Atlas of Genetics and Cytogenetics in Oncology and Haematology


Home   Genes   Leukemias   Solid Tumours   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

YWHAE (tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon)

Identity

Other names14-3-3E
HEL2
KCIP-1
MDCR
MDS
HGNC (Hugo) YWHAE
LocusID (NCBI) 7531
Location 17p13.3
Location_base_pair Starts at 1247834 and ends at 1303556 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas)

Solid Tumors AmeloblastomID5945

External links

Nomenclature
HGNC (Hugo)YWHAE   12851
Cards
Entrez_Gene (NCBI)YWHAE  7531  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon
GeneCards (Weizmann)YWHAE
Ensembl (Hinxton)ENSG00000108953 [Gene_View]  chr17:1247834-1303556 [Contig_View]  YWHAE [Vega]
ICGC DataPortalENSG00000108953
AceView (NCBI)YWHAE
Genatlas (Paris)YWHAE
WikiGenes7531
SOURCE (Princeton)NM_006761
Genomic and cartography
GoldenPath (UCSC)YWHAE  -  17p13.3   chr17:1247834-1303556 -  17p13.3   [Description]    (hg19-Feb_2009)
EnsemblYWHAE - 17p13.3 [CytoView]
Mapping of homologs : NCBIYWHAE [Mapview]
OMIM605066   
Gene and transcription
Genbank (Entrez)AK128785 AK295260 AK295997 AK296050 AK296555
RefSeq transcript (Entrez)NM_006761
RefSeq genomic (Entrez)AC_000149 NC_000017 NC_018928 NG_009233 NT_010718 NT_187613 NW_001838403 NW_004929405
Consensus coding sequences : CCDS (NCBI)YWHAE
Cluster EST : UnigeneHs.513851 [ NCBI ]
CGAP (NCI)Hs.513851
Alternative Splicing : Fast-db (Paris)GSHG0012954
Alternative Splicing GalleryENSG00000108953
Gene ExpressionYWHAE [ NCBI-GEO ]     YWHAE [ SEEK ]   YWHAE [ MEM ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP62258 (Uniprot)
NextProtP62258  [Medical]
With graphics : InterProP62258
Splice isoforms : SwissVarP62258 (Swissvar)
Domaine pattern : Prosite (Expaxy)1433_1 (PS00796)    1433_2 (PS00797)   
Domains : Interpro (EBI)14-3-3    14-3-3_CS    14-3-3_domain   
Related proteins : CluSTrP62258
Domain families : Pfam (Sanger)14-3-3 (PF00244)   
Domain families : Pfam (NCBI)pfam00244   
Domain families : Smart (EMBL)14_3_3 (SM00101)  
DMDM Disease mutations7531
Blocks (Seattle)P62258
PDB (SRS)2BR9    3UAL    3UBW   
PDB (PDBSum)2BR9    3UAL    3UBW   
PDB (IMB)2BR9    3UAL    3UBW   
PDB (RSDB)2BR9    3UAL    3UBW   
Human Protein AtlasENSG00000108953
Peptide AtlasP62258
HPRD05457
IPIIPI00000816   IPI00974544   
Protein Interaction databases
DIP (DOE-UCLA)P62258
IntAct (EBI)P62258
FunCoupENSG00000108953
BioGRIDYWHAE
IntegromeDBYWHAE
STRING (EMBL)YWHAE
Ontologies - Pathways
QuickGOP62258
Ontology : AmiGOG2/M transition of mitotic cell cycle  mitotic cell cycle  neuron migration  regulation of heart rate by hormone  protein binding  mitochondrion  cytosol  kinesin complex  protein targeting  apoptotic process  potassium channel regulator activity  membrane  viral process  enzyme binding  protein domain specific binding  substantia nigra development  hippocampus development  cerebral cortex development  MHC class II protein complex binding  cytoplasmic vesicle membrane  hippo signaling  intracellular signal transduction  melanosome  histone deacetylase binding  regulation of cysteine-type endopeptidase activity involved in apoptotic process  ion channel binding  poly(A) RNA binding  protein heterodimerization activity  neurotrophin TRK receptor signaling pathway  phosphoserine binding  phosphoprotein binding  regulation of membrane repolarization  membrane organization  extracellular vesicular exosome  membrane repolarization during cardiac muscle cell action potential  regulation of heart rate by cardiac conduction  apoptotic signaling pathway  intrinsic apoptotic signaling pathway  positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway  regulation of potassium ion transmembrane transporter activity  negative regulation of peptidyl-serine dephosphorylation  
Ontology : EGO-EBIG2/M transition of mitotic cell cycle  mitotic cell cycle  neuron migration  regulation of heart rate by hormone  protein binding  mitochondrion  cytosol  kinesin complex  protein targeting  apoptotic process  potassium channel regulator activity  membrane  viral process  enzyme binding  protein domain specific binding  substantia nigra development  hippocampus development  cerebral cortex development  MHC class II protein complex binding  cytoplasmic vesicle membrane  hippo signaling  intracellular signal transduction  melanosome  histone deacetylase binding  regulation of cysteine-type endopeptidase activity involved in apoptotic process  ion channel binding  poly(A) RNA binding  protein heterodimerization activity  neurotrophin TRK receptor signaling pathway  phosphoserine binding  phosphoprotein binding  regulation of membrane repolarization  membrane organization  extracellular vesicular exosome  membrane repolarization during cardiac muscle cell action potential  regulation of heart rate by cardiac conduction  apoptotic signaling pathway  intrinsic apoptotic signaling pathway  positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway  regulation of potassium ion transmembrane transporter activity  negative regulation of peptidyl-serine dephosphorylation  
Pathways : KEGGCell cycle    Oocyte meiosis    PI3K-Akt signaling pathway    Hippo signaling pathway    Neurotrophin signaling pathway    Epstein-Barr virus infection    Viral carcinogenesis   
Protein Interaction DatabaseYWHAE
Wikipedia pathwaysYWHAE
Gene fusion - rearrangments
Rearrangement : COSMICYWHAE [17p13.3]  -  FAM22B [1249]
Polymorphisms : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)YWHAE
SNP (GeneSNP Utah)YWHAE
SNP : HGBaseYWHAE
Genetic variants : HAPMAPYWHAE
1000_GenomesYWHAE 
ICGC programENSG00000108953 
Cancer Gene: CensusYWHAE 
CONAN: Copy Number AnalysisYWHAE 
Somatic Mutations in Cancer : COSMICYWHAE 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
DECIPHER (Syndromes)17:1247834-1303556
Mutations and Diseases : HGMDYWHAE
OMIM605066   
MedgenYWHAE
GENETestsYWHAE
Disease Genetic AssociationYWHAE
Huge Navigator YWHAE [HugePedia]  YWHAE [HugeCancerGEM]
Genomic VariantsYWHAE  YWHAE [DGVbeta]
Exome VariantYWHAE
dbVarYWHAE
ClinVarYWHAE
snp3D : Map Gene to Disease7531
General knowledge
Homologs : HomoloGeneYWHAE
Homology/Alignments : Family Browser (UCSC)YWHAE
Phylogenetic Trees/Animal Genes : TreeFamYWHAE
Chemical/Protein Interactions : CTD7531
Chemical/Pharm GKB GenePA37440
Clinical trialYWHAE
Cancer Resource (Charite)ENSG00000108953
Other databases
Probes
Litterature
PubMed241 Pubmed reference(s) in Entrez
CoreMineYWHAE
GoPubMedYWHAE
iHOPYWHAE
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated12-2013Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Sat Nov 8 18:06:13 CET 2014

Home   Genes   Leukemias   Solid Tumours   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.