Atlas of Genetics and Cytogenetics in Oncology and Haematology


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ZBTB4 (zinc finger and BTB domain containing 4)

Identity

Alias_symbol (synonym)KIAA1538
KAISO-L1
ZNF903
Other alias
HGNC (Hugo) ZBTB4
LocusID (NCBI) 57659
Atlas_Id 52684
Location 17p13.1  [Link to chromosome band 17p13]
Location_base_pair Starts at 7459366 and ends at 7479625 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
EMX2OS (10q26.11) / ZBTB4 (17p13.1)SYNE1 (6q25.1) / ZBTB4 (17p13.1)TBL1XR1 (3q26.32) / ZBTB4 (17p13.1)
ZBTB4 (17p13.1) / C6orf62 (6p22.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)ZBTB4   23847
Cards
Entrez_Gene (NCBI)ZBTB4  57659  zinc finger and BTB domain containing 4
AliasesKAISO-L1; ZNF903
GeneCards (Weizmann)ZBTB4
Ensembl hg19 (Hinxton)ENSG00000174282 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000174282 [Gene_View]  chr17:7459366-7479625 [Contig_View]  ZBTB4 [Vega]
ICGC DataPortalENSG00000174282
TCGA cBioPortalZBTB4
AceView (NCBI)ZBTB4
Genatlas (Paris)ZBTB4
WikiGenes57659
SOURCE (Princeton)ZBTB4
Genetics Home Reference (NIH)ZBTB4
Genomic and cartography
GoldenPath hg38 (UCSC)ZBTB4  -     chr17:7459366-7479625 -  17p13.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)ZBTB4  -     17p13.1   [Description]    (hg19-Feb_2009)
EnsemblZBTB4 - 17p13.1 [CytoView hg19]  ZBTB4 - 17p13.1 [CytoView hg38]
Mapping of homologs : NCBIZBTB4 [Mapview hg19]  ZBTB4 [Mapview hg38]
OMIM612308   
Gene and transcription
Genbank (Entrez)AB040971 AK027143 AK122826 AK122971 AY302699
RefSeq transcript (Entrez)NM_001128833 NM_020899
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)ZBTB4
Cluster EST : UnigeneHs.35096 [ NCBI ]
CGAP (NCI)Hs.35096
Alternative Splicing GalleryENSG00000174282
Gene ExpressionZBTB4 [ NCBI-GEO ]   ZBTB4 [ EBI - ARRAY_EXPRESS ]   ZBTB4 [ SEEK ]   ZBTB4 [ MEM ]
Gene Expression Viewer (FireBrowse)ZBTB4 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)57659
GTEX Portal (Tissue expression)ZBTB4
Human Protein AtlasENSG00000174282-ZBTB4 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9P1Z0   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9P1Z0  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9P1Z0
Splice isoforms : SwissVarQ9P1Z0
PhosPhoSitePlusQ9P1Z0
Domaine pattern : Prosite (Expaxy)BTB (PS50097)    ZINC_FINGER_C2H2_1 (PS00028)    ZINC_FINGER_C2H2_2 (PS50157)   
Domains : Interpro (EBI)BTB/POZ_dom    SKP1/BTB/POZ    Znf_C2H2    Znf_C2H2-like    Znf_C2H2/integrase_DNA-bd   
Domain families : Pfam (Sanger)BTB (PF00651)   
Domain families : Pfam (NCBI)pfam00651   
Domain families : Smart (EMBL)BTB (SM00225)  ZnF_C2H2 (SM00355)  
Conserved Domain (NCBI)ZBTB4
DMDM Disease mutations57659
Blocks (Seattle)ZBTB4
SuperfamilyQ9P1Z0
Human Protein Atlas [tissue]ENSG00000174282-ZBTB4 [tissue]
Peptide AtlasQ9P1Z0
HPRD11693
IPIIPI00001835   IPI00830097   
Protein Interaction databases
DIP (DOE-UCLA)Q9P1Z0
IntAct (EBI)Q9P1Z0
FunCoupENSG00000174282
BioGRIDZBTB4
STRING (EMBL)ZBTB4
ZODIACZBTB4
Ontologies - Pathways
QuickGOQ9P1Z0
Ontology : AmiGOnegative regulation of transcription from RNA polymerase II promoter  RNA polymerase II regulatory region sequence-specific DNA binding  transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding  protein binding  nucleus  nucleoplasm  chromosome  cytosol  transcription, DNA-templated  cellular response to DNA damage stimulus  methyl-CpG binding  methyl-CpNpG binding  nuclear body  protein kinase binding  protein homodimerization activity  sequence-specific DNA binding  negative regulation of transcription, DNA-templated  metal ion binding  
Ontology : EGO-EBInegative regulation of transcription from RNA polymerase II promoter  RNA polymerase II regulatory region sequence-specific DNA binding  transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding  protein binding  nucleus  nucleoplasm  chromosome  cytosol  transcription, DNA-templated  cellular response to DNA damage stimulus  methyl-CpG binding  methyl-CpNpG binding  nuclear body  protein kinase binding  protein homodimerization activity  sequence-specific DNA binding  negative regulation of transcription, DNA-templated  metal ion binding  
NDEx NetworkZBTB4
Atlas of Cancer Signalling NetworkZBTB4
Wikipedia pathwaysZBTB4
Orthology - Evolution
OrthoDB57659
GeneTree (enSembl)ENSG00000174282
Phylogenetic Trees/Animal Genes : TreeFamZBTB4
HOVERGENQ9P1Z0
HOGENOMQ9P1Z0
Homologs : HomoloGeneZBTB4
Homology/Alignments : Family Browser (UCSC)ZBTB4
Gene fusions - Rearrangements
Tumor Fusion PortalZBTB4
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerZBTB4 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ZBTB4
dbVarZBTB4
ClinVarZBTB4
1000_GenomesZBTB4 
Exome Variant ServerZBTB4
ExAC (Exome Aggregation Consortium)ENSG00000174282
GNOMAD BrowserENSG00000174282
Genetic variants : HAPMAP57659
Genomic Variants (DGV)ZBTB4 [DGVbeta]
DECIPHERZBTB4 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisZBTB4 
Mutations
ICGC Data PortalZBTB4 
TCGA Data PortalZBTB4 
Broad Tumor PortalZBTB4
OASIS PortalZBTB4 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICZBTB4  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDZBTB4
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch ZBTB4
DgiDB (Drug Gene Interaction Database)ZBTB4
DoCM (Curated mutations)ZBTB4 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)ZBTB4 (select a term)
intoGenZBTB4
Cancer3DZBTB4(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM612308   
Orphanet
DisGeNETZBTB4
MedgenZBTB4
Genetic Testing Registry ZBTB4
NextProtQ9P1Z0 [Medical]
TSGene57659
GENETestsZBTB4
Target ValidationZBTB4
Huge Navigator ZBTB4 [HugePedia]
snp3D : Map Gene to Disease57659
BioCentury BCIQZBTB4
ClinGenZBTB4
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD57659
Chemical/Pharm GKB GenePA134959224
Clinical trialZBTB4
Miscellaneous
canSAR (ICR)ZBTB4 (select the gene name)
Probes
Litterature
PubMed13 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineZBTB4
EVEXZBTB4
GoPubMedZBTB4
iHOPZBTB4
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Nov 21 14:42:06 CET 2017

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