ZBTB4 (zinc finger and BTB domain containing 4)

2012-04-01  

Identity

HGNC
ZBTB4
LOCATION
17p13.1
LOCUSID
57659
ALIAS
KAISO-L1,ZNF903
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 57659
MIM: 612308
HGNC: 23847
Ensembl: ENSG00000174282

Variants:

dbSNP: 57659
ClinVar: 57659
TCGA: ENSG00000174282
COSMIC: ZBTB4

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000174282ENST00000311403Q9P1Z0
ENSG00000174282ENST00000380599Q9P1Z0

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
163546882006A family of human zinc finger proteins that bind methylated DNA and repress transcription.95
217654662012Identification of oncogenic microRNA-17-92/ZBTB4/specificity protein axis in breast cancer.75
204038122010Sequence-specific recognition of methylated DNA by human zinc-finger proteins.55
184518022008Zbtb4 represses transcription of P21CIP1 and controls the cellular response to p53 activation.41
194486682009The human protein kinase HIPK2 phosphorylates and downregulates the methyl-binding transcription factor ZBTB4.13
254992192014The transcriptional repressor ZBTB4 regulates EZH2 through a MicroRNA-ZBTB4-specificity protein signaling axis.12
278153882017Loss of the Methyl-CpG-Binding Protein ZBTB4 Alters Mitotic Checkpoint, Increases Aneuploidy, and Promotes Tumorigenesis.10
294257452018Tumor suppressive ZBTB4 inhibits cell growth by regulating cell cycle progression and apoptosis in Ewing sarcoma.4
290450542018Variants regulating ZBTB4 are associated with age-at-onset of Alzheimer's disease.2
315858142019MicroRNA-301b-3p accelerates the growth of gastric cancer cells by targeting zinc finger and BTB domain containing 4.0

Citation

Dessen P

ZBTB4 (zinc finger and BTB domain containing 4)

Atlas Genet Cytogenet Oncol Haematol. 2012-04-01

Online version: http://atlasgeneticsoncology.org/gene/52684/zbtb4