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YTHDC2 (YTH domain containing 2)

Identity

Alias_symbol (synonym)FLJ2194
FLJ10053
DKFZp564A186
Other aliasCAHL
HGNC (Hugo) YTHDC2
LocusID (NCBI) 64848
Atlas_Id 53834
Location 5q22.2  [Link to chromosome band 5q22]
Location_base_pair Starts at 112849391 and ends at 112930984 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
RAD50 (5q31.1) / YTHDC2 (5q22.2)YTHDC2 (5q22.2) / ST13 (22q13.2)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)YTHDC2   24721
Cards
Entrez_Gene (NCBI)YTHDC2  64848  YTH domain containing 2
AliasesCAHL
GeneCards (Weizmann)YTHDC2
Ensembl hg19 (Hinxton)ENSG00000047188 [Gene_View]  chr5:112849391-112930984 [Contig_View]  YTHDC2 [Vega]
Ensembl hg38 (Hinxton)ENSG00000047188 [Gene_View]  chr5:112849391-112930984 [Contig_View]  YTHDC2 [Vega]
ICGC DataPortalENSG00000047188
TCGA cBioPortalYTHDC2
AceView (NCBI)YTHDC2
Genatlas (Paris)YTHDC2
WikiGenes64848
SOURCE (Princeton)YTHDC2
Genetics Home Reference (NIH)YTHDC2
Genomic and cartography
GoldenPath hg19 (UCSC)YTHDC2  -     chr5:112849391-112930984 +  5q22.2   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)YTHDC2  -     5q22.2   [Description]    (hg38-Dec_2013)
EnsemblYTHDC2 - 5q22.2 [CytoView hg19]  YTHDC2 - 5q22.2 [CytoView hg38]
Mapping of homologs : NCBIYTHDC2 [Mapview hg19]  YTHDC2 [Mapview hg38]
OMIM616530   
Gene and transcription
Genbank (Entrez)AK000915 AK025593 AK095368 AK096486 AK131450
RefSeq transcript (Entrez)NM_022828
RefSeq genomic (Entrez)NC_000005 NC_018916 NT_034772 NW_004929323
Consensus coding sequences : CCDS (NCBI)YTHDC2
Cluster EST : UnigeneHs.231942 [ NCBI ]
CGAP (NCI)Hs.231942
Alternative Splicing GalleryENSG00000047188
Gene ExpressionYTHDC2 [ NCBI-GEO ]   YTHDC2 [ EBI - ARRAY_EXPRESS ]   YTHDC2 [ SEEK ]   YTHDC2 [ MEM ]
Gene Expression Viewer (FireBrowse)YTHDC2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)64848
GTEX Portal (Tissue expression)YTHDC2
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9H6S0   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9H6S0  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9H6S0
Splice isoforms : SwissVarQ9H6S0
Catalytic activity : Enzyme3.6.4.13 [ Enzyme-Expasy ]   3.6.4.133.6.4.13 [ IntEnz-EBI ]   3.6.4.13 [ BRENDA ]   3.6.4.13 [ KEGG ]   
PhosPhoSitePlusQ9H6S0
Domaine pattern : Prosite (Expaxy)ANK_REP_REGION (PS50297)    ANK_REPEAT (PS50088)    HELICASE_ATP_BIND_1 (PS51192)    HELICASE_CTER (PS51194)    R3H (PS51061)    YTH (PS50882)   
Domains : Interpro (EBI)AB_hydrolase    Ankyrin_rpt    Ankyrin_rpt-contain_dom    DEAD/DEAH_box_helicase_dom    DUF1605    Helicase-assoc_dom    Helicase_ATP-bd    Helicase_C    P-loop_NTPase    R3H_dom    YTH_domain   
Domain families : Pfam (Sanger)DEAD (PF00270)    HA2 (PF04408)    Helicase_C (PF00271)    OB_NTP_bind (PF07717)    R3H (PF01424)    YTH (PF04146)   
Domain families : Pfam (NCBI)pfam00270    pfam04408    pfam00271    pfam07717    pfam01424    pfam04146   
Domain families : Smart (EMBL)ANK (SM00248)  DEXDc (SM00487)  HA2 (SM00847)  HELICc (SM00490)  
Conserved Domain (NCBI)YTHDC2
DMDM Disease mutations64848
Blocks (Seattle)YTHDC2
PDB (SRS)2YU6   
PDB (PDBSum)2YU6   
PDB (IMB)2YU6   
PDB (RSDB)2YU6   
Structural Biology KnowledgeBase2YU6   
SCOP (Structural Classification of Proteins)2YU6   
CATH (Classification of proteins structures)2YU6   
SuperfamilyQ9H6S0
Human Protein AtlasENSG00000047188
Peptide AtlasQ9H6S0
HPRD11690
IPIIPI00010200   IPI00968057   IPI00964960   IPI00967660   IPI00964628   
Protein Interaction databases
DIP (DOE-UCLA)Q9H6S0
IntAct (EBI)Q9H6S0
FunCoupENSG00000047188
BioGRIDYTHDC2
STRING (EMBL)YTHDC2
ZODIACYTHDC2
Ontologies - Pathways
QuickGOQ9H6S0
Ontology : AmiGOATP-dependent RNA helicase activity  protein binding  ATP binding  nucleus  endoplasmic reticulum  endoplasmic reticulum  RNA processing  RNA-dependent ATPase activity  response to tumor necrosis factor  poly(A) RNA binding  poly(A) RNA binding  positive regulation by host of viral genome replication  RNA polymerase binding  response to interleukin-1  N6-methyladenosine-containing RNA binding  
Ontology : EGO-EBIATP-dependent RNA helicase activity  protein binding  ATP binding  nucleus  endoplasmic reticulum  endoplasmic reticulum  RNA processing  RNA-dependent ATPase activity  response to tumor necrosis factor  poly(A) RNA binding  poly(A) RNA binding  positive regulation by host of viral genome replication  RNA polymerase binding  response to interleukin-1  N6-methyladenosine-containing RNA binding  
NDEx NetworkYTHDC2
Atlas of Cancer Signalling NetworkYTHDC2
Wikipedia pathwaysYTHDC2
Orthology - Evolution
OrthoDB64848
GeneTree (enSembl)ENSG00000047188
Phylogenetic Trees/Animal Genes : TreeFamYTHDC2
HOVERGENQ9H6S0
HOGENOMQ9H6S0
Homologs : HomoloGeneYTHDC2
Homology/Alignments : Family Browser (UCSC)YTHDC2
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerYTHDC2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)YTHDC2
dbVarYTHDC2
ClinVarYTHDC2
1000_GenomesYTHDC2 
Exome Variant ServerYTHDC2
ExAC (Exome Aggregation Consortium)YTHDC2 (select the gene name)
Genetic variants : HAPMAP64848
Genomic Variants (DGV)YTHDC2 [DGVbeta]
DECIPHER (Syndromes)5:112849391-112930984  ENSG00000047188
CONAN: Copy Number AnalysisYTHDC2 
Mutations
ICGC Data PortalYTHDC2 
TCGA Data PortalYTHDC2 
Broad Tumor PortalYTHDC2
OASIS PortalYTHDC2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICYTHDC2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDYTHDC2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch YTHDC2
DgiDB (Drug Gene Interaction Database)YTHDC2
DoCM (Curated mutations)YTHDC2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)YTHDC2 (select a term)
intoGenYTHDC2
Cancer3DYTHDC2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM616530   
Orphanet
MedgenYTHDC2
Genetic Testing Registry YTHDC2
NextProtQ9H6S0 [Medical]
TSGene64848
GENETestsYTHDC2
Huge Navigator YTHDC2 [HugePedia]
snp3D : Map Gene to Disease64848
BioCentury BCIQYTHDC2
ClinGenYTHDC2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD64848
Chemical/Pharm GKB GenePA134912676
Clinical trialYTHDC2
Miscellaneous
canSAR (ICR)YTHDC2 (select the gene name)
Probes
Litterature
PubMed30 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineYTHDC2
EVEXYTHDC2
GoPubMedYTHDC2
iHOPYTHDC2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Thu Mar 30 15:25:18 CEST 2017

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