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YWHAZ (tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta)

Identity

Other names14-3-3-zeta
HEL-S-3
HEL4
KCIP-1
YWHAD
HGNC (Hugo) YWHAZ
LocusID (NCBI) 7534
Location 8q22.3
Location_base_pair Starts at 101930804 and ends at 101965221 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)YWHAZ   12855
Cards
Entrez_Gene (NCBI)YWHAZ  7534  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta
GeneCards (Weizmann)YWHAZ
Ensembl (Hinxton)ENSG00000164924 [Gene_View]  chr8:101930804-101965221 [Contig_View]  YWHAZ [Vega]
ICGC DataPortalENSG00000164924
cBioPortalYWHAZ
AceView (NCBI)YWHAZ
Genatlas (Paris)YWHAZ
WikiGenes7534
SOURCE (Princeton)NM_001135699 NM_001135700 NM_001135701 NM_001135702 NM_003406 NM_145690
Genomic and cartography
GoldenPath (UCSC)YWHAZ  -  8q22.3   chr8:101930804-101965221 -  8q22.3   [Description]    (hg19-Feb_2009)
EnsemblYWHAZ - 8q22.3 [CytoView]
Mapping of homologs : NCBIYWHAZ [Mapview]
OMIM601288   
Gene and transcription
Genbank (Entrez)AA830489 AK289945 AK294647 AK296902 AK307506
RefSeq transcript (Entrez)NM_001135699 NM_001135700 NM_001135701 NM_001135702 NM_003406 NM_145690
RefSeq genomic (Entrez)AC_000140 NC_000008 NC_018919 NT_008046 NW_001839136 NW_004929340
Consensus coding sequences : CCDS (NCBI)YWHAZ
Cluster EST : UnigeneHs.492407 [ NCBI ]
CGAP (NCI)Hs.492407
Alternative Splicing : Fast-db (Paris)GSHG0029753
Alternative Splicing GalleryENSG00000164924
Gene ExpressionYWHAZ [ NCBI-GEO ]     YWHAZ [ SEEK ]   YWHAZ [ MEM ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP63104 (Uniprot)
NextProtP63104  [Medical]
With graphics : InterProP63104
Splice isoforms : SwissVarP63104 (Swissvar)
Domaine pattern : Prosite (Expaxy)1433_1 (PS00796)    1433_2 (PS00797)   
Domains : Interpro (EBI)14-3-3 [organisation]   14-3-3_CS [organisation]   14-3-3_domain [organisation]  
Related proteins : CluSTrP63104
Domain families : Pfam (Sanger)14-3-3 (PF00244)   
Domain families : Pfam (NCBI)pfam00244   
Domain families : Smart (EMBL)14_3_3 (SM00101)  
DMDM Disease mutations7534
Blocks (Seattle)P63104
PDB (SRS)1IB1    1QJA    1QJB    2C1J    2C1N    2O02    2WH0    3CU8    3NKX    3RDH    4BG6    4FJ3    4HKC    4IHL    4N7G    4N7Y    4N84   
PDB (PDBSum)1IB1    1QJA    1QJB    2C1J    2C1N    2O02    2WH0    3CU8    3NKX    3RDH    4BG6    4FJ3    4HKC    4IHL    4N7G    4N7Y    4N84   
PDB (IMB)1IB1    1QJA    1QJB    2C1J    2C1N    2O02    2WH0    3CU8    3NKX    3RDH    4BG6    4FJ3    4HKC    4IHL    4N7G    4N7Y    4N84   
PDB (RSDB)1IB1    1QJA    1QJB    2C1J    2C1N    2O02    2WH0    3CU8    3NKX    3RDH    4BG6    4FJ3    4HKC    4IHL    4N7G    4N7Y    4N84   
Human Protein AtlasENSG00000164924 [gene] [tissue] [antibody] [cell] [cancer]
Peptide AtlasP63104
HPRD03183
IPIIPI00021263   IPI00790689   IPI00793388   IPI00789337   IPI00979946   IPI00981067   IPI00981450   IPI00982101   IPI01011530   IPI01010931   IPI00983256   
Protein Interaction databases
DIP (DOE-UCLA)P63104
IntAct (EBI)P63104
FunCoupENSG00000164924
BioGRIDYWHAZ
InParanoidP63104
Interologous Interaction database P63104
IntegromeDBYWHAZ
STRING (EMBL)YWHAZ
Ontologies - Pathways
Ontology : AmiGOhistamine secretion by mast cell  protein binding  extracellular space  nucleus  nucleoplasm  cytoplasm  mitochondrion  cytosol  protein targeting to mitochondrion  apoptotic process  signal transduction  blood coagulation  transcription factor binding  gene expression  postsynaptic density  RNA metabolic process  mRNA metabolic process  protein kinase binding  protein domain specific binding  platelet activation  cytoplasmic vesicle membrane  cell leading edge  protein complex binding  melanosome  response to drug  mast cell granule  identical protein binding  negative regulation of apoptotic process  protein complex  poly(A) RNA binding  perinuclear region of cytoplasm  membrane organization  extracellular vesicular exosome  blood microparticle  intrinsic apoptotic signaling pathway  positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway  
Ontology : EGO-EBIhistamine secretion by mast cell  protein binding  extracellular space  nucleus  nucleoplasm  cytoplasm  mitochondrion  cytosol  protein targeting to mitochondrion  apoptotic process  signal transduction  blood coagulation  transcription factor binding  gene expression  postsynaptic density  RNA metabolic process  mRNA metabolic process  protein kinase binding  protein domain specific binding  platelet activation  cytoplasmic vesicle membrane  cell leading edge  protein complex binding  melanosome  response to drug  mast cell granule  identical protein binding  negative regulation of apoptotic process  protein complex  poly(A) RNA binding  perinuclear region of cytoplasm  membrane organization  extracellular vesicular exosome  blood microparticle  intrinsic apoptotic signaling pathway  positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway  
Pathways : KEGGCell cycle    Oocyte meiosis    PI3K-Akt signaling pathway    Hippo signaling pathway    Pathogenic Escherichia coli infection    Hepatitis B    Epstein-Barr virus infection    Viral carcinogenesis   
Protein Interaction DatabaseYWHAZ
Wikipedia pathwaysYWHAZ
Gene fusion - rearrangments
Polymorphisms : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)YWHAZ
snp3D : Map Gene to Disease7534
SNP (GeneSNP Utah)YWHAZ
SNP : HGBaseYWHAZ
Genetic variants : HAPMAPYWHAZ
Exome VariantYWHAZ
1000_GenomesYWHAZ 
ICGC programENSG00000164924 
Somatic Mutations in Cancer : COSMICYWHAZ 
CONAN: Copy Number AnalysisYWHAZ 
Mutations and Diseases : HGMDYWHAZ
Genomic VariantsYWHAZ  YWHAZ [DGVbeta]
dbVarYWHAZ
ClinVarYWHAZ
Pred. of missensesPolyPhen-2  SIFT(SG)  SIFT(JCVI)  Align-GVGD  MutAssessor  Mutanalyser  
Pred. splicesGeneSplicer  Human Splicing Finder  MaxEntScan  
Diseases
OMIM601288   
MedgenYWHAZ
GENETestsYWHAZ
Disease Genetic AssociationYWHAZ
Huge Navigator YWHAZ [HugePedia]  YWHAZ [HugeCancerGEM]
General knowledge
Homologs : HomoloGeneYWHAZ
Homology/Alignments : Family Browser (UCSC)YWHAZ
Phylogenetic Trees/Animal Genes : TreeFamYWHAZ
Chemical/Protein Interactions : CTD7534
Chemical/Pharm GKB GenePA37444
Clinical trialYWHAZ
Cancer Resource (Charite)ENSG00000164924
Other databases
Probes
Litterature
PubMed336 Pubmed reference(s) in Entrez
CoreMineYWHAZ
iHOPYWHAZ
OncoSearchYWHAZ
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated12-2013Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Sat Jul 26 14:52:30 CEST 2014

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