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YTHDC1 (YTH domain containing 1)

Identity

Alias_symbol (synonym)YT521
KIAA1966
YT521-B
Other alias
HGNC (Hugo) YTHDC1
LocusID (NCBI) 91746
Atlas_Id 51760
Location 4q13.2  [Link to chromosome band 4q13]
Location_base_pair Starts at 68310387 and ends at 68350117 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
FITM2 (20q13.12) / YTHDC1 (4q13.2)R3HDM1 (2q21.3) / YTHDC1 (4q13.2)YTHDC1 (4q13.2) / ADAMTS3 (4q13.3)
YTHDC1 (4q13.2) / EMG1 (12p13.31)YTHDC1 (4q13.2) / ING3 (7q31.31)YTHDC1 (4q13.2) / INS-IGF2 (11p15.5)
YTHDC1 (4q13.2) / RBM25 (14q24.2)YTHDC1 (4q13.2) / SULT1B1 (4q13.3)YTHDC1 (4q13.2) / TXNL4A (18q23)
YTHDC1 (4q13.2) / YTHDC1 (4q13.2)YTHDC1 4q13.2 / ADAMTS3 4q13.3YTHDC1 4q13.2 / SULT1B1 4q13.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)YTHDC1   30626
Cards
Entrez_Gene (NCBI)YTHDC1  91746  YTH domain containing 1
AliasesYT521; YT521-B
GeneCards (Weizmann)YTHDC1
Ensembl hg19 (Hinxton)ENSG00000083896 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000083896 [Gene_View]  chr4:68310387-68350117 [Contig_View]  YTHDC1 [Vega]
ICGC DataPortalENSG00000083896
TCGA cBioPortalYTHDC1
AceView (NCBI)YTHDC1
Genatlas (Paris)YTHDC1
WikiGenes91746
SOURCE (Princeton)YTHDC1
Genetics Home Reference (NIH)YTHDC1
Genomic and cartography
GoldenPath hg38 (UCSC)YTHDC1  -     chr4:68310387-68350117 -  4q13.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)YTHDC1  -     4q13.2   [Description]    (hg19-Feb_2009)
EnsemblYTHDC1 - 4q13.2 [CytoView hg19]  YTHDC1 - 4q13.2 [CytoView hg38]
Mapping of homologs : NCBIYTHDC1 [Mapview hg19]  YTHDC1 [Mapview hg38]
OMIM617283   
Gene and transcription
Genbank (Entrez)AB075846 AK056430 AK090836 AK098515 AL049340
RefSeq transcript (Entrez)NM_001031732 NM_001330698 NM_133370
RefSeq genomic (Entrez)NC_000004 NC_018915 NT_167250
Consensus coding sequences : CCDS (NCBI)YTHDC1
Cluster EST : UnigeneHs.175955 [ NCBI ]
CGAP (NCI)Hs.175955
Alternative Splicing GalleryENSG00000083896
Gene ExpressionYTHDC1 [ NCBI-GEO ]   YTHDC1 [ EBI - ARRAY_EXPRESS ]   YTHDC1 [ SEEK ]   YTHDC1 [ MEM ]
Gene Expression Viewer (FireBrowse)YTHDC1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)91746
GTEX Portal (Tissue expression)YTHDC1
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ96MU7   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ96MU7  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ96MU7
Splice isoforms : SwissVarQ96MU7
PhosPhoSitePlusQ96MU7
Domaine pattern : Prosite (Expaxy)YTH (PS50882)   
Domains : Interpro (EBI)YTH_domain   
Domain families : Pfam (Sanger)YTH (PF04146)   
Domain families : Pfam (NCBI)pfam04146   
Conserved Domain (NCBI)YTHDC1
DMDM Disease mutations91746
Blocks (Seattle)YTHDC1
PDB (SRS)2YUD    4R3H    4R3I   
PDB (PDBSum)2YUD    4R3H    4R3I   
PDB (IMB)2YUD    4R3H    4R3I   
PDB (RSDB)2YUD    4R3H    4R3I   
Structural Biology KnowledgeBase2YUD    4R3H    4R3I   
SCOP (Structural Classification of Proteins)2YUD    4R3H    4R3I   
CATH (Classification of proteins structures)2YUD    4R3H    4R3I   
SuperfamilyQ96MU7
Human Protein AtlasENSG00000083896
Peptide AtlasQ96MU7
HPRD11689
IPIIPI00144293   IPI00376222   
Protein Interaction databases
DIP (DOE-UCLA)Q96MU7
IntAct (EBI)Q96MU7
FunCoupENSG00000083896
BioGRIDYTHDC1
STRING (EMBL)YTHDC1
ZODIACYTHDC1
Ontologies - Pathways
QuickGOQ96MU7
Ontology : AmiGORNA binding  protein binding  nucleus  nucleoplasm  plasma membrane  mRNA splice site selection  nuclear speck  regulation of mRNA splicing, via spliceosome  N6-methyladenosine-containing RNA binding  
Ontology : EGO-EBIRNA binding  protein binding  nucleus  nucleoplasm  plasma membrane  mRNA splice site selection  nuclear speck  regulation of mRNA splicing, via spliceosome  N6-methyladenosine-containing RNA binding  
NDEx NetworkYTHDC1
Atlas of Cancer Signalling NetworkYTHDC1
Wikipedia pathwaysYTHDC1
Orthology - Evolution
OrthoDB91746
GeneTree (enSembl)ENSG00000083896
Phylogenetic Trees/Animal Genes : TreeFamYTHDC1
HOVERGENQ96MU7
HOGENOMQ96MU7
Homologs : HomoloGeneYTHDC1
Homology/Alignments : Family Browser (UCSC)YTHDC1
Gene fusions - Rearrangements
Fusion : MitelmanYTHDC1/ADAMTS3 [4q13.2/4q13.3]  
Fusion : MitelmanYTHDC1/SULT1B1 [4q13.2/4q13.3]  [t(4;4)(q13;q13)]  
Fusion: TCGAYTHDC1 4q13.2 ADAMTS3 4q13.3 LUSC
Fusion: TCGAYTHDC1 4q13.2 SULT1B1 4q13.3 LUSC
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerYTHDC1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)YTHDC1
dbVarYTHDC1
ClinVarYTHDC1
1000_GenomesYTHDC1 
Exome Variant ServerYTHDC1
ExAC (Exome Aggregation Consortium)YTHDC1 (select the gene name)
Genetic variants : HAPMAP91746
Genomic Variants (DGV)YTHDC1 [DGVbeta]
DECIPHERYTHDC1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisYTHDC1 
Mutations
ICGC Data PortalYTHDC1 
TCGA Data PortalYTHDC1 
Broad Tumor PortalYTHDC1
OASIS PortalYTHDC1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICYTHDC1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDYTHDC1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch YTHDC1
DgiDB (Drug Gene Interaction Database)YTHDC1
DoCM (Curated mutations)YTHDC1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)YTHDC1 (select a term)
intoGenYTHDC1
Cancer3DYTHDC1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM617283   
Orphanet
MedgenYTHDC1
Genetic Testing Registry YTHDC1
NextProtQ96MU7 [Medical]
TSGene91746
GENETestsYTHDC1
Target ValidationYTHDC1
Huge Navigator YTHDC1 [HugePedia]
snp3D : Map Gene to Disease91746
BioCentury BCIQYTHDC1
ClinGenYTHDC1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD91746
Chemical/Pharm GKB GenePA143485673
Clinical trialYTHDC1
Miscellaneous
canSAR (ICR)YTHDC1 (select the gene name)
Probes
Litterature
PubMed41 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineYTHDC1
EVEXYTHDC1
GoPubMedYTHDC1
iHOPYTHDC1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Wed Jun 7 13:03:11 CEST 2017

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