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YWHAG (tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma)

Identity

Alias_namestyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein
Alias_symbol (synonym)PPP1R170
Other alias14-3-3GAMMA
HGNC (Hugo) YWHAG
LocusID (NCBI) 7532
Atlas_Id 46119
Location 7q11.23  [Link to chromosome band 7q11]
Location_base_pair Starts at 76326791 and ends at 76359025 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
BCYRN1 (Xq13.1) / YWHAG (7q11.23)EIF4G2 (11p15.3) / YWHAG (7q11.23)FN1 (2q35) / YWHAG (7q11.23)
RCHY1 (4q21.1) / YWHAG (7q11.23)SERPINF1 (17p13.3) / YWHAG (7q11.23)YWHAG (7q11.23) / CYB561 (17q23.3)
YWHAG (7q11.23) / CYB561A3 (11q12.2)YWHAG (7q11.23) / LOC100507412 (-)YWHAG (7q11.23) / PDIA3 (15q15.3)
YWHAG (7q11.23) / RAB11FIP1 (8p11.23)YWHAG (7q11.23) / YWHAG (7q11.23)YWHAG 7q11.23 / RAB11FIP1 8p11.23

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)YWHAG   12852
Cards
Entrez_Gene (NCBI)YWHAG  7532  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma
Aliases14-3-3GAMMA; PPP1R170
GeneCards (Weizmann)YWHAG
Ensembl hg19 (Hinxton)ENSG00000170027 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000170027 [Gene_View]  chr7:76326791-76359025 [Contig_View]  YWHAG [Vega]
ICGC DataPortalENSG00000170027
TCGA cBioPortalYWHAG
AceView (NCBI)YWHAG
Genatlas (Paris)YWHAG
WikiGenes7532
SOURCE (Princeton)YWHAG
Genetics Home Reference (NIH)YWHAG
Genomic and cartography
GoldenPath hg38 (UCSC)YWHAG  -     chr7:76326791-76359025 -  7q11.23   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)YWHAG  -     7q11.23   [Description]    (hg19-Feb_2009)
EnsemblYWHAG - 7q11.23 [CytoView hg19]  YWHAG - 7q11.23 [CytoView hg38]
Mapping of homologs : NCBIYWHAG [Mapview hg19]  YWHAG [Mapview hg38]
OMIM605356   
Gene and transcription
Genbank (Entrez)AB024334 AF142498 AK024230 AK293505 AK295029
RefSeq transcript (Entrez)NM_012479
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)YWHAG
Cluster EST : UnigeneHs.744840 [ NCBI ]
CGAP (NCI)Hs.744840
Alternative Splicing GalleryENSG00000170027
Gene ExpressionYWHAG [ NCBI-GEO ]   YWHAG [ EBI - ARRAY_EXPRESS ]   YWHAG [ SEEK ]   YWHAG [ MEM ]
Gene Expression Viewer (FireBrowse)YWHAG [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)7532
GTEX Portal (Tissue expression)YWHAG
Protein : pattern, domain, 3D structure
UniProt/SwissProtP61981   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP61981  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP61981
Splice isoforms : SwissVarP61981
PhosPhoSitePlusP61981
Domaine pattern : Prosite (Expaxy)1433_1 (PS00796)    1433_2 (PS00797)   
Domains : Interpro (EBI)14-3-3    14-3-3_CS    14-3-3_domain   
Domain families : Pfam (Sanger)14-3-3 (PF00244)   
Domain families : Pfam (NCBI)pfam00244   
Domain families : Smart (EMBL)14_3_3 (SM00101)  
Conserved Domain (NCBI)YWHAG
DMDM Disease mutations7532
Blocks (Seattle)YWHAG
PDB (SRS)2B05    3UZD    4E2E    4J6S    4O46    5D3E   
PDB (PDBSum)2B05    3UZD    4E2E    4J6S    4O46    5D3E   
PDB (IMB)2B05    3UZD    4E2E    4J6S    4O46    5D3E   
PDB (RSDB)2B05    3UZD    4E2E    4J6S    4O46    5D3E   
Structural Biology KnowledgeBase2B05    3UZD    4E2E    4J6S    4O46    5D3E   
SCOP (Structural Classification of Proteins)2B05    3UZD    4E2E    4J6S    4O46    5D3E   
CATH (Classification of proteins structures)2B05    3UZD    4E2E    4J6S    4O46    5D3E   
SuperfamilyP61981
Human Protein AtlasENSG00000170027
Peptide AtlasP61981
HPRD05639
IPIIPI00220642   IPI00910779   IPI01014209   
Protein Interaction databases
DIP (DOE-UCLA)P61981
IntAct (EBI)P61981
FunCoupENSG00000170027
BioGRIDYWHAG
STRING (EMBL)YWHAG
ZODIACYWHAG
Ontologies - Pathways
QuickGOP61981
Ontology : AmiGOG2/M transition of mitotic cell cycle  RNA binding  protein kinase C binding  insulin-like growth factor receptor binding  protein binding  mitochondrion  cytosol  focal adhesion  negative regulation of protein kinase activity  protein targeting  protein kinase C inhibitor activity  regulation of signal transduction  membrane  protein domain specific binding  cytoplasmic vesicle membrane  receptor tyrosine kinase binding  cellular response to insulin stimulus  myelin sheath  regulation of neuron differentiation  regulation of synaptic plasticity  membrane organization  extracellular exosome  negative regulation of protein serine/threonine kinase activity  ciliary basal body docking  positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway  
Ontology : EGO-EBIG2/M transition of mitotic cell cycle  RNA binding  protein kinase C binding  insulin-like growth factor receptor binding  protein binding  mitochondrion  cytosol  focal adhesion  negative regulation of protein kinase activity  protein targeting  protein kinase C inhibitor activity  regulation of signal transduction  membrane  protein domain specific binding  cytoplasmic vesicle membrane  receptor tyrosine kinase binding  cellular response to insulin stimulus  myelin sheath  regulation of neuron differentiation  regulation of synaptic plasticity  membrane organization  extracellular exosome  negative regulation of protein serine/threonine kinase activity  ciliary basal body docking  positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway  
Pathways : KEGGCell cycle    Oocyte meiosis    PI3K-Akt signaling pathway    Hippo signaling pathway    Epstein-Barr virus infection    Viral carcinogenesis   
NDEx NetworkYWHAG
Atlas of Cancer Signalling NetworkYWHAG
Wikipedia pathwaysYWHAG
Orthology - Evolution
OrthoDB7532
GeneTree (enSembl)ENSG00000170027
Phylogenetic Trees/Animal Genes : TreeFamYWHAG
HOVERGENP61981
HOGENOMP61981
Homologs : HomoloGeneYWHAG
Homology/Alignments : Family Browser (UCSC)YWHAG
Gene fusions - Rearrangements
Fusion : MitelmanYWHAG/CYB561 [7q11.23/17q23.3]  
Fusion : MitelmanYWHAG/PDIA3 [7q11.23/15q15.3]  [t(7;15)(q11;q15)]  
Fusion : MitelmanYWHAG/RAB11FIP1 [7q11.23/8p11.23]  [t(7;8)(q11;p11)]  
Fusion: TCGAYWHAG 7q11.23 RAB11FIP1 8p11.23 OV
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerYWHAG [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)YWHAG
dbVarYWHAG
ClinVarYWHAG
1000_GenomesYWHAG 
Exome Variant ServerYWHAG
ExAC (Exome Aggregation Consortium)YWHAG (select the gene name)
Genetic variants : HAPMAP7532
Genomic Variants (DGV)YWHAG [DGVbeta]
DECIPHERYWHAG [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisYWHAG 
Mutations
ICGC Data PortalYWHAG 
TCGA Data PortalYWHAG 
Broad Tumor PortalYWHAG
OASIS PortalYWHAG [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICYWHAG  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDYWHAG
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch YWHAG
DgiDB (Drug Gene Interaction Database)YWHAG
DoCM (Curated mutations)YWHAG (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)YWHAG (select a term)
intoGenYWHAG
Cancer3DYWHAG(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM605356   
Orphanet
MedgenYWHAG
Genetic Testing Registry YWHAG
NextProtP61981 [Medical]
TSGene7532
GENETestsYWHAG
Huge Navigator YWHAG [HugePedia]
snp3D : Map Gene to Disease7532
BioCentury BCIQYWHAG
ClinGenYWHAG
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD7532
Chemical/Pharm GKB GenePA37441
Clinical trialYWHAG
Miscellaneous
canSAR (ICR)YWHAG (select the gene name)
Probes
Litterature
PubMed199 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineYWHAG
EVEXYWHAG
GoPubMedYWHAG
iHOPYWHAG
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Fri May 19 12:44:28 CEST 2017

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