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YWHAH (tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide)

Identity

Other namesYWHA1
HGNC (Hugo) YWHAH
LocusID (NCBI) 7533
Location 22q12.3
Location_base_pair Starts at 32340479 and ends at 32353590 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)YWHAH   12853
Cards
Entrez_Gene (NCBI)YWHAH  7533  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide
GeneCards (Weizmann)YWHAH
Ensembl (Hinxton)ENSG00000128245 [Gene_View]  chr22:32340479-32353590 [Contig_View]  YWHAH [Vega]
AceView (NCBI)YWHAH
Genatlas (Paris)YWHAH
WikiGenes7533
SOURCE (Princeton)NM_003405
Genomic and cartography
GoldenPath (UCSC)YWHAH  -  22q12.3   chr22:32340479-32353590 +  22q12.3   [Description]    (hg19-Feb_2009)
EnsemblYWHAH - 22q12.3 [CytoView]
Mapping of homologs : NCBIYWHAH [Mapview]
OMIM113508   
Gene and transcription
Genbank (Entrez)AK312650 AY007132 BC003047 CR456612 CU013208
RefSeq transcript (Entrez)NM_003405
RefSeq genomic (Entrez)AC_000154 NC_000022 NC_018933 NT_011520 NW_001838745 NW_004929430
Consensus coding sequences : CCDS (NCBI)YWHAH
Cluster EST : UnigeneHs.226755 [ NCBI ]
CGAP (NCI)Hs.226755
Alternative Splicing : Fast-db (Paris)GSHG0019965
Alternative Splicing GalleryENSG00000128245
Gene ExpressionYWHAH [ NCBI-GEO ]     YWHAH [ SEEK ]   YWHAH [ MEM ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ04917 (Uniprot)
NextProtQ04917  [Medical]
With graphics : InterProQ04917
Splice isoforms : SwissVarQ04917 (Swissvar)
Domaine pattern : Prosite (Expaxy)1433_1 (PS00796)    1433_2 (PS00797)   
Domains : Interpro (EBI)14-3-3    14-3-3_CS    14-3-3_domain   
Related proteins : CluSTrQ04917
Domain families : Pfam (Sanger)14/03/03 (PF00244)   
Domain families : Pfam (NCBI)pfam00244   
Domain families : Smart (EMBL)14_3_3 (SM00101)  
DMDM Disease mutations7533
Blocks (Seattle)Q04917
PDB (SRS)2C63    2C74   
PDB (PDBSum)2C63    2C74   
PDB (IMB)2C63    2C74   
PDB (RSDB)2C63    2C74   
Human Protein AtlasENSG00000128245
Peptide AtlasQ04917
HPRD00215
IPIIPI00216319   IPI00827595   IPI00794254   IPI00879350   
Protein Interaction databases
DIP (DOE-UCLA)Q04917
IntAct (EBI)Q04917
FunCoupENSG00000128245
BioGRIDYWHAH
InParanoidQ04917
Interologous Interaction database Q04917
IntegromeDBYWHAH
STRING (EMBL)YWHAH
Ontologies - Pathways
Ontology : AmiGOregulation of sodium ion transport  actin binding  insulin-like growth factor receptor binding  protein binding  cytoplasm  cytosol  plasma membrane  glucocorticoid catabolic process  intracellular protein transport  apoptotic process  intercalated disc  sodium channel regulator activity  enzyme binding  protein domain specific binding  cytoplasmic vesicle membrane  glucocorticoid receptor binding  glucocorticoid receptor signaling pathway  ion channel binding  regulation of neuron differentiation  positive regulation of transcription, DNA-dependent  protein heterodimerization activity  regulation of synaptic plasticity  negative regulation of dendrite morphogenesis  extracellular vesicular exosome  membrane depolarization involved in regulation of action potential  intrinsic apoptotic signaling pathway  positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway  regulation of sodium ion transmembrane transporter activity  
Ontology : EGO-EBIregulation of sodium ion transport  actin binding  insulin-like growth factor receptor binding  protein binding  cytoplasm  cytosol  plasma membrane  glucocorticoid catabolic process  intracellular protein transport  apoptotic process  intercalated disc  sodium channel regulator activity  enzyme binding  protein domain specific binding  cytoplasmic vesicle membrane  glucocorticoid receptor binding  glucocorticoid receptor signaling pathway  ion channel binding  regulation of neuron differentiation  positive regulation of transcription, DNA-dependent  protein heterodimerization activity  regulation of synaptic plasticity  negative regulation of dendrite morphogenesis  extracellular vesicular exosome  membrane depolarization involved in regulation of action potential  intrinsic apoptotic signaling pathway  positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway  regulation of sodium ion transmembrane transporter activity  
Pathways : BIOCARTAcdc25 and chk1 Regulatory Pathway in response to DNA damage [Genes]    AKT Signaling Pathway [Genes]    Control of skeletal myogenesis by HDAC & calcium/calmodulin-dependent kinase (CaMK) [Genes]    Regulation of PGC-1a [Genes]    Signal Dependent Regulation of Myogenesis by Corepressor MITR [Genes]    RB Tumor Suppressor/Checkpoint Signaling in response to DNA damage [Genes]    Role of nicotinic acetylcholine receptors in the regulation of apoptosis [Genes]    Cell Cycle: G2/M Checkpoint [Genes]    Regulation of BAD phosphorylation [Genes]    Multiple antiapoptotic pathways from IGF-1R signaling lead to BAD phosphorylation [Genes]    Regulation of cell cycle progression by Plk3 [Genes]   
Pathways : KEGGCell cycle    Oocyte meiosis    PI3K-Akt signaling pathway    Hippo signaling pathway    Epstein-Barr virus infection    Viral carcinogenesis   
REACTOMEYWHAH
Protein Interaction DatabaseYWHAH
Wikipedia pathwaysYWHAH
Gene fusion - rearrangments
Polymorphisms : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)YWHAH
SNP (GeneSNP Utah)YWHAH
SNP : HGBaseYWHAH
Genetic variants : HAPMAPYWHAH
1000_GenomesYWHAH 
ICGC programENSG00000128245 
Somatic Mutations in Cancer : COSMICYWHAH 
CONAN: Copy Number AnalysisYWHAH 
Mutations and Diseases : HGMDYWHAH
OMIM113508   
GENETestsYWHAH
Disease Genetic AssociationYWHAH
Huge Navigator YWHAH [HugePedia]  YWHAH [HugeCancerGEM]
Genomic VariantsYWHAH  YWHAH [DGVbeta]
Exome VariantYWHAH
dbVarYWHAH
ClinVarYWHAH
snp3D : Map Gene to Disease7533
General knowledge
Homologs : HomoloGeneYWHAH
Homology/Alignments : Family Browser (UCSC)YWHAH
Phylogenetic Trees/Animal Genes : TreeFamYWHAH
Chemical/Protein Interactions : CTD7533
Chemical/Pharm GKB GenePA37442
Clinical trialYWHAH
Cancer Resource (Charite)ENSG00000128245
Other databases
Probes
Litterature
PubMed141 Pubmed reference(s) in Entrez
CoreMineYWHAH
iHOPYWHAH
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated12-2013Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Fri Apr 18 17:05:31 CEST 2014

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