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YWHAE (tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide)

Identity

Other names14-3-3E
KCIP-1
MDCR
MDS
HGNC (Hugo) YWHAE
LocusID (NCBI) 7531
Location 17p13.3
Location_base_pair Starts at 1247834 and ends at 1303556 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)YWHAE   12851
Cards
Entrez_Gene (NCBI)YWHAE  7531  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide
GeneCards (Weizmann)YWHAE
Ensembl (Hinxton)ENSG00000108953 [Gene_View]  chr17:1247834-1303556 [Contig_View]  YWHAE [Vega]
AceView (NCBI)YWHAE
Genatlas (Paris)YWHAE
WikiGenes7531
SOURCE (Princeton)NM_006761
Genomic and cartography
GoldenPath (UCSC)YWHAE  -  17p13.3   chr17:1247834-1303556 -  17p13.3   [Description]    (hg19-Feb_2009)
EnsemblYWHAE - 17p13.3 [CytoView]
Mapping of homologs : NCBIYWHAE [Mapview]
OMIM247200   605066   
Gene and transcription
Genbank (Entrez)AK128785 AK295260 AK295997 AK296050 AK296555
RefSeq transcript (Entrez)NM_006761
RefSeq genomic (Entrez)AC_000149 NC_000017 NC_018928 NG_009233 NT_010718 NW_001838403 NW_004929405
Consensus coding sequences : CCDS (NCBI)YWHAE
Cluster EST : UnigeneHs.513851 [ NCBI ]
CGAP (NCI)Hs.513851
Alternative Splicing : Fast-db (Paris)GSHG0012954
Alternative Splicing GalleryENSG00000108953
Gene ExpressionYWHAE [ NCBI-GEO ]     YWHAE [ SEEK ]   YWHAE [ MEM ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP62258 (Uniprot)
NextProtP62258  [Medical]
With graphics : InterProP62258
Splice isoforms : SwissVarP62258 (Swissvar)
Domaine pattern : Prosite (Expaxy)1433_1 (PS00796)    1433_2 (PS00797)   
Domains : Interpro (EBI)14-3-3    14-3-3_CS    14-3-3_domain   
Related proteins : CluSTrP62258
Domain families : Pfam (Sanger)14/03/03 (PF00244)   
Domain families : Pfam (NCBI)pfam00244   
Domain families : Smart (EMBL)14_3_3 (SM00101)  
DMDM Disease mutations7531
Blocks (Seattle)P62258
PDB (SRS)2BR9    3UAL    3UBW   
PDB (PDBSum)2BR9    3UAL    3UBW   
PDB (IMB)2BR9    3UAL    3UBW   
PDB (RSDB)2BR9    3UAL    3UBW   
Human Protein AtlasENSG00000108953
Peptide AtlasP62258
HPRD05457
IPIIPI00000816   IPI00974544   
Protein Interaction databases
DIP (DOE-UCLA)P62258
IntAct (EBI)P62258
FunCoupENSG00000108953
BioGRIDYWHAE
InParanoidP62258
Interologous Interaction database P62258
IntegromeDBYWHAE
STRING (EMBL)YWHAE
Ontologies - Pathways
Ontology : AmiGOG2/M transition of mitotic cell cycle  mitotic cell cycle  neuron migration  regulation of heart rate by hormone  protein binding  mitochondrion  cytosol  kinesin complex  protein targeting  apoptotic process  potassium channel regulator activity  modulation by virus of host morphology or physiology  enzyme binding  protein domain specific binding  hippocampus development  cerebral cortex development  cytoplasmic vesicle membrane  protein complex binding  hippo signaling cascade  intracellular signal transduction  melanosome  histone deacetylase binding  regulation of cysteine-type endopeptidase activity involved in apoptotic process  ion channel binding  protein heterodimerization activity  neurotrophin TRK receptor signaling pathway  phosphoserine binding  phosphoprotein binding  regulation of membrane repolarization  extracellular vesicular exosome  membrane repolarization involved in regulation of cardiac muscle cell action potential  regulation of heart rate by cardiac conduction  apoptotic signaling pathway  intrinsic apoptotic signaling pathway  positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway  regulation of potassium ion transmembrane transporter activity  negative regulation of peptidyl-serine dephosphorylation  
Ontology : EGO-EBIG2/M transition of mitotic cell cycle  mitotic cell cycle  neuron migration  regulation of heart rate by hormone  protein binding  mitochondrion  cytosol  kinesin complex  protein targeting  apoptotic process  potassium channel regulator activity  modulation by virus of host morphology or physiology  enzyme binding  protein domain specific binding  hippocampus development  cerebral cortex development  cytoplasmic vesicle membrane  protein complex binding  hippo signaling cascade  intracellular signal transduction  melanosome  histone deacetylase binding  regulation of cysteine-type endopeptidase activity involved in apoptotic process  ion channel binding  protein heterodimerization activity  neurotrophin TRK receptor signaling pathway  phosphoserine binding  phosphoprotein binding  regulation of membrane repolarization  extracellular vesicular exosome  membrane repolarization involved in regulation of cardiac muscle cell action potential  regulation of heart rate by cardiac conduction  apoptotic signaling pathway  intrinsic apoptotic signaling pathway  positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway  regulation of potassium ion transmembrane transporter activity  negative regulation of peptidyl-serine dephosphorylation  
Pathways : KEGGCell cycle    Oocyte meiosis    PI3K-Akt signaling pathway    Hippo signaling pathway    Neurotrophin signaling pathway    Epstein-Barr virus infection    Viral carcinogenesis   
REACTOMEYWHAE
Protein Interaction DatabaseYWHAE
Wikipedia pathwaysYWHAE
Gene fusion - rearrangments
Rearrangement : COSMICYWHAE [17p13.3]  -  FAM22A []
Rearrangement : COSMICYWHAE [17p13.3]  -  FAM22B []
Polymorphisms : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)YWHAE
SNP (GeneSNP Utah)YWHAE
SNP : HGBaseYWHAE
Genetic variants : HAPMAPYWHAE
1000_GenomesYWHAE 
ICGC programENSG00000108953 
Cancer Gene: CensusYWHAE 
Somatic Mutations in Cancer : COSMICYWHAE 
CONAN: Copy Number AnalysisYWHAE 
Mutations and Diseases : HGMDYWHAE
OMIM247200    605066   
GENETestsYWHAE
Disease Genetic AssociationYWHAE
Huge Navigator YWHAE [HugePedia]  YWHAE [HugeCancerGEM]
Genomic VariantsYWHAE  YWHAE [DGVbeta]
Exome VariantYWHAE
dbVarYWHAE
ClinVarYWHAE
snp3D : Map Gene to Disease7531
General knowledge
Homologs : HomoloGeneYWHAE
Homology/Alignments : Family Browser (UCSC)YWHAE
Phylogenetic Trees/Animal Genes : TreeFamYWHAE
Chemical/Protein Interactions : CTD7531
Chemical/Pharm GKB GenePA37440
Clinical trialYWHAE
Cancer Resource (Charite)ENSG00000108953
Other databases
Probes
Litterature
PubMed226 Pubmed reference(s) in Entrez
CoreMineYWHAE
iHOPYWHAE
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated12-2013Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Fri Apr 18 17:05:23 CEST 2014

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