Atlas of Genetics and Cytogenetics in Oncology and Haematology


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XRCC2 (X-ray repair cross complementing 2)

Identity

Alias_namesX-ray repair complementing defective repair in Chinese hamster cells 2
Alias_symbol (synonym)FANCU
Other alias
HGNC (Hugo) XRCC2
LocusID (NCBI) 7516
Atlas_Id 334
Location 7q36.1  [Link to chromosome band 7q36]
Location_base_pair Starts at 152646502 and ends at 152676165 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
KMT2C (7q36.1) / XRCC2 (7q36.1)PPP1R9A (7q21.3) / XRCC2 (7q36.1)SLC30A9 (4p13) / XRCC2 (7q36.1)
MLL3 XRCC2 7q36.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)XRCC2   12829
Cards
Entrez_Gene (NCBI)XRCC2  7516  X-ray repair cross complementing 2
AliasesFANCU
GeneCards (Weizmann)XRCC2
Ensembl hg19 (Hinxton)ENSG00000196584 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000196584 [Gene_View]  chr7:152646502-152676165 [Contig_View]  XRCC2 [Vega]
ICGC DataPortalENSG00000196584
TCGA cBioPortalXRCC2
AceView (NCBI)XRCC2
Genatlas (Paris)XRCC2
WikiGenes7516
SOURCE (Princeton)XRCC2
Genetics Home Reference (NIH)XRCC2
Genomic and cartography
GoldenPath hg38 (UCSC)XRCC2  -     chr7:152646502-152676165 -  7q36.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)XRCC2  -     7q36.1   [Description]    (hg19-Feb_2009)
EnsemblXRCC2 - 7q36.1 [CytoView hg19]  XRCC2 - 7q36.1 [CytoView hg38]
Mapping of homologs : NCBIXRCC2 [Mapview hg19]  XRCC2 [Mapview hg38]
OMIM600375   617247   
Gene and transcription
Genbank (Entrez)AF035587 AK313607 BC042137 CR749256 Y08837
RefSeq transcript (Entrez)NM_005431
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)XRCC2
Cluster EST : UnigeneHs.647093 [ NCBI ]
CGAP (NCI)Hs.647093
Alternative Splicing GalleryENSG00000196584
Gene ExpressionXRCC2 [ NCBI-GEO ]   XRCC2 [ EBI - ARRAY_EXPRESS ]   XRCC2 [ SEEK ]   XRCC2 [ MEM ]
Gene Expression Viewer (FireBrowse)XRCC2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)7516
GTEX Portal (Tissue expression)XRCC2
Protein : pattern, domain, 3D structure
UniProt/SwissProtO43543   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO43543  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO43543
Splice isoforms : SwissVarO43543
PhosPhoSitePlusO43543
Domaine pattern : Prosite (Expaxy)RECA_2 (PS50162)   
Domains : Interpro (EBI)DNA_recomb/repair_Rad51_C    P-loop_NTPase    RecA_ATP-bd    XRCC2   
Domain families : Pfam (Sanger)Rad51 (PF08423)   
Domain families : Pfam (NCBI)pfam08423   
Conserved Domain (NCBI)XRCC2
DMDM Disease mutations7516
Blocks (Seattle)XRCC2
SuperfamilyO43543
Human Protein AtlasENSG00000196584
Peptide AtlasO43543
HPRD02656
IPIIPI00306229   
Protein Interaction databases
DIP (DOE-UCLA)O43543
IntAct (EBI)O43543
FunCoupENSG00000196584
BioGRIDXRCC2
STRING (EMBL)XRCC2
ZODIACXRCC2
Ontologies - Pathways
QuickGOO43543
Ontology : AmiGOrecombinase activity  mitotic cell cycle  four-way junction DNA binding  meiotic DNA recombinase assembly  double-strand break repair via homologous recombination  DNA synthesis involved in DNA repair  strand displacement  in utero embryonic development  somitogenesis  double-stranded DNA binding  single-stranded DNA binding  endodeoxyribonuclease activity  protein binding  ATP binding  nucleoplasm  nucleoplasm  replication fork  cytoplasm  centrosome  DNA repair  mitotic recombination  centrosome cycle  reciprocal meiotic recombination  DNA-dependent ATPase activity  response to X-ray  response to ionizing radiation  response to gamma radiation  Rad51B-Rad51C-Rad51D-XRCC2 complex  multicellular organism growth  strand invasion  intracellular membrane-bounded organelle  negative regulation of neuron apoptotic process  positive regulation of neurogenesis  meiotic cell cycle  regulation of fibroblast apoptotic process  
Ontology : EGO-EBIrecombinase activity  mitotic cell cycle  four-way junction DNA binding  meiotic DNA recombinase assembly  double-strand break repair via homologous recombination  DNA synthesis involved in DNA repair  strand displacement  in utero embryonic development  somitogenesis  double-stranded DNA binding  single-stranded DNA binding  endodeoxyribonuclease activity  protein binding  ATP binding  nucleoplasm  nucleoplasm  replication fork  cytoplasm  centrosome  DNA repair  mitotic recombination  centrosome cycle  reciprocal meiotic recombination  DNA-dependent ATPase activity  response to X-ray  response to ionizing radiation  response to gamma radiation  Rad51B-Rad51C-Rad51D-XRCC2 complex  multicellular organism growth  strand invasion  intracellular membrane-bounded organelle  negative regulation of neuron apoptotic process  positive regulation of neurogenesis  meiotic cell cycle  regulation of fibroblast apoptotic process  
Pathways : KEGGHomologous recombination   
NDEx NetworkXRCC2
Atlas of Cancer Signalling NetworkXRCC2
Wikipedia pathwaysXRCC2
Orthology - Evolution
OrthoDB7516
GeneTree (enSembl)ENSG00000196584
Phylogenetic Trees/Animal Genes : TreeFamXRCC2
HOVERGENO43543
HOGENOMO43543
Homologs : HomoloGeneXRCC2
Homology/Alignments : Family Browser (UCSC)XRCC2
Gene fusions - Rearrangements
Fusion : MitelmanKMT2C/XRCC2 [7q36.1/7q36.1]  [t(7;7)(q36;q36)]  
Fusion: TCGAMLL3 XRCC2 7q36.1 SKCM
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerXRCC2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)XRCC2
dbVarXRCC2
ClinVarXRCC2
1000_GenomesXRCC2 
Exome Variant ServerXRCC2
ExAC (Exome Aggregation Consortium)XRCC2 (select the gene name)
Genetic variants : HAPMAP7516
Genomic Variants (DGV)XRCC2 [DGVbeta]
DECIPHERXRCC2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisXRCC2 
Mutations
ICGC Data PortalXRCC2 
TCGA Data PortalXRCC2 
Broad Tumor PortalXRCC2
OASIS PortalXRCC2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICXRCC2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDXRCC2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
BioMutasearch XRCC2
DgiDB (Drug Gene Interaction Database)XRCC2
DoCM (Curated mutations)XRCC2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)XRCC2 (select a term)
intoGenXRCC2
Cancer3DXRCC2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM600375    617247   
Orphanet19054   
MedgenXRCC2
Genetic Testing Registry XRCC2
NextProtO43543 [Medical]
TSGene7516
GENETestsXRCC2
Target ValidationXRCC2
Huge Navigator XRCC2 [HugePedia]
snp3D : Map Gene to Disease7516
BioCentury BCIQXRCC2
ClinGenXRCC2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD7516
Chemical/Pharm GKB GenePA37421
Clinical trialXRCC2
Miscellaneous
canSAR (ICR)XRCC2 (select the gene name)
Probes
Litterature
PubMed131 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineXRCC2
EVEXXRCC2
GoPubMedXRCC2
iHOPXRCC2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Aug 1 17:19:04 CEST 2017

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