YTHDC2 (YTH domain containing 2)

2014-03-01  

Identity

HGNC
LOCATION
5q22.2
LOCUSID
ALIAS
CAHL,hYTHDC2
FUSION GENES

Other Information

Locus ID:

NCBI: 64848
MIM: 616530
HGNC: 24721
Ensembl: ENSG00000047188

Variants:

dbSNP: 64848
ClinVar: 64848
TCGA: ENSG00000047188
COSMIC: YTHDC2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000047188ENST00000161863Q9H6S0
ENSG00000047188ENST00000503857D6RF50
ENSG00000047188ENST00000514720D6R9T8
ENSG00000047188ENST00000515883D6RA70

Expression (GTEx)

0
5
10
15
20
25
30
35

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
263184512015Structural Basis for the Discriminative Recognition of N6-Methyladenosine RNA by the Human YT521-B Homology Domain Family of Proteins.47
269963002016RNA helicase YTHDC2 promotes cancer metastasis via the enhancement of the efficiency by which HIF-1α mRNA is translated.41
299705962018The m6A reader protein YTHDC2 interacts with the small ribosomal subunit and the 5'-3' exoribonuclease XRN1.22
215595182011Cyclosporin A associated helicase-like protein facilitates the association of hepatitis C virus RNA polymerase with its cellular cyclophilin B.17
242696722014Transcriptional machinery of TNF-α-inducible YTH domain containing 2 (YTHDC2) gene.11
248347972014Germline copy number variation in the YTHDC2 gene: does it have a role in finding a novel potential molecular target involved in pancreatic adenocarcinoma susceptibility?6
314729572019Crystal structure of human YTHDC2 YTH domain.0

Citation

Dessen P

YTHDC2 (YTH domain containing 2)

Atlas Genet Cytogenet Oncol Haematol. 2014-03-01

Online version: http://atlasgeneticsoncology.org/gene/53834/ythdc2