Atlas of Genetics and Cytogenetics in Oncology and Haematology


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YARS2 (tyrosyl-tRNA synthetase 2)

Identity

Alias (NCBI)CGI-04
MLASA2
MT-TYRRS
TYRRS
HGNC (Hugo) YARS2
HGNC Alias symbFLJ13995
CGI-04
mt-TyrRS
HGNC Alias nametyrosine tRNA ligase 2, mitochondrial
HGNC Previous nametyrosyl-tRNA synthetase 2, mitochondrial
LocusID (NCBI) 51067
Atlas_Id 75803
Location 12p11.21  [Link to chromosome band 12p11]
Location_base_pair Starts at 32746544 and ends at 32755897 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
TPCN1 (12q24.13) / YARS2 (12p11.21)UCHL1 (4p13) / YARS2 (12p11.21)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)YARS2   24249
Cards
Entrez_Gene (NCBI)YARS2    tyrosyl-tRNA synthetase 2
AliasesCGI-04; MLASA2; MT-TYRRS; TYRRS
GeneCards (Weizmann)YARS2
Ensembl hg19 (Hinxton)ENSG00000139131 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000139131 [Gene_View]  ENSG00000139131 [Sequence]  chr12:32746544-32755897 [Contig_View]  YARS2 [Vega]
ICGC DataPortalENSG00000139131
TCGA cBioPortalYARS2
AceView (NCBI)YARS2
Genatlas (Paris)YARS2
SOURCE (Princeton)YARS2
Genetics Home Reference (NIH)YARS2
Genomic and cartography
GoldenPath hg38 (UCSC)YARS2  -     chr12:32746544-32755897 -  12p11.21   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)YARS2  -     12p11.21   [Description]    (hg19-Feb_2009)
GoldenPathYARS2 - 12p11.21 [CytoView hg19]  YARS2 - 12p11.21 [CytoView hg38]
ImmunoBaseENSG00000139131
Genome Data Viewer NCBIYARS2 [Mapview hg19]  
OMIM610957   613561   
Gene and transcription
Genbank (Entrez)AF132939 AI861961 AK024057 AK026619 AK130935
RefSeq transcript (Entrez)NM_001040436 NM_015936
Consensus coding sequences : CCDS (NCBI)YARS2
Gene ExpressionYARS2 [ NCBI-GEO ]   YARS2 [ EBI - ARRAY_EXPRESS ]   YARS2 [ SEEK ]   YARS2 [ MEM ]
Gene Expression Viewer (FireBrowse)YARS2 [ Firebrowse - Broad ]
GenevisibleExpression of YARS2 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)51067
GTEX Portal (Tissue expression)YARS2
Human Protein AtlasENSG00000139131-YARS2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9Y2Z4   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9Y2Z4  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9Y2Z4
PhosPhoSitePlusQ9Y2Z4
Domaine pattern : Prosite (Expaxy)AA_TRNA_LIGASE_I (PS00178)   
Domains : Interpro (EBI)aa-tRNA-synth_I_CS    aa-tRNA-synth_Ic    Rossmann-like_a/b/a_fold    S4_RNA-bd_sf    Tyr-tRNA-ligase    Tyr-tRNA-ligase_bac-type   
Domain families : Pfam (Sanger)tRNA-synt_1b (PF00579)   
Domain families : Pfam (NCBI)pfam00579   
Conserved Domain (NCBI)YARS2
PDB (RSDB)2PID    3ZXI   
PDB Europe2PID    3ZXI   
PDB (PDBSum)2PID    3ZXI   
PDB (IMB)2PID    3ZXI   
Structural Biology KnowledgeBase2PID    3ZXI   
SCOP (Structural Classification of Proteins)2PID    3ZXI   
CATH (Classification of proteins structures)2PID    3ZXI   
SuperfamilyQ9Y2Z4
AlphaFold pdb e-kbQ9Y2Z4   
Human Protein Atlas [tissue]ENSG00000139131-YARS2 [tissue]
HPRD13025
Protein Interaction databases
DIP (DOE-UCLA)Q9Y2Z4
IntAct (EBI)Q9Y2Z4
BioGRIDYARS2
STRING (EMBL)YARS2
ZODIACYARS2
Ontologies - Pathways
QuickGOQ9Y2Z4
Ontology : AmiGOtRNA binding  tRNA binding  RNA binding  tyrosine-tRNA ligase activity  tyrosine-tRNA ligase activity  tyrosine-tRNA ligase activity  protein binding  ATP binding  mitochondrion  mitochondrion  mitochondrion  mitochondrion  mitochondrion  mitochondrial matrix  cytosol  translation  tRNA aminoacylation for protein translation  nuclear body  protein homodimerization activity  tRNA aminoacylation  tRNA aminoacylation  mitochondrial tyrosyl-tRNA aminoacylation  mitochondrial tyrosyl-tRNA aminoacylation  tyrosine binding  
Ontology : EGO-EBItRNA binding  tRNA binding  RNA binding  tyrosine-tRNA ligase activity  tyrosine-tRNA ligase activity  tyrosine-tRNA ligase activity  protein binding  ATP binding  mitochondrion  mitochondrion  mitochondrion  mitochondrion  mitochondrion  mitochondrial matrix  cytosol  translation  tRNA aminoacylation for protein translation  nuclear body  protein homodimerization activity  tRNA aminoacylation  tRNA aminoacylation  mitochondrial tyrosyl-tRNA aminoacylation  mitochondrial tyrosyl-tRNA aminoacylation  tyrosine binding  
Pathways : KEGGPhenylalanine, tyrosine and tryptophan biosynthesis    Aminoacyl-tRNA biosynthesis   
NDEx NetworkYARS2
Atlas of Cancer Signalling NetworkYARS2
Wikipedia pathwaysYARS2
Orthology - Evolution
OrthoDB51067
GeneTree (enSembl)ENSG00000139131
Phylogenetic Trees/Animal Genes : TreeFamYARS2
Homologs : HomoloGeneYARS2
Homology/Alignments : Family Browser (UCSC)YARS2
Gene fusions - Rearrangements
Fusion : QuiverYARS2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerYARS2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)YARS2
dbVarYARS2
ClinVarYARS2
MonarchYARS2
1000_GenomesYARS2 
Exome Variant ServerYARS2
GNOMAD BrowserENSG00000139131
Varsome BrowserYARS2
ACMGYARS2 variants
VarityQ9Y2Z4
Genomic Variants (DGV)YARS2 [DGVbeta]
DECIPHERYARS2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisYARS2 
Mutations
ICGC Data PortalYARS2 
TCGA Data PortalYARS2 
Broad Tumor PortalYARS2
OASIS PortalYARS2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICYARS2  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DYARS2
Mutations and Diseases : HGMDYARS2
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaYARS2
DgiDB (Drug Gene Interaction Database)YARS2
DoCM (Curated mutations)YARS2
CIViC (Clinical Interpretations of Variants in Cancer)YARS2
Cancer3DYARS2
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM610957    613561   
Orphanet1213   
DisGeNETYARS2
MedgenYARS2
Genetic Testing Registry YARS2
NextProtQ9Y2Z4 [Medical]
GENETestsYARS2
Target ValidationYARS2
Huge Navigator YARS2 [HugePedia]
ClinGenYARS2
Clinical trials, drugs, therapy
MyCancerGenomeYARS2
Protein Interactions : CTDYARS2
Pharm GKB GenePA142670559
PharosQ9Y2Z4
Clinical trialYARS2
Miscellaneous
canSAR (ICR)YARS2
HarmonizomeYARS2
DataMed IndexYARS2
Probes
Litterature
PubMed53 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXYARS2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Mon Oct 4 16:28:42 CEST 2021

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