Atlas of Genetics and Cytogenetics in Oncology and Haematology


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ZC3H12A (zinc finger CCCH-type containing 12A)

Identity

Alias_symbol (synonym)FLJ23231
MCPIP1
Other aliasMCPIP
MCPIP-1
Reg1
dJ423B22.1
HGNC (Hugo) ZC3H12A
LocusID (NCBI) 80149
Atlas_Id 53150
Location 1p34.3  [Link to chromosome band 1p34]
Location_base_pair Starts at 37474518 and ends at 37484377 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
CFL1 (11q13.1) / ZC3H12A (1p34.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)ZC3H12A   26259
Cards
Entrez_Gene (NCBI)ZC3H12A  80149  zinc finger CCCH-type containing 12A
AliasesMCPIP; MCPIP-1; MCPIP1; Reg1; 
dJ423B22.1
GeneCards (Weizmann)ZC3H12A
Ensembl hg19 (Hinxton)ENSG00000163874 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000163874 [Gene_View]  chr1:37474518-37484377 [Contig_View]  ZC3H12A [Vega]
ICGC DataPortalENSG00000163874
TCGA cBioPortalZC3H12A
AceView (NCBI)ZC3H12A
Genatlas (Paris)ZC3H12A
WikiGenes80149
SOURCE (Princeton)ZC3H12A
Genetics Home Reference (NIH)ZC3H12A
Genomic and cartography
GoldenPath hg38 (UCSC)ZC3H12A  -     chr1:37474518-37484377 +  1p34.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)ZC3H12A  -     1p34.3   [Description]    (hg19-Feb_2009)
EnsemblZC3H12A - 1p34.3 [CytoView hg19]  ZC3H12A - 1p34.3 [CytoView hg38]
Mapping of homologs : NCBIZC3H12A [Mapview hg19]  ZC3H12A [Mapview hg38]
OMIM610562   
Gene and transcription
Genbank (Entrez)AK026884 AK093343 AY920403 BC005001 CR457364
RefSeq transcript (Entrez)NM_001323550 NM_001323551 NM_025079
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)ZC3H12A
Cluster EST : UnigeneHs.656294 [ NCBI ]
CGAP (NCI)Hs.656294
Alternative Splicing GalleryENSG00000163874
Gene ExpressionZC3H12A [ NCBI-GEO ]   ZC3H12A [ EBI - ARRAY_EXPRESS ]   ZC3H12A [ SEEK ]   ZC3H12A [ MEM ]
Gene Expression Viewer (FireBrowse)ZC3H12A [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)80149
GTEX Portal (Tissue expression)ZC3H12A
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ5D1E8   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ5D1E8  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ5D1E8
Splice isoforms : SwissVarQ5D1E8
PhosPhoSitePlusQ5D1E8
Domains : Interpro (EBI)RNase_Zc3h12_NYN   
Domain families : Pfam (Sanger)RNase_Zc3h12a (PF11977)   
Domain families : Pfam (NCBI)pfam11977   
Conserved Domain (NCBI)ZC3H12A
DMDM Disease mutations80149
Blocks (Seattle)ZC3H12A
PDB (SRS)3V32    3V33    3V34   
PDB (PDBSum)3V32    3V33    3V34   
PDB (IMB)3V32    3V33    3V34   
PDB (RSDB)3V32    3V33    3V34   
Structural Biology KnowledgeBase3V32    3V33    3V34   
SCOP (Structural Classification of Proteins)3V32    3V33    3V34   
CATH (Classification of proteins structures)3V32    3V33    3V34   
SuperfamilyQ5D1E8
Human Protein AtlasENSG00000163874
Peptide AtlasQ5D1E8
HPRD08021
IPIIPI00018002   
Protein Interaction databases
DIP (DOE-UCLA)Q5D1E8
IntAct (EBI)Q5D1E8
FunCoupENSG00000163874
BioGRIDZC3H12A
STRING (EMBL)ZC3H12A
ZODIACZC3H12A
Ontologies - Pathways
QuickGOQ5D1E8
Ontology : AmiGOnuclear-transcribed mRNA catabolic process, endonucleolytic cleavage-dependent decay  P-body  angiogenesis  negative regulation of protein phosphorylation  positive regulation of defense response to virus by host  DNA binding  chromatin binding  RNA binding  mRNA binding  mRNA 3'-UTR binding  endoribonuclease activity  exoribonuclease activity  ribonuclease activity  thiol-dependent ubiquitin-specific protease activity  protein binding  nucleus  nucleoplasm  cytoplasm  rough endoplasmic reticulum  cytoskeleton  transcription, DNA-templated  apoptotic process  inflammatory response  cellular response to DNA damage stimulus  nervous system development  regulation of gene expression  positive regulation of autophagy  positive regulation of endothelial cell migration  positive regulation of gene expression  negative regulation of gene expression  negative regulation of muscle cell apoptotic process  positive regulation of lipid storage  positive regulation of cell death  protein deubiquitination  cell differentiation  rough endoplasmic reticulum membrane  negative regulation of NF-kappaB transcription factor activity  negative regulation of interleukin-6 production  negative regulation of tumor necrosis factor production  cellular response to oxidative stress  miRNA binding  RNA stem-loop binding  mRNA 3'-UTR AU-rich region binding  cellular response to glucose starvation  positive regulation of protein import into nucleus  negative regulation of NF-kappaB import into nucleus  extrinsic component of endoplasmic reticulum membrane  ribosome binding  negative regulation of macrophage activation  negative regulation of I-kappaB kinase/NF-kappaB signaling  negative regulation of I-kappaB kinase/NF-kappaB signaling  protein complex  negative regulation by host of viral genome replication  negative regulation of nitric oxide biosynthetic process  positive regulation of fat cell differentiation  positive regulation of angiogenesis  positive regulation of angiogenesis  positive regulation of transcription from RNA polymerase II promoter  metal ion binding  negative regulation of interleukin-1 beta secretion  protein oligomerization  defense response to virus  negative regulation of cardiac muscle contraction  positive regulation of mRNA catabolic process  positive regulation of mRNA catabolic process  3'-UTR-mediated mRNA destabilization  3'-UTR-mediated mRNA destabilization  cellular response to lipopolysaccharide  cellular response to lipopolysaccharide  cellular response to interleukin-1  cellular response to tumor necrosis factor  RNA phosphodiester bond hydrolysis  RNA phosphodiester bond hydrolysis, endonucleolytic  RNA phosphodiester bond hydrolysis, exonucleolytic  cellular response to virus  negative regulation of cytokine production involved in inflammatory response  positive regulation of execution phase of apoptosis  negative regulation of interleukin-6 secretion  positive regulation of p38MAPK cascade  negative regulation of interferon-gamma secretion  positive regulation of protein deubiquitination  negative regulation of production of miRNAs involved in gene silencing by miRNA  cellular response to sodium arsenite  negative regulation of tumor necrosis factor secretion  cellular response to phorbol 13-acetate 12-myristate  cellular response to ionomycin  cellular response to chemokine  positive regulation of reactive oxygen species metabolic process  positive regulation of miRNA catabolic process  
Ontology : EGO-EBInuclear-transcribed mRNA catabolic process, endonucleolytic cleavage-dependent decay  P-body  angiogenesis  negative regulation of protein phosphorylation  positive regulation of defense response to virus by host  DNA binding  chromatin binding  RNA binding  mRNA binding  mRNA 3'-UTR binding  endoribonuclease activity  exoribonuclease activity  ribonuclease activity  thiol-dependent ubiquitin-specific protease activity  protein binding  nucleus  nucleoplasm  cytoplasm  rough endoplasmic reticulum  cytoskeleton  transcription, DNA-templated  apoptotic process  inflammatory response  cellular response to DNA damage stimulus  nervous system development  regulation of gene expression  positive regulation of autophagy  positive regulation of endothelial cell migration  positive regulation of gene expression  negative regulation of gene expression  negative regulation of muscle cell apoptotic process  positive regulation of lipid storage  positive regulation of cell death  protein deubiquitination  cell differentiation  rough endoplasmic reticulum membrane  negative regulation of NF-kappaB transcription factor activity  negative regulation of interleukin-6 production  negative regulation of tumor necrosis factor production  cellular response to oxidative stress  miRNA binding  RNA stem-loop binding  mRNA 3'-UTR AU-rich region binding  cellular response to glucose starvation  positive regulation of protein import into nucleus  negative regulation of NF-kappaB import into nucleus  extrinsic component of endoplasmic reticulum membrane  ribosome binding  negative regulation of macrophage activation  negative regulation of I-kappaB kinase/NF-kappaB signaling  negative regulation of I-kappaB kinase/NF-kappaB signaling  protein complex  negative regulation by host of viral genome replication  negative regulation of nitric oxide biosynthetic process  positive regulation of fat cell differentiation  positive regulation of angiogenesis  positive regulation of angiogenesis  positive regulation of transcription from RNA polymerase II promoter  metal ion binding  negative regulation of interleukin-1 beta secretion  protein oligomerization  defense response to virus  negative regulation of cardiac muscle contraction  positive regulation of mRNA catabolic process  positive regulation of mRNA catabolic process  3'-UTR-mediated mRNA destabilization  3'-UTR-mediated mRNA destabilization  cellular response to lipopolysaccharide  cellular response to lipopolysaccharide  cellular response to interleukin-1  cellular response to tumor necrosis factor  RNA phosphodiester bond hydrolysis  RNA phosphodiester bond hydrolysis, endonucleolytic  RNA phosphodiester bond hydrolysis, exonucleolytic  cellular response to virus  negative regulation of cytokine production involved in inflammatory response  positive regulation of execution phase of apoptosis  negative regulation of interleukin-6 secretion  positive regulation of p38MAPK cascade  negative regulation of interferon-gamma secretion  positive regulation of protein deubiquitination  negative regulation of production of miRNAs involved in gene silencing by miRNA  cellular response to sodium arsenite  negative regulation of tumor necrosis factor secretion  cellular response to phorbol 13-acetate 12-myristate  cellular response to ionomycin  cellular response to chemokine  positive regulation of reactive oxygen species metabolic process  positive regulation of miRNA catabolic process  
NDEx NetworkZC3H12A
Atlas of Cancer Signalling NetworkZC3H12A
Wikipedia pathwaysZC3H12A
Orthology - Evolution
OrthoDB80149
GeneTree (enSembl)ENSG00000163874
Phylogenetic Trees/Animal Genes : TreeFamZC3H12A
HOVERGENQ5D1E8
HOGENOMQ5D1E8
Homologs : HomoloGeneZC3H12A
Homology/Alignments : Family Browser (UCSC)ZC3H12A
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerZC3H12A [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ZC3H12A
dbVarZC3H12A
ClinVarZC3H12A
1000_GenomesZC3H12A 
Exome Variant ServerZC3H12A
ExAC (Exome Aggregation Consortium)ZC3H12A (select the gene name)
Genetic variants : HAPMAP80149
Genomic Variants (DGV)ZC3H12A [DGVbeta]
DECIPHERZC3H12A [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisZC3H12A 
Mutations
ICGC Data PortalZC3H12A 
TCGA Data PortalZC3H12A 
Broad Tumor PortalZC3H12A
OASIS PortalZC3H12A [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICZC3H12A  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDZC3H12A
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch ZC3H12A
DgiDB (Drug Gene Interaction Database)ZC3H12A
DoCM (Curated mutations)ZC3H12A (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)ZC3H12A (select a term)
intoGenZC3H12A
Cancer3DZC3H12A(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM610562   
Orphanet
MedgenZC3H12A
Genetic Testing Registry ZC3H12A
NextProtQ5D1E8 [Medical]
TSGene80149
GENETestsZC3H12A
Huge Navigator ZC3H12A [HugePedia]
snp3D : Map Gene to Disease80149
BioCentury BCIQZC3H12A
ClinGenZC3H12A
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD80149
Chemical/Pharm GKB GenePA142670537
Clinical trialZC3H12A
Miscellaneous
canSAR (ICR)ZC3H12A (select the gene name)
Probes
Litterature
PubMed47 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineZC3H12A
EVEXZC3H12A
GoPubMedZC3H12A
iHOPZC3H12A
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Fri May 19 12:44:35 CEST 2017

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