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XIAP (X-linked inhibitor of apoptosis)

Identity

Alias_namesAPI3
BIRC4
baculoviral IAP repeat-containing 4
X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase
Alias_symbol (synonym)hILP
Other aliasIAP-3
ILP1
MIHA
XLP2
hIAP-3
hIAP3
HGNC (Hugo) XIAP
LocusID (NCBI) 331
Atlas_Id 796
Location Xq25  [Link to chromosome band Xq25]
Location_base_pair Starts at 123859812 and ends at 123913979 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
PAQR7 (1p36.11) / XIAP (Xq25)RELL1 (4p14) / XIAP (Xq25)SMC1A (Xp11.22) / XIAP (Xq25)
STAG2 (Xq25) / XIAP (Xq25)TMEM52B (12p13.2) / XIAP (Xq25)XIAP (Xq25) / HSP90AB1 (6p21.1)
XIAP (Xq25) / OLR1 (12p13.2)XIAP (Xq25) / STAG2 (Xq25)STAG2 Xq25 / XIAP Xq25

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Leukemias implicated (Data extracted from papers in the Atlas) [ 3 ]
  t(X;12)(q25;p13) OLR1/XIAP
t(X;12)(q25;p13) TMEM52B/XIAP
t(X;12)(q25;p13) XIAP/OLR1

Other Cancer prone implicated (Data extracted from papers in the Atlas) [ 1 ]
  X-linked lymphoproliferative disease (XLP)

External links

Nomenclature
HGNC (Hugo)XIAP   592
LRG (Locus Reference Genomic)LRG_19
Cards
Entrez_Gene (NCBI)XIAP  331  X-linked inhibitor of apoptosis
AliasesAPI3; BIRC4; IAP-3; ILP1; 
MIHA; XLP2; hIAP-3; hIAP3
GeneCards (Weizmann)XIAP
Ensembl hg19 (Hinxton)ENSG00000101966 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000101966 [Gene_View]  ENSG00000101966 [Sequence]  chrX:123859812-123913979 [Contig_View]  XIAP [Vega]
ICGC DataPortalENSG00000101966
TCGA cBioPortalXIAP
AceView (NCBI)XIAP
Genatlas (Paris)XIAP
WikiGenes331
SOURCE (Princeton)XIAP
Genetics Home Reference (NIH)XIAP
Genomic and cartography
GoldenPath hg38 (UCSC)XIAP  -     chrX:123859812-123913979 +  Xq25   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)XIAP  -     Xq25   [Description]    (hg19-Feb_2009)
EnsemblXIAP - Xq25 [CytoView hg19]  XIAP - Xq25 [CytoView hg38]
Mapping of homologs : NCBIXIAP [Mapview hg19]  XIAP [Mapview hg38]
OMIM300079   300635   308240   
Gene and transcription
Genbank (Entrez)AK130423 AK309704 AK313883 BC030771 BC032729
RefSeq transcript (Entrez)NM_001167 NM_001204401
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)XIAP
Cluster EST : UnigeneHs.736565 [ NCBI ]
CGAP (NCI)Hs.736565
Alternative Splicing GalleryENSG00000101966
Gene ExpressionXIAP [ NCBI-GEO ]   XIAP [ EBI - ARRAY_EXPRESS ]   XIAP [ SEEK ]   XIAP [ MEM ]
Gene Expression Viewer (FireBrowse)XIAP [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)331
GTEX Portal (Tissue expression)XIAP
Human Protein AtlasENSG00000101966-XIAP [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP98170   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP98170  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP98170
Splice isoforms : SwissVarP98170
Catalytic activity : Enzyme2.3.2.27 [ Enzyme-Expasy ]   2.3.2.272.3.2.27 [ IntEnz-EBI ]   2.3.2.27 [ BRENDA ]   2.3.2.27 [ KEGG ]   
PhosPhoSitePlusP98170
Domaine pattern : Prosite (Expaxy)BIR_REPEAT_1 (PS01282)    BIR_REPEAT_2 (PS50143)    ZF_RING_2 (PS50089)   
Domains : Interpro (EBI)BIR_rpt    Znf_RING    Znf_RING/FYVE/PHD   
Domain families : Pfam (Sanger)BIR (PF00653)   
Domain families : Pfam (NCBI)pfam00653   
Domain families : Smart (EMBL)BIR (SM00238)  RING (SM00184)  
Conserved Domain (NCBI)XIAP
DMDM Disease mutations331
Blocks (Seattle)XIAP
PDB (SRS)1C9Q    1F9X    1G3F    1G73    1I3O    1I4O    1I51    1KMC    1NW9    1TFQ    1TFT    2ECG    2JK7    2KNA    2OPY    2OPZ    2POI    2POP    2QRA    2VSL    3CLX    3CM2    3CM7    3EYL    3G76    3HL5    3UW4    3UW5    4EC4    4HY0    4IC2    4IC3    4J3Y    4J44    4J45    4J46    4J47    4J48    4KJU    4KJV    4KMP    4MTZ    4OXC    4WVS    4WVT    4WVU    5C0K    5C0L    5C3H    5C3K    5C7A    5C7B    5C7C    5C7D    5C83    5C84    5M6E    5M6F    5M6H    5M6L    5M6M    5O6T   
PDB (PDBSum)1C9Q    1F9X    1G3F    1G73    1I3O    1I4O    1I51    1KMC    1NW9    1TFQ    1TFT    2ECG    2JK7    2KNA    2OPY    2OPZ    2POI    2POP    2QRA    2VSL    3CLX    3CM2    3CM7    3EYL    3G76    3HL5    3UW4    3UW5    4EC4    4HY0    4IC2    4IC3    4J3Y    4J44    4J45    4J46    4J47    4J48    4KJU    4KJV    4KMP    4MTZ    4OXC    4WVS    4WVT    4WVU    5C0K    5C0L    5C3H    5C3K    5C7A    5C7B    5C7C    5C7D    5C83    5C84    5M6E    5M6F    5M6H    5M6L    5M6M    5O6T   
PDB (IMB)1C9Q    1F9X    1G3F    1G73    1I3O    1I4O    1I51    1KMC    1NW9    1TFQ    1TFT    2ECG    2JK7    2KNA    2OPY    2OPZ    2POI    2POP    2QRA    2VSL    3CLX    3CM2    3CM7    3EYL    3G76    3HL5    3UW4    3UW5    4EC4    4HY0    4IC2    4IC3    4J3Y    4J44    4J45    4J46    4J47    4J48    4KJU    4KJV    4KMP    4MTZ    4OXC    4WVS    4WVT    4WVU    5C0K    5C0L    5C3H    5C3K    5C7A    5C7B    5C7C    5C7D    5C83    5C84    5M6E    5M6F    5M6H    5M6L    5M6M    5O6T   
PDB (RSDB)1C9Q    1F9X    1G3F    1G73    1I3O    1I4O    1I51    1KMC    1NW9    1TFQ    1TFT    2ECG    2JK7    2KNA    2OPY    2OPZ    2POI    2POP    2QRA    2VSL    3CLX    3CM2    3CM7    3EYL    3G76    3HL5    3UW4    3UW5    4EC4    4HY0    4IC2    4IC3    4J3Y    4J44    4J45    4J46    4J47    4J48    4KJU    4KJV    4KMP    4MTZ    4OXC    4WVS    4WVT    4WVU    5C0K    5C0L    5C3H    5C3K    5C7A    5C7B    5C7C    5C7D    5C83    5C84    5M6E    5M6F    5M6H    5M6L    5M6M    5O6T   
Structural Biology KnowledgeBase1C9Q    1F9X    1G3F    1G73    1I3O    1I4O    1I51    1KMC    1NW9    1TFQ    1TFT    2ECG    2JK7    2KNA    2OPY    2OPZ    2POI    2POP    2QRA    2VSL    3CLX    3CM2    3CM7    3EYL    3G76    3HL5    3UW4    3UW5    4EC4    4HY0    4IC2    4IC3    4J3Y    4J44    4J45    4J46    4J47    4J48    4KJU    4KJV    4KMP    4MTZ    4OXC    4WVS    4WVT    4WVU    5C0K    5C0L    5C3H    5C3K    5C7A    5C7B    5C7C    5C7D    5C83    5C84    5M6E    5M6F    5M6H    5M6L    5M6M    5O6T   
SCOP (Structural Classification of Proteins)1C9Q    1F9X    1G3F    1G73    1I3O    1I4O    1I51    1KMC    1NW9    1TFQ    1TFT    2ECG    2JK7    2KNA    2OPY    2OPZ    2POI    2POP    2QRA    2VSL    3CLX    3CM2    3CM7    3EYL    3G76    3HL5    3UW4    3UW5    4EC4    4HY0    4IC2    4IC3    4J3Y    4J44    4J45    4J46    4J47    4J48    4KJU    4KJV    4KMP    4MTZ    4OXC    4WVS    4WVT    4WVU    5C0K    5C0L    5C3H    5C3K    5C7A    5C7B    5C7C    5C7D    5C83    5C84    5M6E    5M6F    5M6H    5M6L    5M6M    5O6T   
CATH (Classification of proteins structures)1C9Q    1F9X    1G3F    1G73    1I3O    1I4O    1I51    1KMC    1NW9    1TFQ    1TFT    2ECG    2JK7    2KNA    2OPY    2OPZ    2POI    2POP    2QRA    2VSL    3CLX    3CM2    3CM7    3EYL    3G76    3HL5    3UW4    3UW5    4EC4    4HY0    4IC2    4IC3    4J3Y    4J44    4J45    4J46    4J47    4J48    4KJU    4KJV    4KMP    4MTZ    4OXC    4WVS    4WVT    4WVU    5C0K    5C0L    5C3H    5C3K    5C7A    5C7B    5C7C    5C7D    5C83    5C84    5M6E    5M6F    5M6H    5M6L    5M6M    5O6T   
SuperfamilyP98170
Human Protein Atlas [tissue]ENSG00000101966-XIAP [tissue]
Peptide AtlasP98170
HPRD02094
IPIIPI00303890   IPI00642770   IPI00852814   
Protein Interaction databases
DIP (DOE-UCLA)P98170
IntAct (EBI)P98170
FunCoupENSG00000101966
BioGRIDXIAP
STRING (EMBL)XIAP
ZODIACXIAP
Ontologies - Pathways
QuickGOP98170
Ontology : AmiGOubiquitin-protein transferase activity  protein binding  nucleus  nucleus  nucleoplasm  cytoplasm  cytoplasm  cytosol  apoptotic process  cellular response to DNA damage stimulus  Wnt signaling pathway  protein ubiquitination  regulation of BMP signaling pathway  positive regulation of protein ubiquitination  regulation of cell proliferation  identical protein binding  cysteine-type endopeptidase inhibitor activity involved in apoptotic process  cysteine-type endopeptidase inhibitor activity involved in apoptotic process  negative regulation of apoptotic process  negative regulation of cysteine-type endopeptidase activity involved in apoptotic process  regulation of innate immune response  metal ion binding  regulation of inflammatory response  copper ion homeostasis  ubiquitin protein ligase activity  ubiquitin protein ligase activity  ubiquitin protein ligase activity  regulation of nucleotide-binding oligomerization domain containing signaling pathway  positive regulation of canonical Wnt signaling pathway  positive regulation of canonical Wnt signaling pathway  mitotic spindle assembly  positive regulation of protein linear polyubiquitination  inhibition of cysteine-type endopeptidase activity involved in apoptotic process  
Ontology : EGO-EBIubiquitin-protein transferase activity  protein binding  nucleus  nucleus  nucleoplasm  cytoplasm  cytoplasm  cytosol  apoptotic process  cellular response to DNA damage stimulus  Wnt signaling pathway  protein ubiquitination  regulation of BMP signaling pathway  positive regulation of protein ubiquitination  regulation of cell proliferation  identical protein binding  cysteine-type endopeptidase inhibitor activity involved in apoptotic process  cysteine-type endopeptidase inhibitor activity involved in apoptotic process  negative regulation of apoptotic process  negative regulation of cysteine-type endopeptidase activity involved in apoptotic process  regulation of innate immune response  metal ion binding  regulation of inflammatory response  copper ion homeostasis  ubiquitin protein ligase activity  ubiquitin protein ligase activity  ubiquitin protein ligase activity  regulation of nucleotide-binding oligomerization domain containing signaling pathway  positive regulation of canonical Wnt signaling pathway  positive regulation of canonical Wnt signaling pathway  mitotic spindle assembly  positive regulation of protein linear polyubiquitination  inhibition of cysteine-type endopeptidase activity involved in apoptotic process  
Pathways : KEGGNF-kappa B signaling pathway    Ubiquitin mediated proteolysis    Apoptosis    Focal adhesion    Toxoplasmosis    HTLV-I infection    Pathways in cancer    Small cell lung cancer   
NDEx NetworkXIAP
Atlas of Cancer Signalling NetworkXIAP
Wikipedia pathwaysXIAP
Orthology - Evolution
OrthoDB331
GeneTree (enSembl)ENSG00000101966
Phylogenetic Trees/Animal Genes : TreeFamXIAP
HOVERGENP98170
HOGENOMP98170
Homologs : HomoloGeneXIAP
Homology/Alignments : Family Browser (UCSC)XIAP
Gene fusions - Rearrangements
Fusion : MitelmanTMEM52B/XIAP [12p13.2/Xq25]  [t(X;12)(q25;p13)]  
Fusion : MitelmanXIAP/OLR1 [Xq25/12p13.2]  [t(X;12)(q25;p13)]  
Fusion PortalSTAG2 Xq25 XIAP Xq25 BRCA
Fusion : QuiverXIAP
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerXIAP [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)XIAP
dbVarXIAP
ClinVarXIAP
1000_GenomesXIAP 
Exome Variant ServerXIAP
ExAC (Exome Aggregation Consortium)ENSG00000101966
GNOMAD BrowserENSG00000101966
Varsome BrowserXIAP
Genetic variants : HAPMAP331
Genomic Variants (DGV)XIAP [DGVbeta]
DECIPHERXIAP [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisXIAP 
Mutations
ICGC Data PortalXIAP 
TCGA Data PortalXIAP 
Broad Tumor PortalXIAP
OASIS PortalXIAP [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICXIAP  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDXIAP
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)X-chromosome gene database
LOVD (Leiden Open Variation Database)**PUBLIC** CCHMC Molecular Genetics Laboratory Mutation Database
BioMutasearch XIAP
DgiDB (Drug Gene Interaction Database)XIAP
DoCM (Curated mutations)XIAP (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)XIAP (select a term)
intoGenXIAP
Cancer3DXIAP(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM300079    300635    308240   
Orphanet275   
DisGeNETXIAP
MedgenXIAP
Genetic Testing Registry XIAP
NextProtP98170 [Medical]
TSGene331
GENETestsXIAP
Target ValidationXIAP
Huge Navigator XIAP [HugePedia]
snp3D : Map Gene to Disease331
BioCentury BCIQXIAP
ClinGenXIAP (curated)
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD331
Chemical/Pharm GKB GenePA25361
Clinical trialXIAP
Miscellaneous
canSAR (ICR)XIAP (select the gene name)
Probes
Litterature
PubMed499 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineXIAP
EVEXXIAP
GoPubMedXIAP
iHOPXIAP
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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