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YY1 (YY1 transcription factor)

Identity

Other namesDELTA
INO80S
NF-E1
UCRBP
YIN-YANG-1
HGNC (Hugo) YY1
LocusID (NCBI) 7528
Atlas_Id 42861
Location 14q32.2
Location_base_pair Starts at 100705102 and ends at 100745371 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2015)
EWSR1 - / YY1 14q32.2YY1 14q32.2 / EWSR1 -DIP2C 10p15.3 / YY1 14q32.2
POSTN 13q13.3 / YY1 14q32.2YY1 14q32.2 / CCNK 14q32.2ZC3H3 8q24.3 / YY1 14q32.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas)
  Mesothelioma with t(14;22)(q32;q12) EWSR1/YY1

External links

Nomenclature
HGNC (Hugo)YY1   12856
Cards
Entrez_Gene (NCBI)YY1  7528  YY1 transcription factor
GeneCards (Weizmann)YY1
Ensembl hg19 (Hinxton) [Gene_View]  chr14:100705102-100745371 [Contig_View]  YY1 [Vega]
Ensembl hg38 (Hinxton) [Gene_View]  chr14:100705102-100745371 [Contig_View]  YY1 [Vega]
TCGA cBioPortalYY1
AceView (NCBI)YY1
Genatlas (Paris)YY1
WikiGenes7528
SOURCE (Princeton)YY1
Genomic and cartography
GoldenPath hg19 (UCSC)YY1  -     chr14:100705102-100745371 +  14q32.2   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)YY1  -     14q32.2   [Description]    (hg38-Dec_2013)
EnsemblYY1 - 14q32.2 [CytoView hg19]  YY1 - 14q32.2 [CytoView hg38]
Mapping of homologs : NCBIYY1 [Mapview hg19]  YY1 [Mapview hg38]
OMIM600013   
Gene and transcription
Genbank (Entrez)AF147416 AK025731 AK026497 BC014138 BC020324
RefSeq transcript (Entrez)NM_003403
RefSeq genomic (Entrez)NC_000014 NC_018925 NT_026437 NW_004929393
Consensus coding sequences : CCDS (NCBI)YY1
Cluster EST : UnigeneHs.603118 [ NCBI ]
CGAP (NCI)Hs.603118
Alternative Splicing : Fast-db (Paris)GSHG0009112
Gene ExpressionYY1 [ NCBI-GEO ]     YY1 [ SEEK ]   YY1 [ MEM ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
BioGPS (Tissue expression)7528
Protein : pattern, domain, 3D structure
UniProt/SwissProtP25490 (Uniprot)
NextProtP25490  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP25490
Splice isoforms : SwissVarP25490 (Swissvar)
PhosPhoSitePlusP25490
Domaine pattern : Prosite (Expaxy)ZINC_FINGER_C2H2_1 (PS00028)    ZINC_FINGER_C2H2_2 (PS50157)   
Domains : Interpro (EBI)TF_Yin_yang    Znf_C2H2    Znf_C2H2-like    Znf_C2H2/integrase_DNA-bd   
Domain families : Pfam (Sanger)zf-C2H2 (PF00096)   
Domain families : Pfam (NCBI)pfam00096   
Domain families : Smart (EMBL)ZnF_C2H2 (SM00355)  
DMDM Disease mutations7528
Blocks (Seattle)YY1
PDB (SRS)1UBD    1ZNM    4C5I   
PDB (PDBSum)1UBD    1ZNM    4C5I   
PDB (IMB)1UBD    1ZNM    4C5I   
PDB (RSDB)1UBD    1ZNM    4C5I   
Structural Biology KnowledgeBase1UBD    1ZNM    4C5I   
SCOP (Structural Classification of Proteins)1UBD    1ZNM    4C5I   
CATH (Classification of proteins structures)1UBD    1ZNM    4C5I   
Peptide AtlasP25490
HPRD02482
IPIIPI00014513   IPI01026056   IPI01025682   IPI01025781   
Protein Interaction databases
DIP (DOE-UCLA)P25490
IntAct (EBI)P25490
BioGRIDYY1
IntegromeDBYY1
STRING (EMBL)YY1
ZODIACYY1
Ontologies - Pathways
QuickGOP25490
Ontology : AmiGOnegative regulation of transcription from RNA polymerase II promoter  four-way junction DNA binding  double-strand break repair via homologous recombination  transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding  enhancer sequence-specific DNA binding  DNA binding  transcription factor activity, sequence-specific DNA binding  transcription coactivator activity  transcription corepressor activity  RNA binding  protein binding  nucleus  nucleus  transcription factor complex  cytoplasm  transcription, DNA-templated  regulation of transcription from RNA polymerase II promoter  RNA localization  cellular response to DNA damage stimulus  spermatogenesis  zinc ion binding  anterior/posterior pattern specification  response to UV-C  negative regulation of gene expression  nuclear matrix  cell differentiation  Ino80 complex  PcG protein complex  cellular response to UV  response to prostaglandin F  histone deacetylase binding  transcription regulatory region DNA binding  positive regulation of transcription from RNA polymerase II promoter  SMAD binding  camera-type eye morphogenesis  chromosome organization  cellular response to interleukin-1  
Ontology : EGO-EBInegative regulation of transcription from RNA polymerase II promoter  four-way junction DNA binding  double-strand break repair via homologous recombination  transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding  enhancer sequence-specific DNA binding  DNA binding  transcription factor activity, sequence-specific DNA binding  transcription coactivator activity  transcription corepressor activity  RNA binding  protein binding  nucleus  nucleus  transcription factor complex  cytoplasm  transcription, DNA-templated  regulation of transcription from RNA polymerase II promoter  RNA localization  cellular response to DNA damage stimulus  spermatogenesis  zinc ion binding  anterior/posterior pattern specification  response to UV-C  negative regulation of gene expression  nuclear matrix  cell differentiation  Ino80 complex  PcG protein complex  cellular response to UV  response to prostaglandin F  histone deacetylase binding  transcription regulatory region DNA binding  positive regulation of transcription from RNA polymerase II promoter  SMAD binding  camera-type eye morphogenesis  chromosome organization  cellular response to interleukin-1  
Pathways : BIOCARTAThe PRC2 Complex Sets Long-term Gene Silencing Through Modification of Histone Tails [Genes]   
Protein Interaction DatabaseYY1
Atlas of Cancer Signalling NetworkYY1
Wikipedia pathwaysYY1
Orthology - Evolution
OrthoDB7528
Phylogenetic Trees/Animal Genes : TreeFamYY1
Homologs : HomoloGeneYY1
Homology/Alignments : Family Browser (UCSC)YY1
Gene fusions - Rearrangements
Fusion: TCGADIP2C 10p15.3 YY1 14q32.2 BRCA
Fusion: TCGAPOSTN 13q13.3 YY1 14q32.2 BRCA
Fusion: TCGAYY1 14q32.2 CCNK 14q32.2 LUAD
Fusion: TCGAZC3H3 8q24.3 YY1 14q32.2 BRCA
Polymorphisms : SNP, variants
NCBI Variation ViewerYY1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)YY1
dbVarYY1
ClinVarYY1
1000_GenomesYY1 
Exome Variant ServerYY1
SNP (GeneSNP Utah)YY1
SNP : HGBaseYY1
Genetic variants : HAPMAPYY1
Genomic Variants (DGV)YY1 [DGVbeta]
Mutations
ICGC Data PortalYY1 
TCGA Data PortalYY1 
Tumor PortalYY1
TCGA Copy Number PortalYY1
Somatic Mutations in Cancer : COSMICYY1 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch YY1
DgiDB (Drug Gene Interaction Database)YY1
DoCM (Curated mutations)YY1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)YY1 (select a term)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)14:100705102-100745371
CONAN: Copy Number AnalysisYY1 
Mutations and Diseases : HGMDYY1
OMIM600013   
MedgenYY1
NextProtP25490 [Medical]
TSGene7528
GENETestsYY1
Huge Navigator YY1 [HugePedia]  YY1 [HugeCancerGEM]
snp3D : Map Gene to Disease7528
BioCentury BCIQYY1
General knowledge
Chemical/Protein Interactions : CTD7528
Chemical/Pharm GKB GenePA37445
Clinical trialYY1
Other databases
Probes
Litterature
PubMed256 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineYY1
GoPubMedYY1
iHOPYY1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Sat Jan 16 19:45:50 CET 2016

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