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YY1 (YY1 transcription factor)

Identity

Other namesDELTA
INO80S
NF-E1
UCRBP
YIN-YANG-1
HGNC (Hugo) YY1
LocusID (NCBI) 7528
Atlas_Id 42861
Location 14q32.2  [Link to chromosome band 14q32]
Location_base_pair Starts at 100705102 and ends at 100745371 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
DIP2C (10p15.3) / YY1 (14q32.2)EWSR1 (22q12.2) / YY1 (14q32.2)POSTN (13q13.3) / YY1 (14q32.2)
YY1 (14q32.2) / CCNK (14q32.2)YY1 (14q32.2) / EWSR1 (22q12.2)YY1 (14q32.2) / TUBB2A (6p25.2)
YY1 (14q32.2) / WDR25 (14q32.2)YY1 (14q32.2) / YY1 (14q32.2)ZC3H3 (8q24.3) / YY1 (14q32.2)
YY1 14q32.2 / EWSR1 22q12.2DIP2C 10p15.3 / YY1 14q32.2POSTN 13q13.3 / YY1 14q32.2
YY1 14q32.2 / CCNK 14q32.2ZC3H3 8q24.3 / YY1 14q32.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 0 ]
  Mesothelioma with t(14;22)(q32;q12) EWSR1/YY1

External links

Nomenclature
HGNC (Hugo)YY1   12856
Cards
Entrez_Gene (NCBI)YY1  7528  YY1 transcription factor
AliasesDELTA; INO80S; NF-E1; UCRBP; 
YIN-YANG-1
GeneCards (Weizmann)YY1
Ensembl hg19 (Hinxton)ENSG00000100811 [Gene_View]  chr14:100705102-100745371 [Contig_View]  YY1 [Vega]
Ensembl hg38 (Hinxton)ENSG00000100811 [Gene_View]  chr14:100705102-100745371 [Contig_View]  YY1 [Vega]
ICGC DataPortalENSG00000100811
TCGA cBioPortalYY1
AceView (NCBI)YY1
Genatlas (Paris)YY1
WikiGenes7528
SOURCE (Princeton)YY1
Genomic and cartography
GoldenPath hg19 (UCSC)YY1  -     chr14:100705102-100745371 +  14q32.2   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)YY1  -     14q32.2   [Description]    (hg38-Dec_2013)
EnsemblYY1 - 14q32.2 [CytoView hg19]  YY1 - 14q32.2 [CytoView hg38]
Mapping of homologs : NCBIYY1 [Mapview hg19]  YY1 [Mapview hg38]
OMIM600013   
Gene and transcription
Genbank (Entrez)AF147416 AK025731 AK026497 BC014138 BC020324
RefSeq transcript (Entrez)NM_003403
RefSeq genomic (Entrez)NC_000014 NC_018925 NT_026437 NW_004929393
Consensus coding sequences : CCDS (NCBI)YY1
Cluster EST : UnigeneHs.603118 [ NCBI ]
CGAP (NCI)Hs.603118
Alternative Splicing GalleryENSG00000100811
Gene ExpressionYY1 [ NCBI-GEO ]   YY1 [ EBI - ARRAY_EXPRESS ]   YY1 [ SEEK ]   YY1 [ MEM ]
Gene Expression Viewer (FireBrowse)YY1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)7528
GTEX Portal (Tissue expression)YY1
Protein : pattern, domain, 3D structure
UniProt/SwissProtP25490 (Uniprot)
NextProtP25490  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP25490
Splice isoforms : SwissVarP25490 (Swissvar)
PhosPhoSitePlusP25490
Domaine pattern : Prosite (Expaxy)ZINC_FINGER_C2H2_1 (PS00028)    ZINC_FINGER_C2H2_2 (PS50157)   
Domains : Interpro (EBI)TF_Yin_yang    Znf_C2H2    Znf_C2H2-like    Znf_C2H2/integrase_DNA-bd   
Domain families : Pfam (Sanger)zf-C2H2 (PF00096)   
Domain families : Pfam (NCBI)pfam00096   
Domain families : Smart (EMBL)ZnF_C2H2 (SM00355)  
DMDM Disease mutations7528
Blocks (Seattle)YY1
PDB (SRS)1UBD    1ZNM    4C5I   
PDB (PDBSum)1UBD    1ZNM    4C5I   
PDB (IMB)1UBD    1ZNM    4C5I   
PDB (RSDB)1UBD    1ZNM    4C5I   
Structural Biology KnowledgeBase1UBD    1ZNM    4C5I   
SCOP (Structural Classification of Proteins)1UBD    1ZNM    4C5I   
CATH (Classification of proteins structures)1UBD    1ZNM    4C5I   
SuperfamilyP25490
Human Protein AtlasENSG00000100811
Peptide AtlasP25490
HPRD02482
IPIIPI00014513   IPI01026056   IPI01025682   IPI01025781   
Protein Interaction databases
DIP (DOE-UCLA)P25490
IntAct (EBI)P25490
FunCoupENSG00000100811
BioGRIDYY1
STRING (EMBL)YY1
ZODIACYY1
Ontologies - Pathways
QuickGOP25490
Ontology : AmiGOnegative regulation of transcription from RNA polymerase II promoter  four-way junction DNA binding  double-strand break repair via homologous recombination  transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding  enhancer sequence-specific DNA binding  DNA binding  transcription factor activity, sequence-specific DNA binding  transcription coactivator activity  transcription corepressor activity  RNA binding  protein binding  nucleus  nucleus  transcription, DNA-templated  regulation of transcription from RNA polymerase II promoter  cellular response to DNA damage stimulus  spermatogenesis  zinc ion binding  response to UV-C  negative regulation of gene expression  nuclear matrix  cell differentiation  Ino80 complex  cellular response to UV  transcription regulatory region DNA binding  SMAD binding  
Ontology : EGO-EBInegative regulation of transcription from RNA polymerase II promoter  four-way junction DNA binding  double-strand break repair via homologous recombination  transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding  enhancer sequence-specific DNA binding  DNA binding  transcription factor activity, sequence-specific DNA binding  transcription coactivator activity  transcription corepressor activity  RNA binding  protein binding  nucleus  nucleus  transcription, DNA-templated  regulation of transcription from RNA polymerase II promoter  cellular response to DNA damage stimulus  spermatogenesis  zinc ion binding  response to UV-C  negative regulation of gene expression  nuclear matrix  cell differentiation  Ino80 complex  cellular response to UV  transcription regulatory region DNA binding  SMAD binding  
Pathways : BIOCARTAThe PRC2 Complex Sets Long-term Gene Silencing Through Modification of Histone Tails [Genes]   
NDEx Network
Atlas of Cancer Signalling NetworkYY1
Wikipedia pathwaysYY1
Orthology - Evolution
OrthoDB7528
GeneTree (enSembl)ENSG00000100811
Phylogenetic Trees/Animal Genes : TreeFamYY1
Homologs : HomoloGeneYY1
Homology/Alignments : Family Browser (UCSC)YY1
Gene fusions - Rearrangements
Fusion: TCGADIP2C 10p15.3 YY1 14q32.2 BRCA
Fusion: TCGAPOSTN 13q13.3 YY1 14q32.2 BRCA
Fusion: TCGAYY1 14q32.2 CCNK 14q32.2 LUAD
Fusion: TCGAZC3H3 8q24.3 YY1 14q32.2 BRCA
Polymorphisms : SNP, variants
NCBI Variation ViewerYY1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)YY1
dbVarYY1
ClinVarYY1
1000_GenomesYY1 
Exome Variant ServerYY1
ExAC (Exome Aggregation Consortium)YY1 (select the gene name)
Genetic variants : HAPMAP7528
Genomic Variants (DGV)YY1 [DGVbeta]
Mutations
ICGC Data PortalYY1 
TCGA Data PortalYY1 
Broad Tumor PortalYY1
OASIS PortalYY1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICYY1 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch YY1
DgiDB (Drug Gene Interaction Database)YY1
DoCM (Curated mutations)YY1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)YY1 (select a term)
intoGenYY1
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)14:100705102-100745371  ENSG00000100811
CONAN: Copy Number AnalysisYY1 
Mutations and Diseases : HGMDYY1
OMIM600013   
MedgenYY1
Genetic Testing Registry YY1
NextProtP25490 [Medical]
TSGene7528
GENETestsYY1
Huge Navigator YY1 [HugePedia]
snp3D : Map Gene to Disease7528
BioCentury BCIQYY1
ClinGenYY1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD7528
Chemical/Pharm GKB GenePA37445
Clinical trialYY1
Miscellaneous
canSAR (ICR)YY1 (select the gene name)
Probes
Litterature
PubMed264 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineYY1
EVEXYY1
GoPubMedYY1
iHOPYY1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Aug 9 19:11:24 CEST 2016

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