Atlas of Genetics and Cytogenetics in Oncology and Haematology


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YARS2 (tyrosyl-tRNA synthetase 2)

Identity

Alias_namestyrosyl-tRNA synthetase 2, mitochondrial
Alias_symbol (synonym)FLJ13995
CGI-04
mt-TyrRS
Other aliasMLASA2
MT-TYRRS
TYRRS
HGNC (Hugo) YARS2
LocusID (NCBI) 51067
Atlas_Id 75803
Location 12p11.21  [Link to chromosome band 12p11]
Location_base_pair Starts at 32746544 and ends at 32755953 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
TPCN1 (12q24.13) / YARS2 (12p11.21)UCHL1 (4p13) / YARS2 (12p11.21)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)YARS2   24249
Cards
Entrez_Gene (NCBI)YARS2  51067  tyrosyl-tRNA synthetase 2
AliasesCGI-04; MLASA2; MT-TYRRS; TYRRS
GeneCards (Weizmann)YARS2
Ensembl hg19 (Hinxton)ENSG00000139131 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000139131 [Gene_View]  chr12:32746544-32755953 [Contig_View]  YARS2 [Vega]
ICGC DataPortalENSG00000139131
TCGA cBioPortalYARS2
AceView (NCBI)YARS2
Genatlas (Paris)YARS2
WikiGenes51067
SOURCE (Princeton)YARS2
Genetics Home Reference (NIH)YARS2
Genomic and cartography
GoldenPath hg38 (UCSC)YARS2  -     chr12:32746544-32755953 -  12p11.21   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)YARS2  -     12p11.21   [Description]    (hg19-Feb_2009)
EnsemblYARS2 - 12p11.21 [CytoView hg19]  YARS2 - 12p11.21 [CytoView hg38]
Mapping of homologs : NCBIYARS2 [Mapview hg19]  YARS2 [Mapview hg38]
OMIM610957   613561   
Gene and transcription
Genbank (Entrez)AF132939 AI861961 AK024057 AK026619 AK130935
RefSeq transcript (Entrez)NM_001040436 NM_015936
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)YARS2
Cluster EST : UnigeneHs.706015 [ NCBI ]
CGAP (NCI)Hs.706015
Alternative Splicing GalleryENSG00000139131
Gene ExpressionYARS2 [ NCBI-GEO ]   YARS2 [ EBI - ARRAY_EXPRESS ]   YARS2 [ SEEK ]   YARS2 [ MEM ]
Gene Expression Viewer (FireBrowse)YARS2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)51067
GTEX Portal (Tissue expression)YARS2
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9Y2Z4   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9Y2Z4  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9Y2Z4
Splice isoforms : SwissVarQ9Y2Z4
Catalytic activity : Enzyme6.1.1.1 [ Enzyme-Expasy ]   6.1.1.16.1.1.1 [ IntEnz-EBI ]   6.1.1.1 [ BRENDA ]   6.1.1.1 [ KEGG ]   
PhosPhoSitePlusQ9Y2Z4
Domaine pattern : Prosite (Expaxy)AA_TRNA_LIGASE_I (PS00178)   
Domains : Interpro (EBI)aa-tRNA-synth_I_CS    aa-tRNA-synth_Ic    Rossmann-like_a/b/a_fold    S4_RNA-bd    Tyr-tRNA-ligase    Tyr-tRNA-ligase_bac-type   
Domain families : Pfam (Sanger)tRNA-synt_1b (PF00579)   
Domain families : Pfam (NCBI)pfam00579   
Conserved Domain (NCBI)YARS2
DMDM Disease mutations51067
Blocks (Seattle)YARS2
PDB (SRS)2PID    3ZXI   
PDB (PDBSum)2PID    3ZXI   
PDB (IMB)2PID    3ZXI   
PDB (RSDB)2PID    3ZXI   
Structural Biology KnowledgeBase2PID    3ZXI   
SCOP (Structural Classification of Proteins)2PID    3ZXI   
CATH (Classification of proteins structures)2PID    3ZXI   
SuperfamilyQ9Y2Z4
Human Protein AtlasENSG00000139131
Peptide AtlasQ9Y2Z4
HPRD13025
IPIIPI00165092   IPI01021386   
Protein Interaction databases
DIP (DOE-UCLA)Q9Y2Z4
IntAct (EBI)Q9Y2Z4
FunCoupENSG00000139131
BioGRIDYARS2
STRING (EMBL)YARS2
ZODIACYARS2
Ontologies - Pathways
QuickGOQ9Y2Z4
Ontology : AmiGOtRNA binding  tRNA binding  RNA binding  tyrosine-tRNA ligase activity  tyrosine-tRNA ligase activity  tyrosine-tRNA ligase activity  protein binding  ATP binding  mitochondrion  mitochondrion  mitochondrion  mitochondrion  mitochondrial matrix  cytosol  translation  tRNA aminoacylation for protein translation  nuclear body  protein homodimerization activity  tRNA aminoacylation  mitochondrial tyrosyl-tRNA aminoacylation  mitochondrial tyrosyl-tRNA aminoacylation  tyrosine binding  
Ontology : EGO-EBItRNA binding  tRNA binding  RNA binding  tyrosine-tRNA ligase activity  tyrosine-tRNA ligase activity  tyrosine-tRNA ligase activity  protein binding  ATP binding  mitochondrion  mitochondrion  mitochondrion  mitochondrion  mitochondrial matrix  cytosol  translation  tRNA aminoacylation for protein translation  nuclear body  protein homodimerization activity  tRNA aminoacylation  mitochondrial tyrosyl-tRNA aminoacylation  mitochondrial tyrosyl-tRNA aminoacylation  tyrosine binding  
Pathways : KEGGAminoacyl-tRNA biosynthesis   
NDEx NetworkYARS2
Atlas of Cancer Signalling NetworkYARS2
Wikipedia pathwaysYARS2
Orthology - Evolution
OrthoDB51067
GeneTree (enSembl)ENSG00000139131
Phylogenetic Trees/Animal Genes : TreeFamYARS2
HOVERGENQ9Y2Z4
HOGENOMQ9Y2Z4
Homologs : HomoloGeneYARS2
Homology/Alignments : Family Browser (UCSC)YARS2
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerYARS2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)YARS2
dbVarYARS2
ClinVarYARS2
1000_GenomesYARS2 
Exome Variant ServerYARS2
ExAC (Exome Aggregation Consortium)YARS2 (select the gene name)
Genetic variants : HAPMAP51067
Genomic Variants (DGV)YARS2 [DGVbeta]
DECIPHERYARS2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisYARS2 
Mutations
ICGC Data PortalYARS2 
TCGA Data PortalYARS2 
Broad Tumor PortalYARS2
OASIS PortalYARS2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICYARS2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDYARS2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)Mendelian genes
LOVD (Leiden Open Variation Database)MSeqDR-LSDB Mitochondrial Disease Locus Specific Database
BioMutasearch YARS2
DgiDB (Drug Gene Interaction Database)YARS2
DoCM (Curated mutations)YARS2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)YARS2 (select a term)
intoGenYARS2
Cancer3DYARS2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM610957    613561   
Orphanet1213   
MedgenYARS2
Genetic Testing Registry YARS2
NextProtQ9Y2Z4 [Medical]
TSGene51067
GENETestsYARS2
Huge Navigator YARS2 [HugePedia]
snp3D : Map Gene to Disease51067
BioCentury BCIQYARS2
ClinGenYARS2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD51067
Chemical/Pharm GKB GenePA142670559
Clinical trialYARS2
Miscellaneous
canSAR (ICR)YARS2 (select the gene name)
Probes
Litterature
PubMed30 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineYARS2
EVEXYARS2
GoPubMedYARS2
iHOPYARS2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Fri May 19 12:01:50 CEST 2017

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