ZBTB46 (zinc finger and BTB domain containing 46)

2018-02-01  

Identity

HGNC
LOCATION
20q13.33
LOCUSID
ALIAS
BTBD4,BZEL,RINZF,ZNF340,dJ583P15.7,dJ583P15.8
FUSION GENES

Other Information

Locus ID:

NCBI: 140685
MIM: 614639
HGNC: 16094
Ensembl: ENSG00000130584

Variants:

dbSNP: 140685
ClinVar: 140685
TCGA: ENSG00000130584
COSMIC: ZBTB46

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000130584ENST00000245663Q86UZ6
ENSG00000130584ENST00000302995Q86UZ6
ENSG00000130584ENST00000395104Q86UZ6
ENSG00000130584ENST00000650966A0A494BZW5

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
237399152013MANBA, CXCR5, SOX8, RPS6KB1 and ZBTB46 are genetic risk loci for multiple sclerosis.17
286920462017Inhibition of the androgen receptor induces a novel tumor promoter, ZBTB46, for prostate cancer metastasis.7
303127312019Androgen deprivation-induced ZBTB46-PTGS1 signaling promotes neuroendocrine differentiation of prostate cancer.5
298849092019ZBTB46 is a shear-sensitive transcription factor inhibiting endothelial cell proliferation via gene expression regulation of cell cycle proteins.3
297436542018Expression of the transcription factor ZBTB46 distinguishes human histiocytic disorders of classical dendritic cell origin.1

Citation

Dessen P

ZBTB46 (zinc finger and BTB domain containing 46)

Atlas Genet Cytogenet Oncol Haematol. 2018-02-01

Online version: http://atlasgeneticsoncology.org/gene/57274/zbtb46