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ZACN (zinc activated ion channel)

Identity

Alias_namesLGICZ1
ligand-gated ion channel, zinc activated 1
zinc activated ligand-gated ion channel
Alias_symbol (synonym)LGICZ
L2
ZAC
ZAC1
Other alias
HGNC (Hugo) ZACN
LocusID (NCBI) 353174
Atlas_Id 75830
Location 17q25.1  [Link to chromosome band 17q25]
Location_base_pair Starts at 76079182 and ends at 76082804 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ZACN (17q25.1) / ALG3 (3q27.1)ZACN (17q25.1) / LSM3 (3p25.1)ZACN (17q25.1) / PRRC2A (6p21.33)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)ZACN   29504
Cards
Entrez_Gene (NCBI)ZACN  353174  zinc activated ion channel
AliasesL2; LGICZ; LGICZ1; ZAC; 
ZAC1
GeneCards (Weizmann)ZACN
Ensembl hg19 (Hinxton)ENSG00000186919 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000186919 [Gene_View]  chr17:76079182-76082804 [Contig_View]  ZACN [Vega]
ICGC DataPortalENSG00000186919
TCGA cBioPortalZACN
AceView (NCBI)ZACN
Genatlas (Paris)ZACN
WikiGenes353174
SOURCE (Princeton)ZACN
Genetics Home Reference (NIH)ZACN
Genomic and cartography
GoldenPath hg38 (UCSC)ZACN  -     chr17:76079182-76082804 +  17q25.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)ZACN  -     17q25.1   [Description]    (hg19-Feb_2009)
EnsemblZACN - 17q25.1 [CytoView hg19]  ZACN - 17q25.1 [CytoView hg38]
Mapping of homologs : NCBIZACN [Mapview hg19]  ZACN [Mapview hg38]
OMIM610935   
Gene and transcription
Genbank (Entrez)AB223030 AF512521 AK122638 BC110596 BC110597
RefSeq transcript (Entrez)NM_180990
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)ZACN
Cluster EST : UnigeneHs.714919 [ NCBI ]
CGAP (NCI)Hs.714919
Alternative Splicing GalleryENSG00000186919
Gene ExpressionZACN [ NCBI-GEO ]   ZACN [ EBI - ARRAY_EXPRESS ]   ZACN [ SEEK ]   ZACN [ MEM ]
Gene Expression Viewer (FireBrowse)ZACN [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)353174
GTEX Portal (Tissue expression)ZACN
Human Protein AtlasENSG00000186919-ZACN [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ401N2   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ401N2  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ401N2
Splice isoforms : SwissVarQ401N2
PhosPhoSitePlusQ401N2
Domaine pattern : Prosite (Expaxy)NEUROTR_ION_CHANNEL (PS00236)   
Domains : Interpro (EBI)Acetylcholine_rcpt_TM    Neur_chan_lig-bd    Neur_channel    Neurotrans-gated_channel_TM    Neurotransmitter_ion_chnl_CS   
Domain families : Pfam (Sanger)Neur_chan_LBD (PF02931)   
Domain families : Pfam (NCBI)pfam02931   
Conserved Domain (NCBI)ZACN
DMDM Disease mutations353174
Blocks (Seattle)ZACN
SuperfamilyQ401N2
Human Protein Atlas [tissue]ENSG00000186919-ZACN [tissue]
Peptide AtlasQ401N2
HPRD17271
IPIIPI00329467   IPI00885215   IPI00719125   
Protein Interaction databases
DIP (DOE-UCLA)Q401N2
IntAct (EBI)Q401N2
FunCoupENSG00000186919
BioGRIDZACN
STRING (EMBL)ZACN
ZODIACZACN
Ontologies - Pathways
QuickGOQ401N2
Ontology : AmiGOG-protein coupled serotonin receptor activity  extracellular ligand-gated ion channel activity  plasma membrane  serotonin receptor signaling pathway  zinc ion binding  response to zinc ion  ligand-gated ion channel activity  integral component of membrane  ion transmembrane transport  G-protein coupled serotonin receptor signaling pathway  
Ontology : EGO-EBIG-protein coupled serotonin receptor activity  extracellular ligand-gated ion channel activity  plasma membrane  serotonin receptor signaling pathway  zinc ion binding  response to zinc ion  ligand-gated ion channel activity  integral component of membrane  ion transmembrane transport  G-protein coupled serotonin receptor signaling pathway  
NDEx NetworkZACN
Atlas of Cancer Signalling NetworkZACN
Wikipedia pathwaysZACN
Orthology - Evolution
OrthoDB353174
GeneTree (enSembl)ENSG00000186919
Phylogenetic Trees/Animal Genes : TreeFamZACN
HOVERGENQ401N2
HOGENOMQ401N2
Homologs : HomoloGeneZACN
Homology/Alignments : Family Browser (UCSC)ZACN
Gene fusions - Rearrangements
Fusion: Tumor Portal ZACN
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerZACN [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ZACN
dbVarZACN
ClinVarZACN
1000_GenomesZACN 
Exome Variant ServerZACN
ExAC (Exome Aggregation Consortium)ENSG00000186919
GNOMAD BrowserENSG00000186919
Genetic variants : HAPMAP353174
Genomic Variants (DGV)ZACN [DGVbeta]
DECIPHERZACN [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisZACN 
Mutations
ICGC Data PortalZACN 
TCGA Data PortalZACN 
Broad Tumor PortalZACN
OASIS PortalZACN [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICZACN  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDZACN
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch ZACN
DgiDB (Drug Gene Interaction Database)ZACN
DoCM (Curated mutations)ZACN (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)ZACN (select a term)
intoGenZACN
Cancer3DZACN(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM610935   
Orphanet
MedgenZACN
Genetic Testing Registry ZACN
NextProtQ401N2 [Medical]
TSGene353174
GENETestsZACN
Target ValidationZACN
Huge Navigator ZACN [HugePedia]
snp3D : Map Gene to Disease353174
BioCentury BCIQZACN
ClinGenZACN
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD353174
Chemical/Pharm GKB GenePA162409377
Clinical trialZACN
Miscellaneous
canSAR (ICR)ZACN (select the gene name)
Probes
Litterature
PubMed6 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineZACN
EVEXZACN
GoPubMedZACN
iHOPZACN
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Nov 9 12:36:07 CET 2017

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