Atlas of Genetics and Cytogenetics in Oncology and Haematology


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XPNPEP1 (X-prolyl aminopeptidase 1)

Identity

Alias_namesXPNPEP
XPNPEPL1
XPNPEPL
X-prolyl aminopeptidase (aminopeptidase P)-like
X-prolyl aminopeptidase (aminopeptidase P) 1, soluble
Other aliasAPP1
SAMP
HGNC (Hugo) XPNPEP1
LocusID (NCBI) 7511
Atlas_Id 75790
Location 10q25.1  [Link to chromosome band 10q25]
Location_base_pair Starts at 109864766 and ends at 109923553 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
ADD3 (10q25.1) / XPNPEP1 (10q25.1)MALAT1 (11q13.1) / XPNPEP1 (10q25.1)XPNPEP1 (10q25.1) / ABCC1 (16p13.11)
XPNPEP1 (10q25.1) / CHI3L1 (1q32.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)XPNPEP1   12822
Cards
Entrez_Gene (NCBI)XPNPEP1  7511  X-prolyl aminopeptidase 1
AliasesAPP1; SAMP; XPNPEP; XPNPEPL; 
XPNPEPL1
GeneCards (Weizmann)XPNPEP1
Ensembl hg19 (Hinxton)ENSG00000108039 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000108039 [Gene_View]  chr10:109864766-109923553 [Contig_View]  XPNPEP1 [Vega]
ICGC DataPortalENSG00000108039
TCGA cBioPortalXPNPEP1
AceView (NCBI)XPNPEP1
Genatlas (Paris)XPNPEP1
WikiGenes7511
SOURCE (Princeton)XPNPEP1
Genetics Home Reference (NIH)XPNPEP1
Genomic and cartography
GoldenPath hg38 (UCSC)XPNPEP1  -     chr10:109864766-109923553 -  10q25.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)XPNPEP1  -     10q25.1   [Description]    (hg19-Feb_2009)
EnsemblXPNPEP1 - 10q25.1 [CytoView hg19]  XPNPEP1 - 10q25.1 [CytoView hg38]
Mapping of homologs : NCBIXPNPEP1 [Mapview hg19]  XPNPEP1 [Mapview hg38]
OMIM602443   
Gene and transcription
Genbank (Entrez)AF195530 AF272981 AK093693 AK094900 AK095447
RefSeq transcript (Entrez)NM_001167604 NM_001324128 NM_001324131 NM_001324132 NM_001324133 NM_001324134 NM_001324135 NM_001324136 NM_020383
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)XPNPEP1
Cluster EST : UnigeneHs.390623 [ NCBI ]
CGAP (NCI)Hs.390623
Alternative Splicing GalleryENSG00000108039
Gene ExpressionXPNPEP1 [ NCBI-GEO ]   XPNPEP1 [ EBI - ARRAY_EXPRESS ]   XPNPEP1 [ SEEK ]   XPNPEP1 [ MEM ]
Gene Expression Viewer (FireBrowse)XPNPEP1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)7511
GTEX Portal (Tissue expression)XPNPEP1
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9NQW7   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9NQW7  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9NQW7
Splice isoforms : SwissVarQ9NQW7
Catalytic activity : Enzyme3.4.11.9 [ Enzyme-Expasy ]   3.4.11.93.4.11.9 [ IntEnz-EBI ]   3.4.11.9 [ BRENDA ]   3.4.11.9 [ KEGG ]   
PhosPhoSitePlusQ9NQW7
Domaine pattern : Prosite (Expaxy)PROLINE_PEPTIDASE (PS00491)   
Domains : Interpro (EBI)Creatin/AminoP/Spt16_NTD    Creatinase/Aminopeptidase_P_N    Creatinase_N    Pept_M24    Pept_M24B    Peptidase_M24_C    Peptidase_M24B_aminopep-P_CS   
Domain families : Pfam (Sanger)Creatinase_N (PF01321)    Peptidase_M24 (PF00557)    Peptidase_M24_C (PF16188)   
Domain families : Pfam (NCBI)pfam01321    pfam00557    pfam16188   
Conserved Domain (NCBI)XPNPEP1
DMDM Disease mutations7511
Blocks (Seattle)XPNPEP1
PDB (SRS)3CTZ   
PDB (PDBSum)3CTZ   
PDB (IMB)3CTZ   
PDB (RSDB)3CTZ   
Structural Biology KnowledgeBase3CTZ   
SCOP (Structural Classification of Proteins)3CTZ   
CATH (Classification of proteins structures)3CTZ   
SuperfamilyQ9NQW7
Human Protein AtlasENSG00000108039
Peptide AtlasQ9NQW7
HPRD03899
IPIIPI00793375   IPI00514946   IPI00607814   IPI00513944   IPI01011873   IPI00645898   
Protein Interaction databases
DIP (DOE-UCLA)Q9NQW7
IntAct (EBI)Q9NQW7
FunCoupENSG00000108039
BioGRIDXPNPEP1
STRING (EMBL)XPNPEP1
ZODIACXPNPEP1
Ontologies - Pathways
QuickGOQ9NQW7
Ontology : AmiGOaminopeptidase activity  cytoplasm  cytosol  proteolysis  bradykinin catabolic process  manganese ion binding  protein homodimerization activity  metalloaminopeptidase activity  extracellular exosome  
Ontology : EGO-EBIaminopeptidase activity  cytoplasm  cytosol  proteolysis  bradykinin catabolic process  manganese ion binding  protein homodimerization activity  metalloaminopeptidase activity  extracellular exosome  
NDEx NetworkXPNPEP1
Atlas of Cancer Signalling NetworkXPNPEP1
Wikipedia pathwaysXPNPEP1
Orthology - Evolution
OrthoDB7511
GeneTree (enSembl)ENSG00000108039
Phylogenetic Trees/Animal Genes : TreeFamXPNPEP1
HOVERGENQ9NQW7
HOGENOMQ9NQW7
Homologs : HomoloGeneXPNPEP1
Homology/Alignments : Family Browser (UCSC)XPNPEP1
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerXPNPEP1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)XPNPEP1
dbVarXPNPEP1
ClinVarXPNPEP1
1000_GenomesXPNPEP1 
Exome Variant ServerXPNPEP1
ExAC (Exome Aggregation Consortium)XPNPEP1 (select the gene name)
Genetic variants : HAPMAP7511
Genomic Variants (DGV)XPNPEP1 [DGVbeta]
DECIPHERXPNPEP1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisXPNPEP1 
Mutations
ICGC Data PortalXPNPEP1 
TCGA Data PortalXPNPEP1 
Broad Tumor PortalXPNPEP1
OASIS PortalXPNPEP1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICXPNPEP1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDXPNPEP1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch XPNPEP1
DgiDB (Drug Gene Interaction Database)XPNPEP1
DoCM (Curated mutations)XPNPEP1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)XPNPEP1 (select a term)
intoGenXPNPEP1
Cancer3DXPNPEP1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM602443   
Orphanet
MedgenXPNPEP1
Genetic Testing Registry XPNPEP1
NextProtQ9NQW7 [Medical]
TSGene7511
GENETestsXPNPEP1
Huge Navigator XPNPEP1 [HugePedia]
snp3D : Map Gene to Disease7511
BioCentury BCIQXPNPEP1
ClinGenXPNPEP1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD7511
Chemical/Pharm GKB GenePA37415
Clinical trialXPNPEP1
Miscellaneous
canSAR (ICR)XPNPEP1 (select the gene name)
Probes
Litterature
PubMed32 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineXPNPEP1
EVEXXPNPEP1
GoPubMedXPNPEP1
iHOPXPNPEP1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Fri May 19 12:01:48 CEST 2017

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