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YY1 (YY1 transcription factor)

Identity

Alias (NCBI)DELTA
GADEVS
INO80S
NF-E1
UCRBP
YIN-YANG-1
HGNC (Hugo) YY1
HGNC Alias symbNF-E1
DELTA
UCRBP
YIN-YANG-1
INO80S
HGNC Alias nameINO80 complex subunit S
 Yin and Yang 1 protein
LocusID (NCBI) 7528
Atlas_Id 42861
Location 14q32.2  [Link to chromosome band 14q32]
Location_base_pair Starts at 100239144 and ends at 100282788 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
DIP2C (10p15.3)::YY1 (14q32.2)EWSR1 (22q12.2)::YY1 (14q32.2)POSTN (13q13.3)::YY1 (14q32.2)
YY1 (14q32.2)::CCNK (14q32.2)YY1 (14q32.2)::EWSR1 (22q12.2)YY1 (14q32.2)::TUBB2A (6p25.2)
YY1 (14q32.2)::WDR25 (14q32.2)YY1 (14q32.2)::YY1 (14q32.2)ZC3H3 (8q24.3)::YY1 (14q32.2)
EWSR1 22q12.2::YY1 14q32.2YY1 14q32.2::EWSR1 22q12.2DIP2C 10p15.3::YY1 14q32.2
POSTN 13q13.3::YY1 14q32.2YY1 14q32.2::CCNK 14q32.2ZC3H3 8q24.3::YY1 14q32.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)YY1   12856
Cards
Entrez_Gene (NCBI)YY1    YY1 transcription factor
AliasesDELTA; GADEVS; INO80S; NF-E1; 
UCRBP; YIN-YANG-1
GeneCards (Weizmann)YY1
Ensembl hg19 (Hinxton)ENSG00000100811 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000100811 [Gene_View]  ENSG00000100811 [Sequence]  chr14:100239144-100282788 [Contig_View]  YY1 [Vega]
ICGC DataPortalENSG00000100811
TCGA cBioPortalYY1
AceView (NCBI)YY1
Genatlas (Paris)YY1
SOURCE (Princeton)YY1
Genetics Home Reference (NIH)YY1
Genomic and cartography
GoldenPath hg38 (UCSC)YY1  -     chr14:100239144-100282788 +  14q32.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)YY1  -     14q32.2   [Description]    (hg19-Feb_2009)
GoldenPathYY1 - 14q32.2 [CytoView hg19]  YY1 - 14q32.2 [CytoView hg38]
ImmunoBaseENSG00000100811
Genome Data Viewer NCBIYY1 [Mapview hg19]  
OMIM600013   617557   
Gene and transcription
Genbank (Entrez)AF147416 AK025731 AK026497 BC014138 BC020324
RefSeq transcript (Entrez)NM_003403
Consensus coding sequences : CCDS (NCBI)YY1
Gene ExpressionYY1 [ NCBI-GEO ]   YY1 [ EBI - ARRAY_EXPRESS ]   YY1 [ SEEK ]   YY1 [ MEM ]
Gene Expression Viewer (FireBrowse)YY1 [ Firebrowse - Broad ]
GenevisibleExpression of YY1 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)7528
GTEX Portal (Tissue expression)YY1
Human Protein AtlasENSG00000100811-YY1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP25490   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP25490  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP25490
PhosPhoSitePlusP25490
Domaine pattern : Prosite (Expaxy)ZINC_FINGER_C2H2_1 (PS00028)    ZINC_FINGER_C2H2_2 (PS50157)   
Domains : Interpro (EBI)YY1-like    Znf_C2H2_sf    Znf_C2H2_type   
Domain families : Pfam (Sanger)zf-C2H2 (PF00096)   
Domain families : Pfam (NCBI)pfam00096   
Domain families : Smart (EMBL)ZnF_C2H2 (SM00355)  
Conserved Domain (NCBI)YY1
PDB (RSDB)1UBD    1ZNM    4C5I   
PDB Europe1UBD    1ZNM    4C5I   
PDB (PDBSum)1UBD    1ZNM    4C5I   
PDB (IMB)1UBD    1ZNM    4C5I   
Structural Biology KnowledgeBase1UBD    1ZNM    4C5I   
SCOP (Structural Classification of Proteins)1UBD    1ZNM    4C5I   
CATH (Classification of proteins structures)1UBD    1ZNM    4C5I   
SuperfamilyP25490
AlphaFold pdb e-kbP25490   
Human Protein Atlas [tissue]ENSG00000100811-YY1 [tissue]
HPRD02482
Protein Interaction databases
DIP (DOE-UCLA)P25490
IntAct (EBI)P25490
BioGRIDYY1
STRING (EMBL)YY1
ZODIACYY1
Ontologies - Pathways
QuickGOP25490
Ontology : AmiGOnegative regulation of transcription by RNA polymerase II  negative regulation of transcription by RNA polymerase II  four-way junction DNA binding  double-strand break repair via homologous recombination  transcription cis-regulatory region binding  RNA polymerase II cis-regulatory region sequence-specific DNA binding  RNA polymerase II cis-regulatory region sequence-specific DNA binding  DNA-binding transcription factor activity, RNA polymerase II-specific  cis-regulatory region sequence-specific DNA binding  cis-regulatory region sequence-specific DNA binding  DNA-binding transcription repressor activity  DNA-binding transcription repressor activity, RNA polymerase II-specific  DNA-binding transcription repressor activity, RNA polymerase II-specific  DNA-binding transcription activator activity, RNA polymerase II-specific  DNA binding  chromatin binding  RNA binding  protein binding  nucleus  nucleus  nucleoplasm  transcription regulator complex  chromatin silencing complex  cytoplasm  regulation of DNA replication  chromatin remodeling  regulation of transcription by RNA polymerase II  RNA localization  cellular response to DNA damage stimulus  spermatogenesis  anterior/posterior pattern specification  response to UV-C  positive regulation of gene expression  negative regulation of gene expression  nuclear matrix  B cell differentiation  Ino80 complex  PcG protein complex  negative regulation of interferon-beta production  regulation of chromosome organization  cellular response to UV  response to prostaglandin F  nucleosome mobilization  positive regulation of transcription, DNA-templated  positive regulation of transcription by RNA polymerase II  SMAD binding  metal ion binding  cell development  camera-type eye morphogenesis  regulation of cell cycle  regulation of DNA strand elongation  negative regulation of cell growth involved in cardiac muscle cell development  cellular response to interleukin-1  immunoglobulin heavy chain V-D-J recombination  DNA-binding transcription factor binding  negative regulation of miRNA transcription  sequence-specific double-stranded DNA binding  
Ontology : EGO-EBInegative regulation of transcription by RNA polymerase II  negative regulation of transcription by RNA polymerase II  four-way junction DNA binding  double-strand break repair via homologous recombination  transcription cis-regulatory region binding  RNA polymerase II cis-regulatory region sequence-specific DNA binding  RNA polymerase II cis-regulatory region sequence-specific DNA binding  DNA-binding transcription factor activity, RNA polymerase II-specific  cis-regulatory region sequence-specific DNA binding  cis-regulatory region sequence-specific DNA binding  DNA-binding transcription repressor activity  DNA-binding transcription repressor activity, RNA polymerase II-specific  DNA-binding transcription repressor activity, RNA polymerase II-specific  DNA-binding transcription activator activity, RNA polymerase II-specific  DNA binding  chromatin binding  RNA binding  protein binding  nucleus  nucleus  nucleoplasm  transcription regulator complex  chromatin silencing complex  cytoplasm  regulation of DNA replication  chromatin remodeling  regulation of transcription by RNA polymerase II  RNA localization  cellular response to DNA damage stimulus  spermatogenesis  anterior/posterior pattern specification  response to UV-C  positive regulation of gene expression  negative regulation of gene expression  nuclear matrix  B cell differentiation  Ino80 complex  PcG protein complex  negative regulation of interferon-beta production  regulation of chromosome organization  cellular response to UV  response to prostaglandin F  nucleosome mobilization  positive regulation of transcription, DNA-templated  positive regulation of transcription by RNA polymerase II  SMAD binding  metal ion binding  cell development  camera-type eye morphogenesis  regulation of cell cycle  regulation of DNA strand elongation  negative regulation of cell growth involved in cardiac muscle cell development  cellular response to interleukin-1  immunoglobulin heavy chain V-D-J recombination  DNA-binding transcription factor binding  negative regulation of miRNA transcription  sequence-specific double-stranded DNA binding  
Pathways : BIOCARTABIOCARTA_PRC2PATHWAY   
NDEx NetworkYY1
Atlas of Cancer Signalling NetworkYY1
Wikipedia pathwaysYY1
Orthology - Evolution
OrthoDB7528
GeneTree (enSembl)ENSG00000100811
Phylogenetic Trees/Animal Genes : TreeFamYY1
Homologs : HomoloGeneYY1
Homology/Alignments : Family Browser (UCSC)YY1
Gene fusions - Rearrangements
Fusion : MitelmanDIP2C::YY1 [10p15.3/14q32.2]  
Fusion : MitelmanEWSR1::YY1 [22q12.2/14q32.2]  
Fusion : MitelmanPOSTN::YY1 [13q13.3/14q32.2]  
Fusion : MitelmanYY1::CCNK [14q32.2/14q32.2]  
Fusion : MitelmanZC3H3::YY1 [8q24.3/14q32.2]  
Fusion : QuiverYY1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerYY1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)YY1
dbVarYY1
ClinVarYY1
MonarchYY1
1000_GenomesYY1 
Exome Variant ServerYY1
GNOMAD BrowserENSG00000100811
Varsome BrowserYY1
ACMGYY1 variants
VarityP25490
Genomic Variants (DGV)YY1 [DGVbeta]
DECIPHERYY1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisYY1 
Mutations
ICGC Data PortalYY1 
TCGA Data PortalYY1 
Broad Tumor PortalYY1
OASIS PortalYY1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICYY1  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DYY1
Mutations and Diseases : HGMDYY1
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaYY1
DgiDB (Drug Gene Interaction Database)YY1
DoCM (Curated mutations)YY1
CIViC (Clinical Interpretations of Variants in Cancer)YY1
Cancer3DYY1
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM600013    617557   
Orphanet26451    12875   
DisGeNETYY1
MedgenYY1
Genetic Testing Registry YY1
NextProtP25490 [Medical]
GENETestsYY1
Target ValidationYY1
Huge Navigator YY1 [HugePedia]
ClinGenYY1
Clinical trials, drugs, therapy
MyCancerGenomeYY1
Protein Interactions : CTDYY1
Pharm GKB GenePA37445
PharosP25490
Clinical trialYY1
Miscellaneous
canSAR (ICR)YY1
HarmonizomeYY1
ARCHS4YY1
DataMed IndexYY1
Probes
Litterature
PubMed451 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXYY1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Jan 20 13:06:56 CET 2022

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