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YTHDF2 (YTH N6-methyladenosine RNA binding protein 2)

Identity

Alias (NCBI)CAHL
DF2
HGRG8
NY-REN-2
HGNC (Hugo) YTHDF2
HGNC Alias symbHGRG8
NY-REN-2
CAHL
HGNC Previous nameYTH domain family 2
 YTH domain family, member 2
 YTH N(6)-methyladenosine RNA binding protein 2
LocusID (NCBI) 51441
Atlas_Id 40815
Location 1p35.3  [Link to chromosome band 1p35]
Location_base_pair Starts at 28736940 and ends at 28769775 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ARID1A (1p36.11) / YTHDF2 (1p35.3)ETV6 (12p13.2) / YTHDF2 (1p35.3)RUNX1 (21q22.12) / YTHDF2 (1p35.3)
YIPF1 (1p32.3) / YTHDF2 (1p35.3)YTHDF2 (1p35.3) / RUNX1 (21q22.12)YTHDF2 (1p35.3) / SYTL1 (1p36.11)
ARID1A 1p36.11 / YTHDF2 1p35.3ETV6 12p13.2 / YTHDF2 1p35.3YIPF1 1p32.3 / YTHDF2 1p35.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(1;21)(p35;q22) RUNX1/YTHDF2

External links

 

Nomenclature
HGNC (Hugo)YTHDF2   31675
Cards
Entrez_Gene (NCBI)YTHDF2    YTH N6-methyladenosine RNA binding protein 2
AliasesCAHL; DF2; HGRG8; NY-REN-2
GeneCards (Weizmann)YTHDF2
Ensembl hg19 (Hinxton)ENSG00000198492 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000198492 [Gene_View]  ENSG00000198492 [Sequence]  chr1:28736940-28769775 [Contig_View]  YTHDF2 [Vega]
ICGC DataPortalENSG00000198492
TCGA cBioPortalYTHDF2
AceView (NCBI)YTHDF2
Genatlas (Paris)YTHDF2
SOURCE (Princeton)YTHDF2
Genetics Home Reference (NIH)YTHDF2
Genomic and cartography
GoldenPath hg38 (UCSC)YTHDF2  -     chr1:28736940-28769775 +  1p35.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)YTHDF2  -     1p35.3   [Description]    (hg19-Feb_2009)
GoldenPathYTHDF2 - 1p35.3 [CytoView hg19]  YTHDF2 - 1p35.3 [CytoView hg38]
ImmunoBaseENSG00000198492
Genome Data Viewer NCBIYTHDF2 [Mapview hg19]  
OMIM610640   
Gene and transcription
Genbank (Entrez)AA603037 AB451335 AB451484 AF155095 AF192968
RefSeq transcript (Entrez)NM_001172828 NM_001173128 NM_016258
Consensus coding sequences : CCDS (NCBI)YTHDF2
Gene ExpressionYTHDF2 [ NCBI-GEO ]   YTHDF2 [ EBI - ARRAY_EXPRESS ]   YTHDF2 [ SEEK ]   YTHDF2 [ MEM ]
Gene Expression Viewer (FireBrowse)YTHDF2 [ Firebrowse - Broad ]
GenevisibleExpression of YTHDF2 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)51441
GTEX Portal (Tissue expression)YTHDF2
Human Protein AtlasENSG00000198492-YTHDF2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9Y5A9   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9Y5A9  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9Y5A9
PhosPhoSitePlusQ9Y5A9
Domaine pattern : Prosite (Expaxy)YTH (PS50882)   
Domains : Interpro (EBI)YTH_domain   
Domain families : Pfam (Sanger)YTH (PF04146)   
Domain families : Pfam (NCBI)pfam04146   
Conserved Domain (NCBI)YTHDF2
PDB (RSDB)4RDN    4RDO    4WQN   
PDB Europe4RDN    4RDO    4WQN   
PDB (PDBSum)4RDN    4RDO    4WQN   
PDB (IMB)4RDN    4RDO    4WQN   
Structural Biology KnowledgeBase4RDN    4RDO    4WQN   
SCOP (Structural Classification of Proteins)4RDN    4RDO    4WQN   
CATH (Classification of proteins structures)4RDN    4RDO    4WQN   
SuperfamilyQ9Y5A9
AlphaFold pdb e-kbQ9Y5A9   
Human Protein Atlas [tissue]ENSG00000198492-YTHDF2 [tissue]
HPRD06587
Protein Interaction databases
DIP (DOE-UCLA)Q9Y5A9
IntAct (EBI)Q9Y5A9
BioGRIDYTHDF2
STRING (EMBL)YTHDF2
ZODIACYTHDF2
Ontologies - Pathways
QuickGOQ9Y5A9
Ontology : AmiGOP-body  oocyte maturation  RNA binding  mRNA binding  protein binding  nucleus  cytoplasm  cytoplasm  cytosol  mRNA catabolic process  humoral immune response  cell cycle  gamete generation  spermatogonial cell division  cytoplasmic stress granule  regulation of cell adhesion  stress granule assembly  centriolar satellite  cytoplasmic ribonucleoprotein granule  regulation of mRNA stability  regulation of mRNA stability  innate immune response  negative regulation of Notch signaling pathway  positive regulation of translational initiation  embryonic morphogenesis  regulation of neurogenesis  regulation of neurogenesis  negative regulation of type I interferon-mediated signaling pathway  mRNA destabilization  mRNA destabilization  mRNA destabilization  C5-methylcytidine-containing RNA binding  organelle assembly  hematopoietic stem cell proliferation  endothelial to hematopoietic transition  regulation of hematopoietic stem cell differentiation  regulation of meiotic cell cycle process involved in oocyte maturation  positive regulation of cap-independent translational initiation  N6-methyladenosine-containing RNA binding  N6-methyladenosine-containing RNA binding  regulation of rRNA processing  negative regulation of stem cell differentiation  
Ontology : EGO-EBIP-body  oocyte maturation  RNA binding  mRNA binding  protein binding  nucleus  cytoplasm  cytoplasm  cytosol  mRNA catabolic process  humoral immune response  cell cycle  gamete generation  spermatogonial cell division  cytoplasmic stress granule  regulation of cell adhesion  stress granule assembly  centriolar satellite  cytoplasmic ribonucleoprotein granule  regulation of mRNA stability  regulation of mRNA stability  innate immune response  negative regulation of Notch signaling pathway  positive regulation of translational initiation  embryonic morphogenesis  regulation of neurogenesis  regulation of neurogenesis  negative regulation of type I interferon-mediated signaling pathway  mRNA destabilization  mRNA destabilization  mRNA destabilization  C5-methylcytidine-containing RNA binding  organelle assembly  hematopoietic stem cell proliferation  endothelial to hematopoietic transition  regulation of hematopoietic stem cell differentiation  regulation of meiotic cell cycle process involved in oocyte maturation  positive regulation of cap-independent translational initiation  N6-methyladenosine-containing RNA binding  N6-methyladenosine-containing RNA binding  regulation of rRNA processing  negative regulation of stem cell differentiation  
NDEx NetworkYTHDF2
Atlas of Cancer Signalling NetworkYTHDF2
Wikipedia pathwaysYTHDF2
Orthology - Evolution
OrthoDB51441
GeneTree (enSembl)ENSG00000198492
Phylogenetic Trees/Animal Genes : TreeFamYTHDF2
Homologs : HomoloGeneYTHDF2
Homology/Alignments : Family Browser (UCSC)YTHDF2
Gene fusions - Rearrangements
Fusion : MitelmanARID1A/YTHDF2 [1p36.11/1p35.3]  
Fusion : MitelmanETV6/YTHDF2 [12p13.2/1p35.3]  
Fusion : MitelmanRUNX1/YTHDF2 [21q22.12/1p35.3]  
Fusion : MitelmanYIPF1/YTHDF2 [1p32.3/1p35.3]  
Fusion : MitelmanYTHDF2/SYTL1 [1p35.3/1p36.11]  
Fusion : QuiverYTHDF2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerYTHDF2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)YTHDF2
dbVarYTHDF2
ClinVarYTHDF2
MonarchYTHDF2
1000_GenomesYTHDF2 
Exome Variant ServerYTHDF2
GNOMAD BrowserENSG00000198492
Varsome BrowserYTHDF2
ACMGYTHDF2 variants
VarityQ9Y5A9
Genomic Variants (DGV)YTHDF2 [DGVbeta]
DECIPHERYTHDF2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisYTHDF2 
Mutations
ICGC Data PortalYTHDF2 
TCGA Data PortalYTHDF2 
Broad Tumor PortalYTHDF2
OASIS PortalYTHDF2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICYTHDF2  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DYTHDF2
Mutations and Diseases : HGMDYTHDF2
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaYTHDF2
DgiDB (Drug Gene Interaction Database)YTHDF2
DoCM (Curated mutations)YTHDF2
CIViC (Clinical Interpretations of Variants in Cancer)YTHDF2
Cancer3DYTHDF2
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM610640   
Orphanet
DisGeNETYTHDF2
MedgenYTHDF2
Genetic Testing Registry YTHDF2
NextProtQ9Y5A9 [Medical]
GENETestsYTHDF2
Target ValidationYTHDF2
Huge Navigator YTHDF2 [HugePedia]
ClinGenYTHDF2
Clinical trials, drugs, therapy
MyCancerGenomeYTHDF2
Protein Interactions : CTDYTHDF2
Pharm GKB GenePA134964518
PharosQ9Y5A9
Clinical trialYTHDF2
Miscellaneous
canSAR (ICR)YTHDF2
HarmonizomeYTHDF2
DataMed IndexYTHDF2
Probes
Litterature
PubMed109 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXYTHDF2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:38:41 CEST 2021
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