

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