Atlas of Genetics and Cytogenetics in Oncology and Haematology


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XPO5 (exportin 5)

Identity

Alias_symbol (synonym)KIAA1291
Other aliasexp5
HGNC (Hugo) XPO5
LocusID (NCBI) 57510
Atlas_Id 43077
Location 6p21.1  [Link to chromosome band 6p21]
Location_base_pair Starts at 43522330 and ends at 43576075 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
LRP1 (12q13.3) / XPO5 (6p21.1)UBR2 (6p21.1) / XPO5 (6p21.1)XPO5 (6p21.1) / HSPB1 (7q11.23)
XPO5 (6p21.1) / MRPS10 (6p21.1)XPO5 (6p21.1) / RNF11 (1p32.3)LRP1 12q13.3 / XPO5 6p21.1
UBR2 6p21.1 / XPO5 6p21.1XPO5 6p21.1 / MRPS10 6p21.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)XPO5   17675
Cards
Entrez_Gene (NCBI)XPO5  57510  exportin 5
Aliasesexp5
GeneCards (Weizmann)XPO5
Ensembl hg19 (Hinxton)ENSG00000124571 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000124571 [Gene_View]  chr6:43522330-43576075 [Contig_View]  XPO5 [Vega]
ICGC DataPortalENSG00000124571
TCGA cBioPortalXPO5
AceView (NCBI)XPO5
Genatlas (Paris)XPO5
WikiGenes57510
SOURCE (Princeton)XPO5
Genetics Home Reference (NIH)XPO5
Genomic and cartography
GoldenPath hg38 (UCSC)XPO5  -     chr6:43522330-43576075 -  6p21.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)XPO5  -     6p21.1   [Description]    (hg19-Feb_2009)
EnsemblXPO5 - 6p21.1 [CytoView hg19]  XPO5 - 6p21.1 [CytoView hg38]
Mapping of homologs : NCBIXPO5 [Mapview hg19]  XPO5 [Mapview hg38]
OMIM607845   
Gene and transcription
Genbank (Entrez)AB033117 AF271159 AF298880 AK001195 AK022718
RefSeq transcript (Entrez)NM_020750
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)XPO5
Cluster EST : UnigeneHs.203206 [ NCBI ]
CGAP (NCI)Hs.203206
Alternative Splicing GalleryENSG00000124571
Gene ExpressionXPO5 [ NCBI-GEO ]   XPO5 [ EBI - ARRAY_EXPRESS ]   XPO5 [ SEEK ]   XPO5 [ MEM ]
Gene Expression Viewer (FireBrowse)XPO5 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)57510
GTEX Portal (Tissue expression)XPO5
Human Protein AtlasENSG00000124571-XPO5 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9HAV4   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9HAV4  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9HAV4
Splice isoforms : SwissVarQ9HAV4
PhosPhoSitePlusQ9HAV4
Domains : Interpro (EBI)ARM-like    ARM-type_fold    Exportin-1/Importin-b-like    Importin-beta_N   
Domain families : Pfam (Sanger)Xpo1 (PF08389)   
Domain families : Pfam (NCBI)pfam08389   
Domain families : Smart (EMBL)IBN_N (SM00913)  
Conserved Domain (NCBI)XPO5
DMDM Disease mutations57510
Blocks (Seattle)XPO5
PDB (SRS)3A6P   
PDB (PDBSum)3A6P   
PDB (IMB)3A6P   
PDB (RSDB)3A6P   
Structural Biology KnowledgeBase3A6P   
SCOP (Structural Classification of Proteins)3A6P   
CATH (Classification of proteins structures)3A6P   
SuperfamilyQ9HAV4
Human Protein Atlas [tissue]ENSG00000124571-XPO5 [tissue]
Peptide AtlasQ9HAV4
HPRD06385
IPIIPI00640703   IPI01018709   IPI00747453   IPI00872800   IPI00549861   IPI00553171   IPI00967212   IPI00966132   IPI00964692   IPI00966388   
Protein Interaction databases
DIP (DOE-UCLA)Q9HAV4
IntAct (EBI)Q9HAV4
FunCoupENSG00000124571
BioGRIDXPO5
STRING (EMBL)XPO5
ZODIACXPO5
Ontologies - Pathways
QuickGOQ9HAV4
Ontology : AmiGOtRNA binding  RNA binding  RNA binding  mRNA binding  protein binding  nucleus  nucleoplasm  nucleoplasm  cytoplasm  cytosol  cytosol  protein export from nucleus  Ran GTPase binding  Ran GTPase binding  protein transporter activity  gene silencing by RNA  pre-miRNA export from nucleus  pre-miRNA export from nucleus  RNA nuclear export complex  pre-miRNA binding  pre-miRNA binding  pre-miRNA transporter activity  positive regulation of RNA interference  
Ontology : EGO-EBItRNA binding  RNA binding  RNA binding  mRNA binding  protein binding  nucleus  nucleoplasm  nucleoplasm  cytoplasm  cytosol  cytosol  protein export from nucleus  Ran GTPase binding  Ran GTPase binding  protein transporter activity  gene silencing by RNA  pre-miRNA export from nucleus  pre-miRNA export from nucleus  RNA nuclear export complex  pre-miRNA binding  pre-miRNA binding  pre-miRNA transporter activity  positive regulation of RNA interference  
Pathways : KEGGRNA transport   
NDEx NetworkXPO5
Atlas of Cancer Signalling NetworkXPO5
Wikipedia pathwaysXPO5
Orthology - Evolution
OrthoDB57510
GeneTree (enSembl)ENSG00000124571
Phylogenetic Trees/Animal Genes : TreeFamXPO5
HOVERGENQ9HAV4
HOGENOMQ9HAV4
Homologs : HomoloGeneXPO5
Homology/Alignments : Family Browser (UCSC)XPO5
Gene fusions - Rearrangements
Fusion : MitelmanLRP1/XPO5 [12q13.3/6p21.1]  [t(6;12)(p21;q13)]  
Fusion : MitelmanUBR2/XPO5 [6p21.1/6p21.1]  [t(6;6)(p21;p21)]  
Fusion : MitelmanXPO5/MRPS10 [6p21.1/6p21.1]  [t(6;6)(p21;p21)]  
Fusion: TCGA_MDACCLRP1 12q13.3 XPO5 6p21.1 GBM
Fusion: TCGA_MDACCUBR2 6p21.1 XPO5 6p21.1 PRAD
Fusion: TCGA_MDACCXPO5 6p21.1 MRPS10 6p21.1 KIRC
Tumor Fusion PortalXPO5
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerXPO5 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)XPO5
dbVarXPO5
ClinVarXPO5
1000_GenomesXPO5 
Exome Variant ServerXPO5
ExAC (Exome Aggregation Consortium)ENSG00000124571
GNOMAD BrowserENSG00000124571
Genetic variants : HAPMAP57510
Genomic Variants (DGV)XPO5 [DGVbeta]
DECIPHERXPO5 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisXPO5 
Mutations
ICGC Data PortalXPO5 
TCGA Data PortalXPO5 
Broad Tumor PortalXPO5
OASIS PortalXPO5 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICXPO5  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDXPO5
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch XPO5
DgiDB (Drug Gene Interaction Database)XPO5
DoCM (Curated mutations)XPO5 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)XPO5 (select a term)
intoGenXPO5
Cancer3DXPO5(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM607845   
Orphanet
DisGeNETXPO5
MedgenXPO5
Genetic Testing Registry XPO5
NextProtQ9HAV4 [Medical]
TSGene57510
GENETestsXPO5
Target ValidationXPO5
Huge Navigator XPO5 [HugePedia]
snp3D : Map Gene to Disease57510
BioCentury BCIQXPO5
ClinGenXPO5
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD57510
Chemical/Pharm GKB GenePA134979214
Clinical trialXPO5
Miscellaneous
canSAR (ICR)XPO5 (select the gene name)
Probes
Litterature
PubMed77 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineXPO5
EVEXXPO5
GoPubMedXPO5
iHOPXPO5
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Nov 21 14:41:53 CET 2017

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