Atlas of Genetics and Cytogenetics in Oncology and Haematology


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YWHAB (tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide)

Identity

Other namesGW128
HS1
KCIP-1
YWHAA
HGNC (Hugo) YWHAB
LocusID (NCBI) 7529
Location 20q13.12
Location_base_pair Starts at 43514240 and ends at 43537175 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)YWHAB   12849
Cards
Entrez_Gene (NCBI)YWHAB  7529  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide
GeneCards (Weizmann)YWHAB
Ensembl (Hinxton)ENSG00000166913 [Gene_View]  chr20:43514240-43537175 [Contig_View]  YWHAB [Vega]
ICGC DataPortalENSG00000166913
cBioPortalYWHAB
AceView (NCBI)YWHAB
Genatlas (Paris)YWHAB
WikiGenes7529
SOURCE (Princeton)NM_003404 NM_139323
Genomic and cartography
GoldenPath (UCSC)YWHAB  -  20q13.12   chr20:43514240-43537175 +  20q13.12   [Description]    (hg19-Feb_2009)
EnsemblYWHAB - 20q13.12 [CytoView]
Mapping of homologs : NCBIYWHAB [Mapview]
OMIM601289   
Gene and transcription
Genbank (Entrez)AA845374 AB209759 AB451260 AB451386 AF064847
RefSeq transcript (Entrez)NM_003404 NM_139323
RefSeq genomic (Entrez)AC_000152 NC_000020 NC_018931 NT_011362 NW_001838666 NW_004929418
Consensus coding sequences : CCDS (NCBI)YWHAB
Cluster EST : UnigeneHs.643544 [ NCBI ]
CGAP (NCI)Hs.643544
Alternative Splicing : Fast-db (Paris)GSHG0018774
Alternative Splicing GalleryENSG00000166913
Gene ExpressionYWHAB [ NCBI-GEO ]     YWHAB [ SEEK ]   YWHAB [ MEM ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP31946 (Uniprot)
NextProtP31946  [Medical]
With graphics : InterProP31946
Splice isoforms : SwissVarP31946 (Swissvar)
Domaine pattern : Prosite (Expaxy)1433_1 (PS00796)    1433_2 (PS00797)   
Domains : Interpro (EBI)14-3-3 [organisation]   14-3-3_CS [organisation]   14-3-3_domain [organisation]  
Related proteins : CluSTrP31946
Domain families : Pfam (Sanger)14/03/2003 (PF00244)   
Domain families : Pfam (NCBI)pfam00244   
Domain families : Smart (EMBL)14_3_3 (SM00101)  
DMDM Disease mutations7529
Blocks (Seattle)P31946
PDB (SRS)2BQ0    2C23    4DNK   
PDB (PDBSum)2BQ0    2C23    4DNK   
PDB (IMB)2BQ0    2C23    4DNK   
PDB (RSDB)2BQ0    2C23    4DNK   
Human Protein AtlasENSG00000166913 [gene] [tissue] [antibody] [cell] [cancer]
Peptide AtlasP31946
HPRD03184
IPIIPI00216318   IPI00759832   IPI00383773   IPI00645801   IPI00640721   
Protein Interaction databases
DIP (DOE-UCLA)P31946
IntAct (EBI)P31946
FunCoupENSG00000166913
BioGRIDYWHAB
InParanoidP31946
Interologous Interaction database P31946
IntegromeDBYWHAB
STRING (EMBL)YWHAB
Ontologies - Pathways
Ontology : AmiGOMAPK cascade  activation of MAPKK activity  transcription corepressor activity  protein binding  cytoplasm  cytosol  protein targeting  apoptotic process  epidermal growth factor receptor signaling pathway  small GTPase mediated signal transduction  Ras protein signal transduction  axon guidance  protein C-terminus binding  insulin receptor signaling pathway  fibroblast growth factor receptor signaling pathway  gene expression  RNA metabolic process  mRNA metabolic process  transcriptional repressor complex  enzyme binding  protein domain specific binding  cytoplasmic vesicle membrane  protein complex binding  negative regulation of protein dephosphorylation  hippo signaling cascade  Fc-epsilon receptor signaling pathway  melanosome  histone deacetylase binding  positive regulation of catalytic activity  innate immune response  negative regulation of transcription, DNA-dependent  neurotrophin TRK receptor signaling pathway  perinuclear region of cytoplasm  phosphoserine binding  phosphoprotein binding  cytoplasmic sequestering of protein  protein heterooligomerization  extracellular vesicular exosome  intrinsic apoptotic signaling pathway  positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway  
Ontology : EGO-EBIMAPK cascade  activation of MAPKK activity  transcription corepressor activity  protein binding  cytoplasm  cytosol  protein targeting  apoptotic process  epidermal growth factor receptor signaling pathway  small GTPase mediated signal transduction  Ras protein signal transduction  axon guidance  protein C-terminus binding  insulin receptor signaling pathway  fibroblast growth factor receptor signaling pathway  gene expression  RNA metabolic process  mRNA metabolic process  transcriptional repressor complex  enzyme binding  protein domain specific binding  cytoplasmic vesicle membrane  protein complex binding  negative regulation of protein dephosphorylation  hippo signaling cascade  Fc-epsilon receptor signaling pathway  melanosome  histone deacetylase binding  positive regulation of catalytic activity  innate immune response  negative regulation of transcription, DNA-dependent  neurotrophin TRK receptor signaling pathway  perinuclear region of cytoplasm  phosphoserine binding  phosphoprotein binding  cytoplasmic sequestering of protein  protein heterooligomerization  extracellular vesicular exosome  intrinsic apoptotic signaling pathway  positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway  
Pathways : KEGGCell cycle    Oocyte meiosis    PI3K-Akt signaling pathway    Hippo signaling pathway    Hepatitis B    Epstein-Barr virus infection    Viral carcinogenesis   
Protein Interaction DatabaseYWHAB
Wikipedia pathwaysYWHAB
Gene fusion - rearrangments
Polymorphisms : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)YWHAB
snp3D : Map Gene to Disease7529
SNP (GeneSNP Utah)YWHAB
SNP : HGBaseYWHAB
Genetic variants : HAPMAPYWHAB
Exome VariantYWHAB
1000_GenomesYWHAB 
ICGC programENSG00000166913 
Somatic Mutations in Cancer : COSMICYWHAB 
CONAN: Copy Number AnalysisYWHAB 
Mutations and Diseases : HGMDYWHAB
Genomic VariantsYWHAB  YWHAB [DGVbeta]
dbVarYWHAB
ClinVarYWHAB
Pred. of missensesPolyPhen-2  SIFT(SG)  SIFT(JCVI)  Align-GVGD  MutAssessor  Mutanalyser  
Pred. splicesGeneSplicer  Human Splicing Finder  MaxEntScan  
Diseases
OMIM601289   
MedgenYWHAB
GENETestsYWHAB
Disease Genetic AssociationYWHAB
Huge Navigator YWHAB [HugePedia]  YWHAB [HugeCancerGEM]
General knowledge
Homologs : HomoloGeneYWHAB
Homology/Alignments : Family Browser (UCSC)YWHAB
Phylogenetic Trees/Animal Genes : TreeFamYWHAB
Chemical/Protein Interactions : CTD7529
Chemical/Pharm GKB GenePA37438
Clinical trialYWHAB
Cancer Resource (Charite)ENSG00000166913
Other databases
Probes
Litterature
PubMed232 Pubmed reference(s) in Entrez
CoreMineYWHAB
iHOPYWHAB
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated12-2013Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Fri Jul 11 17:26:18 CEST 2014

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