Atlas of Genetics and Cytogenetics in Oncology and Haematology

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YWHAQ (tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta)

Identity

Alias (NCBI)14-3-3
1C5
HS1
HGNC (Hugo) YWHAQ
HGNC Alias symbHS1
14-3-3
HGNC Alias nameprotein tau
 14-3-3 theta
HGNC Previous nametyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide
 protein, theta
LocusID (NCBI) 10971
Atlas_Id 49987
Location 2p25.1  [Link to chromosome band 2p25]
Location_base_pair Starts at 9583967 and ends at 9630997 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ADAM17 (2p25.1) / YWHAQ (2p25.1)YWHAQ (2p25.1) / AKIRIN1 (1p34.3)YWHAQ (2p25.1) / DDX5 (17q23.3)
YWHAQ (2p25.1) / ENPP3 (6q23.2)YWHAQ (2p25.1) / SFRP1 (8p11.21)YWHAQ (2p25.1) / TDG (12q23.3)
ADAM17 2p25.1 / YWHAQ 2p25.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

 

Nomenclature
HGNC (Hugo)YWHAQ   12854
Cards
Entrez_Gene (NCBI)YWHAQ    tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta
Aliases14-3-3; 1C5; HS1
GeneCards (Weizmann)YWHAQ
Ensembl hg19 (Hinxton)ENSG00000134308 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000134308 [Gene_View]  ENSG00000134308 [Sequence]  chr2:9583967-9630997 [Contig_View]  YWHAQ [Vega]
ICGC DataPortalENSG00000134308
TCGA cBioPortalYWHAQ
AceView (NCBI)YWHAQ
Genatlas (Paris)YWHAQ
SOURCE (Princeton)YWHAQ
Genetics Home Reference (NIH)YWHAQ
Genomic and cartography
GoldenPath hg38 (UCSC)YWHAQ  -     chr2:9583967-9630997 -  2p25.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)YWHAQ  -     2p25.1   [Description]    (hg19-Feb_2009)
GoldenPathYWHAQ - 2p25.1 [CytoView hg19]  YWHAQ - 2p25.1 [CytoView hg38]
ImmunoBaseENSG00000134308
Genome Data Viewer NCBIYWHAQ [Mapview hg19]  
OMIM609009   
Gene and transcription
Genbank (Entrez)AA729400 AF070556 AK297624 AK302208 AK309462
RefSeq transcript (Entrez)NM_006826
Consensus coding sequences : CCDS (NCBI)YWHAQ
Gene ExpressionYWHAQ [ NCBI-GEO ]   YWHAQ [ EBI - ARRAY_EXPRESS ]   YWHAQ [ SEEK ]   YWHAQ [ MEM ]
Gene Expression Viewer (FireBrowse)YWHAQ [ Firebrowse - Broad ]
GenevisibleExpression of YWHAQ in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)10971
GTEX Portal (Tissue expression)YWHAQ
Human Protein AtlasENSG00000134308-YWHAQ [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP27348   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP27348  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP27348
PhosPhoSitePlusP27348
Domaine pattern : Prosite (Expaxy)1433_1 (PS00796)    1433_2 (PS00797)   
Domains : Interpro (EBI)14-3-3    14-3-3_CS    14-3-3_dom_sf    14-3-3_domain    14-3-3_theta   
Domain families : Pfam (Sanger)14-3-3 (PF00244)   
Domain families : Pfam (NCBI)pfam00244   
Domain families : Smart (EMBL)14_3_3 (SM00101)  
Conserved Domain (NCBI)YWHAQ
PDB (RSDB)2BTP    5IQP    6BCR    6BD2    6BQT    6KZG    6KZH   
PDB Europe2BTP    5IQP    6BCR    6BD2    6BQT    6KZG    6KZH   
PDB (PDBSum)2BTP    5IQP    6BCR    6BD2    6BQT    6KZG    6KZH   
PDB (IMB)2BTP    5IQP    6BCR    6BD2    6BQT    6KZG    6KZH   
Structural Biology KnowledgeBase2BTP    5IQP    6BCR    6BD2    6BQT    6KZG    6KZH   
SCOP (Structural Classification of Proteins)2BTP    5IQP    6BCR    6BD2    6BQT    6KZG    6KZH   
CATH (Classification of proteins structures)2BTP    5IQP    6BCR    6BD2    6BQT    6KZG    6KZH   
SuperfamilyP27348
AlphaFold pdb e-kbP27348   
Human Protein Atlas [tissue]ENSG00000134308-YWHAQ [tissue]
HPRD00886
Protein Interaction databases
DIP (DOE-UCLA)P27348
IntAct (EBI)P27348
BioGRIDYWHAQ
STRING (EMBL)YWHAQ
ZODIACYWHAQ
Ontologies - Pathways
QuickGOP27348
Ontology : AmiGOprotein binding  cytoplasm  mitochondrion  cytosol  focal adhesion  protein targeting  small GTPase mediated signal transduction  protein C-terminus binding  membrane  protein domain specific binding  substantia nigra development  protein-containing complex  negative regulation of ion transmembrane transport  identical protein binding  ion channel binding  synapse  negative regulation of transcription, DNA-templated  protein N-terminus binding  extracellular exosome  14-3-3 protein binding  positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway  
Ontology : EGO-EBIprotein binding  cytoplasm  mitochondrion  cytosol  focal adhesion  protein targeting  small GTPase mediated signal transduction  protein C-terminus binding  membrane  protein domain specific binding  substantia nigra development  protein-containing complex  negative regulation of ion transmembrane transport  identical protein binding  ion channel binding  synapse  negative regulation of transcription, DNA-templated  protein N-terminus binding  extracellular exosome  14-3-3 protein binding  positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway  
Pathways : BIOCARTACell Cycle: G2/M Checkpoint [Genes]   
Pathways : KEGGCell cycle    Oocyte meiosis    PI3K-Akt signaling pathway    Hippo signaling pathway    Pathogenic Escherichia coli infection    Hepatitis B    Epstein-Barr virus infection    Viral carcinogenesis   
NDEx NetworkYWHAQ
Atlas of Cancer Signalling NetworkYWHAQ
Wikipedia pathwaysYWHAQ
Orthology - Evolution
OrthoDB10971
GeneTree (enSembl)ENSG00000134308
Phylogenetic Trees/Animal Genes : TreeFamYWHAQ
Homologs : HomoloGeneYWHAQ
Homology/Alignments : Family Browser (UCSC)YWHAQ
Gene fusions - Rearrangements
Fusion : MitelmanADAM17/YWHAQ [2p25.1/2p25.1]  
Fusion : QuiverYWHAQ
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerYWHAQ [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)YWHAQ
dbVarYWHAQ
ClinVarYWHAQ
MonarchYWHAQ
1000_GenomesYWHAQ 
Exome Variant ServerYWHAQ
GNOMAD BrowserENSG00000134308
Varsome BrowserYWHAQ
ACMGYWHAQ variants
VarityP27348
Genomic Variants (DGV)YWHAQ [DGVbeta]
DECIPHERYWHAQ [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisYWHAQ 
Mutations
ICGC Data PortalYWHAQ 
TCGA Data PortalYWHAQ 
Broad Tumor PortalYWHAQ
OASIS PortalYWHAQ [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICYWHAQ  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DYWHAQ
Mutations and Diseases : HGMDYWHAQ
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaYWHAQ
DgiDB (Drug Gene Interaction Database)YWHAQ
DoCM (Curated mutations)YWHAQ
CIViC (Clinical Interpretations of Variants in Cancer)YWHAQ
Cancer3DYWHAQ
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM609009   
Orphanet
DisGeNETYWHAQ
MedgenYWHAQ
Genetic Testing Registry YWHAQ
NextProtP27348 [Medical]
GENETestsYWHAQ
Target ValidationYWHAQ
Huge Navigator YWHAQ [HugePedia]
ClinGenYWHAQ
Clinical trials, drugs, therapy
MyCancerGenomeYWHAQ
Protein Interactions : CTDYWHAQ
Pharm GKB GenePA37443
PharosP27348
Clinical trialYWHAQ
Miscellaneous
canSAR (ICR)YWHAQ
HarmonizomeYWHAQ
DataMed IndexYWHAQ
Probes
Litterature
PubMed430 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXYWHAQ
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Mon Oct 4 15:38:42 CEST 2021
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