ZC3H14 (zinc finger CCCH-type containing 14)

2014-11-01  

Identity

HGNC
LOCATION
14q31.3
LOCUSID
ALIAS
MRT56,MSUT-2,NY-REN-37,SUT2,UKp68
FUSION GENES

Other Information

Locus ID:

NCBI: 79882
MIM: 613279
HGNC: 20509
Ensembl: ENSG00000100722

Variants:

dbSNP: 79882
ClinVar: 79882
TCGA: ENSG00000100722
COSMIC: ZC3H14

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000100722ENST00000251038Q6PJT7
ENSG00000100722ENST00000302216Q6PJT7
ENSG00000100722ENST00000318308Q6PJT7
ENSG00000100722ENST00000336693Q6PJT7
ENSG00000100722ENST00000393514Q6PJT7
ENSG00000100722ENST00000406216Q6PJT7
ENSG00000100722ENST00000553495G3V2X4
ENSG00000100722ENST00000554602G3V473
ENSG00000100722ENST00000555120G3V240
ENSG00000100722ENST00000555755Q6PJT7
ENSG00000100722ENST00000555792H0YJ51
ENSG00000100722ENST00000555799G3V3Y4
ENSG00000100722ENST00000555900G3V411
ENSG00000100722ENST00000556000H0YJA2
ENSG00000100722ENST00000556110H0YJ87
ENSG00000100722ENST00000556158G3V3R9
ENSG00000100722ENST00000556945G3V256
ENSG00000100722ENST00000557047A0A087WTC9
ENSG00000100722ENST00000557607G3V5I6
ENSG00000100722ENST00000557693G3V572
ENSG00000100722ENST00000557737G3V4R5
ENSG00000100722ENST00000649731A0A3B3IT62

Expression (GTEx)

0
5
10
15
20
25
30
35
40

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
176302872007Recognition of polyadenosine RNA by zinc finger proteins.41
217341512011Mutation of the conserved polyadenosine RNA binding protein, ZC3H14/dNab2, impairs neural function in Drosophila and humans.31
193030452009Splice variants of the human ZC3H14 gene generate multiple isoforms of a zinc finger polyadenosine RNA binding protein.25
246717642014A conserved role for the zinc finger polyadenosine RNA binding protein, ZC3H14, in control of poly(A) tail length.21
213550462011MSUT2 is a determinant of susceptibility to tau neurotoxicity.20
275630652016The Polyadenosine RNA-binding Protein, Zinc Finger Cys3His Protein 14 (ZC3H14), Regulates the Pre-mRNA Processing of a Key ATP Synthase Subunit mRNA.7
206589872010The role of MSUT-2 in tau neurotoxicity: a target for neuroprotection in tauopathy?3
303717402019Downregulation of ZC3H14 driven by chromosome 14q31 deletion promotes hepatocellular carcinoma progression by activating integrin signaling.1

Citation

Dessen P

ZC3H14 (zinc finger CCCH-type containing 14)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/75881/zc3h14