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ZBTB46 (zinc finger and BTB domain containing 46)

Identity

Alias (NCBI)BTBD4
BZEL
RINZF
ZNF340
dJ583P15.7
dJ583P15.8
HGNC (Hugo) ZBTB46
HGNC Alias symbFLJ13502
RINZF
BZEL
HGNC Alias nameBTB-ZF protein expressed in effector lymphocytes
HGNC Previous nameZNF340
 BTBD4
HGNC Previous nameBTB (POZ) domain containing 4
LocusID (NCBI) 140685
Atlas_Id 57274
Location 20q13.33  [Link to chromosome band 20q13]
Location_base_pair Starts at 63743670 and ends at 63805503 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
DYRK1A (21q22.13) / ZBTB46 (20q13.33)HEBP1 (12p13.1) / ZBTB46 (20q13.33)MYO18A (17q11.2) / ZBTB46 (20q13.33)
ZBTB46 (20q13.33) / MAFB (20q12)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)ZBTB46   16094
Cards
Entrez_Gene (NCBI)ZBTB46    zinc finger and BTB domain containing 46
AliasesBTBD4; BZEL; RINZF; ZNF340; 
dJ583P15.7; dJ583P15.8
GeneCards (Weizmann)ZBTB46
Ensembl hg19 (Hinxton)ENSG00000130584 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000130584 [Gene_View]  ENSG00000130584 [Sequence]  chr20:63743670-63805503 [Contig_View]  ZBTB46 [Vega]
ICGC DataPortalENSG00000130584
TCGA cBioPortalZBTB46
AceView (NCBI)ZBTB46
Genatlas (Paris)ZBTB46
SOURCE (Princeton)ZBTB46
Genetics Home Reference (NIH)ZBTB46
Genomic and cartography
GoldenPath hg38 (UCSC)ZBTB46  -     chr20:63743670-63805503 -  20q13.33   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)ZBTB46  -     20q13.33   [Description]    (hg19-Feb_2009)
GoldenPathZBTB46 - 20q13.33 [CytoView hg19]  ZBTB46 - 20q13.33 [CytoView hg38]
ImmunoBaseENSG00000130584
Genome Data Viewer NCBIZBTB46 [Mapview hg19]  
OMIM614639   
Gene and transcription
Genbank (Entrez)AK023564 AK126720 AK131482 BC052269 BC073800
RefSeq transcript (Entrez)NM_001369741 NM_025224
Consensus coding sequences : CCDS (NCBI)ZBTB46
Gene ExpressionZBTB46 [ NCBI-GEO ]   ZBTB46 [ EBI - ARRAY_EXPRESS ]   ZBTB46 [ SEEK ]   ZBTB46 [ MEM ]
Gene Expression Viewer (FireBrowse)ZBTB46 [ Firebrowse - Broad ]
GenevisibleExpression of ZBTB46 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)140685
GTEX Portal (Tissue expression)ZBTB46
Human Protein AtlasENSG00000130584-ZBTB46 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ86UZ6   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ86UZ6  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ86UZ6
PhosPhoSitePlusQ86UZ6
Domaine pattern : Prosite (Expaxy)BTB (PS50097)    ZINC_FINGER_C2H2_1 (PS00028)    ZINC_FINGER_C2H2_2 (PS50157)   
Domains : Interpro (EBI)BTB/POZ_dom    SKP1/BTB/POZ_sf    Znf_C2H2_sf    Znf_C2H2_type   
Domain families : Pfam (Sanger)BTB (PF00651)   
Domain families : Pfam (NCBI)pfam00651   
Domain families : Smart (EMBL)BTB (SM00225)  ZnF_C2H2 (SM00355)  
Conserved Domain (NCBI)ZBTB46
SuperfamilyQ86UZ6
AlphaFold pdb e-kbQ86UZ6   
Human Protein Atlas [tissue]ENSG00000130584-ZBTB46 [tissue]
Protein Interaction databases
DIP (DOE-UCLA)Q86UZ6
IntAct (EBI)Q86UZ6
BioGRIDZBTB46
STRING (EMBL)ZBTB46
ZODIACZBTB46
Ontologies - Pathways
QuickGOQ86UZ6
Ontology : AmiGOchromatin  RNA polymerase II transcription regulatory region sequence-specific DNA binding  DNA-binding transcription factor activity, RNA polymerase II-specific  nucleus  regulation of transcription by RNA polymerase II  negative regulation of granulocyte differentiation  negative regulation of macrophage differentiation  negative regulation of monocyte differentiation  metal ion binding  negative regulation of dendritic cell differentiation  positive regulation of dendritic cell differentiation  
Ontology : EGO-EBIchromatin  RNA polymerase II transcription regulatory region sequence-specific DNA binding  DNA-binding transcription factor activity, RNA polymerase II-specific  nucleus  regulation of transcription by RNA polymerase II  negative regulation of granulocyte differentiation  negative regulation of macrophage differentiation  negative regulation of monocyte differentiation  metal ion binding  negative regulation of dendritic cell differentiation  positive regulation of dendritic cell differentiation  
NDEx NetworkZBTB46
Atlas of Cancer Signalling NetworkZBTB46
Wikipedia pathwaysZBTB46
Orthology - Evolution
OrthoDB140685
GeneTree (enSembl)ENSG00000130584
Phylogenetic Trees/Animal Genes : TreeFamZBTB46
Homologs : HomoloGeneZBTB46
Homology/Alignments : Family Browser (UCSC)ZBTB46
Gene fusions - Rearrangements
Fusion : QuiverZBTB46
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerZBTB46 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ZBTB46
dbVarZBTB46
ClinVarZBTB46
MonarchZBTB46
1000_GenomesZBTB46 
Exome Variant ServerZBTB46
GNOMAD BrowserENSG00000130584
Varsome BrowserZBTB46
ACMGZBTB46 variants
VarityQ86UZ6
Genomic Variants (DGV)ZBTB46 [DGVbeta]
DECIPHERZBTB46 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisZBTB46 
Mutations
ICGC Data PortalZBTB46 
TCGA Data PortalZBTB46 
Broad Tumor PortalZBTB46
OASIS PortalZBTB46 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICZBTB46  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DZBTB46
Mutations and Diseases : HGMDZBTB46
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaZBTB46
DgiDB (Drug Gene Interaction Database)ZBTB46
DoCM (Curated mutations)ZBTB46
CIViC (Clinical Interpretations of Variants in Cancer)ZBTB46
Cancer3DZBTB46
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM614639   
Orphanet
DisGeNETZBTB46
MedgenZBTB46
Genetic Testing Registry ZBTB46
NextProtQ86UZ6 [Medical]
GENETestsZBTB46
Target ValidationZBTB46
Huge Navigator ZBTB46 [HugePedia]
ClinGenZBTB46
Clinical trials, drugs, therapy
MyCancerGenomeZBTB46
Protein Interactions : CTDZBTB46
Pharm GKB GenePA25441
PharosQ86UZ6
Clinical trialZBTB46
Miscellaneous
canSAR (ICR)ZBTB46
HarmonizomeZBTB46
DataMed IndexZBTB46
Probes
Litterature
PubMed22 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXZBTB46
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:38:47 CEST 2021

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