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YWHAB (tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta)

Identity

Other namesGW128
HEL-S-1
HS1
KCIP-1
YWHAA
HGNC (Hugo) YWHAB
LocusID (NCBI) 7529
Atlas_Id 46599
Location 20q13.12  [Link to chromosome band 20q13]
Location_base_pair Starts at 43514240 and ends at 43537175 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
COL3A1 (2q32.2) / YWHAB (20q13.12)PABPC1L (20q13.12) / YWHAB (20q13.12)SDC4 (20q13.12) / YWHAB (20q13.12)
TSG101 (11p15.1) / YWHAB (20q13.12)YWHAB (20q13.12) / ARHGAP32 (11q24.3)YWHAB (20q13.12) / DZIP1 (13q32.1)
YWHAB (20q13.12) / GJA1 (6q22.31)YWHAB (20q13.12) / SLC29A3 (10q22.1)YWHAB (20q13.12) / YWHAB (20q13.12)
SDC4 20q13.12 / YWHAB 20q13.12YWHAB 20q13.12 / ARHGAP32 11q24.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)YWHAB   12849
Cards
Entrez_Gene (NCBI)YWHAB  7529  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta
AliasesGW128; HEL-S-1; HS1; KCIP-1; 
YWHAA
GeneCards (Weizmann)YWHAB
Ensembl hg19 (Hinxton)ENSG00000166913 [Gene_View]  chr20:43514240-43537175 [Contig_View]  YWHAB [Vega]
Ensembl hg38 (Hinxton)ENSG00000166913 [Gene_View]  chr20:43514240-43537175 [Contig_View]  YWHAB [Vega]
ICGC DataPortalENSG00000166913
TCGA cBioPortalYWHAB
AceView (NCBI)YWHAB
Genatlas (Paris)YWHAB
WikiGenes7529
SOURCE (Princeton)YWHAB
Genomic and cartography
GoldenPath hg19 (UCSC)YWHAB  -     chr20:43514240-43537175 +  20q13.12   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)YWHAB  -     20q13.12   [Description]    (hg38-Dec_2013)
EnsemblYWHAB - 20q13.12 [CytoView hg19]  YWHAB - 20q13.12 [CytoView hg38]
Mapping of homologs : NCBIYWHAB [Mapview hg19]  YWHAB [Mapview hg38]
OMIM601289   
Gene and transcription
Genbank (Entrez)AA845374 AB209759 AB451260 AB451386 AF064847
RefSeq transcript (Entrez)NM_003404 NM_139323
RefSeq genomic (Entrez)NC_000020 NC_018931 NT_011362 NW_004929418
Consensus coding sequences : CCDS (NCBI)YWHAB
Cluster EST : UnigeneHs.643544 [ NCBI ]
CGAP (NCI)Hs.643544
Alternative Splicing GalleryENSG00000166913
Gene ExpressionYWHAB [ NCBI-GEO ]   YWHAB [ EBI - ARRAY_EXPRESS ]   YWHAB [ SEEK ]   YWHAB [ MEM ]
Gene Expression Viewer (FireBrowse)YWHAB [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)7529
GTEX Portal (Tissue expression)YWHAB
Protein : pattern, domain, 3D structure
UniProt/SwissProtP31946 (Uniprot)
NextProtP31946  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP31946
Splice isoforms : SwissVarP31946 (Swissvar)
PhosPhoSitePlusP31946
Domaine pattern : Prosite (Expaxy)1433_1 (PS00796)    1433_2 (PS00797)   
Domains : Interpro (EBI)14-3-3    14-3-3_CS    14-3-3_domain   
Domain families : Pfam (Sanger)3/14/2003 (PF00244)   
Domain families : Pfam (NCBI)pfam00244   
Domain families : Smart (EMBL)14_3_3 (SM00101)  
DMDM Disease mutations7529
Blocks (Seattle)YWHAB
PDB (SRS)2BQ0    2C23    4DNK   
PDB (PDBSum)2BQ0    2C23    4DNK   
PDB (IMB)2BQ0    2C23    4DNK   
PDB (RSDB)2BQ0    2C23    4DNK   
Structural Biology KnowledgeBase2BQ0    2C23    4DNK   
SCOP (Structural Classification of Proteins)2BQ0    2C23    4DNK   
CATH (Classification of proteins structures)2BQ0    2C23    4DNK   
SuperfamilyP31946
Human Protein AtlasENSG00000166913
Peptide AtlasP31946
HPRD03184
IPIIPI00216318   IPI00759832   IPI00383773   IPI00645801   IPI00640721   
Protein Interaction databases
DIP (DOE-UCLA)P31946
IntAct (EBI)P31946
FunCoupENSG00000166913
BioGRIDYWHAB
STRING (EMBL)YWHAB
ZODIACYWHAB
Ontologies - Pathways
QuickGOP31946
Ontology : AmiGOMAPK cascade  transcription corepressor activity  protein binding  nucleus  cytoplasm  mitochondrion  cytosol  focal adhesion  protein targeting  protein C-terminus binding  membrane  viral process  transcriptional repressor complex  enzyme binding  protein domain specific binding  cytoplasmic vesicle membrane  protein complex binding  negative regulation of protein dephosphorylation  hippo signaling  melanosome  histone deacetylase binding  positive regulation of catalytic activity  regulation of mRNA stability  negative regulation of G-protein coupled receptor protein signaling pathway  negative regulation of transcription, DNA-templated  perinuclear region of cytoplasm  phosphoserine binding  phosphoprotein binding  cytoplasmic sequestering of protein  protein heterooligomerization  membrane organization  extracellular exosome  positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway  
Ontology : EGO-EBIMAPK cascade  transcription corepressor activity  protein binding  nucleus  cytoplasm  mitochondrion  cytosol  focal adhesion  protein targeting  protein C-terminus binding  membrane  viral process  transcriptional repressor complex  enzyme binding  protein domain specific binding  cytoplasmic vesicle membrane  protein complex binding  negative regulation of protein dephosphorylation  hippo signaling  melanosome  histone deacetylase binding  positive regulation of catalytic activity  regulation of mRNA stability  negative regulation of G-protein coupled receptor protein signaling pathway  negative regulation of transcription, DNA-templated  perinuclear region of cytoplasm  phosphoserine binding  phosphoprotein binding  cytoplasmic sequestering of protein  protein heterooligomerization  membrane organization  extracellular exosome  positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway  
Pathways : KEGGCell cycle    Oocyte meiosis    PI3K-Akt signaling pathway    Hippo signaling pathway    Hepatitis B    Epstein-Barr virus infection    Viral carcinogenesis   
NDEx Network
Atlas of Cancer Signalling NetworkYWHAB
Wikipedia pathwaysYWHAB
Orthology - Evolution
OrthoDB7529
GeneTree (enSembl)ENSG00000166913
Phylogenetic Trees/Animal Genes : TreeFamYWHAB
Homologs : HomoloGeneYWHAB
Homology/Alignments : Family Browser (UCSC)YWHAB
Gene fusions - Rearrangements
Fusion: TCGASDC4 20q13.12 YWHAB 20q13.12 LUAD
Fusion: TCGAYWHAB 20q13.12 ARHGAP32 11q24.3 BRCA
Polymorphisms : SNP, variants
NCBI Variation ViewerYWHAB [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)YWHAB
dbVarYWHAB
ClinVarYWHAB
1000_GenomesYWHAB 
Exome Variant ServerYWHAB
ExAC (Exome Aggregation Consortium)YWHAB (select the gene name)
Genetic variants : HAPMAP7529
Genomic Variants (DGV)YWHAB [DGVbeta]
Mutations
ICGC Data PortalYWHAB 
TCGA Data PortalYWHAB 
Broad Tumor PortalYWHAB
OASIS PortalYWHAB [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICYWHAB 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch YWHAB
DgiDB (Drug Gene Interaction Database)YWHAB
DoCM (Curated mutations)YWHAB (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)YWHAB (select a term)
intoGenYWHAB
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)20:43514240-43537175  ENSG00000166913
CONAN: Copy Number AnalysisYWHAB 
Mutations and Diseases : HGMDYWHAB
OMIM601289   
MedgenYWHAB
Genetic Testing Registry YWHAB
NextProtP31946 [Medical]
TSGene7529
GENETestsYWHAB
Huge Navigator YWHAB [HugePedia]
snp3D : Map Gene to Disease7529
BioCentury BCIQYWHAB
ClinGenYWHAB
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD7529
Chemical/Pharm GKB GenePA37438
Clinical trialYWHAB
Miscellaneous
canSAR (ICR)YWHAB (select the gene name)
Probes
Litterature
PubMed285 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineYWHAB
EVEXYWHAB
GoPubMedYWHAB
iHOPYWHAB
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Aug 9 19:11:24 CEST 2016

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