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YARS (tyrosyl-tRNA synthetase)

Identity

Alias_namescytoplasmic
Alias_symbol (synonym)YTS
YRS
tyrRS
Other aliasCMTDIC
TYRRS
HGNC (Hugo) YARS
LocusID (NCBI) 8565
Atlas_Id 55036
Location 1p35.1  [Link to chromosome band 1p35]
Location_base_pair Starts at 32775239 and ends at 32818032 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
BSDC1 (1p35.1) / YARS (1p35.1)ITGB3 (17q21.32) / YARS (1p35.1)NDUFA6 (22q13.2) / YARS (1p35.1)
PIGU (20q11.22) / YARS (1p35.1)YARS (1p35.1) / ADM5 (19q13.33)YARS (1p35.1) / RNF19B (1p35.1)
YARS (1p35.1) / SPEN (1p36.21)ZBTB8OS (1p35.1) / YARS (1p35.1)BSDC1 1p35.1 / YARS 1p35.1
YARS 1p35.1 C19orf76YARS 1p35.1 / RNF19B 1p35.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)YARS   12840
LRG (Locus Reference Genomic)LRG_273
Cards
Entrez_Gene (NCBI)YARS  8565  tyrosyl-tRNA synthetase
AliasesCMTDIC; TYRRS; YRS; YTS
GeneCards (Weizmann)YARS
Ensembl hg19 (Hinxton)ENSG00000134684 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000134684 [Gene_View]  chr1:32775239-32818032 [Contig_View]  YARS [Vega]
ICGC DataPortalENSG00000134684
TCGA cBioPortalYARS
AceView (NCBI)YARS
Genatlas (Paris)YARS
WikiGenes8565
SOURCE (Princeton)YARS
Genetics Home Reference (NIH)YARS
Genomic and cartography
GoldenPath hg38 (UCSC)YARS  -     chr1:32775239-32818032 -  1p35.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)YARS  -     1p35.1   [Description]    (hg19-Feb_2009)
EnsemblYARS - 1p35.1 [CytoView hg19]  YARS - 1p35.1 [CytoView hg38]
Mapping of homologs : NCBIYARS [Mapview hg19]  YARS [Mapview hg38]
OMIM603623   608323   
Gene and transcription
Genbank (Entrez)AK026535 AK125213 AK126444 AK127182 AK127879
RefSeq transcript (Entrez)NM_003680
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)YARS
Cluster EST : UnigeneHs.213264 [ NCBI ]
CGAP (NCI)Hs.213264
Alternative Splicing GalleryENSG00000134684
Gene ExpressionYARS [ NCBI-GEO ]   YARS [ EBI - ARRAY_EXPRESS ]   YARS [ SEEK ]   YARS [ MEM ]
Gene Expression Viewer (FireBrowse)YARS [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)8565
GTEX Portal (Tissue expression)YARS
Protein : pattern, domain, 3D structure
UniProt/SwissProtP54577   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP54577  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP54577
Splice isoforms : SwissVarP54577
Catalytic activity : Enzyme6.1.1.1 [ Enzyme-Expasy ]   6.1.1.16.1.1.1 [ IntEnz-EBI ]   6.1.1.1 [ BRENDA ]   6.1.1.1 [ KEGG ]   
PhosPhoSitePlusP54577
Domaine pattern : Prosite (Expaxy)TRBD (PS50886)   
Domains : Interpro (EBI)aa-tRNA-synth_Ic    NA-bd_OB-fold    Rossmann-like_a/b/a_fold    tRNA-bd_dom    Tyr-tRNA-ligase   
Domain families : Pfam (Sanger)tRNA-synt_1b (PF00579)    tRNA_bind (PF01588)   
Domain families : Pfam (NCBI)pfam00579    pfam01588   
Conserved Domain (NCBI)YARS
DMDM Disease mutations8565
Blocks (Seattle)YARS
PDB (SRS)1N3L    1NTG    1Q11    4Q93    4QBT   
PDB (PDBSum)1N3L    1NTG    1Q11    4Q93    4QBT   
PDB (IMB)1N3L    1NTG    1Q11    4Q93    4QBT   
PDB (RSDB)1N3L    1NTG    1Q11    4Q93    4QBT   
Structural Biology KnowledgeBase1N3L    1NTG    1Q11    4Q93    4QBT   
SCOP (Structural Classification of Proteins)1N3L    1NTG    1Q11    4Q93    4QBT   
CATH (Classification of proteins structures)1N3L    1NTG    1Q11    4Q93    4QBT   
SuperfamilyP54577
Human Protein AtlasENSG00000134684
Peptide AtlasP54577
HPRD09153
IPIIPI00007074   
Protein Interaction databases
DIP (DOE-UCLA)P54577
IntAct (EBI)P54577
FunCoupENSG00000134684
BioGRIDYARS
STRING (EMBL)YARS
ZODIACYARS
Ontologies - Pathways
QuickGOP54577
Ontology : AmiGOtRNA binding  RNA binding  tyrosine-tRNA ligase activity  signal transducer activity  interleukin-8 receptor binding  protein binding  ATP binding  extracellular space  cytoplasm  cytosol  cytosol  tRNA aminoacylation for protein translation  tRNA aminoacylation for protein translation  tyrosyl-tRNA aminoacylation  apoptotic process  signal transduction  nuclear body  aminoacyl-tRNA synthetase multienzyme complex  methionyl glutamyl tRNA synthetase complex  
Ontology : EGO-EBItRNA binding  RNA binding  tyrosine-tRNA ligase activity  signal transducer activity  interleukin-8 receptor binding  protein binding  ATP binding  extracellular space  cytoplasm  cytosol  cytosol  tRNA aminoacylation for protein translation  tRNA aminoacylation for protein translation  tyrosyl-tRNA aminoacylation  apoptotic process  signal transduction  nuclear body  aminoacyl-tRNA synthetase multienzyme complex  methionyl glutamyl tRNA synthetase complex  
Pathways : KEGGAminoacyl-tRNA biosynthesis   
NDEx NetworkYARS
Atlas of Cancer Signalling NetworkYARS
Wikipedia pathwaysYARS
Orthology - Evolution
OrthoDB8565
GeneTree (enSembl)ENSG00000134684
Phylogenetic Trees/Animal Genes : TreeFamYARS
HOVERGENP54577
HOGENOMP54577
Homologs : HomoloGeneYARS
Homology/Alignments : Family Browser (UCSC)YARS
Gene fusions - Rearrangements
Fusion : MitelmanBSDC1/YARS [1p35.1/1p35.1]  [t(1;1)(p35;p35)]  
Fusion : MitelmanYARS/ADM5 [1p35.1/19q13.33]  [t(1;19)(p35;q13)]  
Fusion : MitelmanYARS/RNF19B [1p35.1/1p35.1]  [t(1;1)(p35;p35)]  
Fusion: TCGABSDC1 1p35.1 YARS 1p35.1 BRCA
Fusion: TCGAYARS 1p35.1 C19orf76 BRCA
Fusion: TCGAYARS 1p35.1 RNF19B 1p35.1 GBM
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerYARS [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)YARS
dbVarYARS
ClinVarYARS
1000_GenomesYARS 
Exome Variant ServerYARS
ExAC (Exome Aggregation Consortium)YARS (select the gene name)
Genetic variants : HAPMAP8565
Genomic Variants (DGV)YARS [DGVbeta]
DECIPHERYARS [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisYARS 
Mutations
ICGC Data PortalYARS 
TCGA Data PortalYARS 
Broad Tumor PortalYARS
OASIS PortalYARS [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICYARS  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDYARS
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)Leiden Muscular Dystrophy pages
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch YARS
DgiDB (Drug Gene Interaction Database)YARS
DoCM (Curated mutations)YARS (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)YARS (select a term)
intoGenYARS
Cancer3DYARS(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM603623    608323   
Orphanet14618   
MedgenYARS
Genetic Testing Registry YARS
NextProtP54577 [Medical]
TSGene8565
GENETestsYARS
Target ValidationYARS
Huge Navigator YARS [HugePedia]
snp3D : Map Gene to Disease8565
BioCentury BCIQYARS
ClinGenYARS
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD8565
Chemical/Pharm GKB GenePA37431
Clinical trialYARS
Miscellaneous
canSAR (ICR)YARS (select the gene name)
Probes
Litterature
PubMed57 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineYARS
EVEXYARS
GoPubMedYARS
iHOPYARS
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed Jun 7 13:03:08 CEST 2017

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