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XIAP (X-linked inhibitor of apoptosis)

Identity

Other namesAPI3
BIRC4
IAP-3
ILP1
MIHA
XLP2
hIAP-3
hIAP3
HGNC (Hugo) XIAP
LocusID (NCBI) 331
Location Xq25
Location_base_pair Starts at 122994017 and ends at 123047829 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)XIAP   592
Cards
Entrez_Gene (NCBI)XIAP  331  X-linked inhibitor of apoptosis
GeneCards (Weizmann)XIAP
Ensembl hg19 (Hinxton)ENSG00000101966 [Gene_View]  chrX:122994017-123047829 [Contig_View]  XIAP [Vega]
Ensembl hg38 (Hinxton)ENSG00000101966 [Gene_View]  chrX:122994017-123047829 [Contig_View]  XIAP [Vega]
ICGC DataPortalENSG00000101966
cBioPortalXIAP
AceView (NCBI)XIAP
Genatlas (Paris)XIAP
WikiGenes331
SOURCE (Princeton)XIAP
Genomic and cartography
GoldenPath hg19 (UCSC)XIAP  -     chrX:122994017-123047829 +  Xq25   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)XIAP  -     Xq25   [Description]    (hg38-Dec_2013)
EnsemblXIAP - Xq25 [CytoView hg19]  XIAP - Xq25 [CytoView hg38]
Mapping of homologs : NCBIXIAP [Mapview hg19]  XIAP [Mapview hg38]
OMIM300079   300635   308240   
Gene and transcription
Genbank (Entrez)AK130423 AK309704 AK313883 BC030771 BC032729
RefSeq transcript (Entrez)NM_001167 NM_001204401
RefSeq genomic (Entrez)AC_000155 NC_000023 NC_018934 NG_007264 NT_011786 NW_001842397 NW_004929446
Consensus coding sequences : CCDS (NCBI)XIAP
Cluster EST : UnigeneHs.736565 [ NCBI ]
CGAP (NCI)Hs.736565
Alternative Splicing : Fast-db (Paris)GSHG0031797
Alternative Splicing GalleryENSG00000101966
Gene ExpressionXIAP [ NCBI-GEO ]     XIAP [ SEEK ]   XIAP [ MEM ]
SOURCE (Princeton)Expression in : [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP98170 (Uniprot)
NextProtP98170  [Medical]
With graphics : InterProP98170
Splice isoforms : SwissVarP98170 (Swissvar)
Catalytic activity : Enzyme6.3.2.- [ Enzyme-Expasy ]   6.3.2.-6.3.2.- [ IntEnz-EBI ]   6.3.2.- [ BRENDA ]   6.3.2.- [ KEGG ]   
Domaine pattern : Prosite (Expaxy)BIR_REPEAT_1 (PS01282)    BIR_REPEAT_2 (PS50143)    ZF_RING_2 (PS50089)   
Domains : Interpro (EBI)BIR    Znf_RING   
Related proteins : CluSTrP98170
Domain families : Pfam (Sanger)BIR (PF00653)   
Domain families : Pfam (NCBI)pfam00653   
Domain families : Smart (EMBL)BIR (SM00238)  RING (SM00184)  
DMDM Disease mutations331
Blocks (Seattle)P98170
PDB (SRS)1C9Q    1F9X    1G3F    1G73    1I3O    1I4O    1I51    1KMC    1NW9    1TFQ    1TFT    2ECG    2JK7    2KNA    2OPY    2OPZ    2POI    2POP    2QRA    2VSL    3CLX    3CM2    3CM7    3EYL    3G76    3HL5    3UW4    3UW5    4EC4    4HY0    4IC2    4IC3    4J3Y    4J44    4J45    4J46    4J47    4J48    4KJU    4KJV   
PDB (PDBSum)1C9Q    1F9X    1G3F    1G73    1I3O    1I4O    1I51    1KMC    1NW9    1TFQ    1TFT    2ECG    2JK7    2KNA    2OPY    2OPZ    2POI    2POP    2QRA    2VSL    3CLX    3CM2    3CM7    3EYL    3G76    3HL5    3UW4    3UW5    4EC4    4HY0    4IC2    4IC3    4J3Y    4J44    4J45    4J46    4J47    4J48    4KJU    4KJV   
PDB (IMB)1C9Q    1F9X    1G3F    1G73    1I3O    1I4O    1I51    1KMC    1NW9    1TFQ    1TFT    2ECG    2JK7    2KNA    2OPY    2OPZ    2POI    2POP    2QRA    2VSL    3CLX    3CM2    3CM7    3EYL    3G76    3HL5    3UW4    3UW5    4EC4    4HY0    4IC2    4IC3    4J3Y    4J44    4J45    4J46    4J47    4J48    4KJU    4KJV   
PDB (RSDB)1C9Q    1F9X    1G3F    1G73    1I3O    1I4O    1I51    1KMC    1NW9    1TFQ    1TFT    2ECG    2JK7    2KNA    2OPY    2OPZ    2POI    2POP    2QRA    2VSL    3CLX    3CM2    3CM7    3EYL    3G76    3HL5    3UW4    3UW5    4EC4    4HY0    4IC2    4IC3    4J3Y    4J44    4J45    4J46    4J47    4J48    4KJU    4KJV   
Human Protein AtlasENSG00000101966
Peptide AtlasP98170
HPRD02094
IPIIPI00303890   IPI00642770   IPI00852814   
Protein Interaction databases
DIP (DOE-UCLA)P98170
IntAct (EBI)P98170
FunCoupENSG00000101966
BioGRIDXIAP
IntegromeDBXIAP
STRING (EMBL)XIAP
Ontologies - Pathways
QuickGOP98170
Ontology : AmiGOubiquitin-protein transferase activity  protein binding  nucleus  cytoplasm  cytosol  apoptotic process  cellular response to DNA damage stimulus  zinc ion binding  Wnt signaling pathway  protein ubiquitination  ligase activity  regulation of BMP signaling pathway  positive regulation of protein ubiquitination  regulation of cell proliferation  cysteine-type endopeptidase inhibitor activity involved in apoptotic process  negative regulation of apoptotic process  negative regulation of cysteine-type endopeptidase activity involved in apoptotic process  regulation of innate immune response  regulation of inflammatory response  copper ion homeostasis  regulation of nucleotide-binding oligomerization domain containing signaling pathway  positive regulation of canonical Wnt signaling pathway  intrinsic apoptotic signaling pathway  positive regulation of protein linear polyubiquitination  
Ontology : EGO-EBIubiquitin-protein transferase activity  protein binding  nucleus  cytoplasm  cytosol  apoptotic process  cellular response to DNA damage stimulus  zinc ion binding  Wnt signaling pathway  protein ubiquitination  ligase activity  regulation of BMP signaling pathway  positive regulation of protein ubiquitination  regulation of cell proliferation  cysteine-type endopeptidase inhibitor activity involved in apoptotic process  negative regulation of apoptotic process  negative regulation of cysteine-type endopeptidase activity involved in apoptotic process  regulation of innate immune response  regulation of inflammatory response  copper ion homeostasis  regulation of nucleotide-binding oligomerization domain containing signaling pathway  positive regulation of canonical Wnt signaling pathway  intrinsic apoptotic signaling pathway  positive regulation of protein linear polyubiquitination  
Pathways : BIOCARTACaspase Cascade in Apoptosis [Genes]    B Cell Survival Pathway [Genes]    Role of Mitochondria in Apoptotic Signaling [Genes]    HIV-I Nef: negative effector of Fas and TNF [Genes]    Induction of apoptosis through DR3 and DR4/5 Death Receptors [Genes]   
Pathways : KEGGNF-kappa B signaling pathway    Ubiquitin mediated proteolysis    Apoptosis    Focal adhesion    Toxoplasmosis    HTLV-I infection    Pathways in cancer    Small cell lung cancer   
Protein Interaction DatabaseXIAP
DoCM (Curated mutations)XIAP
Wikipedia pathwaysXIAP
Gene fusion - rearrangements
Polymorphisms : SNP, variants
NCBI Variation ViewerXIAP [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)XIAP
dbVarXIAP
ClinVarXIAP
1000_GenomesXIAP 
Exome Variant ServerXIAP
SNP (GeneSNP Utah)XIAP
SNP : HGBaseXIAP
Genetic variants : HAPMAPXIAP
Genomic VariantsXIAP  XIAP [DGVbeta]
Mutations
ICGC Data PortalENSG00000101966 
Somatic Mutations in Cancer : COSMICXIAP 
CONAN: Copy Number AnalysisXIAP 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)X-chromosome gene database
LOVD (Leiden Open Variation Database)**PUBLIC** CCHMC Molecular Genetics Laboratory Mutation Database
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)X:122994017-123047829
Mutations and Diseases : HGMDXIAP
OMIM300079    300635    308240   
MedgenXIAP
NextProtP98170 [Medical]
GENETestsXIAP
Disease Genetic AssociationXIAP
Huge Navigator XIAP [HugePedia]  XIAP [HugeCancerGEM]
snp3D : Map Gene to Disease331
DGIdb (Drug Gene Interaction db)XIAP
General knowledge
Homologs : HomoloGeneXIAP
Homology/Alignments : Family Browser (UCSC)XIAP
Phylogenetic Trees/Animal Genes : TreeFamXIAP
Chemical/Protein Interactions : CTD331
Chemical/Pharm GKB GenePA25361
Clinical trialXIAP
Cancer Resource (Charite)ENSG00000101966
Other databases
Probes
Litterature
PubMed380 Pubmed reference(s) in Entrez
CoreMineXIAP
GoPubMedXIAP
iHOPXIAP
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated12-2014Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Sun Dec 21 02:19:20 CET 2014
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