Atlas of Genetics and Cytogenetics in Oncology and Haematology

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ZADH2 (zinc binding alcohol dehydrogenase domain containing 2)

Identity

Alias_symbol (synonym)MGC45594
Other aliasPRG-3
HGNC (Hugo) ZADH2
LocusID (NCBI) 284273
Atlas_Id 75831
Location 18q22.3  [Link to chromosome band 18q22]
Location_base_pair Starts at 75195110 and ends at 75205513 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ZADH2 (18q22.3) / AP2B1 (17q12)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(18;21)(q22;q22) RUNX1/ZADH2

External links

Nomenclature
HGNC (Hugo)ZADH2   28697
Cards
Entrez_Gene (NCBI)ZADH2  284273  zinc binding alcohol dehydrogenase domain containing 2
AliasesPRG-3
GeneCards (Weizmann)ZADH2
Ensembl hg19 (Hinxton)ENSG00000180011 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000180011 [Gene_View]  ENSG00000180011 [Sequence]  chr18:75195110-75205513 [Contig_View]  ZADH2 [Vega]
ICGC DataPortalENSG00000180011
TCGA cBioPortalZADH2
AceView (NCBI)ZADH2
Genatlas (Paris)ZADH2
WikiGenes284273
SOURCE (Princeton)ZADH2
Genetics Home Reference (NIH)ZADH2
Genomic and cartography
GoldenPath hg38 (UCSC)ZADH2  -     chr18:75195110-75205513 -  18q22.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)ZADH2  -     18q22.3   [Description]    (hg19-Feb_2009)
EnsemblZADH2 - 18q22.3 [CytoView hg19]  ZADH2 - 18q22.3 [CytoView hg38]
Mapping of homologs : NCBIZADH2 [Mapview hg19]  ZADH2 [Mapview hg38]
Gene and transcription
Genbank (Entrez)AK292880 AK302801 BC010734 BC018081 BC033780
RefSeq transcript (Entrez)NM_001306093 NM_175907
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)ZADH2
Cluster EST : UnigeneHs.719383 [ NCBI ]
CGAP (NCI)Hs.719383
Alternative Splicing GalleryENSG00000180011
Gene ExpressionZADH2 [ NCBI-GEO ]   ZADH2 [ EBI - ARRAY_EXPRESS ]   ZADH2 [ SEEK ]   ZADH2 [ MEM ]
Gene Expression Viewer (FireBrowse)ZADH2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)284273
GTEX Portal (Tissue expression)ZADH2
Human Protein AtlasENSG00000180011-ZADH2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ8N4Q0   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ8N4Q0  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ8N4Q0
Splice isoforms : SwissVarQ8N4Q0
PhosPhoSitePlusQ8N4Q0
Domaine pattern : Prosite (Expaxy)QOR_ZETA_CRYSTAL (PS01162)   
Domains : Interpro (EBI)ADH_C    ADH_N    GroES-like    NAD(P)-bd_dom    PKS_ER    Quin_OxRdtase/zeta-crystal_CS   
Domain families : Pfam (Sanger)ADH_N (PF08240)    ADH_zinc_N (PF00107)   
Domain families : Pfam (NCBI)pfam08240    pfam00107   
Domain families : Smart (EMBL)PKS_ER (SM00829)  
Conserved Domain (NCBI)ZADH2
DMDM Disease mutations284273
Blocks (Seattle)ZADH2
PDB (RSDB)2C0C    2WEK    2X1H    2X7H   
PDB Europe2C0C    2WEK    2X1H    2X7H   
PDB (PDBSum)2C0C    2WEK    2X1H    2X7H   
PDB (IMB)2C0C    2WEK    2X1H    2X7H   
Structural Biology KnowledgeBase2C0C    2WEK    2X1H    2X7H   
SCOP (Structural Classification of Proteins)2C0C    2WEK    2X1H    2X7H   
CATH (Classification of proteins structures)2C0C    2WEK    2X1H    2X7H   
SuperfamilyQ8N4Q0
Human Protein Atlas [tissue]ENSG00000180011-ZADH2 [tissue]
Peptide AtlasQ8N4Q0
HPRD15685
IPIIPI00166738   IPI01015337   
Protein Interaction databases
DIP (DOE-UCLA)Q8N4Q0
IntAct (EBI)Q8N4Q0
FunCoupENSG00000180011
BioGRIDZADH2
STRING (EMBL)ZADH2
ZODIACZADH2
Ontologies - Pathways
QuickGOQ8N4Q0
Ontology : AmiGOmolecular_function  mitochondrion  peroxisome  prostaglandin metabolic process  biological_process  zinc ion binding  13-prostaglandin reductase activity  negative regulation of fat cell differentiation  15-oxoprostaglandin 13-oxidase activity  oxidation-reduction process  
Ontology : EGO-EBImolecular_function  mitochondrion  peroxisome  prostaglandin metabolic process  biological_process  zinc ion binding  13-prostaglandin reductase activity  negative regulation of fat cell differentiation  15-oxoprostaglandin 13-oxidase activity  oxidation-reduction process  
NDEx NetworkZADH2
Atlas of Cancer Signalling NetworkZADH2
Wikipedia pathwaysZADH2
Orthology - Evolution
OrthoDB284273
GeneTree (enSembl)ENSG00000180011
Phylogenetic Trees/Animal Genes : TreeFamZADH2
HOGENOMQ8N4Q0
Homologs : HomoloGeneZADH2
Homology/Alignments : Family Browser (UCSC)ZADH2
Gene fusions - Rearrangements
Fusion : QuiverZADH2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerZADH2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ZADH2
dbVarZADH2
ClinVarZADH2
1000_GenomesZADH2 
Exome Variant ServerZADH2
ExAC (Exome Aggregation Consortium)ENSG00000180011
GNOMAD BrowserENSG00000180011
Varsome BrowserZADH2
Genetic variants : HAPMAP284273
Genomic Variants (DGV)ZADH2 [DGVbeta]
DECIPHERZADH2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisZADH2 
Mutations
ICGC Data PortalZADH2 
TCGA Data PortalZADH2 
Broad Tumor PortalZADH2
OASIS PortalZADH2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICZADH2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDZADH2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)MSeqDR-LSDB Mitochondrial Disease Locus Specific Database
BioMutasearch ZADH2
DgiDB (Drug Gene Interaction Database)ZADH2
DoCM (Curated mutations)ZADH2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)ZADH2 (select a term)
intoGenZADH2
Cancer3DZADH2(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM
Orphanet
DisGeNETZADH2
MedgenZADH2
Genetic Testing Registry ZADH2
NextProtQ8N4Q0 [Medical]
TSGene284273
GENETestsZADH2
Target ValidationZADH2
Huge Navigator ZADH2 [HugePedia]
snp3D : Map Gene to Disease284273
BioCentury BCIQZADH2
ClinGenZADH2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD284273
Chemical/Pharm GKB GenePA134951623
Clinical trialZADH2
Miscellaneous
canSAR (ICR)ZADH2 (select the gene name)
DataMed IndexZADH2
Probes
Litterature
PubMed11 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineZADH2
EVEXZADH2
GoPubMedZADH2
iHOPZADH2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Thu Feb 14 16:12:29 CET 2019
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