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YWHAB (tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta)

Identity

Alias (NCBI)GW128
HEL-S-1
HS1
KCIP-1
YWHAA
HGNC (Hugo) YWHAB
HGNC Alias name14-3-3 beta
 14-3-3 alpha
HGNC Previous nameYWHAA
HGNC Previous nametyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, alpha polypeptide
 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide
LocusID (NCBI) 7529
Atlas_Id 46599
Location 20q13.12  [Link to chromosome band 20q13]
Location_base_pair Starts at 44885705 and ends at 44908532 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
COL3A1 (2q32.2) / YWHAB (20q13.12)PABPC1L (20q13.12) / YWHAB (20q13.12)SDC4 (20q13.12) / YWHAB (20q13.12)
TSG101 (11p15.1) / YWHAB (20q13.12)YWHAB (20q13.12) / ARHGAP32 (11q24.3)YWHAB (20q13.12) / DZIP1 (13q32.1)
YWHAB (20q13.12) / GJA1 (6q22.31)YWHAB (20q13.12) / SLC29A3 (10q22.1)YWHAB (20q13.12) / YWHAB (20q13.12)
SDC4 20q13.12 / YWHAB 20q13.12YWHAB 20q13.12 / ARHGAP32 11q24.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(20;20)(q13;q13) PABPC1L/YWHAB


External links

 

Nomenclature
HGNC (Hugo)YWHAB   12849
Cards
Entrez_Gene (NCBI)YWHAB    tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta
AliasesGW128; HEL-S-1; HS1; KCIP-1; 
YWHAA
GeneCards (Weizmann)YWHAB
Ensembl hg19 (Hinxton)ENSG00000166913 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000166913 [Gene_View]  ENSG00000166913 [Sequence]  chr20:44885705-44908532 [Contig_View]  YWHAB [Vega]
ICGC DataPortalENSG00000166913
TCGA cBioPortalYWHAB
AceView (NCBI)YWHAB
Genatlas (Paris)YWHAB
SOURCE (Princeton)YWHAB
Genetics Home Reference (NIH)YWHAB
Genomic and cartography
GoldenPath hg38 (UCSC)YWHAB  -     chr20:44885705-44908532 +  20q13.12   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)YWHAB  -     20q13.12   [Description]    (hg19-Feb_2009)
GoldenPathYWHAB - 20q13.12 [CytoView hg19]  YWHAB - 20q13.12 [CytoView hg38]
ImmunoBaseENSG00000166913
Genome Data Viewer NCBIYWHAB [Mapview hg19]  
OMIM601289   
Gene and transcription
Genbank (Entrez)AA845374 AB209759 AB451260 AB451386 AF064847
RefSeq transcript (Entrez)NM_003404 NM_139323
Consensus coding sequences : CCDS (NCBI)YWHAB
Gene ExpressionYWHAB [ NCBI-GEO ]   YWHAB [ EBI - ARRAY_EXPRESS ]   YWHAB [ SEEK ]   YWHAB [ MEM ]
Gene Expression Viewer (FireBrowse)YWHAB [ Firebrowse - Broad ]
GenevisibleExpression of YWHAB in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)7529
GTEX Portal (Tissue expression)YWHAB
Human Protein AtlasENSG00000166913-YWHAB [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP31946   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP31946  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP31946
PhosPhoSitePlusP31946
Domaine pattern : Prosite (Expaxy)1433_1 (PS00796)    1433_2 (PS00797)   
Domains : Interpro (EBI)14-3-3    14-3-3_CS    14-3-3_dom_sf    14-3-3_domain   
Domain families : Pfam (Sanger)14-3-3 (PF00244)   
Domain families : Pfam (NCBI)pfam00244   
Domain families : Smart (EMBL)14_3_3 (SM00101)  
Conserved Domain (NCBI)YWHAB
PDB (RSDB)2BQ0    2C23    4DNK    5N10    6A5Q    6BYK    6GN0    6GN8    6GNJ    6GNK    6GNN    6HEP   
PDB Europe2BQ0    2C23    4DNK    5N10    6A5Q    6BYK    6GN0    6GN8    6GNJ    6GNK    6GNN    6HEP   
PDB (PDBSum)2BQ0    2C23    4DNK    5N10    6A5Q    6BYK    6GN0    6GN8    6GNJ    6GNK    6GNN    6HEP   
PDB (IMB)2BQ0    2C23    4DNK    5N10    6A5Q    6BYK    6GN0    6GN8    6GNJ    6GNK    6GNN    6HEP   
Structural Biology KnowledgeBase2BQ0    2C23    4DNK    5N10    6A5Q    6BYK    6GN0    6GN8    6GNJ    6GNK    6GNN    6HEP   
SCOP (Structural Classification of Proteins)2BQ0    2C23    4DNK    5N10    6A5Q    6BYK    6GN0    6GN8    6GNJ    6GNK    6GNN    6HEP   
CATH (Classification of proteins structures)2BQ0    2C23    4DNK    5N10    6A5Q    6BYK    6GN0    6GN8    6GNJ    6GNK    6GNN    6HEP   
SuperfamilyP31946
AlphaFold pdb e-kbP31946   
Human Protein Atlas [tissue]ENSG00000166913-YWHAB [tissue]
HPRD03184
Protein Interaction databases
DIP (DOE-UCLA)P31946
IntAct (EBI)P31946
BioGRIDYWHAB
STRING (EMBL)YWHAB
ZODIACYWHAB
Ontologies - Pathways
QuickGOP31946
Ontology : AmiGOMAPK cascade  activation of MAPKK activity  adaptive immune response  protein kinase inhibitor activity  protein binding  nucleus  cytoplasm  mitochondrion  vacuolar membrane  cytosol  cytosol  focal adhesion  negative regulation of protein kinase activity  protein targeting  protein C-terminus binding  membrane  transcription repressor complex  enzyme binding  protein domain specific binding  negative regulation of protein dephosphorylation  hippo signaling  melanosome  identical protein binding  histone deacetylase binding  positive regulation of catalytic activity  regulation of mRNA stability  protein-containing complex binding  cadherin binding  negative regulation of G protein-coupled receptor signaling pathway  negative regulation of transcription, DNA-templated  perinuclear region of cytoplasm  phosphoserine residue binding  phosphoprotein binding  cytoplasmic sequestering of protein  extracellular exosome  positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway  
Ontology : EGO-EBIMAPK cascade  activation of MAPKK activity  adaptive immune response  protein kinase inhibitor activity  protein binding  nucleus  cytoplasm  mitochondrion  vacuolar membrane  cytosol  cytosol  focal adhesion  negative regulation of protein kinase activity  protein targeting  protein C-terminus binding  membrane  transcription repressor complex  enzyme binding  protein domain specific binding  negative regulation of protein dephosphorylation  hippo signaling  melanosome  identical protein binding  histone deacetylase binding  positive regulation of catalytic activity  regulation of mRNA stability  protein-containing complex binding  cadherin binding  negative regulation of G protein-coupled receptor signaling pathway  negative regulation of transcription, DNA-templated  perinuclear region of cytoplasm  phosphoserine residue binding  phosphoprotein binding  cytoplasmic sequestering of protein  extracellular exosome  positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway  
Pathways : KEGGCell cycle    Oocyte meiosis    PI3K-Akt signaling pathway    Hippo signaling pathway    Hepatitis B    Epstein-Barr virus infection    Viral carcinogenesis   
NDEx NetworkYWHAB
Atlas of Cancer Signalling NetworkYWHAB
Wikipedia pathwaysYWHAB
Orthology - Evolution
OrthoDB7529
GeneTree (enSembl)ENSG00000166913
Phylogenetic Trees/Animal Genes : TreeFamYWHAB
Homologs : HomoloGeneYWHAB
Homology/Alignments : Family Browser (UCSC)YWHAB
Gene fusions - Rearrangements
Fusion : MitelmanSDC4/YWHAB [20q13.12/20q13.12]  
Fusion : MitelmanYWHAB/ARHGAP32 [20q13.12/11q24.3]  
Fusion : QuiverYWHAB
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerYWHAB [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)YWHAB
dbVarYWHAB
ClinVarYWHAB
MonarchYWHAB
1000_GenomesYWHAB 
Exome Variant ServerYWHAB
GNOMAD BrowserENSG00000166913
Varsome BrowserYWHAB
ACMGYWHAB variants
VarityP31946
Genomic Variants (DGV)YWHAB [DGVbeta]
DECIPHERYWHAB [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisYWHAB 
Mutations
ICGC Data PortalYWHAB 
TCGA Data PortalYWHAB 
Broad Tumor PortalYWHAB
OASIS PortalYWHAB [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICYWHAB  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DYWHAB
Mutations and Diseases : HGMDYWHAB
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaYWHAB
DgiDB (Drug Gene Interaction Database)YWHAB
DoCM (Curated mutations)YWHAB
CIViC (Clinical Interpretations of Variants in Cancer)YWHAB
Cancer3DYWHAB
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM601289   
Orphanet
DisGeNETYWHAB
MedgenYWHAB
Genetic Testing Registry YWHAB
NextProtP31946 [Medical]
GENETestsYWHAB
Target ValidationYWHAB
Huge Navigator YWHAB [HugePedia]
ClinGenYWHAB
Clinical trials, drugs, therapy
MyCancerGenomeYWHAB
Protein Interactions : CTDYWHAB
Pharm GKB GenePA37438
PharosP31946
Clinical trialYWHAB
Miscellaneous
canSAR (ICR)YWHAB
HarmonizomeYWHAB
DataMed IndexYWHAB
Probes
Litterature
PubMed385 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXYWHAB
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Oct 4 15:38:41 CEST 2021

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