XIAP (X-linked inhibitor of apoptosis)

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XIAP (X-linked inhibitor of apoptosis)

Identity

Other names	API3
	BIRC4
	IAP-3
	ILP1
	MIHA
	XLP2
	hIAP-3
	hIAP3
HGNC (Hugo)	XIAP
LocusID (NCBI)	331
Atlas_Id	796
Location	Xq25 [Link to chromosome band Xq25]
Location_base_pair	Starts at 122994017 and ends at 123047829 bp from pter ( according to hg19-Feb_2009)

Fusion genes (updated 2016)	PAQR7 (1p36.11) / XIAP (Xq25)	RELL1 (4p14) / XIAP (Xq25)	SMC1A (Xp11.22) / XIAP (Xq25)
	STAG2 (Xq25) / XIAP (Xq25)	TMEM52B (12p13.2) / XIAP (Xq25)	XIAP (Xq25) / HSP90AB1 (6p21.1)
	XIAP (Xq25) / OLR1 (12p13.2)	XIAP (Xq25) / STAG2 (Xq25)	STAG2 Xq25 / XIAP Xq25

Note	Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, go to How to contribute

DNA/RNA

Other Cancer prone implicated (Data extracted from papers in the Atlas) [ 1 ]

X-linked lymphoproliferative disease (XLP)

External links

	Nomenclature
HGNC (Hugo)	XIAP 592
	Cards
Entrez_Gene (NCBI)	XIAP 331 X-linked inhibitor of apoptosis
Aliases	API3; BIRC4; IAP-3; ILP1;
	MIHA; XLP2; hIAP-3; hIAP3
GeneCards (Weizmann)	XIAP
Ensembl hg19 (Hinxton)	ENSG00000101966 [Gene_View] chrX:122994017-123047829 [Contig_View] XIAP [Vega]
Ensembl hg38 (Hinxton)	ENSG00000101966 [Gene_View] chrX:122994017-123047829 [Contig_View] XIAP [Vega]
ICGC DataPortal	ENSG00000101966
TCGA cBioPortal	XIAP
AceView (NCBI)	XIAP
Genatlas (Paris)	XIAP
WikiGenes	331
SOURCE (Princeton)	XIAP
	Genomic and cartography
GoldenPath hg19 (UCSC)	XIAP - chrX:122994017-123047829 + Xq25 [Description] (hg19-Feb_2009)
GoldenPath hg38 (UCSC)	XIAP - Xq25 [Description] (hg38-Dec_2013)
Ensembl	XIAP - Xq25 [CytoView hg19] XIAP - Xq25 [CytoView hg38]
Mapping of homologs : NCBI	XIAP [Mapview hg19] XIAP [Mapview hg38]
OMIM	300079 300635 308240
	Gene and transcription
Genbank (Entrez)	AK130423 AK309704 AK313883 BC030771 BC032729
RefSeq transcript (Entrez)	NM_001167 NM_001204401
RefSeq genomic (Entrez)	NC_000023 NC_018934 NG_007264 NT_011786 NW_004929446
Consensus coding sequences : CCDS (NCBI)	XIAP
Cluster EST : Unigene	Hs.736565 [ NCBI ]
CGAP (NCI)	Hs.736565
Alternative Splicing Gallery	ENSG00000101966
Gene Expression	XIAP [ NCBI-GEO ] XIAP [ EBI - ARRAY_EXPRESS ] XIAP [ SEEK ] XIAP [ MEM ]
Gene Expression Viewer (FireBrowse)	XIAP [ Firebrowse - Broad ]
SOURCE (Princeton)	Expression in : [Datasets] [Normal Tissue Atlas] [carcinoma Classsification] [NCI60]
Genevisible	Expression in : [tissues] [cell-lines] [cancer] [perturbations]
BioGPS (Tissue expression)	331
GTEX Portal (Tissue expression)	XIAP
	Protein : pattern, domain, 3D structure
UniProt/SwissProt	P98170 (Uniprot)
NextProt	P98170 [Sequence] [Exons] [Medical] [Publications]
With graphics : InterPro	P98170
Splice isoforms : SwissVar	P98170 (Swissvar)
Catalytic activity : Enzyme	6.3.2.- [ Enzyme-Expasy ] 6.3.2.-6.3.2.- [ IntEnz-EBI ] 6.3.2.- [ BRENDA ] 6.3.2.- [ KEGG ]
PhosPhoSitePlus	P98170
Domaine pattern : Prosite (Expaxy)	BIR_REPEAT_1 (PS01282) BIR_REPEAT_2 (PS50143) ZF_RING_2 (PS50089)
Domains : Interpro (EBI)	BIR_rpt Znf_RING
Domain families : Pfam (Sanger)	BIR (PF00653)
Domain families : Pfam (NCBI)	pfam00653
Domain families : Smart (EMBL)	BIR (SM00238) RING (SM00184)
DMDM Disease mutations	331
Blocks (Seattle)	XIAP
PDB (SRS)	1C9Q 1F9X 1G3F 1G73 1I3O 1I4O 1I51 1KMC 1NW9 1TFQ 1TFT 2ECG 2JK7 2KNA 2OPY 2OPZ 2POI 2POP 2QRA 2VSL 3CLX 3CM2 3CM7 3EYL 3G76 3HL5 3UW4 3UW5 4EC4 4HY0 4IC2 4IC3 4J3Y 4J44 4J45 4J46 4J47 4J48 4KJU 4KJV 4KMP 4MTZ 4OXC 4WVS 4WVT 4WVU 5C0K 5C0L 5C3H 5C3K 5C7A 5C7B 5C7C 5C7D 5C83 5C84
PDB (PDBSum)	1C9Q 1F9X 1G3F 1G73 1I3O 1I4O 1I51 1KMC 1NW9 1TFQ 1TFT 2ECG 2JK7 2KNA 2OPY 2OPZ 2POI 2POP 2QRA 2VSL 3CLX 3CM2 3CM7 3EYL 3G76 3HL5 3UW4 3UW5 4EC4 4HY0 4IC2 4IC3 4J3Y 4J44 4J45 4J46 4J47 4J48 4KJU 4KJV 4KMP 4MTZ 4OXC 4WVS 4WVT 4WVU 5C0K 5C0L 5C3H 5C3K 5C7A 5C7B 5C7C 5C7D 5C83 5C84
PDB (IMB)	1C9Q 1F9X 1G3F 1G73 1I3O 1I4O 1I51 1KMC 1NW9 1TFQ 1TFT 2ECG 2JK7 2KNA 2OPY 2OPZ 2POI 2POP 2QRA 2VSL 3CLX 3CM2 3CM7 3EYL 3G76 3HL5 3UW4 3UW5 4EC4 4HY0 4IC2 4IC3 4J3Y 4J44 4J45 4J46 4J47 4J48 4KJU 4KJV 4KMP 4MTZ 4OXC 4WVS 4WVT 4WVU 5C0K 5C0L 5C3H 5C3K 5C7A 5C7B 5C7C 5C7D 5C83 5C84
PDB (RSDB)	1C9Q 1F9X 1G3F 1G73 1I3O 1I4O 1I51 1KMC 1NW9 1TFQ 1TFT 2ECG 2JK7 2KNA 2OPY 2OPZ 2POI 2POP 2QRA 2VSL 3CLX 3CM2 3CM7 3EYL 3G76 3HL5 3UW4 3UW5 4EC4 4HY0 4IC2 4IC3 4J3Y 4J44 4J45 4J46 4J47 4J48 4KJU 4KJV 4KMP 4MTZ 4OXC 4WVS 4WVT 4WVU 5C0K 5C0L 5C3H 5C3K 5C7A 5C7B 5C7C 5C7D 5C83 5C84
Structural Biology KnowledgeBase	1C9Q 1F9X 1G3F 1G73 1I3O 1I4O 1I51 1KMC 1NW9 1TFQ 1TFT 2ECG 2JK7 2KNA 2OPY 2OPZ 2POI 2POP 2QRA 2VSL 3CLX 3CM2 3CM7 3EYL 3G76 3HL5 3UW4 3UW5 4EC4 4HY0 4IC2 4IC3 4J3Y 4J44 4J45 4J46 4J47 4J48 4KJU 4KJV 4KMP 4MTZ 4OXC 4WVS 4WVT 4WVU 5C0K 5C0L 5C3H 5C3K 5C7A 5C7B 5C7C 5C7D 5C83 5C84
SCOP (Structural Classification of Proteins)	1C9Q 1F9X 1G3F 1G73 1I3O 1I4O 1I51 1KMC 1NW9 1TFQ 1TFT 2ECG 2JK7 2KNA 2OPY 2OPZ 2POI 2POP 2QRA 2VSL 3CLX 3CM2 3CM7 3EYL 3G76 3HL5 3UW4 3UW5 4EC4 4HY0 4IC2 4IC3 4J3Y 4J44 4J45 4J46 4J47 4J48 4KJU 4KJV 4KMP 4MTZ 4OXC 4WVS 4WVT 4WVU 5C0K 5C0L 5C3H 5C3K 5C7A 5C7B 5C7C 5C7D 5C83 5C84
CATH (Classification of proteins structures)	1C9Q 1F9X 1G3F 1G73 1I3O 1I4O 1I51 1KMC 1NW9 1TFQ 1TFT 2ECG 2JK7 2KNA 2OPY 2OPZ 2POI 2POP 2QRA 2VSL 3CLX 3CM2 3CM7 3EYL 3G76 3HL5 3UW4 3UW5 4EC4 4HY0 4IC2 4IC3 4J3Y 4J44 4J45 4J46 4J47 4J48 4KJU 4KJV 4KMP 4MTZ 4OXC 4WVS 4WVT 4WVU 5C0K 5C0L 5C3H 5C3K 5C7A 5C7B 5C7C 5C7D 5C83 5C84
Superfamily	P98170
Human Protein Atlas	ENSG00000101966
Peptide Atlas	P98170
HPRD	02094
IPI	IPI00303890 IPI00642770 IPI00852814
	Protein Interaction databases
DIP (DOE-UCLA)	P98170
IntAct (EBI)	P98170
FunCoup	ENSG00000101966
BioGRID	XIAP
STRING (EMBL)	XIAP
ZODIAC	XIAP
	Ontologies - Pathways
QuickGO	P98170
Ontology : AmiGO	ubiquitin-protein transferase activity protein binding nucleus nucleoplasm cytoplasm cytosol spindle microtubule cellular response to DNA damage stimulus zinc ion binding Wnt signaling pathway protein ubiquitination ligase activity regulation of BMP signaling pathway positive regulation of protein ubiquitination regulation of cell proliferation cysteine-type endopeptidase inhibitor activity involved in apoptotic process negative regulation of apoptotic process negative regulation of cysteine-type endopeptidase activity involved in apoptotic process regulation of innate immune response regulation of inflammatory response copper ion homeostasis ubiquitin protein ligase activity regulation of nucleotide-binding oligomerization domain containing signaling pathway positive regulation of canonical Wnt signaling pathway mitotic spindle assembly positive regulation of protein linear polyubiquitination inhibition of cysteine-type endopeptidase activity involved in apoptotic process
Ontology : EGO-EBI	ubiquitin-protein transferase activity protein binding nucleus nucleoplasm cytoplasm cytosol spindle microtubule cellular response to DNA damage stimulus zinc ion binding Wnt signaling pathway protein ubiquitination ligase activity regulation of BMP signaling pathway positive regulation of protein ubiquitination regulation of cell proliferation cysteine-type endopeptidase inhibitor activity involved in apoptotic process negative regulation of apoptotic process negative regulation of cysteine-type endopeptidase activity involved in apoptotic process regulation of innate immune response regulation of inflammatory response copper ion homeostasis ubiquitin protein ligase activity regulation of nucleotide-binding oligomerization domain containing signaling pathway positive regulation of canonical Wnt signaling pathway mitotic spindle assembly positive regulation of protein linear polyubiquitination inhibition of cysteine-type endopeptidase activity involved in apoptotic process
Pathways : BIOCARTA	Caspase Cascade in Apoptosis [Genes] B Cell Survival Pathway [Genes] Role of Mitochondria in Apoptotic Signaling [Genes] HIV-I Nef: negative effector of Fas and TNF [Genes] Induction of apoptosis through DR3 and DR4/5 Death Receptors [Genes]
Pathways : KEGG	NF-kappa B signaling pathway Ubiquitin mediated proteolysis Apoptosis Focal adhesion Toxoplasmosis HTLV-I infection Pathways in cancer Small cell lung cancer
NDEx Network	XIAP
Atlas of Cancer Signalling Network	XIAP
Wikipedia pathways	XIAP
	Orthology - Evolution
OrthoDB	331
GeneTree (enSembl)	ENSG00000101966
Phylogenetic Trees/Animal Genes : TreeFam	XIAP
Homologs : HomoloGene	XIAP
Homology/Alignments : Family Browser (UCSC)	XIAP
	Gene fusions - Rearrangements
Fusion: TCGA	STAG2 Xq25 XIAP Xq25 BRCA
	Polymorphisms : SNP, variants
NCBI Variation Viewer	XIAP [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)	XIAP
dbVar	XIAP
ClinVar	XIAP
1000_Genomes	XIAP
Exome Variant Server	XIAP
ExAC (Exome Aggregation Consortium)	XIAP (select the gene name)
Genetic variants : HAPMAP	331
Genomic Variants (DGV)	XIAP [DGVbeta]
	Mutations
ICGC Data Portal	XIAP
TCGA Data Portal	XIAP
Broad Tumor Portal	XIAP
OASIS Portal	XIAP [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMIC	XIAP
LOVD (Leiden Open Variation Database)	Whole genome datasets
LOVD (Leiden Open Variation Database)	LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)	LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)	X-chromosome gene database
LOVD (Leiden Open Variation Database)	PUBLIC CCHMC Molecular Genetics Laboratory Mutation Database
BioMuta	search XIAP
DgiDB (Drug Gene Interaction Database)	XIAP
DoCM (Curated mutations)	XIAP (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)	XIAP (select a term)
intoGen	XIAP
Impact of mutations	[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor]
	Diseases
DECIPHER (Syndromes)	X:122994017-123047829 ENSG00000101966
CONAN: Copy Number Analysis	XIAP
Mutations and Diseases : HGMD	XIAP
OMIM	300079 300635 308240
Medgen	XIAP
Genetic Testing Registry	XIAP
NextProt	P98170 [Medical]
TSGene	331
GENETests	XIAP
Huge Navigator	XIAP [HugePedia]
snp3D : Map Gene to Disease	331
BioCentury BCIQ	XIAP
ClinGen	XIAP
	Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD	331
Chemical/Pharm GKB Gene	PA25361
Clinical trial	XIAP
	Miscellaneous
canSAR (ICR)	XIAP (select the gene name)
	Probes
	Litterature
PubMed	444 Pubmed reference(s) in Entrez
GeneRIFs	Gene References Into Functions (Entrez)
CoreMine	XIAP
EVEX	XIAP
GoPubMed	XIAP
iHOP	XIAP

Genes in title	automatic search in PubMed
REVIEW articles	automatic search in PubMed
Last year publications	automatic search in PubMed

Search in all EBI NCBI

indexed on : Mon Sep 19 19:19:53 CEST 2016

Home Genes Leukemias Solid Tumours Cancer-Prone Deep Insight Case Reports Journals Portal Teaching

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jlhuret@AtlasGeneticsOncology.org.

Atlas of Genetics and Cytogenetics in Oncology and Haematology

XIAP (X-linked inhibitor of apoptosis)

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, go to How to contribute

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to How to contribute