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ZAP70 (zeta-chain (TCR) associated protein kinase 70kDa)

Identity

Other namesSRK
STCD
STD
TZK
ZAP-70
HGNC (Hugo) ZAP70
LocusID (NCBI) 7535
Location 2q11.2
Location_base_pair Starts at 98330031 and ends at 98356323 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Leukemias implicated (Data extracted from papers in the Atlas)

Leukemias t0817q24q22ID1494 t1119q23p13ID1540

External links

Nomenclature
HGNC (Hugo)ZAP70   12858
Cards
Entrez_Gene (NCBI)ZAP70  7535  zeta-chain (TCR) associated protein kinase 70kDa
GeneCards (Weizmann)ZAP70
Ensembl (Hinxton)ENSG00000115085 [Gene_View]  chr2:98330031-98356323 [Contig_View]  ZAP70 [Vega]
ICGC DataPortalENSG00000115085
cBioPortalZAP70
AceView (NCBI)ZAP70
Genatlas (Paris)ZAP70
WikiGenes7535
SOURCE (Princeton)NM_001079 NM_207519
Genomic and cartography
GoldenPath (UCSC)ZAP70  -  2q11.2   chr2:98330031-98356323 +  2q11.2   [Description]    (hg19-Feb_2009)
EnsemblZAP70 - 2q11.2 [CytoView]
Mapping of homologs : NCBIZAP70 [Mapview]
OMIM176947   269840   
Gene and transcription
Genbank (Entrez)AB083211 AK303341 AK310628 AK310637 AL832287
RefSeq transcript (Entrez)NM_001079 NM_207519
RefSeq genomic (Entrez)AC_000134 NC_000002 NC_018913 NG_007727 NT_022171 NW_001838818 NW_004929303
Consensus coding sequences : CCDS (NCBI)ZAP70
Cluster EST : UnigeneHs.234569 [ NCBI ]
CGAP (NCI)Hs.234569
Alternative Splicing : Fast-db (Paris)GSHG0016697
Alternative Splicing GalleryENSG00000115085
Gene ExpressionZAP70 [ NCBI-GEO ]     ZAP70 [ SEEK ]   ZAP70 [ MEM ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP43403 (Uniprot)
NextProtP43403  [Medical]
With graphics : InterProP43403
Splice isoforms : SwissVarP43403 (Swissvar)
Catalytic activity : Enzyme2.7.10.2 [ Enzyme-Expasy ]   2.7.10.22.7.10.2 [ IntEnz-EBI ]   2.7.10.2 [ BRENDA ]   2.7.10.2 [ KEGG ]   
Domaine pattern : Prosite (Expaxy)PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_TYR (PS00109)    SH2 (PS50001)   
Domains : Interpro (EBI)Kinase-like_dom [organisation]   Kinase_SYK/ZAP-70_inter-SH2 [organisation]   Prot_kinase_dom [organisation]   Protein_kinase_ATP_BS [organisation]   Ser-Thr/Tyr_kinase_cat_dom [organisation]   SH2 [organisation]   Tyr_kinase_AS [organisation]   Tyr_kinase_cat_dom [organisation]   Tyr_kinase_non-rcpt_SYK/ZAP70 [organisation]  
Related proteins : CluSTrP43403
Domain families : Pfam (Sanger)Pkinase_Tyr (PF07714)    SH2 (PF00017)   
Domain families : Pfam (NCBI)pfam07714    pfam00017   
Domain families : Smart (EMBL)SH2 (SM00252)  TyrKc (SM00219)  
DMDM Disease mutations7535
Blocks (Seattle)P43403
PDB (SRS)1FBV    1M61    1U59    2CBL    2OQ1    2OZO    2Y1N    3ZNI    4A4B    4A4C    4K2R   
PDB (PDBSum)1FBV    1M61    1U59    2CBL    2OQ1    2OZO    2Y1N    3ZNI    4A4B    4A4C    4K2R   
PDB (IMB)1FBV    1M61    1U59    2CBL    2OQ1    2OZO    2Y1N    3ZNI    4A4B    4A4C    4K2R   
PDB (RSDB)1FBV    1M61    1U59    2CBL    2OQ1    2OZO    2Y1N    3ZNI    4A4B    4A4C    4K2R   
Human Protein AtlasENSG00000115085 [gene] [tissue] [antibody] [cell] [cancer]
Peptide AtlasP43403
HPRD01495
IPIIPI00329789   IPI00410185   IPI00885038   
Protein Interaction databases
DIP (DOE-UCLA)P43403
IntAct (EBI)P43403
FunCoupENSG00000115085
BioGRIDZAP70
InParanoidP43403
Interologous Interaction database P43403
IntegromeDBZAP70
STRING (EMBL)ZAP70
Ontologies - Pathways
Ontology : AmiGOimmunological synapse  phosphotyrosine binding  adaptive immune response  protein tyrosine kinase activity  protein tyrosine kinase activity  protein tyrosine kinase activity  non-membrane spanning protein tyrosine kinase activity  protein binding  ATP binding  cytoplasm  cytosol  plasma membrane  protein phosphorylation  protein phosphorylation  immune response  intracellular protein kinase cascade  peptidyl-tyrosine phosphorylation  T cell differentiation  T cell receptor complex  T cell activation  B cell activation  beta selection  positive thymic T cell selection  negative thymic T cell selection  positive regulation of T cell differentiation  positive regulation of alpha-beta T cell differentiation  positive regulation of alpha-beta T cell proliferation  protein autophosphorylation  positive regulation of calcium-mediated signaling  T cell receptor signaling pathway  T cell aggregation  T cell migration  
Ontology : EGO-EBIimmunological synapse  phosphotyrosine binding  adaptive immune response  protein tyrosine kinase activity  protein tyrosine kinase activity  protein tyrosine kinase activity  non-membrane spanning protein tyrosine kinase activity  protein binding  ATP binding  cytoplasm  cytosol  plasma membrane  protein phosphorylation  protein phosphorylation  immune response  intracellular protein kinase cascade  peptidyl-tyrosine phosphorylation  T cell differentiation  T cell receptor complex  T cell activation  B cell activation  beta selection  positive thymic T cell selection  negative thymic T cell selection  positive regulation of T cell differentiation  positive regulation of alpha-beta T cell differentiation  positive regulation of alpha-beta T cell proliferation  protein autophosphorylation  positive regulation of calcium-mediated signaling  T cell receptor signaling pathway  T cell aggregation  T cell migration  
Pathways : BIOCARTAActivation of Csk by cAMP-dependent Protein Kinase Inhibits Signaling through the T Cell Receptor [Genes]    T Cell Receptor Signaling Pathway [Genes]    Lck and Fyn tyrosine kinases in initiation of TCR Activation [Genes]   
Pathways : KEGGRas signaling pathway    NF-kappa B signaling pathway    Natural killer cell mediated cytotoxicity    T cell receptor signaling pathway    Primary immunodeficiency   
Protein Interaction DatabaseZAP70
Wikipedia pathwaysZAP70
Gene fusion - rearrangments
Polymorphisms : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)ZAP70
snp3D : Map Gene to Disease7535
SNP (GeneSNP Utah)ZAP70
SNP : HGBaseZAP70
Genetic variants : HAPMAPZAP70
Exome VariantZAP70
1000_GenomesZAP70 
ICGC programENSG00000115085 
Somatic Mutations in Cancer : COSMICZAP70 
CONAN: Copy Number AnalysisZAP70 
Mutations and Diseases : HGMDZAP70
Genomic VariantsZAP70  ZAP70 [DGVbeta]
dbVarZAP70
ClinVarZAP70
Pred. of missensesPolyPhen-2  SIFT(SG)  SIFT(JCVI)  Align-GVGD  MutAssessor  Mutanalyser  
Pred. splicesGeneSplicer  Human Splicing Finder  MaxEntScan  
Diseases
OMIM176947    269840   
MedgenZAP70
GENETestsZAP70
Disease Genetic AssociationZAP70
Huge Navigator ZAP70 [HugePedia]  ZAP70 [HugeCancerGEM]
General knowledge
Homologs : HomoloGeneZAP70
Homology/Alignments : Family Browser (UCSC)ZAP70
Phylogenetic Trees/Animal Genes : TreeFamZAP70
Chemical/Protein Interactions : CTD7535
Chemical/Pharm GKB GenePA37447
Clinical trialZAP70
Cancer Resource (Charite)ENSG00000115085
Other databases
Probes
Litterature
PubMed261 Pubmed reference(s) in Entrez
CoreMineZAP70
iHOPZAP70
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated12-2013Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Fri Jul 11 17:26:21 CEST 2014

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