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YTHDF2 (YTH N6-methyladenosine RNA binding protein 2)

Identity

Alias_namesYTH domain family 2
YTH domain family, member 2
YTH N(6)-methyladenosine RNA binding protein 2
Alias_symbol (synonym)HGRG8
NY-REN-2
CAHL
Other alias
HGNC (Hugo) YTHDF2
LocusID (NCBI) 51441
Atlas_Id 40815
Location 1p35.3  [Link to chromosome band 1p35]
Location_base_pair Starts at 28736624 and ends at 28769775 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ARID1A (1p36.11) / YTHDF2 (1p35.3)ETV6 (12p13.2) / YTHDF2 (1p35.3)RUNX1 (21q22.12) / YTHDF2 (1p35.3)
YIPF1 (1p32.3) / YTHDF2 (1p35.3)YTHDF2 (1p35.3) / RUNX1 (21q22.12)YTHDF2 (1p35.3) / SYTL1 (1p36.11)
ARID1A 1p36.11 / YTHDF2 1p35.3ETV6 12p13.2 / YTHDF2 1p35.3YIPF1 1p32.3 / YTHDF2 1p35.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Leukemias implicated (Data extracted from papers in the Atlas)

Leukemias t0121p35q22ID1447

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 4 ]

Solid Tumors TT_t0101p32p35ID103651 TT_t0101p35p36ID103736 TT_t0101p35p36ID103747 TT_t0112p35p13ID104152

External links

Nomenclature
HGNC (Hugo)YTHDF2   31675
Cards
Entrez_Gene (NCBI)YTHDF2  51441  YTH N6-methyladenosine RNA binding protein 2
AliasesCAHL; HGRG8; NY-REN-2
GeneCards (Weizmann)YTHDF2
Ensembl hg19 (Hinxton)ENSG00000198492 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000198492 [Gene_View]  ENSG00000198492 [Sequence]  chr1:28736624-28769775 [Contig_View]  YTHDF2 [Vega]
ICGC DataPortalENSG00000198492
TCGA cBioPortalYTHDF2
AceView (NCBI)YTHDF2
Genatlas (Paris)YTHDF2
WikiGenes51441
SOURCE (Princeton)YTHDF2
Genetics Home Reference (NIH)YTHDF2
Genomic and cartography
GoldenPath hg38 (UCSC)YTHDF2  -     chr1:28736624-28769775 +  1p35.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)YTHDF2  -     1p35.3   [Description]    (hg19-Feb_2009)
GoldenPathYTHDF2 - 1p35.3 [CytoView hg19]  YTHDF2 - 1p35.3 [CytoView hg38]
ImmunoBaseENSG00000198492
Mapping of homologs : NCBIYTHDF2 [Mapview hg19]  YTHDF2 [Mapview hg38]
OMIM610640   
Gene and transcription
Genbank (Entrez)AA603037 AB451335 AB451484 AF155095 AF192968
RefSeq transcript (Entrez)NM_001172828 NM_001173128 NM_016258
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)YTHDF2
Cluster EST : UnigeneHs.532286 [ NCBI ]
CGAP (NCI)Hs.532286
Alternative Splicing GalleryENSG00000198492
Gene ExpressionYTHDF2 [ NCBI-GEO ]   YTHDF2 [ EBI - ARRAY_EXPRESS ]   YTHDF2 [ SEEK ]   YTHDF2 [ MEM ]
Gene Expression Viewer (FireBrowse)YTHDF2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)51441
GTEX Portal (Tissue expression)YTHDF2
Human Protein AtlasENSG00000198492-YTHDF2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9Y5A9   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9Y5A9  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9Y5A9
Splice isoforms : SwissVarQ9Y5A9
PhosPhoSitePlusQ9Y5A9
Domaine pattern : Prosite (Expaxy)YTH (PS50882)   
Domains : Interpro (EBI)YTH_domain   
Domain families : Pfam (Sanger)YTH (PF04146)   
Domain families : Pfam (NCBI)pfam04146   
Conserved Domain (NCBI)YTHDF2
DMDM Disease mutations51441
Blocks (Seattle)YTHDF2
PDB (RSDB)4RDN    4RDO    4WQN   
PDB Europe4RDN    4RDO    4WQN   
PDB (PDBSum)4RDN    4RDO    4WQN   
PDB (IMB)4RDN    4RDO    4WQN   
Structural Biology KnowledgeBase4RDN    4RDO    4WQN   
SCOP (Structural Classification of Proteins)4RDN    4RDO    4WQN   
CATH (Classification of proteins structures)4RDN    4RDO    4WQN   
SuperfamilyQ9Y5A9
Human Protein Atlas [tissue]ENSG00000198492-YTHDF2 [tissue]
Peptide AtlasQ9Y5A9
HPRD06587
IPIIPI00306043   IPI00397024   IPI01010739   
Protein Interaction databases
DIP (DOE-UCLA)Q9Y5A9
IntAct (EBI)Q9Y5A9
FunCoupENSG00000198492
BioGRIDYTHDF2
STRING (EMBL)YTHDF2
ZODIACYTHDF2
Ontologies - Pathways
QuickGOQ9Y5A9
Ontology : AmiGOP-body  oocyte maturation  RNA binding  protein binding  nucleus  microtubule organizing center  cytosol  mRNA catabolic process  humoral immune response  cytoplasmic ribonucleoprotein granule  regulation of mRNA stability  negative regulation of Notch signaling pathway  embryonic morphogenesis  regulation of neurogenesis  negative regulation of type I interferon-mediated signaling pathway  mRNA destabilization  mRNA destabilization  hematopoietic stem cell proliferation  endothelial to hematopoietic transition  regulation of hematopoietic stem cell differentiation  regulation of meiotic cell cycle process involved in oocyte maturation  positive regulation of cap-independent translational initiation  N6-methyladenosine-containing RNA binding  
Ontology : EGO-EBIP-body  oocyte maturation  RNA binding  protein binding  nucleus  microtubule organizing center  cytosol  mRNA catabolic process  humoral immune response  cytoplasmic ribonucleoprotein granule  regulation of mRNA stability  negative regulation of Notch signaling pathway  embryonic morphogenesis  regulation of neurogenesis  negative regulation of type I interferon-mediated signaling pathway  mRNA destabilization  mRNA destabilization  hematopoietic stem cell proliferation  endothelial to hematopoietic transition  regulation of hematopoietic stem cell differentiation  regulation of meiotic cell cycle process involved in oocyte maturation  positive regulation of cap-independent translational initiation  N6-methyladenosine-containing RNA binding  
NDEx NetworkYTHDF2
Atlas of Cancer Signalling NetworkYTHDF2
Wikipedia pathwaysYTHDF2
Orthology - Evolution
OrthoDB51441
GeneTree (enSembl)ENSG00000198492
Phylogenetic Trees/Animal Genes : TreeFamYTHDF2
HOGENOMQ9Y5A9
Homologs : HomoloGeneYTHDF2
Homology/Alignments : Family Browser (UCSC)YTHDF2
Gene fusions - Rearrangements
Fusion : MitelmanARID1A/YTHDF2 [1p36.11/1p35.3]  [t(1;1)(p35;p36)]  
Fusion : MitelmanETV6/YTHDF2 [12p13.2/1p35.3]  [t(1;12)(p35;p13)]  
Fusion : MitelmanRUNX1/YTHDF2 [21q22.12/1p35.3]  [t(1;21)(p35;q22)]  
Fusion : MitelmanYIPF1/YTHDF2 [1p32.3/1p35.3]  [t(1;1)(p32;p35)]  
Fusion : MitelmanYTHDF2/SYTL1 [1p35.3/1p36.11]  [t(1;1)(p35;p36)]  
Fusion PortalARID1A 1p36.11 YTHDF2 1p35.3 BRCA
Fusion PortalETV6 12p13.2 YTHDF2 1p35.3 BRCA
Fusion PortalYIPF1 1p32.3 YTHDF2 1p35.3 HNSC
Fusion : QuiverYTHDF2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerYTHDF2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)YTHDF2
dbVarYTHDF2
ClinVarYTHDF2
1000_GenomesYTHDF2 
Exome Variant ServerYTHDF2
ExAC (Exome Aggregation Consortium)ENSG00000198492
GNOMAD BrowserENSG00000198492
Varsome BrowserYTHDF2
Genetic variants : HAPMAP51441
Genomic Variants (DGV)YTHDF2 [DGVbeta]
DECIPHERYTHDF2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisYTHDF2 
Mutations
ICGC Data PortalYTHDF2 
TCGA Data PortalYTHDF2 
Broad Tumor PortalYTHDF2
OASIS PortalYTHDF2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICYTHDF2  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DYTHDF2
Mutations and Diseases : HGMDYTHDF2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch YTHDF2
DgiDB (Drug Gene Interaction Database)YTHDF2
DoCM (Curated mutations)YTHDF2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)YTHDF2 (select a term)
intoGenYTHDF2
Cancer3DYTHDF2(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM610640   
Orphanet
DisGeNETYTHDF2
MedgenYTHDF2
Genetic Testing Registry YTHDF2
NextProtQ9Y5A9 [Medical]
TSGene51441
GENETestsYTHDF2
Target ValidationYTHDF2
Huge Navigator YTHDF2 [HugePedia]
snp3D : Map Gene to Disease51441
BioCentury BCIQYTHDF2
ClinGenYTHDF2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD51441
Chemical/Pharm GKB GenePA134964518
Clinical trialYTHDF2
Miscellaneous
canSAR (ICR)YTHDF2 (select the gene name)
DataMed IndexYTHDF2
Probes
Litterature
PubMed58 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineYTHDF2
EVEXYTHDF2
GoPubMedYTHDF2
iHOPYTHDF2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Aug 26 18:35:39 CEST 2019
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