XCL1 (X-C motif chemokine ligand 1)

2011-03-01  

Identity

HGNC
LOCATION
1q24.2
LOCUSID
ALIAS
ATAC,LPTN,LTN,SCM-1,SCM-1a,SCM1,SCM1A,SCYC1

Other Information

Locus ID:

NCBI: 6375
MIM: 600250
HGNC: 10645
Ensembl: ENSG00000143184

Variants:

dbSNP: 6375
ClinVar: 6375
TCGA: ENSG00000143184
COSMIC: XCL1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000143184ENST00000367818P47992

Expression (GTEx)

0
1
2
3
4
5
6

Pathways

PathwaySourceExternal ID
Cytokine-cytokine receptor interactionKEGGko04060
Cytokine-cytokine receptor interactionKEGGhsa04060
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR ligand bindingREACTOMER-HSA-500792
Class A/1 (Rhodopsin-like receptors)REACTOMER-HSA-373076
Peptide ligand-binding receptorsREACTOMER-HSA-375276
Chemokine receptors bind chemokinesREACTOMER-HSA-380108
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (q) signalling eventsREACTOMER-HSA-416476
Gastrin-CREB signalling pathway via PKC and MAPKREACTOMER-HSA-881907

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
365721942023XCL1, a serum biomarker in neurological diseases; HTLV-1-associated myelopathy and multiple sclerosis.1
372338952023Thermodynamic Evolution of a Metamorphic Protein: A Theoretical-Computational Study of Human Lymphotactin.0
365721942023XCL1, a serum biomarker in neurological diseases; HTLV-1-associated myelopathy and multiple sclerosis.1
372338952023Thermodynamic Evolution of a Metamorphic Protein: A Theoretical-Computational Study of Human Lymphotactin.0
345184572022XCL1 Aggravates Diabetic Nephropathy-Mediated Renal Glomerular Endothelial Cell Apoptosis and Inflammatory Response via Regulating p53/Nuclear Factor-Kappa B Pathway.4
345184572022XCL1 Aggravates Diabetic Nephropathy-Mediated Renal Glomerular Endothelial Cell Apoptosis and Inflammatory Response via Regulating p53/Nuclear Factor-Kappa B Pathway.4
329868582021Specific binding-induced modulation of the XCL1 metamorphic equilibrium.0
333843772021Evolution of fold switching in a metamorphic protein.36
329868582021Specific binding-induced modulation of the XCL1 metamorphic equilibrium.0
333843772021Evolution of fold switching in a metamorphic protein.36
319048722020A functional variant near XCL1 gene improves breast cancer survival via promoting cancer immunity.9
319539842020Diepoxybutane induces the expression of a novel p53-target gene XCL1 that mediates apoptosis in exposed human lymphoblasts.1
321155732020XCL1 expression correlates with CD8-positive T cells infiltration and PD-L1 expression in squamous cell carcinoma arising from mature cystic teratoma of the ovary.25
333748492020Involvement of the ERK/HIF-1α/EMT Pathway in XCL1-Induced Migration of MDA-MB-231 and SK-BR-3 Breast Cancer Cells.11
319048722020A functional variant near XCL1 gene improves breast cancer survival via promoting cancer immunity.9

Citation

Dessen P

XCL1 (X-C motif chemokine ligand 1)

Atlas Genet Cytogenet Oncol Haematol. 2011-03-01

Online version: http://atlasgeneticsoncology.org/gene/52145/xcl1