ZC3H12A (zinc finger CCCH-type containing 12A)

2013-01-01  

Identity

HGNC
LOCATION
1p34.3
LOCUSID
ALIAS
MCPIP,MCPIP-1,MCPIP1,Reg1,dJ423B22.1
FUSION GENES

Other Information

Locus ID:

NCBI: 80149
MIM: 610562
HGNC: 26259
Ensembl: ENSG00000163874

Variants:

dbSNP: 80149
ClinVar: 80149
TCGA: ENSG00000163874
COSMIC: ZC3H12A

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000163874ENST00000373087Q5D1E8
ENSG00000163874ENST00000471012R4GN17
ENSG00000163874ENST00000640233A0A1W2PQC8

Expression (GTEx)

0
10
20
30
40
50
60
70
80

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
220551882011MCPIP1 ribonuclease antagonizes dicer and terminates microRNA biogenesis through precursor microRNA degradation.98
165749012006Monocyte chemoattractant protein-1 induces a novel transcription factor that causes cardiac myocyte apoptosis and ventricular dysfunction.96
181785542008A novel CCCH-zinc finger protein family regulates proinflammatory activation of macrophages.82
183643572008Monocyte chemotactic protein (MCP)-1 promotes angiogenesis via a novel transcription factor, MCP-1-induced protein (MCPIP).78
197472622009Regulatory feedback loop between NF-kappaB and MCP-1-induced protein 1 RNase.40
233556152013MCPIP1 ribonuclease exhibits broad-spectrum antiviral effects through viral RNA binding and degradation.40
242705722013USP10 inhibits genotoxic NF-κB activation by MCPIP1-facilitated deubiquitination of NEMO.34
231854552012MCPIP1 down-regulates IL-2 expression through an ARE-independent pathway.29
221961382011Participation of MCP-induced protein 1 in lipopolysaccharide preconditioning-induced ischemic stroke tolerance by regulating the expression of proinflammatory cytokines.25
219710512011Monocyte chemotactic protein-induced protein 1 (MCPIP1) suppresses stress granule formation and determines apoptosis under stress.24

Citation

Dessen P

ZC3H12A (zinc finger CCCH-type containing 12A)

Atlas Genet Cytogenet Oncol Haematol. 2013-01-01

Online version: http://atlasgeneticsoncology.org/gene/53150/zc3h12a